Acute adverse reactions attributed to allopurinol in hospitalised patients.

abstract：OBJECTIVES:Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA). METHODS:Immunohistochemistry was performed in synovial biopsies from patients with RA (n=20), osteoarthritis (...

journal_title：Annals of the rheumatic diseases

authors： Chemel M,Le Goff B,Brion R,Cozic C,Berreur M,Amiaud J,Bougras G,Touchais S,Blanchard F,Heymann MF,Berthelot JM,Verrecchia F,Heymann D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cancellous bone from patients with osteoarthritis (OA) has been reported to be undermineralised and that from patients with osteoporosis (OP) is more liable to fracture. Changes in the mineral component might be implicated in these processes. OBJECTIVES:To investigate the thermal stability and the mineral s...

journal_title：Annals of the rheumatic diseases

authors： Mkukuma LD,Imrie CT,Skakle JM,Hukins DW,Aspden RM

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:To compare ultrasound measurement of median nerve cross-sectional area (CSA) at different anatomical landmarks and to assess the value of power Doppler signals within the median nerve for diagnosis of carpal tunnel syndrome (CTS). METHODS:A prospective study of 135 consecutive patients with suspected CTS und...

journal_title：Annals of the rheumatic diseases

authors： Dejaco C,Stradner M,Zauner D,Seel W,Simmet NE,Klammer A,Heitzer P,Brickmann K,Gretler J,Fürst-Moazedi FC,Thonhofer R,Husic R,Hermann J,Graninger WB,Quasthoff S

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that high concentrations of extracellular inorganic pyrophosphate (PPi), which associate with increased cell synthesis and turnover in cartilage, may act as a marker for structural outcome in knee osteoarthritis (OA). METHOD:One hundred and thirty five consecutive patients referred to ...

journal_title：Annals of the rheumatic diseases

authors： Doherty M,Belcher C,Regan M,Jones A,Ledingham J

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To assess the incremental diagnostic value of spine MRI evaluated separately from and combined with sacroiliac joint (SIJ) MRI in non-radiographic axial spondyloarthritis (nr-axSpA) compared with SIJ MRI alone. METHODS:The study sample comprised two independent cohorts A/B of 130 consecutive patients aged ≤5...

journal_title：Annals of the rheumatic diseases

authors： Weber U,Zubler V,Zhao Z,Lambert RG,Chan SM,Pedersen SJ,Østergaard M,Rufibach K,Maksymowych WP

更新日期：2015-06-01 00:00:00

abstract：:Cell electrophoresis identifies two main subpopulations of blood polymorphonuclear cells (PMNs), which in terms of the speed of their anodic migration are referred to as the fast and slow population. When blood PMNs from normal healthy subjects were incubated in medium containing 20% RA serum there was a decrease in t...

journal_title：Annals of the rheumatic diseases

authors： Brown KA,McCarthy D,Perry JD,Dumonde DC

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Population mean changes from clinical trials are difficult to apply to individuals in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration. METHODS:The numbers of patients with pain relief over baseline (> or =15%, > or =30%, > or =50%, > or ...

journal_title：Annals of the rheumatic diseases

authors： Moore RA,Moore OA,Derry S,Peloso PM,Gammaitoni AR,Wang H

更新日期：2010-02-01 00:00:00

abstract：:The relationship between the tensile properties of articular cartilage and age has been investigated in vitro in the human knee joint. Specimens orientated parallel to the articular surface were excised from the superficial and deep zones of the femoral condyles of knee joints of persons in the age range from 8 to 91 ...

journal_title：Annals of the rheumatic diseases

authors： Kempson GE

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVES:The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown, but growth factors and hormones probably play an important part. The effects of glucocorticosteroids (prednisolone and triamcinolone), in combination with insuli...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,Postma NS,Verbunt J,van den Berg WB

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNα production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including IRF5. Genetic variat...

journal_title：Annals of the rheumatic diseases

authors： Niewold TB,Kelly JA,Kariuki SN,Franek BS,Kumar AA,Kaufman KM,Thomas K,Walker D,Kamp S,Frost JM,Wong AK,Merrill JT,Alarcón-Riquelme ME,Tikly M,Ramsey-Goldman R,Reveille JD,Petri MA,Edberg JC,Kimberly RP,Alarcón GS,

