Antibodies to citrullinated α-enolase peptide 1 and clinical and radiological outcomes in rheumatoid arthritis.

abstract：OBJECTIVES:Advanced imaging studies have demonstrated that urate deposition in periarticular structures, such as tendons, is common in gout. The aim of this study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on tenocyte viability and function. METHODS:The histological appearance of ten...

journal_title：Annals of the rheumatic diseases

authors： Chhana A,Callon KE,Dray M,Pool B,Naot D,Gamble GD,Coleman B,McCarthy G,McQueen FM,Cornish J,Dalbeth N

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:Different prevalences of generalised osteoarthritis (GOA) in patients with knee and hip OA have been reported. The aim of this investigation was to evaluate radiographic and clinical patterns of disease in a hospital based population of patient subgroups with advanced hip and knee OA and to compare the preva...

journal_title：Annals of the rheumatic diseases

authors： Günther KP,Stürmer T,Sauerland S,Zeissig I,Sun Y,Kessler S,Scharf HP,Brenner H,Puhl W

更新日期：1998-12-01 00:00:00

abstract：AIM:to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design. METHODS:All patients from the Dutch Rheumatoid Arthritis Monitoring (DREAM) register starting on tumour necrosis factor (TNF)alpha-blocking...

journal_title：Annals of the rheumatic diseases

authors： Kievit W,Adang EM,Fransen J,Kuper HH,van de Laar MA,Jansen TL,De Gendt CM,De Rooij DJ,Brus HL,Van Oijen PC,Van Riel PC

更新日期：2008-09-01 00:00:00

abstract：:To transcribe the treat-to-target (T2T) recommendations into a version that can be easily understood by patients. A core group of physicians and patients involved in the elaboration of the T2T recommendations produced a draft version of the T2T recommendations in lay language. This version was discussed, changed and r...

journal_title：Annals of the rheumatic diseases

authors： de Wit MP,Smolen JS,Gossec L,van der Heijde DM

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

journal_title：Annals of the rheumatic diseases

authors： Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS:Four single-nucleotide polymorphisms (SNP), rs7517847, r...

journal_title：Annals of the rheumatic diseases

authors： Jiang Z,Yang P,Hou S,Du L,Xie L,Zhou H,Kijlstra A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Antibodies targeting citrullinated antigens are specific for rheumatoid arthritis (RA). Citrullination is catalysed by the peptidylarginine deiminase (PAD) enzyme family. Critical enzymes are often targeted by disease-specific antibodies in complex immune-mediated diseases. Here, we have tested for autoantib...

journal_title：Annals of the rheumatic diseases

authors： Halvorsen EH,Pollmann S,Gilboe IM,van der Heijde D,Landewé R,Ødegård S,Kvien TK,Molberg Ø

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To compare median nerve conduction velocity measured using a new, portable electroneurometer with measurements made using conventional hospital nerve conduction apparatus. METHODS:Twenty five patients were studied who were consecutively referred to a hospital neurophysiology department with a clinical diagno...

journal_title：Annals of the rheumatic diseases

authors： Dunne CA,Thompson PW,Cole J,Dunning J,Martyn CN,Coggon D,Cooper C

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVES:To investigate the presence and functionality of oestrogen receptor alpha (ERalpha) in interleukin (IL)1beta-treated rabbit articular chondrocytes in culture, and to determine the mechanisms of 17beta oestradiol (E2) effects on IL1beta-induced inducible nitric oxide synthase (iNOS) expression. METHODS:The p...

journal_title：Annals of the rheumatic diseases

authors： Richette P,Dumontier MF,Tahiri K,Widerak M,Torre A,Benallaoua M,Rannou F,Corvol MT,Savouret JF

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To determine the difference in shape of the distal femur, viewed axially in two dimensions, between eburnated and non-eburnated femora. METHODS:A comparison of 52 non-eburnated and 16 eburnated femora drawn from a large archeological skeletal population. Eburnation was taken to indicate late stage osteoarth...

journal_title：Annals of the rheumatic diseases

authors： Shepstone L,Rogers J,Kirwan J,Silverman B

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:To assess the value of advanced imaging techniques in the detection of hand osteoarthritis (OA) and hand OA progression. METHODS:PubMed/Medline and Embase were searched until April 2012 for studies on imaging of hand OA that presented quantitative data on validity, reliability or responsiveness. Articles pre...

journal_title：Annals of the rheumatic diseases

authors： Saltzherr MS,Selles RW,Bierma-Zeinstra SM,Muradin GS,Coert JH,van Neck JW,Luime JJ

更新日期：2014-02-01 00:00:00

abstract：:Defined antinuclear antibodies (ANA), such as antibodies to Ro/SS-A, La/SS-B, Sm, and nRNP, are often present in serum samples from patients with systemic lupus erythematosus (SLE) or other connective tissue diseases (CTD). Most data on associations between the presence of these antibodies and defined disease features...

journal_title：Annals of the rheumatic diseases

authors： Swaak AJ,Huysen V,Smeenk RJ

更新日期：1993-02-01 00:00:00

abstract：:Serum C2 activity was measured in 135 individuals drawn from a panel of 418 tissue-typed blood donors. The study group included all donors with HLA antigens A10 and B18. Heterozygote C2 deficiency (C2Dhet) was defined by reference to the range of C2 activity in previously studied obligate heterozygotes. Five donors we...

journal_title：Annals of the rheumatic diseases

authors： Rynes RI,Britten AF,Pickering RJ

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVES:Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without prim...

journal_title：Annals of the rheumatic diseases

authors： van Rossum AP,Huitema MG,Stegeman CA,Bijl M,de Leeuw K,Van Leeuwen MA,Limburg PC,Kallenberg CG

