Relationship between the tensile properties of articular cartilage from the human knee and age.

abstract：OBJECTIVE:To examine the imaging-detected mechanism of reduction of structural joint damage progression by tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) using MRI. METHODS:In a substudy of a randomised, double-blind, phase 3b study (ACT-RAY) of biologic-naïve patients with RA who were methotrexate (MTX)...

journal_title：Annals of the rheumatic diseases

authors： Conaghan PG,Peterfy C,Olech E,Kaine J,Ridley D,Dicarlo J,Friedman J,Devenport J,Troum O

更新日期：2014-05-01 00:00:00

abstract：:Evidence is presented that a single injection of bacterial antigen in oil into a footpad of rats of 5 strains induced different clinical forms of adjuvant disease in the individual rat strains. Rats were injected with 300 micrograms heat-killed Mycobacterium tuberculosis in 50 microliters paraffin. Inflammatory lesion...

journal_title：Annals of the rheumatic diseases

authors： Muir VY,Dumonde DC

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE:To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the exp...

journal_title：Annals of the rheumatic diseases

authors： Yatabe T,Mochizuki S,Takizawa M,Chijiiwa M,Okada A,Kimura T,Fujita Y,Matsumoto H,Toyama Y,Okada Y

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:To determine the probability of drug continuation in a large cohort of methotrexate treated rheumatoid arthritis (RA) patients, the reasons for discontinuation of methotrexate, the overall survival of the members of this cohort, and the causes of death in these patients. METHODS:Yearly follow up was conduct...

journal_title：Annals of the rheumatic diseases

authors： Alarcón GS,Tracy IC,Strand GM,Singh K,Macaluso M

更新日期：1995-09-01 00:00:00

abstract：:Antibodies to cytomegalovirus (CMV) and Epstein-Barr virus capsid antigen (EBVCA) were examined in 41 patients with rheumatoid arthritis (RA), 26 patients with primary sicca syndrome, and 26 healthy subjects of similar age and sex. IgG antibody titres to EBVCA and CMV were similar in all three groups, apart from a tri...

journal_title：Annals of the rheumatic diseases

authors： Venables PJ,Ross MG,Charles PJ,Melsom RD,Griffiths PD,Maini RN

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVES:To describe the influence of the reading order (chronological v paired) on radiographic scoring results in ankylosing spondylitis. To investigate whether this method is sufficiently sensitive to change because paired reading is requested for establishing drug efficacy in clinical trials. METHODS:Films obtai...

journal_title：Annals of the rheumatic diseases

authors： Wanders A,Landewé R,Spoorenberg A,de Vlam K,Mielants H,Dougados M,van der Linden S,van der Heijde D

更新日期：2004-12-01 00:00:00

abstract：:HLA A, B, and C antigens were studied in 25 patients with ankylosing hyperostosis. There was no evidence of an increased frequency of any antigen in association with the condition itself. However, a high frequency of several antigens was found, reflecting the predominance of Jewish patients in the series. ...

journal_title：Annals of the rheumatic diseases

authors： Perry JD,Wolf H,Festenstein H,Storey GO

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVE:To investigate changes in the levels of circulating cytokines with a focus on the Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS). METHODS:Plasma and serum samples of 34 pregnant patients, 19 with RA, ...

journal_title：Annals of the rheumatic diseases

authors： Østensen M,Förger F,Nelson JL,Schuhmacher A,Hebisch G,Villiger PM

更新日期：2005-06-01 00:00:00

abstract：:Arthralgias have previously been reported in association with acne fulminans, but the following case in the first report of osseous lesions associated with this disease. The destructive bony lesion was rapid in onset but self-limited. ...

journal_title：Annals of the rheumatic diseases

authors： Hunter LY,Hensinger RN

更新日期：1980-08-01 00:00:00

abstract：:Patients with Sjögren's syndrome alone (Ss), Sjögren's syndrome with rheumatoid arthritis (Ss-RA), and Sjögren's syndrome with Raynaud's phenomenon (Ss-RP) were typed for the HLA DR and MT antigens. Ss-RA patients had higher frequencies of HLA DR4 than did Ss patients. HLA-DR4 was also increased in frequency in patien...

