Optimal use of methotrexate: the advantages of tight control.

abstract：:The effect of auranofin on human neutrophil (PMN) 5-lipoxygenase activity and leucotriene B4 (LTB4) chemotaxis was investigated. [1-14C]Arachidonic acid was incorporated into the purified cells until steady state conditions were obtained. After preincubations with serial dilutions of auranofin arachidonic acid release...

journal_title：Annals of the rheumatic diseases

authors： Elmgreen J,Ahnfelt-Rønne I,Nielsen OH

更新日期：1989-02-01 00:00:00

abstract：:Peripheral and axial bone mass and fracture incidence were studied in a group of 104 postmenopausal patients with rheumatoid arthritis (RA). Patients were divided into non-corticosteroid and low dose corticosteroid treated groups after elimination of patients with concomitant disease or therapy which might affect bone...

journal_title：Annals of the rheumatic diseases

authors： Verstraeten A,Dequeker J

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:To investigate the first-ever incidence of acute myocardial infarction and stroke in a community based RA cohort compared with the general population. METHODS:The RA cohort consisted of all patients in a local RA register in Malmö, Sweden (n = 1022). The patients were recruited from private and hospital base...

journal_title：Annals of the rheumatic diseases

authors： Turesson C,Jarenros A,Jacobsson L

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It is unknown whether this relation is linear, referring to a common 'the-earlier-the-better principle', or whether a transient time frame in which the disease is more suscep...

journal_title：Annals of the rheumatic diseases

authors： van Nies JA,Tsonaka R,Gaujoux-Viala C,Fautrel B,van der Helm-van Mil AH

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To determine how acute but transient inflammation affects the cartilage proteoglycan aggrecan and the value of analyses of synovial fluid to study this. METHODS:For 96 hours after a single intra-articular injection of rabbit knees with human interleukin-1 alpha (IL-1 alpha) or vehicle, articular cartilage an...

journal_title：Annals of the rheumatic diseases

authors： Lundberg C,Asberg I,Ionescu M,Reiner A,Smedegård G,Poole AR

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:To perform a prospective long term follow up study comparing conventional radiography (CR), ultrasonography (US), and magnetic resonance imaging (MRI) in the detection of bone erosions and synovitis in rheumatoid arthritis (RA) finger joints. METHODS:The metacarpophalangeal and proximal interphalangeal joint...

journal_title：Annals of the rheumatic diseases

authors： Scheel AK,Hermann KG,Ohrndorf S,Werner C,Schirmer C,Detert J,Bollow M,Hamm B,Müller GA,Burmester GR,Backhaus M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Low sulphate levels in blood may contribute to osteoarthritis by decreasing cartilage chondroitin sulphation. OBJECTIVE:To measure serum levels of sulphate during 3 h of fasting or glucose ingestion after overnight fasts to determine how much sulphate lowering may occur during this period. METHODS:Sera fro...

journal_title：Annals of the rheumatic diseases

authors： Blinn CM,Biggee BA,McAlindon TE,Nuite M,Silbert JE

更新日期：2006-09-01 00:00:00

abstract：:We report two patients with systemic lupus erythematosus who subsequently developed thrombotic thrombocytopenic purpura. In each case the coexistence of these two conditions was confirmed by pathological findings. Both patients responded to treatment, but one eventually died. A review of the literature suggests a poss...

journal_title：Annals of the rheumatic diseases

authors： Fox DA,Faix JD,Coblyn J,Fraser P,Smith B,Weinblatt ME

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVES:Hyperplasia of synovial fibroblasts, infiltration with lymphocytes and tissue hypoxia are major characteristics of rheumatoid arthritis (RA). Extensive data support a key role for toll-like receptors (TLRs) in RA. Little is known regarding the impact of hypoxia on TLR-induced inflammation in RA. The aim of t...

journal_title：Annals of the rheumatic diseases

authors： Hu F,Mu R,Zhu J,Shi L,Li Y,Liu X,Shao W,Li G,Li M,Su Y,Cohen PL,Qiu X,Li Z

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Previous data have shown that etanercept levels are associated with clinical response in rheumatoid arthritis. However, for ankylosing spondylitis (AS), data regarding this topic are inconclusive. OBJECTIVES:To investigate the relationship between etanercept levels and clinical response in patients with AS....

journal_title：Annals of the rheumatic diseases

authors： Kneepkens EL,Krieckaert CL,van der Kleij D,Nurmohamed MT,van der Horst-Bruinsma IE,Rispens T,Wolbink GJ

