Polymyositis as a cause of total gut failure.

abstract：OBJECTIVE:To evaluate the contribution of polymorphisms in the vitamin D receptor (VDR) gene to ethnic variations in bone mass in mother and children from different ethnic origins. METHODS:VDR genotypes and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. Al...

journal_title：Annals of the rheumatic diseases

authors： Nelson DA,Vande Vord PJ,Wooley PH

更新日期：2000-08-01 00:00:00

abstract：:Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia an...

journal_title：Annals of the rheumatic diseases

authors： Granfors K,Toivanen A

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Antibodies targeting citrullinated antigens are specific for rheumatoid arthritis (RA). Citrullination is catalysed by the peptidylarginine deiminase (PAD) enzyme family. Critical enzymes are often targeted by disease-specific antibodies in complex immune-mediated diseases. Here, we have tested for autoantib...

journal_title：Annals of the rheumatic diseases

authors： Halvorsen EH,Pollmann S,Gilboe IM,van der Heijde D,Landewé R,Ødegård S,Kvien TK,Molberg Ø

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Based upon findings in juvenile idiopathic arthritis, the genetic contribution of the VTCN1 region to rheumatoid arthritis (RA) susceptibility and anticitrullinated protein antibody (ACPA) status was investigated. VTCN1 is known to play a pivotal role in regulation of the immune system and, in soluble form, h...

journal_title：Annals of the rheumatic diseases

authors： Daha NA,Lie BA,Trouw LA,Stoeken G,Schonkeren JJ,Ding B,Kvien TK,Schilham MW,Padyukov L,Huizinga TW,Toes R

更新日期：2012-04-01 00:00:00

abstract：:Joint damage in rheumatoid arthritis is assessed radiologically. Previous studies have not examined in detail its long term progression. We evaluated the overall changes of peripheral joint damage radiologically in 50 rheumatoid patients followed up at one rheumatology centre for 10 years. All peripheral joints were s...

journal_title：Annals of the rheumatic diseases

authors： Scott DL,Coulton BL,Popert AJ

更新日期：1986-05-01 00:00:00

abstract：:105 consecutive patients who presented to a rheumatologist because of joint disease and who also had evidence of deposition of calcium pyrophosphate dihydrate (CPD) were studied clinically and radiologically. There were 76 women (mean age 73) and 29 men (mean age 62). Of only 18 patients below the age of 60 at present...

journal_title：Annals of the rheumatic diseases

authors： Dieppe PA,Alexander GJ,Jones HE,Doherty M,Scott DG,Manhire A,Watt I

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence and characteristics of musculoskeletal manifestations in polymyalgia rheumatica (PMR) and temporal arteritis (TA). METHODS:The records of 163 cases of PMR or TA diagnosed over a 15 year period in one area of Spain were reviewed for the presence and type of musculoskeletal manifestat...

journal_title：Annals of the rheumatic diseases

authors： Narváez J,Nolla-Solé JM,Narváez JA,Clavaguera MT,Valverde-García J,Roig-Escofet D

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To assess the intra and interobserver reproducibility of musculoskeletal ultrasonography (US) among rheumatologists in detecting destructive and inflammatory shoulder abnormalities in patients with rheumatoid arthritis (RA) and to determine the overall agreement between US and MRI. METHODS:A total of 14 obse...

journal_title：Annals of the rheumatic diseases

authors： Bruyn GA,Naredo E,Möller I,Moragues C,Garrido J,de Bock GH,d'Agostino MA,Filippucci E,Iagnocco A,Backhaus M,Swen WA,Balint P,Pineda C,Milutinovic S,Kane D,Kaeley G,Narvaez FJ,Wakefield RJ,Narvaez JA,de Augustin J,

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:In a post-hoc analysis, we aimed to validate the Lupus Low Disease Activity State (LLDAS) definition as an endpoint in an systemic lupus erythematosus (SLE) Phase IIb randomised controlled trial (RCT) (MUSE [NCT01438489]) and then utilize LLDAS to discriminate between anifrolumab and placebo. METHODS:Patien...

