Salivary and serum hyaluronic acid concentrations in patients with Sjögren's syndrome.

abstract：BACKGROUND:Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable; knowledge of genetic factors may increase our understanding of the mechanisms underlying joint destruction. The activity of the Wnt/β-catenin pathway influences osteoblast differentiation. Dickkopf-1 (Dkk-1) and sclerostin (So...

journal_title：Annals of the rheumatic diseases

authors： de Rooy DP,Yeremenko NG,Wilson AG,Knevel R,Lindqvist E,Saxne T,Krabben A,Leijsma MK,Daha NA,Tsonaka S,Zhernakova A,Houwing-Duistermaat JJ,Huizinga TW,Toes RE,Baeten DL,Brouwer E,van der Helm-van Mil AH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease. OBJECTIVE:To combine hrMRI and cadaveric histological studie...

journal_title：Annals of the rheumatic diseases

authors： Tan AL,Toumi H,Benjamin M,Grainger AJ,Tanner SF,Emery P,McGonagle D

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:(a) To characterise the lipid profile in psoriatic arthritis and investigate whether there are similarities to the dyslipoproteinaemia reported in rheumatoid arthritis and other inflammatory forms of joint disease; (b) to investigate whether there is an atherogenic lipid profile in psoriatic arthritis, which...

journal_title：Annals of the rheumatic diseases

authors： Jones SM,Harris CP,Lloyd J,Stirling CA,Reckless JP,McHugh NJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:The influence of dexamethasone on interleukin 10 (IL10) production and the type 1 (T1)/type 2 (T2) T cell balance found in rheumatoid arthritis (RA) was studied. METHODS:Peripheral blood mononuclear cells (PB MNC) were isolated from 14 RA patients both before and 7 and 42 days after high dose dexamethasone ...

journal_title：Annals of the rheumatic diseases

authors： Verhoef CM,van Roon JA,Vianen ME,Lafeber FP,Bijlsma JW

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To analyse tender and swollen joint counts in three cohorts of patients with rheumatoid arthritis (RA), with a focus on the proportions of patients who had fewer than 6-12 tender or swollen joints, as possible evidence based information toward more generalisable inclusion criteria for current and future RA cl...

journal_title：Annals of the rheumatic diseases

authors： Pincus T,Sokka T,Chung CP,Cawkwell G

更新日期：2006-07-01 00:00:00

abstract：:The possible contribution of immunological mechanisms in the development of Libman-Sacks endocarditis was studied in 2 patients with systemic lupus erythematosus who underwent aortic valve replacement. Sections of verrucous lesions, stained with haematoxylin and eosin, showed three apparently distinct zones: an outer ...

journal_title：Annals of the rheumatic diseases

authors： Shapiro RF,Gamble CN,Wiesner KB,Castles JJ,Wolf AW,Hurley EJ,Salel AF

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVES:Different prevalences of generalised osteoarthritis (GOA) in patients with knee and hip OA have been reported. The aim of this investigation was to evaluate radiographic and clinical patterns of disease in a hospital based population of patient subgroups with advanced hip and knee OA and to compare the preva...

journal_title：Annals of the rheumatic diseases

authors： Günther KP,Stürmer T,Sauerland S,Zeissig I,Sun Y,Kessler S,Scharf HP,Brenner H,Puhl W

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It is unknown whether this relation is linear, referring to a common 'the-earlier-the-better principle', or whether a transient time frame in which the disease is more suscep...

journal_title：Annals of the rheumatic diseases

authors： van Nies JA,Tsonaka R,Gaujoux-Viala C,Fautrel B,van der Helm-van Mil AH

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS:A total of 116 patients with SSc were classifi...

journal_title：Annals of the rheumatic diseases

authors： Frezza D,Giambra V,Tolusso B,De Santis M,Bosello S,Vettori S,Triolo G,Valentini G,Ferraccioli G

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular ...

journal_title：Annals of the rheumatic diseases

authors： Urano W,Taniguchi A,Anzai N,Inoue E,Kanai Y,Yamanaka M,Endou H,Kamatani N,Yamanaka H