journal_title：Annals of the rheumatic diseases

authors： Mann DL,Moutsopoulos HM

更新日期：1983-10-01 00:00:00

abstract：:The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and...

journal_title：Annals of the rheumatic diseases

authors： Gale R,Bertouch JV,Bradley J,Roberts-Thomson PJ

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for rheumatoid arthritis (RA). Peptidylcitrulline can be generated by post-translational conversion of arginine residues. This process, citrullination, is catalysed by a group of calcium dependent peptid...

journal_title：Annals of the rheumatic diseases

authors： Vossenaar ER,Radstake TR,van der Heijden A,van Mansum MA,Dieteren C,de Rooij DJ,Barrera P,Zendman AJ,van Venrooij WJ

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:To forecast, on the basis of the past and present position of rheumatologists in Europe, the competence needed in the future to secure and promote the specialty within the healthcare network. METHODS:Union Européenne des Médecins Spécialistes/European Board of Rheumatology (UEMS/EBR) questionnaire on (a) tr...

journal_title：Annals of the rheumatic diseases

authors： Amor B

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to test the hypothesis that the reason for non-response (caused by immunogenicity or not) to a first tumour necrosis factor (TNF) inhibitor defines whether a second TNF inhibitor will be effective. METHODS:This cohort study consisted of 292 consecutive patients with rheumatoid arthr...

journal_title：Annals of the rheumatic diseases

authors： Jamnitski A,Bartelds GM,Nurmohamed MT,van Schouwenburg PA,van Schaardenburg D,Stapel SO,Dijkmans BA,Aarden L,Wolbink GJ

更新日期：2011-02-01 00:00:00

abstract：:The relation between the basal and stimulated gastric acid secretion, plasma gastrin, and the gastric microflora was examined in 45 patients with rheumatoid arthritis. Sixteen patients (36%) had basal achlorhydria, and of these, 10 (22%) had achlorhydria or hypochlorhydria after stimulation with pentagastrin. The peak...

journal_title：Annals of the rheumatic diseases

authors： Henriksson K,Uvnäs-Moberg K,Nord CE,Johansson C,Gullberg R

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

journal_title：Annals of the rheumatic diseases

authors： Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:The anticyclic citrullinated peptide 2 (anti-CCP2) assay is a generic test for antibodies to citrullinated proteins, among which there is a subset of about 50% with antibodies to citrullinated enolase peptide 1 (CEP-1). The anti-CEP-1 positive subset is strongly associated with the HLA-DRB1 shared epitope ...

journal_title：Annals of the rheumatic diseases

authors： Fisher BA,Plant D,Brode M,van Vollenhoven RF,Mathsson L,Symmons D,Lundberg K,Rönnelid J,Venables PJ

更新日期：2011-06-01 00:00:00

abstract：:Fifteen consecutive patients with acute arthritis were studied. Careful culture and microscopy of swabs from mucosal sites were performed to examine the hypothesis that the acute tropical polyarthritis commonly seen in Zimbabwe is due to undiagnosed gonococcal infection. Rheumatic fever and Reiter's disease accounted ...

journal_title：Annals of the rheumatic diseases

authors： Stein CM,Hanly MG

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVES:To identify genetic associations with hip osteoarthritis (HOA), we performed a meta-analysis of genome-wide association studies (GWAS) of HOA. METHODS:The GWAS meta-analysis included approximately 2.5 million imputed HapMap single nucleotide polymorphisms (SNPs). HOA cases and controls defined radiographica...

journal_title：Annals of the rheumatic diseases

authors： Evans DS,Cailotto F,Parimi N,Valdes AM,Castaño-Betancourt MC,Liu Y,Kaplan RC,Bidlingmaier M,Vasan RS,Teumer A,Tranah GJ,Nevitt MC,Cummings SR,Orwoll ES,Barrett-Connor E,Renner JB,Jordan JM,Doherty M,Doherty SA,Uitte