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To determine the circulating serum concentrations of nerve growth factor (NGF) and compare them with indices of disease activity in juvenile chronic arthritis. METHODS:NGF concentrations were evaluated with a two site immunoenzymatic assay (ELISA), in 17 children with systemic, 39 with polyarticular, and 24 ...

journal_title：Annals of the rheumatic diseases

authors： Falcini F,Matucci Cerinic M,Lombardi A,Generini S,Pignone A,Tirassa P,Ermini M,Lepore L,Partsch G,Aloe L

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVES:Target trial emulation is an intuitive design framework that encourages investigators to formulate their comparative effectiveness research (CER) question as a hypothetical randomised controlled trial (RCT). Our aim was to systematically review CER studies in rheumatoid arthritis (RA) to provide examples of ...

journal_title：Annals of the rheumatic diseases

authors： Zhao SS,Lyu H,Solomon DH,Yoshida K

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the long-term safety (up to 3 years) of treatment with pegloticase in patients with refractory chronic gout. METHODS:This open-label extension (OLE) study was conducted at 46 sites in the USA, Canada and Mexico. Patients completing either of two replicate randomised placebo-controlled 6-month tri...

journal_title：Annals of the rheumatic diseases

authors： Becker MA,Baraf HS,Yood RA,Dillon A,Vázquez-Mellado J,Ottery FD,Khanna D,Sundy JS

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To analyse the association between chondrocalcinosis and osteoarthritis (OA) of the hands and knees in an unselected elderly rural population. METHODS:A community based cross sectional study was performed in individuals randomly selected from a previous epidemiological survey on the prevalence of chondrocal...

journal_title：Annals of the rheumatic diseases

authors： Sanmarti R,Kanterewicz E,Pladevall M,Pañella D,Tarradellas JB,Gomez JM

更新日期：1996-01-01 00:00:00

abstract：:The circulating levels of hyaluronate were determined in 36 patients with scleroderma and in 36 control subjects matched for age and sex. The mean serum hyaluronate concentration in patients with progressive systemic sclerosis (n = 25) was 131 +/- 67 (SD) microgram/l and significantly greater (p less than 0.001) than ...

journal_title：Annals of the rheumatic diseases

authors： Engström-Laurent A,Feltelius N,Hällgren R,Wasteson A

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:There is increased cardiovascular disease mortality in rheumatoid arthritis. This may reflect an increased prevalence of cardiovascular disease or an increased case fatality in patients with rheumatoid arthritis. OBJECTIVES:To examine whether rheumatoid patients with disease onset in the 1980s-1990s have in...

journal_title：Annals of the rheumatic diseases

authors： Goodson N,Marks J,Lunt M,Symmons D

更新日期：2005-11-01 00:00:00

abstract：:The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

journal_title：Annals of the rheumatic diseases

authors： Stevenson AC,Silcock SR,Scott JT

更新日期：1976-04-01 00:00:00

abstract：INTRODUCTION:The molecular mechanisms of syndesmophyte formation in ankylosing spondylitis (AS) are yet to be characterised. Molecules involved in bone formation such as Wnt proteins and their antagonists probably drive syndesmophyte formation in AS. METHODS:This study investigated sequential serum levels of functiona...

journal_title：Annals of the rheumatic diseases

authors： Heiland GR,Appel H,Poddubnyy D,Zwerina J,Hueber A,Haibel H,Baraliakos X,Listing J,Rudwaleit M,Schett G,Sieper J

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Compare the radiographic progression of ankylosing spondylitis (AS) patients treated with infliximab (INF) versus historical controls (Herne cohort, HC) never treated with tumour necrosis factor (TNF)-blockers over 8 years. METHODS:Patients were selected based on the availability of lateral cervical and lumb...

journal_title：Annals of the rheumatic diseases

authors： Baraliakos X,Haibel H,Listing J,Sieper J,Braun J

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Physical function in rheumatoid arthritis (RA) has reversible and irreversible components, and is typically assessed by the Health Assessment Questionnaire Disability Index (HAQ). Since irreversible components are expected to increase with longer duration of RA and reduce the ability for improvement in physi...

journal_title：Annals of the rheumatic diseases

authors： Aletaha D,Strand V,Smolen JS,Ward MM

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To examine the imaging-detected mechanism of reduction of structural joint damage progression by tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) using MRI. METHODS:In a substudy of a randomised, double-blind, phase 3b study (ACT-RAY) of biologic-naïve patients with RA who were methotrexate (MTX)...

