Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs.

abstract：BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

journal_title：Annals of the rheumatic diseases

authors： Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:To clarify the effect of pressure on the expressions of proteoglycan core protein and metabolism related cytokines in a chondrocyte-like cell line, HCS-2/8. METHODS:HCS-2/8 cells were exposed to 1, 5, 10, or 50 MPa of hydrostatic pressure (HP) for two hours, and mRNA expressions of interleukin 6 (IL6) and t...

journal_title：Annals of the rheumatic diseases

authors： Takahashi K,Kubo T,Arai Y,Kitajima I,Takigawa M,Imanishi J,Hirasawa Y

更新日期：1998-04-01 00:00:00

abstract：:(1) An epidemiological study of a rural African community has been carried out in the Western Transvaal. Altogether 801 respondents over 15 years old were examined; radiographs of the hands and feet were obtained in all these individuals. Serological tests for rheumatoid factor were carried out on 516 blood samples. (...

journal_title：Annals of the rheumatic diseases

authors： Beighton P,Solomon L,Valkenburg HA

更新日期：1975-04-01 00:00:00

abstract：OBJECTIVE:To elucidate factors involved in the arthritogenicity of bacterial cell walls. METHODS:For characterisation of an arthritogenic Eubacterium aerofaciens cell wall, peptidoglycan-polysaccharide (PG-PS) polymers were isolated by removing cell wall associated proteins (CWPs), PG and PS moieties were separated, a...

journal_title：Annals of the rheumatic diseases

authors： Zhang X,Rimpiläinen M,Simelyte E,Toivanen P

更新日期：2001-03-01 00:00:00

abstract：:In a double blind, single observer, 48 week study the effects of sulphasalazine (2 g daily) and hydroxychloroquine (400 mg daily months 0-6, thereafter 200 mg daily) were compared in 60 patients with definite or classical rheumatoid arthritis. They had not been treated previously with second line drugs. The onset of r...

journal_title：Annals of the rheumatic diseases

authors： Nuver-Zwart IH,van Riel PL,van de Putte LB,Gribnau FW

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:To determine the diagnostic value of beta 2 microglobulin in parotid saliva, its concentration in relation to salivary flow was determined in 29 patients with primary Sjögren's syndrome and in 30 normal controls. The specific secretion rate of beta 2 microglobulin was calculated. METHODS:Parotid saliva samp...

journal_title：Annals of the rheumatic diseases

authors： van der Geest SA,Markusse HM,Swaak AJ

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Antibodies targeting citrullinated antigens are specific for rheumatoid arthritis (RA). Citrullination is catalysed by the peptidylarginine deiminase (PAD) enzyme family. Critical enzymes are often targeted by disease-specific antibodies in complex immune-mediated diseases. Here, we have tested for autoantib...

journal_title：Annals of the rheumatic diseases

authors： Halvorsen EH,Pollmann S,Gilboe IM,van der Heijde D,Landewé R,Ødegård S,Kvien TK,Molberg Ø

更新日期：2008-03-01 00:00:00

abstract：:A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other t...

journal_title：Annals of the rheumatic diseases

authors： Allard SA,King RH,Thomas PK,Bourke BE

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:To identify differentially expressed genes in peripheral blood mononuclear cells (PBMCs) from patients with ankylosing spondylitis (AS) compared with healthy individuals. METHODS:RNA was extracted from PBMCs collected from 18 patients with active disease and 18 gender-matched and age-matched controls. Expres...

journal_title：Annals of the rheumatic diseases

authors： Duan R,Leo P,Bradbury L,Brown MA,Thomas G

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Advances in health measurement have led to the application of Rasch Item Response Theory (IRT) analysis (Rasch analysis) to evaluate instruments measuring health status and quality of life of patients, including the Health Assessment Questionnaire and SF-36. This study investigated the extent to which the Wes...

journal_title：Annals of the rheumatic diseases

authors： Wolfe F,Kong SX

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/β-catenin pathway influences osteoblast differentiation. Dickkopf-1 (Dkk-1) and sclerostin (So...

