PRINTO/PRES international website for families of children with rheumatic diseases: www.pediatric-rheumatology.printo.it.

abstract：OBJECTIVE:In an unselected community sample of adults, to assess the role and importance of exposure to mechanical factors both at work and leisure in the aetiology of hip pain. METHOD:A population based prevalence case-control study. Cases and controls were identified from a population survey of 3847 subjects registe...

journal_title：Annals of the rheumatic diseases

authors： Pope DP,Hunt IM,Birrell FN,Silman AJ,Macfarlane GJ

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:We report on a workshop on ethical and legal constraints on data sharing between countries in multinational epidemiologic research in Europe that was held in January 2007 in Potsdam, Germany. The participants were experienced epidemiologic and clinical researchers from eight European countries. The aim of th...

journal_title：Annals of the rheumatic diseases

authors： Zink A,Silman AJ

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:In juvenile idiopathic arthritis (JIA), the efficacy of very early disease-modifying drug therapy, synthetic or biological, is not well known. Three alternative strategies were compared for treating recent-onset polyarticular JIA. METHODS:In a 54-week multicentre open-label clinical trial, 60 disease-modify...

journal_title：Annals of the rheumatic diseases

authors： Tynjälä P,Vähäsalo P,Tarkiainen M,Kröger L,Aalto K,Malin M,Putto-Laurila A,Honkanen V,Lahdenne P

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVES:To forecast, on the basis of the past and present position of rheumatologists in Europe, the competence needed in the future to secure and promote the specialty within the healthcare network. METHODS:Union Européenne des Médecins Spécialistes/European Board of Rheumatology (UEMS/EBR) questionnaire on (a) tr...

journal_title：Annals of the rheumatic diseases

authors： Amor B

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:To clarify the effect of pressure on the expressions of proteoglycan core protein and metabolism related cytokines in a chondrocyte-like cell line, HCS-2/8. METHODS:HCS-2/8 cells were exposed to 1, 5, 10, or 50 MPa of hydrostatic pressure (HP) for two hours, and mRNA expressions of interleukin 6 (IL6) and t...

journal_title：Annals of the rheumatic diseases

authors： Takahashi K,Kubo T,Arai Y,Kitajima I,Takigawa M,Imanishi J,Hirasawa Y

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the efficacy and safety of adalimumab+methotrexate (MTX) in Japanese patients with early rheumatoid arthritis (RA) who had not previously received MTX or biologics. METHODS:This randomised, double-blind, placebo-controlled, multicentre study evaluated adalimumab 40 mg every other week+MTX 6-8 mg...

journal_title：Annals of the rheumatic diseases

authors： Takeuchi T,Yamanaka H,Ishiguro N,Miyasaka N,Mukai M,Matsubara T,Uchida S,Akama H,Kupper H,Arora V,Tanaka Y

更新日期：2014-03-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Roberts-Thomson PJ

更新日期：1990-02-01 00:00:00

abstract：:Superantigens are bacterial, viral, or retroviral proteins which can activate specifically a large proportion of T cells. In contrast with classical peptide antigen recognition, superantigens do not require processing to small peptides but act as complete or partially processed proteins. They can bind to major histoco...

journal_title：Annals of the rheumatic diseases

authors： Acha-Orbea H

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of monotherapy with adalimumab in patients with RA for whom previous DMARD treatment has failed. METHODS:In a 26 week, double blind, placebo controlled, phase III trial, 544 patients with RA were randomised to monotherapy with adalimumab 20 mg every other week, 20 mg weekl...

journal_title：Annals of the rheumatic diseases

authors： van de Putte LB,Atkins C,Malaise M,Sany J,Russell AS,van Riel PL,Settas L,Bijlsma JW,Todesco S,Dougados M,Nash P,Emery P,Walter N,Kaul M,Fischkoff S,Kupper H

更新日期：2004-05-01 00:00:00

abstract：:Animals were injected intra-articularly with antigen after prior immunization with that antigen in Freund's incomplete adjuvant in order to precipitate immune complexes in the surfaces of menisci, ligaments, and cartilage. On reimmunization with antigen in Freund's complete adjuvant 10 weeks later, generally an arthri...

