Antibodies to citrullinated α-enolase peptide 1 and clinical and radiological outcomes in rheumatoid arthritis.


INTRODUCTION:The anticyclic citrullinated peptide 2 (anti-CCP2) assay is a generic test for antibodies to citrullinated proteins, among which there is a subset of about 50% with antibodies to citrullinated enolase peptide 1 (CEP-1). The anti-CEP-1 positive subset is strongly associated with the HLA-DRB1 shared epitope and its interaction with smoking. OBJECTIVE:To investigate whether anti-CEP-1 antibodies may be helpful in predicting outcome. METHODS:Anti-CEP-1 and anti-CCP2 antibodies were measured in two prospective cohorts of patients (Karolinska n=272, Norfolk Arthritis Register (NOAR) n=408) with early rheumatoid arthritis (RA). Outcomes measured were C-reactive protein, erythrocyte sedimentation rate, visual analogue scales for pain and global assessment of disease activity, Health Assessment Questionnaire, physician's assessment, swollen and tender joint counts and radiological progression. RESULTS:Anti-CCP2 antibodies were present in 57% and 50%, and anti-CEP-1 in 27% and 24% of the Karolinska and NOAR cohorts, respectively. Importantly, no statistically significant differences in clinical outcomes were demonstrated between the anti-CEP-1-/CCP2+ and the anti-CEP-1+/CCP2+ subsets in either cohort, or in radiological outcomes in the Karolinska cohort. CONCLUSION:Although antibodies to specific citrullinated proteins may have distinct genetic and environmental risk factors, the similarity in clinical phenotype suggests that they share common pathways in the pathogenesis of joint disease in RA.


Ann Rheum Dis


Fisher BA,Plant D,Brode M,van Vollenhoven RF,Mathsson L,Symmons D,Lundberg K,Rönnelid J,Venables PJ




Has Abstract


2011-06-01 00:00:00














  • Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout.

    abstract:OBJECTIVES:Advanced imaging studies have demonstrated that urate deposition in periarticular structures, such as tendons, is common in gout. The aim of this study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on tenocyte viability and function. METHODS:The histological appearance of ten...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Chhana A,Callon KE,Dray M,Pool B,Naot D,Gamble GD,Coleman B,McCarthy G,McQueen FM,Cornish J,Dalbeth N

    更新日期:2014-09-01 00:00:00

  • Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs.

    abstract:BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

    更新日期:2004-02-01 00:00:00

  • Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study.

    abstract:OBJECTIVES:Different prevalences of generalised osteoarthritis (GOA) in patients with knee and hip OA have been reported. The aim of this investigation was to evaluate radiographic and clinical patterns of disease in a hospital based population of patient subgroups with advanced hip and knee OA and to compare the preva...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


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    更新日期:1998-12-01 00:00:00

  • The effectiveness and medication costs of three anti-tumour necrosis factor alpha agents in the treatment of rheumatoid arthritis from prospective clinical practice data.

    abstract:AIM:to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design. METHODS:All patients from the Dutch Rheumatoid Arthritis Monitoring (DREAM) register starting on tumour necrosis factor (TNF)alpha-blocking...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Kievit W,Adang EM,Fransen J,Kuper HH,van de Laar MA,Jansen TL,De Gendt CM,De Rooij DJ,Brus HL,Van Oijen PC,Van Riel PC

    更新日期:2008-09-01 00:00:00

  • Treating rheumatoid arthritis to target: the patient version of the international recommendations.

    abstract::To transcribe the treat-to-target (T2T) recommendations into a version that can be easily understood by patients. A core group of physicians and patients involved in the elaboration of the T2T recommendations produced a draft version of the T2T recommendations in lay language. This version was discussed, changed and r...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章


    authors: de Wit MP,Smolen JS,Gossec L,van der Heijde DM

    更新日期:2011-06-01 00:00:00

  • FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue.

    abstract:OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

    更新日期:2010-04-01 00:00:00

  • IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population.

    abstract:PURPOSE:IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS:Four single-nucleotide polymorphisms (SNP), rs7517847, r...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


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    更新日期:2010-07-01 00:00:00

  • Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity.

    abstract:BACKGROUND:Antibodies targeting citrullinated antigens are specific for rheumatoid arthritis (RA). Citrullination is catalysed by the peptidylarginine deiminase (PAD) enzyme family. Critical enzymes are often targeted by disease-specific antibodies in complex immune-mediated diseases. Here, we have tested for autoantib...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Halvorsen EH,Pollmann S,Gilboe IM,van der Heijde D,Landewé R,Ødegård S,Kvien TK,Molberg Ø

    更新日期:2008-03-01 00:00:00

  • Carpal tunnel syndrome: evaluation of a new method of assessing median nerve conduction at the wrist.

