Rituximab combined with Peg-interferon-ribavirin in refractory hepatitis C virus-associated cryoglobulinaemia vasculitis.

abstract：BACKGROUND:Previous studies have reported an interaction between ever cigarette smoking and the presence of the human leukocyte antigen (HLA)-DRB1 shared epitope (SE) genotype and rheumatoid arthritis (RA) risk. To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the...

journal_title：Annals of the rheumatic diseases

authors： Karlson EW,Chang SC,Cui J,Chibnik LB,Fraser PA,De Vivo I,Costenbader KH

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To determine how acute but transient inflammation affects the cartilage proteoglycan aggrecan and the value of analyses of synovial fluid to study this. METHODS:For 96 hours after a single intra-articular injection of rabbit knees with human interleukin-1 alpha (IL-1 alpha) or vehicle, articular cartilage an...

journal_title：Annals of the rheumatic diseases

authors： Lundberg C,Asberg I,Ionescu M,Reiner A,Smedegård G,Poole AR

更新日期：1996-08-01 00:00:00

abstract：:Information has been collected on 10 patients, 9 with marrow depression and 1 in whom the diagnosis was presumed. Six of the 10 patients died. The sequentially recorded blood counts on at least 5 of the patients showed a downward trend of the white cell and platelet counts while D-penicillamine was still being adminis...

journal_title：Annals of the rheumatic diseases

authors： Kay AG

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVES:To show whether intra-articular steroid injections are effective in osteoarthritis; to determine factors that predict response; and to determine whether injection has a beneficial effect on muscle strength. METHODS:Double blind, placebo controlled, crossover study in 59 patients with symptomatic osteoarthri...

journal_title：Annals of the rheumatic diseases

authors： Jones A,Doherty M

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVES:Expression of major histocompatibility complex (MHC) class II genes is almost exclusively regulated by the class II transactivator. A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarctio...

journal_title：Annals of the rheumatic diseases

authors： Martínez A,Sánchez-Lopez M,Varadé J,Mas A,Martín MC,de Las Heras V,Arroyo R,Mendoza JL,Díaz-Rubio M,Fernández-Gutiérrez B,de la Concha EG,Urcelay E

更新日期：2007-03-01 00:00:00

abstract：:In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune...

journal_title：Annals of the rheumatic diseases

authors： French MA,Harrison G,Penning CA,Cunningham J,Hughes P,Rowell NR

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously t...

journal_title：Annals of the rheumatic diseases

authors： Bergmann C,Brandt A,Merlevede B,Hallenberger L,Dees C,Wohlfahrt T,Pötter S,Zhang Y,Chen CW,Mallano T,Liang R,Kagwiria R,Kreuter A,Pantelaki I,Bozec A,Abraham D,Rieker R,Ramming A,Distler O,Schett G,Distler JHW

更新日期：2018-01-01 00:00:00

abstract：:Whole gut lavage fluid is a useful source of material for the study of intestinal immunity and inflammation in humans. Systemic and mucosal antibodies to Klebsiella pneumoniae were measured by enzyme linked immunosorbent assay (ELISA) in serum samples and whole gut lavage fluid from 14 patients with ankylosing spondyl...

journal_title：Annals of the rheumatic diseases

authors： O'Mahony S,Anderson N,Nuki G,Ferguson A

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVE:To analyse matrix metalloproteinases (MMPs) and tissue inhibitor-1 of MMPs (TIMP-1) levels in the systemic circulation and synovial fluid (SF) of patients with RA and to compare these levels with inflammatory and collagen degradation markers. METHODS:ProMMP-1, -2, -3, -8, -9, TIMP-1, levels of MMP/alpha(2)-m...

journal_title：Annals of the rheumatic diseases

authors： Tchetverikov I,Ronday HK,Van El B,Kiers GH,Verzijl N,TeKoppele JM,Huizinga TW,DeGroot J,Hanemaaijer R

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:A disease activity-guided dose optimisation strategy of adalimumab or etanercept (TNFi (tumour necrosis factor inhibitors)) has shown to be non-inferior in maintaining disease control in patients with rheumatoid arthritis (RA) compared with usual care. However, the cost-effectiveness of this strategy is stil...