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To propose e-learning methods that address the fundamental problems related to sonographic training in rheumatology. METHODS:The project was designed for rheumatologists with strong motivation to learn ultrasound. A modular approach was constructed, consisting of a basic 3-day residential course, followed by...

journal_title：Annals of the rheumatic diseases

authors： Filippucci E,Meenagh G,Ciapetti A,Iagnocco A,Taggart A,Grassi W

更新日期：2007-07-01 00:00:00

abstract：:On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by...

journal_title：Annals of the rheumatic diseases

authors： Marshall JL,Fraser JR,Muirden KD

更新日期：1977-04-01 00:00:00

abstract：:In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune...

journal_title：Annals of the rheumatic diseases

authors： French MA,Harrison G,Penning CA,Cunningham J,Hughes P,Rowell NR

更新日期：1985-02-01 00:00:00

abstract：:While rheumatoid-factor-producing haemolytic plaque-forming cells (RF--PFC) of the human peripheral blood were easily inhibited by cycloheximide, mouse spleen cells immune to sheep red cells (anti-SRC PFC) were inhibited only after prolonged preincubation in the drug. The RF--PFC were easily inhibited by propranolol, ...

journal_title：Annals of the rheumatic diseases

authors： Moore TL,Rose JE,Vaughan JH

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an...

journal_title：Annals of the rheumatic diseases

authors： Möller I,Janta I,Backhaus M,Ohrndorf S,Bong DA,Martinoli C,Filippucci E,Sconfienza LM,Terslev L,Damjanov N,Hammer HB,Sudol-Szopinska I,Grassi W,Balint P,Bruyn GAW,D'Agostino MA,Hollander D,Siddle HJ,Supp G,Schmidt W

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:(a)To determine the accuracy and reliability of arthroscopic measurements of cartilage lesion diameter in an artificial right knee model; (b) to determine whether the use of a set of variable angle elongated probes improves performance; and (c) to identify other sources of variability. METHODS:Ovoid "lesion...

journal_title：Annals of the rheumatic diseases

authors： Oakley SP,Portek I,Szomor Z,Turnbull A,Murrell GA,Kirkham BW,Lassere MN

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Hand exercises are recommended for patients with hand osteoarthritis (HOA), though evidence for their effect is conflicting. OBJECTIVE:To evaluate, in a randomised controlled trial, the effect of HOA information plus home-based hand exercises (exercise group) compared with information only (control group) i...

journal_title：Annals of the rheumatic diseases

authors： Hennig T,Hæhre L,Hornburg VT,Mowinckel P,Norli ES,Kjeken I

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To investigate whether the risk allele for systemic lupus erythematosus (SLE) in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism (SNP) rs10181656(G), is associated with vascular events and/or presence of prothrombotic anti-phospholipid ...

journal_title：Annals of the rheumatic diseases

authors： Svenungsson E,Gustafsson J,Leonard D,Sandling J,Gunnarsson I,Nordmark G,Jönsen A,Bengtsson AA,Sturfelt G,Rantapää-Dahlqvist S,Elvin K,Sundin U,Garnier S,Simard JF,Sigurdsson S,Padyukov L,Syvänen AC,Rönnblom L

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Infectious agents like parvovirus have been implicated as exogenous factors that could trigger onset of systemic lupus erythematosus (SLE). A number of case reports describing a SLE-like presentation of acute human parvovirus B19 infection have been published, but no systematic investigation of the actual se...

journal_title：Annals of the rheumatic diseases

authors： Bengtsson A,Widell A,Elmstâhl S,Sturfelt G

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To describe the associations between overweight measures in childhood and knee pain, stiffness and dysfunction among adults 25 years later. METHODS:Subjects broadly representative of the Australian population (n=449, aged 31-41 years, female 48%) were selected from the Australian Schools Health and Fitness S...

journal_title：Annals of the rheumatic diseases

authors： Antony B,Jones G,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Ding C