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and suppressive capacity of regulatory T cells (T(reg)) and their association with clinical parameters in patients with systemic scleroderma (SSc). METHODS:Peripheral blood from 25 patients with SSc, 15 patients with localised scleroderma (LS) and 29 healthy controls (HC) was studi...

journal_title：Annals of the rheumatic diseases

authors： Klein S,Kretz CC,Ruland V,Stumpf C,Haust M,Hartschuh W,Hartmann M,Enk A,Suri-Payer E,Oberle N,Krammer PH,Kuhn A

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:To assess sensory function in skin overlying the joints of patients with rheumatoid arthritis, in relation to the pain and tenderness which commonly arises in structures not directly involved in the inflammatory process. METHODS:An intradermal injection of capsaicin 0.05 microgram in 10 microliters was made ...

journal_title：Annals of the rheumatic diseases

authors： Jolliffe VA,Anand P,Kidd BL

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:To assess the long-term effect of bariatric surgery on the incidence of gout and hyperuricaemia in participants of the Swedish Obese Subjects (SOS) study. METHODS:This report includes 1982 subjects who underwent bariatric surgery and 1999 obese controls from the SOS study, a prospective intervention trial d...

journal_title：Annals of the rheumatic diseases

authors： Maglio C,Peltonen M,Neovius M,Jacobson P,Jacobsson L,Rudin A,Carlsson LM

更新日期：2017-04-01 00:00:00

abstract：:The radiographic changes of ankylosing spondylitis were studied in 50 females and 82 males. There was a tendency for the males to have more severe arthritic changes in the sacroiliac joints than the females, but the difference did not reach statistical significance. Males significantly more often had radiological invo...

journal_title：Annals of the rheumatic diseases

authors： Gran JT,Husby G,Hordvik M,Størmer J,Romberg-Andersen O

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:To elaborate a clinical practice decision tree for the choice of the first disease modifying antirheumatic drug (DMARD) for untreated rheumatoid arthritis of less than six months' duration. METHODS:Four steps were employed: (1) review of published reports on DMARD efficacy against rheumatoid arthritis; (2) i...

journal_title：Annals of the rheumatic diseases

authors： Le Loët X,Berthelot JM,Cantagrel A,Combe B,De Bandt M,Fautrel B,Flipo RM,Lioté F,Maillefert JF,Meyer O,Saraux A,Wendling D,Guillemin F

更新日期：2006-01-01 00:00:00

abstract：:The incidence of exacerbations in the disease course was investigated in 110 patients with systemic lupus erythematosus (SLE) who were studied prospectively at our institute for lupus research. At the time of disease onset and diagnosis the male patients were much older than the female patients (about 10 years); exace...

journal_title：Annals of the rheumatic diseases

authors： Swaak AJ,Nossent JC,Bronsveld W,van Rooyen A,Nieuwenhuys EJ,Theuns L,Smeenk RJ

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE:To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the exp...

journal_title：Annals of the rheumatic diseases

authors： Yatabe T,Mochizuki S,Takizawa M,Chijiiwa M,Okada A,Kimura T,Fujita Y,Matsumoto H,Toyama Y,Okada Y

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:To determine the diagnostic value of beta 2 microglobulin in parotid saliva, its concentration in relation to salivary flow was determined in 29 patients with primary Sjögren's syndrome and in 30 normal controls. The specific secretion rate of beta 2 microglobulin was calculated. METHODS:Parotid saliva samp...

journal_title：Annals of the rheumatic diseases

authors： van der Geest SA,Markusse HM,Swaak AJ

更新日期：1993-06-01 00:00:00

abstract：:Antibodies to histones (AHA) are commonly found in patients with systemic lupus erythematosus (SLE). However, the full profile of AHA and their clinical associations remains unclear. A total of 111 patients with SLE were studied, including 13 patients in whom multiple serum samples were available over several years. I...

journal_title：Annals of the rheumatic diseases

authors： Cohen MG,Pollard KM,Webb J

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To study the ability of low-cost low-field dedicated extremity magnetic resonance imaging (E-MRI) to assess and predict erosive joint damage in the wrist and metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis. METHODS:24 previously untreated patients with rheumatoid arthritis with j...

