High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis.

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibodies (ACPAs) are the hallmark of rheumatoid arthritis (RA). Protein citrullination is believed to drive autoantigen selection in RA. Nonetheless, several autoantigens in RA are targeted as native (unmodified) proteins. Here, the study of hnRNP A2/B1 (RA33) provides a framewor...

journal_title：Annals of the rheumatic diseases

authors： Konig MF,Giles JT,Nigrovic PA,Andrade F

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis (RA) in populations of Northern European descent. The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (I...

journal_title：Annals of the rheumatic diseases

authors： Naseem H,Thomson W,Silman A,Worthington J,Symmons D,Barton A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of calcium phosphate mineral salt accumulation in degenerative supraspinatus 'tendinitis' compared with a normal sample of human tendons, and to determine whether there is an association of calcium salt deposition with pathological changes in the tendon extracellular matrix. ME...

journal_title：Annals of the rheumatic diseases

authors： Riley GP,Harrall RL,Constant CR,Cawston TE,Hazleman BL

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:To compare the effects of etanercept (ETN) 50 mg once weekly plus methotrexate (MTX) versus MTX alone on patient-reported outcomes (PROs) and the relationship between remission and PRO improvement. METHODS:In this double-blind, randomised clinical trial (COMET), PROs included: the Health Assessment Question...

journal_title：Annals of the rheumatic diseases

authors： Kekow J,Moots RJ,Emery P,Durez P,Koenig A,Singh A,Pedersen R,Robertson D,Freundlich B,Sato R

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To study immunological markers and compare these markers with standard measures for the clinical and immunological follow up of vasculitis activity in hepatitis C virus (HCV) associated cryoglobulinaemic vasculitis (CV). METHODS:Serial serum samples from eight patients with newly diagnosed HCV associated CV ...

journal_title：Annals of the rheumatic diseases

authors： Lamprecht P,Moosig F,Gause A,Herlyn K,Csernok E,Hansen H,Gross WL

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. METHODS:This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs ...

journal_title：Annals of the rheumatic diseases

authors： Conaghan PG,D'Agostino MA,Le Bars M,Baron G,Schmidely N,Wakefield R,Ravaud P,Grassi W,Martin-Mola E,So A,Backhaus M,Malaise M,Emery P,Dougados M

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To investigate the hypothesis that synovial fluid (SF) from patients with osteoarthritis (OA) may contain calcium phosphate crystals that are either too small, or too few in number to be identified by conventional light microscopy techniques. METHODS:Twelve SF from 11 patients with established knee OA, five...

journal_title：Annals of the rheumatic diseases

authors： Swan A,Chapman B,Heap P,Seward H,Dieppe P

更新日期：1994-07-01 00:00:00

abstract：:An acute inflammatory arthritis has been induced in 76% of rats injected intradermally with native bovine type II collagen emulsified in Freund's complete (CFA) or incomplete (ICFA) adjuvant. The arthritis became chronic in 14 out of 31 rats, and ear and tail lesions were noted in some rats. No arthritis was induced b...

journal_title：Annals of the rheumatic diseases

authors： Morgan K,Clague RB,Shaw MJ,Holt PJ

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVES:The aim of this report is to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) equivalence as well as similar efficacy, safety and immunogenicity between GP2013, a biosimilar rituximab, and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA) with inadequate response or intolerance to...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Cohen SB,Tony HP,Scheinberg M,Kivitz A,Balanescu A,Gomez-Reino J,Cen L,Zhu P,Shisha T

更新日期：2017-09-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Roberts-Thomson PJ

更新日期：1990-02-01 00:00:00

abstract：:Cultures of synovial cells obtained at surgery from patients with rheumatoid arthritis produced a protein which inhibits the mitosis of normal rabbit and human synovial cells, and of human lung fibroblasts. This mitotic inhibitory effect can be transferred to rabbit synovial cells by intra-articular injection of the a...

journal_title：Annals of the rheumatic diseases

authors： Smith CA

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To maintain and optimise the quality of care provided by health professionals in rheumatology (HPRs), adequate educational offerings are needed. This task force (TF) aimed to develop evidence-based recommendations for the generic core competences of HPRs, with specific reference to nurses, physica...

journal_title：Annals of the rheumatic diseases

authors： Edelaar L,Nikiphorou E,Fragoulis GE,Iagnocco A,Haines C,Bakkers M,Barbosa L,Cikes N,Ndosi M,Primdahl J,Prior Y,Pchelnikova P,Ritschl V,Schäfer VS,Smucrova H,Storrønning I,Testa M,Wiek D,Vliet Vlieland TPM

更新日期：2020-01-01 00:00:00

abstract：:Neutrophil chemiluminescence was determined in patients with active rheumatoid arthritis. Twelve patients were randomly assigned either to a diet high in polyunsaturated fatty acids supplemented with eicosapentaenoic and docosahexaenoic acids or to a diet high in saturated fatty acids. A correlation with clinical and ...

journal_title：Annals of the rheumatic diseases

authors： Magaro M,Altomonte L,Zoli A,Mirone L,De Sole P,Di Mario G,Lippa S,Oradei A

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVES:To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS:A web-based exercise and subsequent patien...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Scirè CA,Adinolfi A,Damjanov NS,Carrara G,Bruyn GAW,Cazenave T,D'Agostino MA,Delle Sedie A,Di Sabatino V,Diaz Cortes ME,Filippucci E,Gandjbakhch F,Gutierrez M,Maccarter DK,Micu M,Möller Parera I,Mouterde G,