journal_title：Annals of the rheumatic diseases

authors： de Rooy DP,Yeremenko NG,Wilson AG,Knevel R,Lindqvist E,Saxne T,Krabben A,Leijsma MK,Daha NA,Tsonaka S,Zhernakova A,Houwing-Duistermaat JJ,Huizinga TW,Toes RE,Baeten DL,Brouwer E,van der Helm-van Mil AH

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:To study the reliability and construct validity of ultrasound in interphalangeal finger joints affected by erosive osteoarthritis (EOA) and non-EOA with MRI as the reference method. METHODS:252 joints were examined by ultrasound, conventional radiography and clinical examination. Ultrasound was performed us...

journal_title：Annals of the rheumatic diseases

authors： Wittoek R,Jans L,Lambrecht V,Carron P,Verstraete K,Verbruggen G

更新日期：2011-02-01 00:00:00

abstract：:Antibody production in response to the primary immunogen bacteriophage phi X174 was investigated in 14 patients with previous yersinia arthritis (YA) and in 15 controls. HLA-B27 occurred in 10 patients with YA and in three controls. After primary and secondary immunisation the antibody responses were essentially simil...

journal_title：Annals of the rheumatic diseases

authors： Bucknall R,Leirisalo-Repo M,Laitinen O,Jones JV

更新日期：1987-12-01 00:00:00

abstract：:Overdiagnosis is a term coined by experts in cancer screening to point to indolent cancers detected by screening that would have never led to manifest health problems. Overdiagnosis leads to unnecessary medical care (overtreatment), anxiety and cost. In rheumatology overdiagnosis and overtreatment are hardly discussed...

journal_title：Annals of the rheumatic diseases

authors： Landewé RBM

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

journal_title：Annals of the rheumatic diseases

authors： Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Whether preradiographic lesions in knees at risk for osteoarthritis are incidental versus disease is unclear. We hypothesised, in persons without but at higher risk for knee osteoarthritis, that: 12-48 month MRI lesion status worsening is associated with 12-48 month incident radiographic osteoarthritis (obje...

journal_title：Annals of the rheumatic diseases

authors： Sharma L,Nevitt M,Hochberg M,Guermazi A,Roemer FW,Crema M,Eaton C,Jackson R,Kwoh K,Cauley J,Almagor O,Chmiel JS

更新日期：2016-09-01 00:00:00

abstract：:This paper reports the spontaneous development of synovitis in 'Old English' rabbits concurrent with serum IgM rheumatoid factor. Female rabbits developed lesions at a higher incidence than males (42% compared with 17%) and the pathology was of a more severe nature. In the female rabbits synovitis was associated with ...

journal_title：Annals of the rheumatic diseases

authors： Hanglow AC,Welsh CJ,Conn P,Thomas DS,Coombs RR

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVES:The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early,...

journal_title：Annals of the rheumatic diseases

authors： Gohar F,McArdle A,Jones M,Callan N,Hernandez B,Kessel C,Miranda-Garcia M,Lavric M,Holzinger D,Pretzer C,Lainka E,Vastert SJ,de Roock S,FitzGerald O,Pennington SR,Foell D

更新日期：2019-08-01 00:00:00

abstract：:The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine patellae was studied. Exogenously added TGF beta up to a concentration of 200 pmol/l had no effect on proteoglycan synthesis in intact articular cartilage. Neutralisat...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,van den Berg WB

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS:970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The pri...

journal_title：Annals of the rheumatic diseases

authors： Lohmander LS,McKeith D,Svensson O,Malmenäs M,Bolin L,Kalla A,Genti G,Szechinski J,Ramos-Remus C,STAR Multinational Study Group.

