Abstract:
OBJECTIVES:To compare the prevalence and pattern of neuropsychiatric (NP) syndromes observed in systemic lupus erythematosus (SLE) to patients with Primary Sjögren syndrome (PSS) using the American College of Rheumatology (ACR) criteria for the 19 NP syndromes seen in SLE. METHODS:A population-based study was conducted including 68 patients with SLE (mean (SD) age 43.8 (13.6) years) and 72 with PSS (age 57.8 (13.0) years). Specialists in internal medicine, neurology and neuropsychology performed standardised examinations. Cerebral MRI scans and neurophysiological studies were performed in all patients. RESULTS:Similar prevalences in SLE and PSS were observed for headaches (87% vs 78%, p = 0.165), cognitive dysfunction (46% vs 50%, p = 0.273), mood disorders (26% vs 33%, p = 0.376), anxiety disorders (12% vs 4%, p = 0.095), cranial neuropathy (1% vs 4%, p = 0.339) and seizure disorders (7% vs 3%, p = 0.208). Cerebrovascular disease was more common in SLE than PSS (12% vs 3%, p = 0.049); but mononeuropathy (0% vs 8%, p = 0.015) and polyneuropathy (18% vs 56%, p<0.001) were less common in SLE than PSS. Other syndromes were rare or absent in both patient groups. CONCLUSIONS:Headache, cognitive dysfunction and mood disorders are common in both diseases, but otherwise there are distinct differences in NP involvement, with cerebrovascular diseases more prevalent in SLE and neuropathies more common in PSS. This indicates that some NP disease mechanisms are shared while others differ between the two diseases.
journal_name
Ann Rheum Disjournal_title
Annals of the rheumatic diseasesauthors
Harboe E,Tjensvoll AB,Maroni S,Gøransson LG,Greve OJ,Beyer MK,Herigstad A,Kvaløy JT,Omdal Rdoi
10.1136/ard.2008.098301subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1541-6issue
10eissn
0003-4967issn
1468-2060pii
ard.2008.098301journal_volume
68pub_type
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:An increased proportion of circulating follicular helper T (Tfh) cells was reported in rheumatoid arthritis (RA), but it remains uncertain how Tfh cells affect antibody hyposialylation. We investigated the regulation of autoantibody hyposialylation by Tfh cells in RA using murine model. METHODS:Behaviours of...
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pub_type: 共识发展会议,杂志文章,实务指引
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更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.61.11.1027
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更新日期:2012-09-01 00:00:00
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更新日期:2019-09-01 00:00:00
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2004.030221
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.46.6.468
更新日期:1987-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.55.4.237
更新日期:1996-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2004.021998
更新日期:2005-02-01 00:00:00
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2007.072686
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.39.2.164
更新日期:1980-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.57.8.506
更新日期:1998-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.46.4.327
更新日期:1987-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00