journal_title：Annals of the rheumatic diseases

authors： Fox A,Glynn LE

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:To study the associations between structural abnormalities on ultrasound (US) or conventional x-rays (CR) and pain in hand osteoarthritis (HOA). METHODS:In 55 consecutive patients with HOA (mean age 61 years, 86% women) fulfilling the American College of Rheumatology criteria, pain in 30 separate hand joints...

journal_title：Annals of the rheumatic diseases

authors： Kortekaas MC,Kwok WY,Reijnierse M,Huizinga TW,Kloppenburg M

更新日期：2011-10-01 00:00:00

abstract：:Two patients are described with severe and progressive rheumatoid arthritis in whom methotrexate was reintroduced despite previous methotrexate related pneumonitis. In both patients a marked improvement in disease control occurred without a recurrence of the pneumonitis. ...

journal_title：Annals of the rheumatic diseases

authors： Cook NJ,Carroll GJ

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibodies (ACPAs) are the hallmark of rheumatoid arthritis (RA). Protein citrullination is believed to drive autoantigen selection in RA. Nonetheless, several autoantigens in RA are targeted as native (unmodified) proteins. Here, the study of hnRNP A2/B1 (RA33) provides a framewor...

journal_title：Annals of the rheumatic diseases

authors： Konig MF,Giles JT,Nigrovic PA,Andrade F

更新日期：2016-11-01 00:00:00

abstract：:Synovial fluid isolated from 16 patients with rheumatoid arthritis activated luminol dependent chemiluminescence in bloodstream neutrophils, and the maximal activity stimulated varied over a 50-fold range. In contrast, these same fluids only activated a much lower range (two- to threefold) of maximal rates of lucigeni...

journal_title：Annals of the rheumatic diseases

authors： Nurcombe HL,Bucknall RC,Edwards SW

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) may be an important mediator of insulin resistance. Infliximab is a chimeric monoclonal, high affinity antibody against the soluble and transmembrane TNFalpha, which can reduce markedly the biological activity of circulating and tissue TNFalpha and is used to treat var...

journal_title：Annals of the rheumatic diseases

authors： Kiortsis DN,Mavridis AK,Vasakos S,Nikas SN,Drosos AA

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To define the mechanisms whereby methotrexate (MTX) manifests its effects in patients with rheumatoid arthritis. METHODS:T and B cells from peripheral blood and rheumatoid synovial tissues, synovial adherent cells, and the human fibrosarcoma cell line HT1080 and its mutant (defective in an enzyme in the nucl...

journal_title：Annals of the rheumatic diseases

authors： Nakajima A,Hakoda M,Yamanaka H,Kamatani N,Kashiwazaki S

更新日期：1996-04-01 00:00:00

abstract：:An explant method for the isolation of fibroblasts from adult human tendon is described. Cells were successfully isolated from 22 out of 27 common biceps tendons obtained from cadaveric donors (age range 11-83 years). The fibroblasts could be maintained in culture using standard methods and morphologically resembled t...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Wright JK,Hazleman BL

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVES:The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown, but growth factors and hormones probably play an important part. The effects of glucocorticosteroids (prednisolone and triamcinolone), in combination with insuli...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,Postma NS,Verbunt J,van den Berg WB

更新日期：1993-10-01 00:00:00

abstract：:Decreased immunoglobulin production in pokeweed mitogen driven lymphocyte cultures has been reported in rheumatoid arthritis (RA). Here various activators and experimental designs have been used to determine the contribution of B cells, T cells, or monocytes to this low response. Sixty patients with RA and paired cont...

journal_title：Annals of the rheumatic diseases

authors： Jokinen I,Poikonen K,Möttönen T,Hannonen P,Oka M,Ilonen J,Surcel HM,Karttunen R,Arvilommi H

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Myeloid inhibitory C-type lectin-like receptor (MICL, Clec12A) is a C-type lectin receptor (CLR) expressed predominantly by myeloid cells. Previous studies have suggested that MICL is involved in controlling inflammation. OBJECTIVE:To determine the role of this CLR in inflammatory pathology using Clec12A(-/...

journal_title：Annals of the rheumatic diseases

authors： Redelinghuys P,Whitehead L,Augello A,Drummond RA,Levesque JM,Vautier S,Reid DM,Kerscher B,Taylor JA,Nigrovic PA,Wright J,Murray GI,Willment JA,Hocking LJ,Fernandes MJ,De Bari C,Mcinnes IB,Brown GD