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To determine whether abnormalities in the function of the autonomic nervous system are associated with oral and ocular dryness in rheumatoid arthritis. METHODS:Pupillography was done using an infrared light reflection method (IRIS) to measure both parasympathetic function (constriction latency and the latenc...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van der Heijde GL,Breedveld FC,Markusse HM

更新日期：1996-09-01 00:00:00

abstract：:Current drug development programs produce high quality data on the efficacy of new drugs, substantial data on safety, but little data on actual applicability of the new product compared to standard of care. After successful registration and launch, such data require years to accumulate and often remain incomplete. Thi...

journal_title：Annals of the rheumatic diseases

authors： Boers M

更新日期：2010-01-01 00:00:00

abstract：:A series of observations have led to the hypothesis that normal intestinal microbiota in patients with rheumatoid arthritis may harbour, for genetic reasons, bacteria with cell walls capable of inducing arthritis. Differences occur between bacterial species, and even between strains of a single species, because some c...

journal_title：Annals of the rheumatic diseases

authors： Toivanen P

更新日期：2003-09-01 00:00:00

abstract：:Three patients, two with typical primary Sjögren's syndrome (SS) and the third with several features of SS, including abnormal sialography and reduced tear secretion, developed B cell non-Hodgkin's lymphoma (NHL) of parotid or lung, or both. Isoelectric focusing of concentrated urine specimens in agarose, followed by ...

journal_title：Annals of the rheumatic diseases

authors： Walters MT,Stevenson FK,Herbert A,Cawley MI,Smith JL

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterised by synovitis and destruction of articular cartilage/bone. Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA. OBJECTIVES:To examine the effect of t...

journal_title：Annals of the rheumatic diseases

authors： Gao W,McGarry T,Orr C,McCormick J,Veale DJ,Fearon U

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:A study was undertaken to investigate the in vivo pathogenic role of Toll-like receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying the thrombogenic antiphospholipid (aPL) activity in lipopolysaccharide (LPS) non-responsive (LPS-/-) mice and the association between tlr4 gene polymorphisms and...

journal_title：Annals of the rheumatic diseases

authors： Pierangeli SS,Vega-Ostertag ME,Raschi E,Liu X,Romay-Penabad Z,De Micheli V,Galli M,Moia M,Tincani A,Borghi MO,Nguyen-Oghalai T,Meroni PL

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS:A web-based exercise and subsequent patien...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Scirè CA,Adinolfi A,Damjanov NS,Carrara G,Bruyn GAW,Cazenave T,D'Agostino MA,Delle Sedie A,Di Sabatino V,Diaz Cortes ME,Filippucci E,Gandjbakhch F,Gutierrez M,Maccarter DK,Micu M,Möller Parera I,Mouterde G,

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. METHODS:Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatolo...

journal_title：Annals of the rheumatic diseases

authors： Lundberg IE,Tjärnlund A,Bottai M,Werth VP,Pilkington C,Visser M,Alfredsson L,Amato AA,Barohn RJ,Liang MH,Singh JA,Aggarwal R,Arnardottir S,Chinoy H,Cooper RG,Dankó K,Dimachkie MM,Feldman BM,Torre IG,Gordon P,Hayas

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Physical function in rheumatoid arthritis (RA) has reversible and irreversible components, and is typically assessed by the Health Assessment Questionnaire Disability Index (HAQ). Since irreversible components are expected to increase with longer duration of RA and reduce the ability for improvement in physi...

journal_title：Annals of the rheumatic diseases

authors： Aletaha D,Strand V,Smolen JS,Ward MM

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:To compare the effect of a single infusion of zoledronic acid (ZA) with placebo on knee pain and bone marrow lesions (BMLs). METHODS:Adults aged 50-80 years (n=59) with clinical knee osteoarthritis and knee BMLs were randomised to receive either ZA (5 mg/100 ml) or placebo. BMLs were determined using proton...

journal_title：Annals of the rheumatic diseases

authors： Laslett LL,Doré DA,Quinn SJ,Boon P,Ryan E,Winzenberg TM,Jones G

更新日期：2012-08-01 00:00:00