Early abnormalities of pisiform and triquetrum in rheumatoid arthritis.

abstract：OBJECTIVE:To assess pooled golimumab safety up to year 3 of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) trials. METHODS:Golimumab 50 and 100 mg, administered subcutaneously (SC) every 4 weeks (q4wk), were assessed in patients with active RA (methotrexate-naïve, methotrexate-exp...

journal_title：Annals of the rheumatic diseases

authors： Kay J,Fleischmann R,Keystone E,Hsia EC,Hsu B,Mack M,Goldstein N,Braun J,Kavanaugh A

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using coronary CT angiography (CCTA). METHODS:Ninety consecutive patients with PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls (male: 137(57.1%); 49.6±10.7 years) without known cardiovasc...

journal_title：Annals of the rheumatic diseases

authors： Shen J,Wong KT,Cheng IT,Shang Q,Li EK,Wong P,Kun EW,Law MY,Yip R,Yim I,Ying S,Li M,Li TK,Wong CK,Zhu TY,Lee JJ,Chang M,Lee AP,Tam LS

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α). This study was aimed at investigating the role of PGRN in degradat...

journal_title：Annals of the rheumatic diseases

authors： Zhao YP,Liu B,Tian QY,Wei JL,Richbourgh B,Liu CJ

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:To compare the prevalence and pattern of neuropsychiatric (NP) syndromes observed in systemic lupus erythematosus (SLE) to patients with Primary Sjögren syndrome (PSS) using the American College of Rheumatology (ACR) criteria for the 19 NP syndromes seen in SLE. METHODS:A population-based study was conducte...

journal_title：Annals of the rheumatic diseases

authors： Harboe E,Tjensvoll AB,Maroni S,Gøransson LG,Greve OJ,Beyer MK,Herigstad A,Kvaløy JT,Omdal R

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. METHODS:A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (...

journal_title：Annals of the rheumatic diseases

authors： Doherty M,Hawkey C,Goulder M,Gibb I,Hill N,Aspley S,Reader S

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term effects of induction therapy with adalimumab (ADA) plus methotrexate (MTX) in comparison with placebo (PBO) plus MTX in DMARD-naïve patients with active early rheumatoid arthritis (RA). METHODS:Patients with active early RA (disease duration of ≤12 months) were randomly assigned ...

journal_title：Annals of the rheumatic diseases

authors： Detert J,Bastian H,Listing J,Weiß A,Wassenberg S,Liebhaber A,Rockwitz K,Alten R,Krüger K,Rau R,Simon C,Gremmelsbacher E,Braun T,Marsmann B,Höhne-Zimmer V,Egerer K,Buttgereit F,Burmester GR

更新日期：2013-06-01 00:00:00

abstract：:Thirty two patients with ankylosing spondylitis were investigated with a set of pulmonary function tests and the results compared with those for a control population. The patients had no complaints about lung symptoms and their chest radiographs were normal. The main pathological findings were reduced lung volumes, a ...

journal_title：Annals of the rheumatic diseases

authors： Feltelius N,Hedenström H,Hillerdal G,Hällgren R

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

journal_title：Annals of the rheumatic diseases

authors： Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of psoriatic arthritis (PsA) among patients with psoriasis exposed to physical trauma. METHODS:A matched cohort study was performed using data from The Health Improvement Network (THIN). Patients with psoriasis exposed to trauma were randomly matched to up to five unexposed psoriasis co...

journal_title：Annals of the rheumatic diseases

authors： Thorarensen SM,Lu N,Ogdie A,Gelfand JM,Choi HK,Love TJ

更新日期：2017-03-01 00:00:00

abstract：:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals in the treatment and follow-u...

journal_title：Annals of the rheumatic diseases

authors： Ozen S,Demirkaya E,Erer B,Livneh A,Ben-Chetrit E,Giancane G,Ozdogan H,Abu I,Gattorno M,Hawkins PN,Yuce S,Kallinich T,Bilginer Y,Kastner D,Carmona L

更新日期：2016-04-01 00:00:00

abstract：:Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship bet...

journal_title：Annals of the rheumatic diseases

authors： Walsh L,Davies P,McConkey B

更新日期：1979-08-01 00:00:00

abstract：:A 21-year-old woman developed persistent polyarthritis indistinguishable from rheumatoid arthritis after rubella. The arthritis persisted for approximately 30 months and was associated with high levels of antibody to rubella virus and with rheumatoid factor. The antibody titres declined pari passu with clinical improv...

journal_title：Annals of the rheumatic diseases

authors： McCormick JN,Duthie JJ,Gerber H,Hart H,Baker S,Marmion BP

更新日期：1978-06-01 00:00:00

abstract：:Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia an...

journal_title：Annals of the rheumatic diseases

authors： Granfors K,Toivanen A

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA). METHODS:A randomised, double-blind, placebo-controlled, dose-e...

journal_title：Annals of the rheumatic diseases

authors： Burmester GR,Feist E,Sleeman MA,Wang B,White B,Magrini F

更新日期：2011-09-01 00:00:00

abstract：:A patient with systemic lupus erythematosus who developed pneumococcal epiglottitis is described and the literature reviewed. This infection is extremely rare in adults, and only 10 cases, none of them with SLE, have so far been reported. Epiglottitis is usually caused by Haemophilus influenzae. However, in immunocomp...

journal_title：Annals of the rheumatic diseases

authors： Shalit M,Gross DJ,Levo Y

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:To assess the intra and interobserver reproducibility of musculoskeletal ultrasonography (US) among rheumatologists in detecting destructive and inflammatory shoulder abnormalities in patients with rheumatoid arthritis (RA) and to determine the overall agreement between US and MRI. METHODS:A total of 14 obse...