journal_title：Annals of the rheumatic diseases

authors： Morand EF,Trasieva T,Berglind A,Illei GG,Tummala R

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:A disease activity-guided dose optimisation strategy of adalimumab or etanercept (TNFi (tumour necrosis factor inhibitors)) has shown to be non-inferior in maintaining disease control in patients with rheumatoid arthritis (RA) compared with usual care. However, the cost-effectiveness of this strategy is stil...

journal_title：Annals of the rheumatic diseases

authors： Kievit W,van Herwaarden N,van den Hoogen FH,van Vollenhoven RF,Bijlsma JW,van den Bemt BJ,van der Maas A,den Broeder AA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE. METHODS:The relationship between maternal age at littering and frequency of AE was analy...

journal_title：Annals of the rheumatic diseases

authors： Weinreich S,Hoebe B,Ivanyi P

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis (RA) in populations of Northern European descent. The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (I...

journal_title：Annals of the rheumatic diseases

authors： Naseem H,Thomson W,Silman A,Worthington J,Symmons D,Barton A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Prevalence estimates of rheumatoid arthritis (RA) vary across Europe. Recent estimates in southern European countries showed a lower prevalence than in northern countries. OBJECTIVES:To estimate the prevalence of RA in France in a multiregional representative sample in the year 2001. METHODS:A two stage ra...

journal_title：Annals of the rheumatic diseases

authors： Guillemin F,Saraux A,Guggenbuhl P,Roux CH,Fardellone P,Le Bihan E,Cantagrel A,Chary-Valckenaere I,Euller-Ziegler L,Flipo RM,Juvin R,Behier JM,Fautrel B,Masson C,Coste J

更新日期：2005-10-01 00:00:00

abstract：:Gout and classical rheumatoid arthritis rarely coexist. We report a patient with strong evidence for both these diseases. Possible reasons for the negative correlation between these diseases are summarised. One hypothesis suggests inhibition of surface activity of monosodium urate crystals (MSU) by binding of rheumato...

journal_title：Annals of the rheumatic diseases

authors： Gordon TP,Ahern MJ,Reid C,Roberts-Thomson PJ

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:To investigate the efficacy and safety of peficitinib, an oral Janus kinase inhibitor, in patients with rheumatoid arthritis (RA). METHODS:In this double-blind phase III study, patients with RA and an inadequate response to prior disease-modifying anti-rheumatic drugs (DMARDs) were randomised to peficitinib...

journal_title：Annals of the rheumatic diseases

authors： Tanaka Y,Takeuchi T,Tanaka S,Kawakami A,Iwasaki M,Song YW,Chen YH,Wei JC,Lee SH,Rokuda M,Izutsu H,Ushijima S,Kaneko Y,Akazawa R,Shiomi T,Yamada E

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The contribution of rheumatology nurses to improved patient outcomes is increasingly recognised but more research is needed about the effects of interventions. The patient's role in deciding about healthcare quality is considered pivotal and therefore patients' opinions and expectations should be directional ...

journal_title：Annals of the rheumatic diseases

authors： van Eijk-Hustings Y,Ammerlaan J,Voorneveld-Nieuwenhuis H,Maat B,Veldhuizen C,Repping-Wuts H

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Previous data have shown that etanercept levels are associated with clinical response in rheumatoid arthritis. However, for ankylosing spondylitis (AS), data regarding this topic are inconclusive. OBJECTIVES:To investigate the relationship between etanercept levels and clinical response in patients with AS....

journal_title：Annals of the rheumatic diseases

authors： Kneepkens EL,Krieckaert CL,van der Kleij D,Nurmohamed MT,van der Horst-Bruinsma IE,Rispens T,Wolbink GJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The Health Assessment Questionnaire Disability Index (HAQ-DI) is the most widely used measure of function in rheumatoid arthritis (RA). OBJECTIVE:To evaluate individualised forms of the HAQ-DI and thus enhance the incorporation of patients' views in outcome assessment. PATIENTS AND METHODS:HAQ-DI data were...

journal_title：Annals of the rheumatic diseases

authors： Seror R,Tubach F,Baron G,Guillemin F,Ravaud P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) tends to remit during pregnancy, with more patients achieving remission in the third trimester, coinciding with an increase in levels of alpha-fetoprotein (AFP). In vitro and animal studies have shown that AFP has immunomodulatory properties. MM-093 is a non-glycosylated, recombinan...

