Lysosomal activation by neutral saccharides in cell cultures of synovium.

Abstract:

:On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by raised intracellular lysosomal enzyme activity without corresponding increases in the extracellular level of these enzymes. Structural changes and enzymic responses were less intense during exposure to the neutral polysaccharides. The secretion of large polymers of hyaluronic acid was consistently decreased during sucrose treatment. Evidence of heightened hyaluronidase-like activity was found in cellular extracts of sucrose-treated cultures, but not in the culture medium.

journal_name

Ann Rheum Dis

authors

Marshall JL,Fraser JR,Muirden KD

doi

10.1136/ard.36.2.130

subject

Has Abstract

pub_date

1977-04-01 00:00:00

pages

130-8

issue

2

eissn

0003-4967

issn

1468-2060

journal_volume

36

pub_type

杂志文章
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    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章,评审

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    authors: Smolen JS,Landewé R,Breedveld FC,Dougados M,Emery P,Gaujoux-Viala C,Gorter S,Knevel R,Nam J,Schoels M,Aletaha D,Buch M,Gossec L,Huizinga T,Bijlsma JW,Burmester G,Combe B,Cutolo M,Gabay C,Gomez-Reino J,Kouloumas M

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    更新日期:2016-09-01 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验

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  • Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis.

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  • Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden.

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    pub_type: 杂志文章

    doi:10.1136/ard.2004.033688

    authors: Rhodes LA,Conaghan PG,Radjenovic A,Grainger AJ,Emery P,McGonagle D

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    doi:10.1136/ard.2008.094730

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