Alefacept for psoriasis and psoriatic arthritis.

abstract：:An 85 year old man with a longstanding history of non-tophaceous gout developed a single large tophus, unassociated with inflammation, on his paretic leg over a six week period following an acute hemiplegia. The rapidity of tophus formation, its localisation to the paretic limb, and the apparent blunting of the acute ...

journal_title：Annals of the rheumatic diseases

authors： Donegan CF,Berman P,Doherty M

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVES:To determine if the presence of low percentages of CD8 positive cells or high levels of soluble interleukin-2 receptors (sIL-2R) define a subgroup of patients with more severe polymyalgia rheumatica and giant cell arteritis (PMR/GCA). METHODS:38 PMR/GCA patients were followed up prospectively. Serum levels ...

journal_title：Annals of the rheumatic diseases

authors： Salvarani C,Boiardi L,Macchioni P,Rossi F,Tartoni P,Casadei Maldini M,Mancini R,Beltrandi E,Portioli I

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:To improve the understanding of the pathogenesis of rheumatoid arthritis (RA) by identifying novel, disease specific autoantibodies. METHODS:Total protein preparations from synovial membranes were separated electrophoretically and immunoblotted. Sera from RA patients were screened for predominant immunoreact...

journal_title：Annals of the rheumatic diseases

authors： Bläss S,Specker C,Lakomek HJ,Schneider EM,Schwochau M

更新日期：1995-05-01 00:00:00

abstract：:A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in p...

journal_title：Annals of the rheumatic diseases

authors： Martin MF,Dieppe PA,Jones HE,Warren C,Whicher J,Kohn J

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVE:To formulate EULAR recommendations for the management of early arthritis. METHODS:In accordance with EULAR's "standardised operating procedures", the task force pursued an evidence based approach and an approach based on expert opinion. A steering group comprised of 14 rheumatologists representing 10 Europea...

journal_title：Annals of the rheumatic diseases

authors： Combe B,Landewe R,Lukas C,Bolosiu HD,Breedveld F,Dougados M,Emery P,Ferraccioli G,Hazes JM,Klareskog L,Machold K,Martin-Mola E,Nielsen H,Silman A,Smolen J,Yazici H

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

journal_title：Annals of the rheumatic diseases

authors： Majeed M,McQueen F,Yeoman S,McLean L

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population. METHOD:The screening questionnaire was based on signs and symptoms, previous diagnosis of OA and validated OA criteria. A random sample of telephone nu...

journal_title：Annals of the rheumatic diseases

authors： Roux CH,Saraux A,Mazieres B,Pouchot J,Morvan J,Fautrel B,Testa J,Fardellone P,Rat AC,Coste J,Guillemin F,Euller-Ziegler L,KHOALA Osteoarthritis Group.

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Antiphospholipid antibodies (aPLA) have been shown to enhance thrombus formation by increasing the expression of adhesive receptors such as P-selectin on endothelial cells. The P-selectin counter-receptor on leucocytes is P-selectin glycoprotein ligand-1 (PSGL-1). We have previously described a variable numb...

journal_title：Annals of the rheumatic diseases

authors： Diz-Kucukkaya R,Inanc M,Afshar-Kharghan V,Zhang QE,López JA,Pekcelen Y

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Prior studies have suggested a potential link between nasal microbes and granulomatosis with polyangiitis (GPA; Wegener's), but these studies relied on culture-dependent methods. This study comprehensively examined the entire community of nasal microbiota (bacteria and fungi) in participants with GPA compare...

journal_title：Annals of the rheumatic diseases

authors： Rhee RL,Sreih AG,Najem CE,Grayson PC,Zhao C,Bittinger K,Collman RG,Merkel PA

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Gastrointestinal manifestations are seen in systemic sclerosis and mixed connective tissue disorders but are rare in pure polymyositis. CASE REPORT:A 44 year old woman with polymyositis who developed total gut failure requiring treatment with total parenteral nutrition is described. RESULTS:The patient's p...

journal_title：Annals of the rheumatic diseases

authors： Hughes AJ,Ferguson I,Rankin E,Kane K

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Target trial emulation is an intuitive design framework that encourages investigators to formulate their comparative effectiveness research (CER) question as a hypothetical randomised controlled trial (RCT). Our aim was to systematically review CER studies in rheumatoid arthritis (RA) to provide examples of ...