更新日期：2018-08-01 00:00:00

abstract：:The possible contribution of immunological mechanisms in the development of Libman-Sacks endocarditis was studied in 2 patients with systemic lupus erythematosus who underwent aortic valve replacement. Sections of verrucous lesions, stained with haematoxylin and eosin, showed three apparently distinct zones: an outer ...

journal_title：Annals of the rheumatic diseases

authors： Shapiro RF,Gamble CN,Wiesner KB,Castles JJ,Wolf AW,Hurley EJ,Salel AF

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:To perform a prospective long term follow up study comparing conventional radiography (CR), ultrasonography (US), and magnetic resonance imaging (MRI) in the detection of bone erosions and synovitis in rheumatoid arthritis (RA) finger joints. METHODS:The metacarpophalangeal and proximal interphalangeal joint...

journal_title：Annals of the rheumatic diseases

authors： Scheel AK,Hermann KG,Ohrndorf S,Werner C,Schirmer C,Detert J,Bollow M,Hamm B,Müller GA,Burmester GR,Backhaus M

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. METHODS:A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing ...

journal_title：Annals of the rheumatic diseases

authors： Reginster JY,Dudler J,Blicharski T,Pavelka K

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:Improved DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology was used to monitor the changes in the galactosylation status of serum immunoglobulins during the immune response and therapy of autoimmune arthritis. METHODS:Collagen-induced arthritis (CIA) was induced in ...

journal_title：Annals of the rheumatic diseases

authors： Van Beneden K,Coppieters K,Laroy W,De Keyser F,Hoffman IE,Van den Bosch F,Vander Cruyssen B,Drennan M,Jacques P,Rottiers P,Verbruggen G,Contreras R,Callewaert N,Elewaut D

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS). METHODS:Thirty-six patients with primary APS, 42 control patients with non-systemic lupus erythematosus (SLE) connective tissue diseases, and 36 healthy volunteers were analysed retrospectively....

journal_title：Annals of the rheumatic diseases

authors： Oku K,Atsumi T,Bohgaki M,Amengual O,Kataoka H,Horita T,Yasuda S,Koike T

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routi...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Breedveld FC,Burmester GR,Bykerk V,Dougados M,Emery P,Kvien TK,Navarro-Compán MV,Oliver S,Schoels M,Scholte-Voshaar M,Stamm T,Stoffer M,Takeuchi T,Aletaha D,Andreu JL,Aringer M,Bergman M,Betteridge N,Bijls

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

journal_title：Annals of the rheumatic diseases

authors： Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. METHODS:Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatolo...

journal_title：Annals of the rheumatic diseases

authors： Lundberg IE,Tjärnlund A,Bottai M,Werth VP,Pilkington C,Visser M,Alfredsson L,Amato AA,Barohn RJ,Liang MH,Singh JA,Aggarwal R,Arnardottir S,Chinoy H,Cooper RG,Dankó K,Dimachkie MM,Feldman BM,Torre IG,Gordon P,Hayas

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is considered a pauci-immune systemic vasculitis based on the absence of immune deposits in renal biopsies of patients with active disease. In animal models of antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis, immune deposits along the glomerular capillar...

journal_title：Annals of the rheumatic diseases

authors： Brons RH,de Jong MC,de Boer NK,Stegeman CA,Kallenberg CG,Tervaert JW

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:To determine whether occurrence, characteristics, and progression of systemic lupus erythematosus (SLE) are associated with polymorphism of the mannose binding lectin (MBL) gene and with serum MBL concentration. METHODS:Codon 54 MBL gene polymorphism of 147 patients with SLE and 160 healthy controls was dete...

journal_title：Annals of the rheumatic diseases

authors： Takahashi R,Tsutsumi A,Ohtani K,Muraki Y,Goto D,Matsumoto I,Wakamiya N,Sumida T

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is associated with high morbidity and mortality in rheumatoid arthritis (RA). Citrullinated proteins are observed in RA lung tissues; however, the association of specific anticitrullinated peptide antibodies (ACPA) with ILD in RA is unknown. METHODS:RA patients underwent mult...

journal_title：Annals of the rheumatic diseases

authors： Giles JT,Danoff SK,Sokolove J,Wagner CA,Winchester R,Pappas DA,Siegelman S,Connors G,Robinson WH,Bathon JM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease. OBJECTIVE:To combine hrMRI and cadaveric histological studie...

journal_title：Annals of the rheumatic diseases

authors： Tan AL,Toumi H,Benjamin M,Grainger AJ,Tanner SF,Emery P,McGonagle D

更新日期：2006-10-01 00:00:00

abstract：:Erosions on the triquetrum and pisiform are frequent in early rheumatoid arthritis and occur characteristically at 3 sites. (a) A shallow erosion on the proximal medial triquetral "bare" area is related to synovial proliferation at the margin of the radiocarpal cavity, although compressive forces from an adjacent long...

journal_title：Annals of the rheumatic diseases

authors： Resnick D

更新日期：1976-02-01 00:00:00

abstract：OBJECTIVES:There is a lipid paradox in rheumatoid arthritis describing that despite low lipids related to systemic inflammation, there is an increased cardiovascular (CV) risk. Our aim was to evaluate if baseline lipid levels or baseline systemic inflammation were associated with the statin dose sufficient to achieve l...

journal_title：Annals of the rheumatic diseases

authors： Rollefstad S,Ikdahl E,Hisdal J,Kvien TK,Pedersen TR,Holme I,Semb AG

更新日期：2015-08-01 00:00:00