journal_title：Annals of the rheumatic diseases

authors： Lindegaard HM,Vallø J,Hørslev-Petersen K,Junker P,Østergaard M

更新日期：2006-09-01 00:00:00

abstract：:The phenomenon of increased spontaneous incorporation of 3H-thymidine (3H-TdR) into peripheral blood mononuclear cells in rheumatoid arthritis (RA) has been investigated. The activity was found to be short lived and affected less than 1% of cells. Using a Percoll density gradient we identified two populations of activ...

journal_title：Annals of the rheumatic diseases

authors： Froebel K,Dickson R,Lewis D,Jasani MK,Sturrock RD

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVES:Target trial emulation is an intuitive design framework that encourages investigators to formulate their comparative effectiveness research (CER) question as a hypothetical randomised controlled trial (RCT). Our aim was to systematically review CER studies in rheumatoid arthritis (RA) to provide examples of ...

journal_title：Annals of the rheumatic diseases

authors： Zhao SS,Lyu H,Solomon DH,Yoshida K

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To investigate the role of CD8 cell subsets in the pathogenesis of rheumatoid arthritis (RA) and the phenotypes of T cells adherent or non-adherent to the target cells (endothelial cells and synovial cells) pre-treated with IL-1 beta. METHODS:The expression of S6F1 on CD8 cells and that of an activation mark...

journal_title：Annals of the rheumatic diseases

authors： Ueki Y,Eguchi K,Miyake S,Nagataki S,Tominaga Y

更新日期：1994-12-01 00:00:00

abstract：:Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associ...

journal_title：Annals of the rheumatic diseases

authors： Clegg DO,Zone JJ,Samuelson CO Jr,Ward JR

更新日期：1985-04-01 00:00:00

abstract：:Premature death has been long recognised as a manifestation of rheumatoid arthritis (RA). Three lines of evidence can explain why patients with RA die prematurely and why the mortality gap between patients with RA and the general population appears to widening. First, patients with RA have a higher risk of several ser...

journal_title：Annals of the rheumatic diseases

authors： Gabriel SE

更新日期：2008-12-01 00:00:00

abstract：:The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of ea...

journal_title：Annals of the rheumatic diseases

authors： Garrett R,Manthey B,Vernon-Roberts B,Brooks PM

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:To assess the extent of calcium pyrophosphate dihydrate (CPP) crystal deposition and the distribution of affected sites, using ultrasonography (US), in patients affected by CPP deposition disease (CPPD). PATIENTS AND METHODS:42 consecutive patients affected by definite CPPD according to the McCarty criteria ...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Filippucci E,Tardella M,Bertoldi I,Di Carlo M,Adinolfi A,Grassi W,Frediani B

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To clarify the effect of pressure on the expressions of proteoglycan core protein and metabolism related cytokines in a chondrocyte-like cell line, HCS-2/8. METHODS:HCS-2/8 cells were exposed to 1, 5, 10, or 50 MPa of hydrostatic pressure (HP) for two hours, and mRNA expressions of interleukin 6 (IL6) and t...

journal_title：Annals of the rheumatic diseases

authors： Takahashi K,Kubo T,Arai Y,Kitajima I,Takigawa M,Imanishi J,Hirasawa Y

更新日期：1998-04-01 00:00:00

abstract：:Peritoneal serositis is not a widely recognised aspect of systemic lupus erythematosus (SLE). Indeed, ascites in SLE is said to occur only when complicated by the nephrotic syndrome, congestive cardiac failure, or hepatic cirrhosis. We describe two patients who developed ascites that could be attributed to none of the...

journal_title：Annals of the rheumatic diseases

authors： Mier A,Weir W

更新日期：1985-11-01 00:00:00

abstract：:The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR task force was form...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde D,van der Helm-van Mil AH,Aletaha D,Bingham CO,Burmester GR,Dougados M,Emery P,Felson D,Knevel R,Kvien TK,Landewé RB,Lukas C,McInnes I,Silman AJ,Smolen JS,Stanislawska-Biernat E,Zink A,Combe B

更新日期：2013-04-01 00:00:00