    abstract:OBJECTIVE:To compare median nerve conduction velocity measured using a new, portable electroneurometer with measurements made using conventional hospital nerve conduction apparatus. METHODS:Twenty five patients were studied who were consecutively referred to a hospital neurophysiology department with a clinical diagno...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


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    更新日期:1996-06-01 00:00:00

  • Oestrogens inhibit interleukin 1beta-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment.

    abstract:OBJECTIVES:To investigate the presence and functionality of oestrogen receptor alpha (ERalpha) in interleukin (IL)1beta-treated rabbit articular chondrocytes in culture, and to determine the mechanisms of 17beta oestradiol (E2) effects on IL1beta-induced inducible nitric oxide synthase (iNOS) expression. METHODS:The p...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Richette P,Dumontier MF,Tahiri K,Widerak M,Torre A,Benallaoua M,Rannou F,Corvol MT,Savouret JF

    更新日期:2007-03-01 00:00:00

  • The shape of the distal femur: a palaeopathological comparison of eburnated and non-eburnated femora.

    abstract:OBJECTIVES:To determine the difference in shape of the distal femur, viewed axially in two dimensions, between eburnated and non-eburnated femora. METHODS:A comparison of 52 non-eburnated and 16 eburnated femora drawn from a large archeological skeletal population. Eburnation was taken to indicate late stage osteoarth...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Shepstone L,Rogers J,Kirwan J,Silverman B

    更新日期:1999-02-01 00:00:00

  • Metric properties of advanced imaging methods in osteoarthritis of the hand: a systematic review.

    abstract:OBJECTIVE:To assess the value of advanced imaging techniques in the detection of hand osteoarthritis (OA) and hand OA progression. METHODS:PubMed/Medline and Embase were searched until April 2012 for studies on imaging of hand OA that presented quantitative data on validity, reliability or responsiveness. Articles pre...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Saltzherr MS,Selles RW,Bierma-Zeinstra SM,Muradin GS,Coert JH,van Neck JW,Luime JJ

    更新日期:2014-02-01 00:00:00

  • Antinuclear antibodies in routine analysis: the relevance of putative clinical associations.

    abstract::Defined antinuclear antibodies (ANA), such as antibodies to Ro/SS-A, La/SS-B, Sm, and nRNP, are often present in serum samples from patients with systemic lupus erythematosus (SLE) or other connective tissue diseases (CTD). Most data on associations between the presence of these antibodies and defined disease features...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Swaak AJ,Huysen V,Smeenk RJ

    更新日期:1993-02-01 00:00:00

  • Deficiency of the second complement component association with the HLA haplotype A10, B18 in a normal population.

    abstract::Serum C2 activity was measured in 135 individuals drawn from a panel of 418 tissue-typed blood donors. The study group included all donors with HLA antigens A10 and B18. Heterozygote C2 deficiency (C2Dhet) was defined by reference to the range of C2 activity in previously studied obligate heterozygotes. Five donors we...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Rynes RI,Britten AF,Pickering RJ

    更新日期:1982-02-01 00:00:00

  • Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.

    abstract:OBJECTIVES:Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without prim...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van Rossum AP,Huitema MG,Stegeman CA,Bijl M,de Leeuw K,Van Leeuwen MA,Limburg PC,Kallenberg CG

    更新日期:2007-10-01 00:00:00

  • Relationship between erythrocyte sedimentation rate and serum C-reactive protein in rheumatoid arthritis.

    abstract::Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship bet...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Walsh L,Davies P,McConkey B

    更新日期:1979-08-01 00:00:00

  • Radiographic patterns and response to corticosteroid hip injection.

    abstract:OBJECTIVES:A prospective, open study of corticosteroid hip injection (CHI) was performed to determine if different radiological patterns of arthritis vary in their response. METHODS:Forty five patients (15 with rheumatoid arthritis, 27 with osteoarthritis, and three with anklyosing spondylitis) underwent hip injection...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Plant MJ,Borg AA,Dziedzic K,Saklatvala J,Dawes PT

    更新日期:1997-08-01 00:00:00

  • Influence of long term silicone implantation on type II collagen induced arthritis in mice.

    abstract:OBJECTIVES:The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence up...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Schaefer CJ,Lawrence WD,Wooley PH

    更新日期:1999-08-01 00:00:00

  • Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis.

    abstract:OBJECTIVES:To investigate the relation between anatomic changes of the synovium, the bone, the bone marrow and the cartilage to biochemical properties of the cartilage in patients with rheumatoid arthritis (RA). METHODS:33 patients with RA received 3-T MRI scans of the metacarpophalangeal joints. Two independent metho...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Herz B,Albrecht A,Englbrecht M,Welsch GH,Uder M,Renner N,Schlechtweg P,Paul D,Lauer L,Engelke K,Janka R,Rech J,Schett G,Finzel S