journal_title：Annals of the rheumatic diseases

authors： Pollard LC,Murray J,Moody M,Stewart EJ,Choy EH

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:Infectious agents like parvovirus have been implicated as exogenous factors that could trigger onset of systemic lupus erythematosus (SLE). A number of case reports describing a SLE-like presentation of acute human parvovirus B19 infection have been published, but no systematic investigation of the actual se...

journal_title：Annals of the rheumatic diseases

authors： Bengtsson A,Widell A,Elmstâhl S,Sturfelt G

更新日期：2000-01-01 00:00:00

abstract：:The relation between common rheumatic diseases such as osteoarthrosis, arthralgia without definite signs of osteoarthrosis, subacromial shoulder pain, different forms of tendinitis, low back pain and neck pain, and the level of formal education, occupational workload and some lifestyle factors were examined in 502 of ...

journal_title：Annals of the rheumatic diseases

authors： Jacobsson L,Lindgärde F,Manthorpe R,Ohlsson K

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVES:A prospective randomised trial to compare two different durations of maintenance immunosuppressive therapy for the prevention of relapse in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). METHODS:Patients with AAV were recruited 18-24 months after diagnosis if they were in stable ...

journal_title：Annals of the rheumatic diseases

authors： Karras A,Pagnoux C,Haubitz M,Groot K,Puechal X,Tervaert JWC,Segelmark M,Guillevin L,Jayne D,European Vasculitis Society.

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Osteoarthritis is the most frequent chronic joint disease causing pain and disability. Besides biomechanical mechanisms, the pathogenesis of osteoarthritis may involve inflammation, vascular alterations and dysregulation of lipid metabolism. As statins are able to modulate many of these processes, this study...

journal_title：Annals of the rheumatic diseases

authors： Clockaerts S,Van Osch GJ,Bastiaansen-Jenniskens YM,Verhaar JA,Van Glabbeek F,Van Meurs JB,Kerkhof HJ,Hofman A,Stricker BH,Bierma-Zeinstra SM

更新日期：2012-05-01 00:00:00

abstract：:In the use of anti-inflammatory compounds, sustained serum levels are thought to be related to drug efficacy. This study shows that frequent clinical administration of indomethacin can result in sustained serum levels of the drug and that food and antacid may have important modifying effects on serum indomethacin conc...

journal_title：Annals of the rheumatic diseases

authors： Emori HW,Paulus H,Bluestone R,Champion GD,Pearson C

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVES:To investigate the association of lifestyle factors with risk of inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). METHODS:The European Prospective Investigation of Cancer, Norfolk, UK (EPIC-Norfolk) gathered lifestyle data from participants aged 40-79 years from 1993 to 1997. Individuals who s...

journal_title：Annals of the rheumatic diseases

authors： Lahiri M,Luben RN,Morgan C,Bunn DK,Marshall T,Lunt M,Verstappen SM,Symmons DP,Khaw KT,Wareham N,Bruce IN

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. METHODS:Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 ...

journal_title：Annals of the rheumatic diseases

authors： Tolusso B,Frezza D,Mattioli C,Fedele AL,Bosello S,Faustini F,Peluso G,Giambra V,Pietrapertosa D,Morelli A,Gremese E,De Santis M,Ferraccioli GF

更新日期：2009-03-01 00:00:00

abstract：:Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients...

journal_title：Annals of the rheumatic diseases

authors： McInnes GT,Lawson DH,Jick H

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:To examine the hypothesis that aggrecan, cartilage oligomeric matrix protein (COMP), and bone sialoprotein (BSP) concentrations in synovial fluid could provide information on variations of progression of joint destruction in rheumatoid arthritis. METHODS:Aggrecan, COMP, and BSP were quantified by enzyme link...

journal_title：Annals of the rheumatic diseases

authors： Månsson B,Geborek P,Saxne T

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVES:An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity ...

journal_title：Annals of the rheumatic diseases

authors： Hørslev-Petersen K,Hetland ML,Junker P,Pødenphant J,Ellingsen T,Ahlquist P,Lindegaard H,Linauskas A,Schlemmer A,Dam MY,Hansen I,Horn HC,Ammitzbøll CG,Jørgensen A,Krintel SB,Raun J,Johansen JS,Østergaard M,Stengaard-Pe

更新日期：2014-04-01 00:00:00