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Oxidative stress in RA synovial tissue can cause DNA damage and suppress the DNA mismatch repair (MMR) system in cultured synoviocytes. This mechanism includes two enzyme complexes, hMutSalpha (hMSH2/hMSH6) and hMutSbeta (hMSH2/hMSH3). OBJECTIVE:To examine the expression and distribution of MMR enzymes in s...

journal_title：Annals of the rheumatic diseases

authors： Simelyte E,Boyle DL,Firestein GS

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To improve the understanding of the pathogenesis of rheumatoid arthritis (RA) by identifying novel, disease specific autoantibodies. METHODS:Total protein preparations from synovial membranes were separated electrophoretically and immunoblotted. Sera from RA patients were screened for predominant immunoreact...

journal_title：Annals of the rheumatic diseases

authors： Bläss S,Specker C,Lakomek HJ,Schneider EM,Schwochau M

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Several studies have reported an association between the presence of the shared epitope (SE) and susceptibility to rheumatoid arthritis (RA). Recent studies have shown that certain HLA-DRB1 alleles in combination with predisposing DQB1 and DQA1 alleles may protect against the development of RA. This model is...

journal_title：Annals of the rheumatic diseases

authors： Molenaar ET,Voskuyl AE,van der Horst-Bruinsma IE,Schreuder GM,Zanelli E,Dijkmans BA

更新日期：2002-04-01 00:00:00

abstract：:Thirty two patients with ankylosing spondylitis were investigated with a set of pulmonary function tests and the results compared with those for a control population. The patients had no complaints about lung symptoms and their chest radiographs were normal. The main pathological findings were reduced lung volumes, a ...

journal_title：Annals of the rheumatic diseases

authors： Feltelius N,Hedenström H,Hillerdal G,Hällgren R

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functio...

journal_title：Annals of the rheumatic diseases

authors： Bocelli-Tyndall C,Trella E,Frachet A,Zajac P,Pfaff D,Geurts J,Heiler S,Barbero A,Mumme M,Resink TJ,Schaeren S,Spagnoli GC,Tyndall A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission rec...

journal_title：Annals of the rheumatic diseases

authors： Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.

更新日期：2009-07-01 00:00:00

abstract：:A patient with systemic lupus erythematosus who developed pneumococcal epiglottitis is described and the literature reviewed. This infection is extremely rare in adults, and only 10 cases, none of them with SLE, have so far been reported. Epiglottitis is usually caused by Haemophilus influenzae. However, in immunocomp...

journal_title：Annals of the rheumatic diseases

authors： Shalit M,Gross DJ,Levo Y

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routi...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Breedveld FC,Burmester GR,Bykerk V,Dougados M,Emery P,Kvien TK,Navarro-Compán MV,Oliver S,Schoels M,Scholte-Voshaar M,Stamm T,Stoffer M,Takeuchi T,Aletaha D,Andreu JL,Aringer M,Bergman M,Betteridge N,Bijls

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of monotherapy with adalimumab in patients with RA for whom previous DMARD treatment has failed. METHODS:In a 26 week, double blind, placebo controlled, phase III trial, 544 patients with RA were randomised to monotherapy with adalimumab 20 mg every other week, 20 mg weekl...

journal_title：Annals of the rheumatic diseases

authors： van de Putte LB,Atkins C,Malaise M,Sany J,Russell AS,van Riel PL,Settas L,Bijlsma JW,Todesco S,Dougados M,Nash P,Emery P,Walter N,Kaul M,Fischkoff S,Kupper H

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:An abnormal CD4+ T cell subset related to inflammation exposure (inflammation-related cells, IRC) has been identified in rheumatoid arthritis (RA). Patients with inflammatory and non-inflammatory diseases were used to examine the relationship between inflammation and this T cell subset in vivo. METHODS:Bloo...

journal_title：Annals of the rheumatic diseases

authors： Burgoyne CH,Field SL,Brown AK,Hensor EM,English A,Bingham SL,Verburg R,Fearon U,Lawson CA,Hamlin PJ,Straszynski L,Veale D,Conaghan P,Hull MA,van Laar JM,Tennant A,Emery P,Isaacs JD,Ponchel F

更新日期：2008-06-01 00:00:00