journal_title：Annals of the rheumatic diseases

authors： Kievit W,van Herwaarden N,van den Hoogen FH,van Vollenhoven RF,Bijlsma JW,van den Bemt BJ,van der Maas A,den Broeder AA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the ability of ultrasound (US) to detect the presence and change of Achilles erosions in spondyloarthritis (SpA). METHODS:A blind prospective two-dimensional (2D) and three-dimensional (3D) US study of Achilles enthesis erosions in early SpA was undertaken. US examinations were performed at basel...

journal_title：Annals of the rheumatic diseases

authors： de Miguel E,Falcao S,Castillo C,Plasencia C,García M,Branco JC,Martín-Mola E

更新日期：2011-11-01 00:00:00

abstract：:Results are reported from the first prospective study of gout in New Zealand Maoris based on a sample of 388 males and 378 females. At baseline, high mean levels of serum uric acid (SUA) were found, 0.422 +/- 0.092 mmol/1 (7.05 +/- 1.54 mg/100 ml) in males and 0.350 +/- 0.091 mmol/1 (5.85 +/- 1.52 mg/100 ml) in female...

journal_title：Annals of the rheumatic diseases

authors： Brauer GW,Prior IA

更新日期：1978-10-01 00:00:00

abstract：:The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming growth factor beta (TGF-beta) was investigated in vitro and in vivo. In vitro TGF-beta (400 pmol/l) had no effect on basal proteoglycan degradation. Proteoglycan degradation induced by IL-1, ho...

journal_title：Annals of the rheumatic diseases

authors： van Beuningen HM,van der Kraan PM,Arntz OJ,van den Berg WB

更新日期：1993-03-01 00:00:00

abstract：:Spontaneous production of the interferon induced enzyme 2',5'-oligoadenylate synthetase (2',5'-A synthetase) was significantly greater in blood lymphocytes of patients with systemic lupus erythematosus (SLE), Behçet's syndrome, and rheumatoid arthritis than in control lymphocytes. Alpha interferon (IFN-alpha) induced ...

journal_title：Annals of the rheumatic diseases

authors： Hylton W,Cayley J,Dore C,Denman AM

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Rheumatoid factors (RFs) and antibodies against cyclic citrullinated peptides (CCPs) of IgG, IgA and IgM isotype have been shown to precede disease onset by years. OBJECTIVE:To evaluate serological risk markers in first-degree relatives from multicase families in relation to genetic and environmental risk f...

journal_title：Annals of the rheumatic diseases

authors： Ärlestig L,Mullazehi M,Kokkonen H,Rocklöv J,Rönnelid J,Dahlqvist SR

更新日期：2012-06-01 00:00:00

abstract：:Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less...

journal_title：Annals of the rheumatic diseases

authors： Schumacher HR,Dorwart BB,Bond J,Alavi A,Miller W

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation may contribute to accelerated atherosclerosis and increased arterial stiffness in patients with rheumatoid arthritis (RA). In addition to lowering cholesterol, statins have immunomodulatory effects which may be especially beneficial in patients with RA who have systemic immune a...

journal_title：Annals of the rheumatic diseases

authors： Van Doornum S,McColl G,Wicks IP

更新日期：2004-12-01 00:00:00

abstract：:Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia an...

journal_title：Annals of the rheumatic diseases

authors： Granfors K,Toivanen A

更新日期：1986-07-01 00:00:00

abstract：:Serum immunoglobulins were measured in 122 patients with ankylosing spondylitis (AS) during various phases of disease activity and compared to those in 58 healthy subjects. The mean serum IgA was 38% higher in patients (306.9 mg/dl) than in controls (222.7 mg/dl) (P < 0.005), but there was no significant difference in...

journal_title：Annals of the rheumatic diseases

authors： Cowling P,Ebringer R,Ebringer A

更新日期：1980-12-01 00:00:00

abstract：OBJECTIVES:To determine if the presence of low percentages of CD8 positive cells or high levels of soluble interleukin-2 receptors (sIL-2R) define a subgroup of patients with more severe polymyalgia rheumatica and giant cell arteritis (PMR/GCA). METHODS:38 PMR/GCA patients were followed up prospectively. Serum levels ...

journal_title：Annals of the rheumatic diseases

authors： Salvarani C,Boiardi L,Macchioni P,Rossi F,Tartoni P,Casadei Maldini M,Mancini R,Beltrandi E,Portioli I