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To evaluate changes in health-related quality of life (HRQoL) in patients with refractory juvenile idiopathic arthritis (JIA) who are being treated with etanercept. METHODS:53 patients with JIA from seven Dutch centres were included. HRQoL was measured by the Childhood Health Assessment Questionnaire (CHAQ),...

journal_title：Annals of the rheumatic diseases

authors： Prince FH,Geerdink LM,Borsboom GJ,Twilt M,van Rossum MA,Hoppenreijs EP,Cate RT,Koopman-Keemink Y,van Santen-Hoeufft M,Raat H,van Suijlekom-Smit LW

更新日期：2010-01-01 00:00:00

abstract：:Two patients (one male, one female) with ankylosing spondylitis (AS) and IgA nephropathy are described. The female patient is the first reported case to have AS and IgA nephropathy concurrently. Contrary to previously reported cases, her renal manifestation preceded her rheumatic symptoms. It is suggested that women w...

journal_title：Annals of the rheumatic diseases

authors： Lai KN,Li PK,Hawkins B,Lai FM

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. METHODS:This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs ...

journal_title：Annals of the rheumatic diseases

authors： Conaghan PG,D'Agostino MA,Le Bars M,Baron G,Schmidely N,Wakefield R,Ravaud P,Grassi W,Martin-Mola E,So A,Backhaus M,Malaise M,Emery P,Dougados M

更新日期：2010-04-01 00:00:00

abstract：:A previous report that C3 activation products are demonstrable in the plasma of subjects with rheumatoid arthritis was reinvestigated using 2-dimensional immunoelectrophoresis. Initially it seemed that results were in agreement, but the occurrence of similar patterns in normal sera and poor reproducibility of results ...

journal_title：Annals of the rheumatic diseases

authors： Shadforth MF,McNaughton DC

更新日期：1978-02-01 00:00:00

abstract：:We report two cases of osteomyelitis secondary to staphylococcal septicaemia, presenting with large sterile effusions in adjacent joints. In both cases the clinical features were suggestive of septic arthritis. Multiple joints were involved in each patient. Initial radiographs showed no abnormalities. ...

journal_title：Annals of the rheumatic diseases

authors： Platt PN,Griffiths ID

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:The MEFV gene is responsible for familial Mediterranean fever (FMF). Several disease associated mutations have been identified. The range of genetic variation in MEFV in Greek patients has not been determined. OBJECTIVE:To describe a method that facilitates the routine screening of the entire coding sequenc...

journal_title：Annals of the rheumatic diseases

authors： Ritis K,Giaglis S,Spathari N,Micheli A,Zonios D,Tzoanopoulos D,Deltas CC,Rafail S,Mean R,Papadopoulos V,Tzioufas AG,Moutsopoulos HM,Kartalis G

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). OBJECTIVES:To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. METHODS:Male Sprague Dawley rats (140-260 g) were...

journal_title：Annals of the rheumatic diseases

authors： Sagar DR,Ashraf S,Xu L,Burston JJ,Menhinick MR,Poulter CL,Bennett AJ,Walsh DA,Chapman V

更新日期：2014-08-01 00:00:00

abstract：:In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in response to alterations in the environment owing to mechanical injury and inflammation. These processes not only stimulate the production of enzymes that degrade the cartilage matrix but also inhibit repair. With the use of in vitro ...

journal_title：Annals of the rheumatic diseases

authors： Goldring MB,Otero M,Tsuchimochi K,Ijiri K,Li Y

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:The effect of adalimumab on hand osteoporosis was examined and related to radiographic joint damage in the three treatment arms of the PREMIER study: adalimumab plus methotrexate, adalimumab and methotrexate monotherapy. Predictors of hand bone loss were also searched for. METHODS:768 patients (537 fulfilled...

journal_title：Annals of the rheumatic diseases

authors： Hoff M,Kvien TK,Kälvesten J,Elden A,Haugeberg G

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Increased apoptosis may induce autoimmune conditions. Apoptosis is induced by binding of death receptor ligands, members of the tumour necrosis factor (TNF) superfamily, to their cognate receptors. The Fas-Fas ligand pathway has been studied extensively in relation to systemic lupus erythematosus (SLE). Howe...

journal_title：Annals of the rheumatic diseases

authors： Lub-de Hooge MN,de Vries EG,de Jong S,Bijl M

更新日期：2005-06-01 00:00:00