    更新日期:2014-06-01 00:00:00

  • Gastrin, gastric acid secretion, and gastric microflora in patients with rheumatoid arthritis.

    abstract::The relation between the basal and stimulated gastric acid secretion, plasma gastrin, and the gastric microflora was examined in 45 patients with rheumatoid arthritis. Sixteen patients (36%) had basal achlorhydria, and of these, 10 (22%) had achlorhydria or hypochlorhydria after stimulation with pentagastrin. The peak...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


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    更新日期:1986-06-01 00:00:00

  • Increased circulating nerve growth factor is directly correlated with disease activity in juvenile chronic arthritis.

    abstract:OBJECTIVE:To determine the circulating serum concentrations of nerve growth factor (NGF) and compare them with indices of disease activity in juvenile chronic arthritis. METHODS:NGF concentrations were evaluated with a two site immunoenzymatic assay (ELISA), in 17 children with systemic, 39 with polyarticular, and 24 ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


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    更新日期:1996-10-01 00:00:00

  • Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes.

    abstract:OBJECTIVE:To determine whether 17beta-oestradiol (E2) modulates interleukin (IL) 1beta-induced proteoglycan degradation in chondrocytes, and to analyse the part played by metalloproteinases (MMPs) in this process. METHODS:Primary cultured rabbit articular chondrocytes were prepared and treated with 10 ng/ml IL1beta co...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Richette P,Dumontier MF,François M,Tsagris L,Korwin-Zmijowska C,Rannou F,Corvol MT

    更新日期:2004-02-01 00:00:00

  • Studies on the chronic phase of adjuvant arthritis: effect of SR 41319, a new diphosphonate.

    abstract::We studied the course of adjuvant arthritis in rats by measuring clinical, biochemical, and histological parameters on day 36 after induction (representing the secondary reaction) and on day 171, which is at the stage of permanent deformity. The effect of SR 41319, a new diphosphonate, was evaluated on days 36 and 171...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Barbier A,Breliére JC,Remandet B,Roncucci R

    更新日期:1986-01-01 00:00:00

  • Effect of intra-articular corticosteroid injections on primate cartilage.

    abstract::An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Gibson T,Burry HC,Poswillo D,Glass J

    更新日期:1977-02-01 00:00:00

  • The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis.

    abstract:BACKGROUND:Immunogenicity of aTNFs is one of the mechanisms behind treatment failure. OBJECTIVE:To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab, adalimumab and etanercept, and the effect of immunosuppression on ADA detection, in patients with Rheumatoid Arthritis, Spondyloarthritis, P...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Garcês S,Demengeot J,Benito-Garcia E

    更新日期:2013-12-01 00:00:00

  • Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis.

    abstract:OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

    更新日期:2020-11-04 00:00:00

  • Polymorphism in the vitamin D receptor gene and bone mass in African-American and white mothers and children: a preliminary report.

    abstract:OBJECTIVE:To evaluate the contribution of polymorphisms in the vitamin D receptor (VDR) gene to ethnic variations in bone mass in mother and children from different ethnic origins. METHODS:VDR genotypes and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. Al...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Nelson DA,Vande Vord PJ,Wooley PH

    更新日期:2000-08-01 00:00:00

  • Examination of complement C3 metabolism in rheumatoid arthritis using 2-dimensional immunoelectrophoresis.

    abstract::A previous report that C3 activation products are demonstrable in the plasma of subjects with rheumatoid arthritis was reinvestigated using 2-dimensional immunoelectrophoresis. Initially it seemed that results were in agreement, but the occurrence of similar patterns in normal sera and poor reproducibility of results ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Shadforth MF,McNaughton DC

    更新日期:1978-02-01 00:00:00

  • Urinary albumin excretion in patients with systemic lupus erythematosus without renal disease.

    abstract:OBJECTIVES:To investigate the prevalence of microalbuminuria, urinary albumin excretion (UAE) between 20-200 micrograms/min, in systemic lupus erythematosus (SLE) patients without clinical renal disease, and to discover if this could predict the development of renal disease. METHODS:This study made six monthly measure...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Batlle-Gualda E,Martínez AC,Guerra RA,Pascual E

    更新日期:1997-06-01 00:00:00

  • Esculetin inhibits cartilage resorption induced by interleukin 1alpha in combination with oncostatin M.

    abstract:OBJECTIVE:To determine if a new inhibitor, esculetin (EST), can block resorption of cartilage. METHODS:Interleukin 1alpha (IL1alpha, 0.04-5 ng/ml) and oncostatin M (OSM, 0.4-50 ng/ml) were used to stimulate the release of proteoglycan and collagen from bovine nasal cartilage and human articular cartilage in explant cu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Elliott S,Rowan AD,Carrère S,Koshy P,Catterall JB,Cawston TE

    更新日期:2001-02-01 00:00:00