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The study aimed to evaluate the use of positron emission tomography/computed tomography (PET/CT) with (68)Ga-PRGD2 as the tracer for imaging of synovial angiogenesis in patients with rheumatoid arthritis (RA). METHODS:Twenty untreated active patients with RA underwent (68)Ga-PRGD2 PET/CT and (18)F-FDG PET/C...

journal_title：Annals of the rheumatic diseases

authors： Zhu Z,Yin Y,Zheng K,Li F,Chen X,Zhang F,Zhang X

更新日期：2014-06-01 00:00:00

abstract：:One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is unclear, but has been suggested to be a lipoprotein. Sera from patients with (1) systemic necrotising arteritis (polyarter...

journal_title：Annals of the rheumatic diseases

authors： Blake DR,Winyard P,Scott DG,Brailsford S,Blann A,Lunec J

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The MEFV gene is responsible for familial Mediterranean fever (FMF). Several disease associated mutations have been identified. The range of genetic variation in MEFV in Greek patients has not been determined. OBJECTIVE:To describe a method that facilitates the routine screening of the entire coding sequenc...

journal_title：Annals of the rheumatic diseases

authors： Ritis K,Giaglis S,Spathari N,Micheli A,Zonios D,Tzoanopoulos D,Deltas CC,Rafail S,Mean R,Papadopoulos V,Tzioufas AG,Moutsopoulos HM,Kartalis G

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To evaluate new classification criteria for peripheral spondyloarthritis (SpA) in patients with SpA with peripheral manifestations only. METHODS:In this Assessment of SpondyloArthritis international Society (ASAS) study, two prespecified sets of criteria were compared against the European Spondylarthropathy ...

journal_title：Annals of the rheumatic diseases

authors： Rudwaleit M,van der Heijde D,Landewé R,Akkoc N,Brandt J,Chou CT,Dougados M,Huang F,Gu J,Kirazli Y,Van den Bosch F,Olivieri I,Roussou E,Scarpato S,Sørensen IJ,Valle-Oñate R,Weber U,Wei J,Sieper J

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the amount of joint cartilage in healthy, middle aged men is stable or changes over time, and what factors may influence this. METHODS:In a cohort study, 28 healthy men (70% of the original cohort; mean (SD) age, 51.9 (12.8) years) had baseline knee magnetic resonance imaging (MRI) of th...

journal_title：Annals of the rheumatic diseases

authors： Hanna F,Ebeling PR,Wang Y,O'Sullivan R,Davis S,Wluka AE,Cicuttini FM

更新日期：2005-07-01 00:00:00

abstract：:On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by...

journal_title：Annals of the rheumatic diseases

authors： Marshall JL,Fraser JR,Muirden KD

更新日期：1977-04-01 00:00:00

abstract：:The success of anti-tumour necrosis factor (TNF) treatment, either using antibodies or soluble receptors, has defined TNF as a major factor of the inflammatory response in rheumatoid arthritis (RA). As a result of this success, much attention has been devoted to understanding the molecular mechanisms by which TNF expr...

journal_title：Annals of the rheumatic diseases

authors： Foxwell BM,Bondeson J,Brennan F,Feldmann M

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:To identify predictors of clinical remission as well as of no x-ray progression in a cohort of early rheumatoid arthritis (ERA) treated with a tight-control protocol. METHODS:A total of 121 consecutive patients with ERA were treated to reach European League Against Rheumatism (EULAR) and/or American College...

journal_title：Annals of the rheumatic diseases

authors： Bosello S,Fedele AL,Peluso G,Gremese E,Tolusso B,Ferraccioli G

更新日期：2011-07-01 00:00:00

abstract：:Fourteen patients with cystic fibrosis arthritis and eight patients with cystic fibrosis and hypertrophic osteoarthropathy were typed for HLA-A, B, C, DR, and DQ antigens and were compared with age and sex matched controls with cystic fibrosis. The diagnosis of cystic fibrosis arthritis and hypertrophic osteoarthropat...

journal_title：Annals of the rheumatic diseases

authors： Rush PJ,Gladman DD,Shore A,Anhorn KA

更新日期：1991-11-01 00:00:00