journal_title：Annals of the rheumatic diseases

authors： Bruyn GA,Naredo E,Möller I,Moragues C,Garrido J,de Bock GH,d'Agostino MA,Filippucci E,Iagnocco A,Backhaus M,Swen WA,Balint P,Pineda C,Milutinovic S,Kane D,Kaeley G,Narvaez FJ,Wakefield RJ,Narvaez JA,de Augustin J,

更新日期：2009-03-01 00:00:00

abstract：:The serological diagnosis of juvenile rheumatoid arthritis (JRA) is difficult, with only 7-10% of patients 19S IgM rheumatoid factor positive. About 60-70% of patients are positive for hidden 19S IgM rheumatoid factor, but this test requires serum separation and is not available in most laboratories. Antiperinuclear f...

journal_title：Annals of the rheumatic diseases

authors： Nesher G,Moore TL,Grisanti MW,el-Najdawi E,Osborn TG

更新日期：1992-03-01 00:00:00

abstract：:Four patients with Neisseria meningitidis infection complicated by arthritis are described. Three patients had an acute polyarthritis which responded quickly to antimicrobial therapy. A fourth patient developed a prolonged arthritis which occurred after the initial infection had been successfully treated. Tenosynoviti...

journal_title：Annals of the rheumatic diseases

authors： Kidd BL,Hart HH,Grigor RR

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVES:This prospective study was designed to clarify the frequency, causes, and clinical course of renal disease in patients with early rheumatoid arthritis (RA). METHODS:235 patients (185 women, mean age 49.4 years) with early RA of less than one year's duration were enrolled and assessed monthly. Proteinuria wa...

journal_title：Annals of the rheumatic diseases

authors： Koseki Y,Terai C,Moriguchi M,Uesato M,Kamatani N

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:The MEFV gene is responsible for familial Mediterranean fever (FMF). Several disease associated mutations have been identified. The range of genetic variation in MEFV in Greek patients has not been determined. OBJECTIVE:To describe a method that facilitates the routine screening of the entire coding sequenc...

journal_title：Annals of the rheumatic diseases

authors： Ritis K,Giaglis S,Spathari N,Micheli A,Zonios D,Tzoanopoulos D,Deltas CC,Rafail S,Mean R,Papadopoulos V,Tzioufas AG,Moutsopoulos HM,Kartalis G

更新日期：2004-04-01 00:00:00

abstract：:It has been proposed that the process of hypoxic-reperfusion injury contributes to the persistence of synovitis in the inflamed human joint. The generation of pathological, exercise induced, intra-articular pressure leading to occlusion of the synovial microcirculation is central to this mechanism. However, acute trau...

journal_title：Annals of the rheumatic diseases

authors： Merry P,Williams R,Cox N,King JB,Blake DR

更新日期：1991-12-01 00:00:00

abstract：:Three patients, two with typical primary Sjögren's syndrome (SS) and the third with several features of SS, including abnormal sialography and reduced tear secretion, developed B cell non-Hodgkin's lymphoma (NHL) of parotid or lung, or both. Isoelectric focusing of concentrated urine specimens in agarose, followed by ...

journal_title：Annals of the rheumatic diseases

authors： Walters MT,Stevenson FK,Herbert A,Cawley MI,Smith JL

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：:Plasma DNA has been measured by a new physiochemical approach based on fluorimetric analysis of phenol extracted nucleic acids electrophoresed on polyacrylamide gels. This method is specific for native double-stranded DNA of molecular weight greater than 5 x 10(6). The use of plasma rigorously freed of leucocytes is e...

journal_title：Annals of the rheumatic diseases

authors： Klemp P,Meyers OL,Harley EH

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVES:Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not b...

journal_title：Annals of the rheumatic diseases

authors： Belkhir R,Burel SL,Dunogeant L,Marabelle A,Hollebecque A,Besse B,Leary A,Voisin AL,Pontoizeau C,Coutte L,Pertuiset E,Mouterde G,Fain O,Lambotte O,Mariette X

更新日期：2017-10-01 00:00:00

abstract：:A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited a...

journal_title：Annals of the rheumatic diseases

authors： Dinarello CA

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown, but growth factors and hormones probably play an important part. The effects of glucocorticosteroids (prednisolone and triamcinolone), in combination with insuli...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,Postma NS,Verbunt J,van den Berg WB

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVES:Millions of patients worldwide are treated with therapeutic monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss of response. Fully human biological agents, such as the anti-tumour necrosis factor α (anti-TNFα) antibody adalimu...

journal_title：Annals of the rheumatic diseases

authors： van Schouwenburg PA,van de Stadt LA,de Jong RN,van Buren EE,Kruithof S,de Groot E,Hart M,van Ham SM,Rispens T,Aarden L,Wolbink GJ,Wouters D

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

journal_title：Annals of the rheumatic diseases

authors： Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:Improved DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology was used to monitor the changes in the galactosylation status of serum immunoglobulins during the immune response and therapy of autoimmune arthritis. METHODS:Collagen-induced arthritis (CIA) was induced in ...

journal_title：Annals of the rheumatic diseases

authors： Van Beneden K,Coppieters K,Laroy W,De Keyser F,Hoffman IE,Van den Bosch F,Vander Cruyssen B,Drennan M,Jacques P,Rottiers P,Verbruggen G,Contreras R,Callewaert N,Elewaut D

更新日期：2009-08-01 00:00:00