journal_title：Annals of the rheumatic diseases

authors： Zhao SS,Lyu H,Solomon DH,Yoshida K

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Assess golimumab's long-term efficacy/safety in psoriatic arthritis (PsA). METHODS:Adults with active PsA (≥3 swollen and tender joints, active psoriasis) were randomly assigned to subcutaneous placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks (q4wks) through wk20. All patients received golimumab ...

journal_title：Annals of the rheumatic diseases

authors： Kavanaugh A,McInnes IB,Mease P,Krueger GG,Gladman D,van der Heijde D,Zhou Y,Lu J,Leu JH,Goldstein N,Beutler A

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I). METHODS:Arthritis patients from the DANBIO database were followed-up for cancer in the Danish Cancer Registry during 2000-2008. RESULTS:Hazard ratio for cancer overall was 1.02 (95% confidence inte...

journal_title：Annals of the rheumatic diseases

authors： Dreyer L,Mellemkjær L,Andersen AR,Bennett P,Poulsen UE,Juulsgaard Ellingsen T,Hansen TH,Jensen DV,Linde L,Lindegaard HM,Loft AG,Nordin H,Omerovic E,Rasmussen C,Schlemmer A,Tarp U,Hetland ML

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with arthritis demonstrated tyrosine hydroxylase-positive (TH(+)) cells in arthritic synovium and parallel loss of sympathetic nerve fibres. The exact function of TH(+) cells and mode of TH induction are not known. METHODS:Synovial cells of ...

journal_title：Annals of the rheumatic diseases

authors： Jenei-Lanzl Z,Capellino S,Kees F,Fleck M,Lowin T,Straub RH

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To assess survival and identify predictors of survival in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated in the Scleroderma Lung Studies (SLS) I and II. METHODS:SLS I randomised 158 patients with SSc-ILD to 1  year of oral cyclophosphamide (CYC) vs placebo. SLS II rando...

journal_title：Annals of the rheumatic diseases

authors： Volkmann ER,Tashkin DP,Sim M,Li N,Goldmuntz E,Keyes-Elstein L,Pinckney A,Furst DE,Clements PJ,Khanna D,Steen V,Schraufnagel DE,Arami S,Hsu V,Roth MD,Elashoff RM,Sullivan KM,SLS I and SLS II study groups.

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint cartilage tissue homeostasis and the modulating effect herein of Dio2 deficiency. METHODS:Wild-type and C57BL/6-Dio2(-/-) -mice were s...

journal_title：Annals of the rheumatic diseases

authors： Bomer N,Cornelis FM,Ramos YF,den Hollander W,Storms L,van der Breggen R,Lakenberg N,Slagboom PE,Meulenbelt I,Lories RJ

更新日期：2016-03-01 00:00:00

abstract：:Twenty seven patients with primary or possible Sjögren's syndrome with neurological manifestations were compared immunologically with 21 patients with Sjögren's syndrome with an intact nervous system. Patients with Sjögren's syndrome were divided into seropositive and seronegative subgroups with respect to the occurre...

journal_title：Annals of the rheumatic diseases

authors： Hietaharju A,Korpela M,Ilonen J,Frey H

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA). METHODS:A randomised, double-blind, placebo-controlled, dose-e...

journal_title：Annals of the rheumatic diseases

authors： Burmester GR,Feist E,Sleeman MA,Wang B,White B,Magrini F

更新日期：2011-09-01 00:00:00

abstract：:Serum IgG antibodies to native and denatured human type II collagen (Col II) were measured using an enzyme linked immunosorbent assay (ELISA). One hundred and thirty one patients with various forms of arthritis such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PSA). Reiter's Syndrome...

journal_title：Annals of the rheumatic diseases

authors： Choi EK,Gatenby PA,McGill NW,Bateman JF,Cole WG,York JR

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVES:To identify predictors of clinical remission as well as of no x-ray progression in a cohort of early rheumatoid arthritis (ERA) treated with a tight-control protocol. METHODS:A total of 121 consecutive patients with ERA were treated to reach European League Against Rheumatism (EULAR) and/or American College...