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:To characterise activation of the type I interferon (IFN) pathway in patients with systemic lupus erythematosus (SLE), dermatomyositis (DM), polymyositis (PM), rheumatoid arthritis (RA) and systemic scleroderma (SSc) and to evaluate the potential to develop a molecular diagnostic tool from the peripheral bloo...

journal_title：Annals of the rheumatic diseases

authors： Higgs BW,Liu Z,White B,Zhu W,White WI,Morehouse C,Brohawn P,Kiener PA,Richman L,Fiorentino D,Greenberg SA,Jallal B,Yao Y

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The Health Assessment Questionnaire Disability Index (HAQ-DI) is the most widely used measure of function in rheumatoid arthritis (RA). OBJECTIVE:To evaluate individualised forms of the HAQ-DI and thus enhance the incorporation of patients' views in outcome assessment. PATIENTS AND METHODS:HAQ-DI data were...

journal_title：Annals of the rheumatic diseases

authors： Seror R,Tubach F,Baron G,Guillemin F,Ravaud P

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To investigate the inflammatory response in giant cell arteritis (GCA) by characterising the DNA methylation pattern within the temporal artery microenvironment. METHODS:Twelve patients with non-equivocal histological evidence for GCA and 12 age-matched, sex-matched and ethnicity-matched controls with normal...

journal_title：Annals of the rheumatic diseases

authors： Coit P,De Lott LB,Nan B,Elner VM,Sawalha AH

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To investigate the involvement of interleukin-1 (IL-1) in the induction or maintenance of the insulin-like growth factor 1 (IGF-1) non-responsive state of chondrocytes during experimental arthritis in mouse knee joints. METHODS:To characterise IGF-1 nonresponsiveness during arthritis, we measured chondrocyte...

journal_title：Annals of the rheumatic diseases

authors： Verschure PJ,Joosten LA,Van de Loo FA,Van den Berg WB

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular cartilage structure predict knee replacement, and to establish their utility as outcomes in cli...

journal_title：Annals of the rheumatic diseases

authors： Eckstein F,Kwoh CK,Boudreau RM,Wang Z,Hannon MJ,Cotofana S,Hudelmaier MI,Wirth W,Guermazi A,Nevitt MC,John MR,Hunter DJ,OAI investigators.

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To investigate quantitatively the mRNA expression levels of YKL-40, an established marker of rheumatoid and osteoarthritic cartilage degeneration in synovial fluid and serum, and a closely related molecule YKL-39, in articular chondrocytes. METHODS:cDNA array and online quantitative polymerase chain reaction...

journal_title：Annals of the rheumatic diseases

authors： Knorr T,Obermayr F,Bartnik E,Zien A,Aigner T

更新日期：2003-10-01 00:00:00

abstract：:The phenomenon of increased spontaneous incorporation of 3H-thymidine (3H-TdR) into peripheral blood mononuclear cells in rheumatoid arthritis (RA) has been investigated. The activity was found to be short lived and affected less than 1% of cells. Using a Percoll density gradient we identified two populations of activ...

journal_title：Annals of the rheumatic diseases

authors： Froebel K,Dickson R,Lewis D,Jasani MK,Sturrock RD

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:To compare responsiveness of the Harris Hip Score with generic measures (that is, the Short Form-36 (SF-36), and a test of walking speed and pain during walking) in patients with osteoarthritis (OA) of the hip. METHOD:The first 75 cases within the population of a randomised clinical trial on manual therapy a...

journal_title：Annals of the rheumatic diseases

authors： Hoeksma HL,Van Den Ende CH,Ronday HK,Heering A,Breedveld FC

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Certain sequences present in the hypervariable region of human leucocyte antigen (HLA)-DRB1 known as the shared epitope (SE) are hypothesised to increase the risk of rheumatoid arthritis (RA), whereas alleles encoding aspartic acid at position 70 (D70 alleles) may have a protective effect. METHODS:Patient H...

journal_title：Annals of the rheumatic diseases

authors： Shadick NA,Heller JE,Weinblatt ME,Maher NE,Cui J,Ginsburg G,Coblyn J,Anderson R,Solomon DH,Roubenoff R,Parker A

更新日期：2007-11-01 00:00:00