更新日期：2007-10-01 00:00:00

abstract：:Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship bet...

journal_title：Annals of the rheumatic diseases

authors： Walsh L,Davies P,McConkey B

更新日期：1979-08-01 00:00:00

abstract：OBJECTIVES:A prospective, open study of corticosteroid hip injection (CHI) was performed to determine if different radiological patterns of arthritis vary in their response. METHODS:Forty five patients (15 with rheumatoid arthritis, 27 with osteoarthritis, and three with anklyosing spondylitis) underwent hip injection...

journal_title：Annals of the rheumatic diseases

authors： Plant MJ,Borg AA,Dziedzic K,Saklatvala J,Dawes PT

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVES:The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence up...

journal_title：Annals of the rheumatic diseases

authors： Schaefer CJ,Lawrence WD,Wooley PH

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:To investigate the relation between anatomic changes of the synovium, the bone, the bone marrow and the cartilage to biochemical properties of the cartilage in patients with rheumatoid arthritis (RA). METHODS:33 patients with RA received 3-T MRI scans of the metacarpophalangeal joints. Two independent metho...

journal_title：Annals of the rheumatic diseases

authors： Herz B,Albrecht A,Englbrecht M,Welsch GH,Uder M,Renner N,Schlechtweg P,Paul D,Lauer L,Engelke K,Janka R,Rech J,Schett G,Finzel S

更新日期：2014-06-01 00:00:00

abstract：:The relation between the basal and stimulated gastric acid secretion, plasma gastrin, and the gastric microflora was examined in 45 patients with rheumatoid arthritis. Sixteen patients (36%) had basal achlorhydria, and of these, 10 (22%) had achlorhydria or hypochlorhydria after stimulation with pentagastrin. The peak...

journal_title：Annals of the rheumatic diseases

authors： Henriksson K,Uvnäs-Moberg K,Nord CE,Johansson C,Gullberg R

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:To determine the circulating serum concentrations of nerve growth factor (NGF) and compare them with indices of disease activity in juvenile chronic arthritis. METHODS:NGF concentrations were evaluated with a two site immunoenzymatic assay (ELISA), in 17 children with systemic, 39 with polyarticular, and 24 ...

journal_title：Annals of the rheumatic diseases

authors： Falcini F,Matucci Cerinic M,Lombardi A,Generini S,Pignone A,Tirassa P,Ermini M,Lepore L,Partsch G,Aloe L

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To determine whether 17beta-oestradiol (E2) modulates interleukin (IL) 1beta-induced proteoglycan degradation in chondrocytes, and to analyse the part played by metalloproteinases (MMPs) in this process. METHODS:Primary cultured rabbit articular chondrocytes were prepared and treated with 10 ng/ml IL1beta co...

journal_title：Annals of the rheumatic diseases

authors： Richette P,Dumontier MF,François M,Tsagris L,Korwin-Zmijowska C,Rannou F,Corvol MT

更新日期：2004-02-01 00:00:00

abstract：:We studied the course of adjuvant arthritis in rats by measuring clinical, biochemical, and histological parameters on day 36 after induction (representing the secondary reaction) and on day 171, which is at the stage of permanent deformity. The effect of SR 41319, a new diphosphonate, was evaluated on days 36 and 171...

journal_title：Annals of the rheumatic diseases

authors： Barbier A,Breliére JC,Remandet B,Roncucci R

更新日期：1986-01-01 00:00:00

abstract：:An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

journal_title：Annals of the rheumatic diseases

authors： Gibson T,Burry HC,Poswillo D,Glass J

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Immunogenicity of aTNFs is one of the mechanisms behind treatment failure. OBJECTIVE:To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab, adalimumab and etanercept, and the effect of immunosuppression on ADA detection, in patients with Rheumatoid Arthritis, Spondyloarthritis, P...

journal_title：Annals of the rheumatic diseases

authors： Garcês S,Demengeot J,Benito-Garcia E

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

journal_title：Annals of the rheumatic diseases

authors： Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of polymorphisms in the vitamin D receptor (VDR) gene to ethnic variations in bone mass in mother and children from different ethnic origins. METHODS:VDR genotypes and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. Al...

journal_title：Annals of the rheumatic diseases

authors： Nelson DA,Vande Vord PJ,Wooley PH

更新日期：2000-08-01 00:00:00

abstract：:A previous report that C3 activation products are demonstrable in the plasma of subjects with rheumatoid arthritis was reinvestigated using 2-dimensional immunoelectrophoresis. Initially it seemed that results were in agreement, but the occurrence of similar patterns in normal sera and poor reproducibility of results ...

journal_title：Annals of the rheumatic diseases

authors： Shadforth MF,McNaughton DC

更新日期：1978-02-01 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of microalbuminuria, urinary albumin excretion (UAE) between 20-200 micrograms/min, in systemic lupus erythematosus (SLE) patients without clinical renal disease, and to discover if this could predict the development of renal disease. METHODS:This study made six monthly measure...

journal_title：Annals of the rheumatic diseases

authors： Batlle-Gualda E,Martínez AC,Guerra RA,Pascual E

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To determine if a new inhibitor, esculetin (EST), can block resorption of cartilage. METHODS:Interleukin 1alpha (IL1alpha, 0.04-5 ng/ml) and oncostatin M (OSM, 0.4-50 ng/ml) were used to stimulate the release of proteoglycan and collagen from bovine nasal cartilage and human articular cartilage in explant cu...

journal_title：Annals of the rheumatic diseases

authors： Elliott S,Rowan AD,Carrère S,Koshy P,Catterall JB,Cawston TE

更新日期：2001-02-01 00:00:00