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Factors influencing longitudinal change in knee cartilage volume measured from magnetic resonance imaging in healthy men.

Abstract：

OBJECTIVE:To determine whether the amount of joint cartilage in healthy, middle aged men is stable or changes over time, and what factors may influence this. METHODS:In a cohort study, 28 healthy men (70% of the original cohort; mean (SD) age, 51.9 (12.8) years) had baseline knee magnetic resonance imaging (MRI) of their dominant knee and repeat MRI of the same knee approximately 2.0 years later. Knee cartilage volume was measured at baseline and follow up. Risk factors assessed at baseline, including sex hormones and metabolic bone markers, were tested for their association with change in knee cartilage volume over time. RESULTS:Mean (SD) reduction in tibial cartilage volume per year was 162 (93) microl. This represented a 2.8% reduction in total tibial articular cartilage per year (95% confidence interval, 0.2% to 5.5%). Tibial cartilage loss was associated with serum free testosterone level, independently of age, body mass index, baseline tibial cartilage volume tibial plateau area, and total bone mineral content. Overall, testosterone accounted for 14.5% (partial r2) of the variation in change in tibial cartilage volume. There was a trend towards a positive association between tibial cartilage loss and urinary N-telopeptide cross-links of type I collagen (Ntx) (p = 0.057). CONCLUSIONS:Further studies will be required to determine whether hormonal manipulation or treatment with antiresorptive drugs will reduce the risk of knee osteoarthritis in men in later life.

journal_name

Ann Rheum Dis

journal_title

Annals of the rheumatic diseases

authors

Hanna F,Ebeling PR,Wang Y,O'Sullivan R,Davis S,Wluka AE,Cicuttini FM

doi

10.1136/ard.2004.029355

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

1038-42

issue

7

eissn

0003-4967

issn

1468-2060

pii

ard.2004.029355

journal_volume

64

pub_type

杂志文章

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