journal_title：Annals of the rheumatic diseases

authors： Bosello S,Fedele AL,Peluso G,Gremese E,Tolusso B,Ferraccioli G

更新日期：2011-07-01 00:00:00

abstract：:Evidence is presented that a single injection of bacterial antigen in oil into a footpad of rats of 5 strains induced different clinical forms of adjuvant disease in the individual rat strains. Rats were injected with 300 micrograms heat-killed Mycobacterium tuberculosis in 50 microliters paraffin. Inflammatory lesion...

journal_title：Annals of the rheumatic diseases

authors： Muir VY,Dumonde DC

更新日期：1982-10-01 00:00:00

abstract：:A study of the walking activities of 243 individuals was carried out. The individuals came from four different occupations and had an age range of 17-83 years. The survey carried out in this investigation showed surprisingly little correlation between variables such as age, height, and weight of individuals and their ...

journal_title：Annals of the rheumatic diseases

authors： Seedhom BB,Wallbridge NC

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the influences of radiographic severity, quadriceps strength, knee pain, age, and gender on functional ability in patients with osteoarthritis of the knee. METHODS:Equal numbers of knee pain positive and negative respondents to a survey of registrants aged more than 55 years at a general practic...

journal_title：Annals of the rheumatic diseases

authors： McAlindon TE,Cooper C,Kirwan JR,Dieppe PA

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

更新日期：2004-02-01 00:00:00

abstract：:A 15 year old girl who had pain, oedema of her left hand, and fever of four months' duration is described. Marked demineralisation of her hand was shown by radiography, and increased articular uptake by technetium-99m bone scan. All these changes were indistinguishable from reflex sympathetic dystrophy. After two admi...

journal_title：Annals of the rheumatic diseases

authors： Rodriguez-Moreno J,Ruiz-Martin JM,Mateo-Soria L,Rozadilla A,Roig-Escofet D

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. METH...

journal_title：Annals of the rheumatic diseases

authors： Rasmussen A,Ice JA,Li H,Grundahl K,Kelly JA,Radfar L,Stone DU,Hefner KS,Anaya JM,Rohrer M,Gopalakrishnan R,Houston GD,Lewis DM,Chodosh J,Harley JB,Hughes P,Maier-Moore JS,Montgomery CG,Rhodus NL,Farris AD,Segal BM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Physical function in rheumatoid arthritis (RA) has reversible and irreversible components, and is typically assessed by the Health Assessment Questionnaire Disability Index (HAQ). Since irreversible components are expected to increase with longer duration of RA and reduce the ability for improvement in physi...

journal_title：Annals of the rheumatic diseases

authors： Aletaha D,Strand V,Smolen JS,Ward MM

更新日期：2008-02-01 00:00:00

abstract：:A 17-year-old female patient with systemic lupus erythematosus (SLE) developed chronic tophaceous gout, chondrocalcinosis and articular capsule calcification in several joints. Analysis of synovial fluid and tophi revealed the coexistence of monosodium urate, calcium pyrophosphate, hydroxyapatite, and cholesterol crys...

journal_title：Annals of the rheumatic diseases

authors： Rodríguez MA,Paul H,Abadí I,Bravo JR,Armas P

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVES:Little is known about the likelihood of developing inflammatory arthritis (IA) in individuals who screen autoantibody positive (aAb+) in a non-clinical research setting. METHODS:We screened for serum cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor isotype aAbs in subjects who were at ...

journal_title：Annals of the rheumatic diseases

authors： Bemis EA,Demoruelle MK,Seifert JA,Polinski KJ,Weisman MH,Buckner JH,Gregersen PK,Mikuls TR,ODell JR,Keating RM,Deane KD,Holers VM,Norris JM

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether methotrexate or tumour necrosis factor inhibitors (TNFi) affect osteophyte formation in patients with psoriatic arthritis (PsA). METHODS:41 patients with PsA were examined for the presence of osteophytes and erosions at the metacarpophalangeal joints by high-resolution micro-CT imagin...

journal_title：Annals of the rheumatic diseases

authors： Finzel S,Kraus S,Schmidt S,Hueber A,Rech J,Engelke K,Englbrecht M,Schett G

更新日期：2013-07-01 00:00:00