journal_title：Annals of the rheumatic diseases

authors： Conaghan PG,Peterfy C,Olech E,Kaine J,Ridley D,Dicarlo J,Friedman J,Devenport J,Troum O

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To elucidate the clinical importance of the anti-signal recognition particle (SRP) autoantibody in patients with myositis. METHODS:Retrospective systematic assessment of the clinical, laboratory and histological characteristics of 23 anti-SRP-positive patients from six European centres. Data were compared wi...

journal_title：Annals of the rheumatic diseases

authors： Hengstman GJ,ter Laak HJ,Vree Egberts WT,Lundberg IE,Moutsopoulos HM,Vencovsky J,Doria A,Mosca M,van Venrooij WJ,van Engelen BG

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:To report the results of a pilot study using rituximab combined with Peg-interferon (IFN) alpha2b-ribavirin in severe refractory hepatitis C virus (HCV) related mixed cryoglobulinaemia (MC) vasculitis. METHODS:Sixteen consecutive patients with severe HCV-MC vasculitis that were resistant (n = 11) or relapse...

journal_title：Annals of the rheumatic diseases

authors： Saadoun D,Resche-Rigon M,Sene D,Perard L,Karras A,Cacoub P

更新日期：2008-10-01 00:00:00

abstract：:A patient with systemic lupus erythematosus was first diagnosed after she had developed the Budd-Chiari syndrome. We believe that the Budd-Chiari syndrome was part of her tendency for thrombosis, induced by the presence of a lupus anticoagulant. The association between enhanced thrombosis and the lupus anticoagulant i...

journal_title：Annals of the rheumatic diseases

authors： Averbuch M,Levo Y

更新日期：1986-05-01 00:00:00

abstract：:The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9....

journal_title：Annals of the rheumatic diseases

authors： Tokunaga M,Ohuchi K,Yoshizawa S,Tsurufuji S,Rikimaru A,Wakamatsu E

更新日期：1981-10-01 00:00:00

abstract：:(1) The phagocytosis of human IgG, IgM, and C3 by granulocytes from various rheumatoid and nonrheumatoid sera and synovial fluids (SF) was investigated by direct examination of the patient's leucocytes and indirect testing by incubation of normal donor leucocytes with various sera and SF. (2) In rheumatoid arthritis (...

journal_title：Annals of the rheumatic diseases

authors： Cats A,Lafeber GJ,Klein F

更新日期：1975-04-01 00:00:00

abstract：OBJECTIVE:To investigate the rate of incident diabetes mellitus (DM) in patients with rheumatoid arthritis (RA) and the impact of disease-modifying antirheumatic drug (DMARD) and statin treatments. METHODS:We studied patients with RA and ≥1 year participation in the National Data Bank for Rheumatic Diseases without ba...

journal_title：Annals of the rheumatic diseases

authors： Ozen G,Pedro S,Holmqvist ME,Avery M,Wolfe F,Michaud K

更新日期：2017-05-01 00:00:00

abstract：:The response of synovial lymphocytes from a 65-year-old lady with persistent polyarthritis, to rubella antigen and a number of other microbial agents was studied over a period of 11 months by [3H]thymidine incorporation. The results were correlated with the ability to isolate rubella virus from both peripheral blood a...

journal_title：Annals of the rheumatic diseases

authors： Chantler JK,da Roza DM,Bonnie ME,Reid GD,Ford DK

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate the association between MRI findings (cartilage defects, bone marrow lesions (BML), osteophytes, meniscal lesion, effusion/synovitis, ligamentous abnormalities, subchondral cysts and bone attrition) and pain in patients with knee osteoarthritis (OA) in order to establish the relevan...

journal_title：Annals of the rheumatic diseases

authors： Yusuf E,Kortekaas MC,Watt I,Huizinga TW,Kloppenburg M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the value of power Doppler ultrasound (PDUS) in combination with routine management in a cohort of patients with very early inflammatory arthritis (IA). METHODS:50 patients with < or =12 weeks of inflammatory symptoms with or without signs had clinical, laboratory and ima...

journal_title：Annals of the rheumatic diseases

authors： Freeston JE,Wakefield RJ,Conaghan PG,Hensor EM,Stewart SP,Emery P

更新日期：2010-02-01 00:00:00