Complement activation in patients with primary antiphospholipid syndrome.

abstract：OBJECTIVES:To determine the one year period prevalence of falls by age and sex in patients with rheumatoid arthritis and the influence of concurrent medical treatment and disability on the occurrence of falls in this group. METHODS:A consecutive series of rheumatoid patients aged 35 years and over, attending hospital ...

journal_title：Annals of the rheumatic diseases

authors： Armstrong C,Swarbrick CM,Pye SR,O'Neill TW

更新日期：2005-11-01 00:00:00

abstract：:Sepsis is a severe complication of abdominal infections such as peritonitis and is associated with high mortality. Unfortunately, the molecular mechanisms controlling the development of sepsis are still incompletely understood. Interestingly, the interleukin (IL) 12 family member IL27 seems to play a key role in sepsi...

journal_title：Annals of the rheumatic diseases

authors： Neurath MF

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To determine the stability and the degree of variation of antiphospholipid antibody (aPL) results over time in a large cohort of well evaluated aPL positive patients; and to analyse factors contributing to aPL variation and the validity of aPL in a real world setting in which aPL tests are done in multiple la...

journal_title：Annals of the rheumatic diseases

authors： Erkan D,Derksen WJ,Kaplan V,Sammaritano L,Pierangeli SS,Roubey R,Lockshin MD

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS:970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The pri...

journal_title：Annals of the rheumatic diseases

authors： Lohmander LS,McKeith D,Svensson O,Malmenäs M,Bolin L,Kalla A,Genti G,Szechinski J,Ramos-Remus C,STAR Multinational Study Group.

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjögren's syndrome (SS). METHODS:A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice...

journal_title：Annals of the rheumatic diseases

authors： Tsifetaki N,Kitsos G,Paschides CA,Alamanos Y,Eftaxias V,Voulgari PV,Psilas K,Drosos AA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To characterise activation of the type I interferon (IFN) pathway in patients with systemic lupus erythematosus (SLE), dermatomyositis (DM), polymyositis (PM), rheumatoid arthritis (RA) and systemic scleroderma (SSc) and to evaluate the potential to develop a molecular diagnostic tool from the peripheral bloo...

journal_title：Annals of the rheumatic diseases

authors： Higgs BW,Liu Z,White B,Zhu W,White WI,Morehouse C,Brohawn P,Kiener PA,Richman L,Fiorentino D,Greenberg SA,Jallal B,Yao Y

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of upregulation of interferon (IFN) type I inducible genes, the so called 'IFN type I signature', in CD14 monocytes in 69 patients with primary Sjögren's syndrome (pSS) and 44 healthy controls (HC) and correlate it with disease manifestations and expression of B cell activating fac...

journal_title：Annals of the rheumatic diseases

authors： Brkic Z,Maria NI,van Helden-Meeuwsen CG,van de Merwe JP,van Daele PL,Dalm VA,Wildenberg ME,Beumer W,Drexhage HA,Versnel MA

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown, but growth factors and hormones probably play an important part. The effects of glucocorticosteroids (prednisolone and triamcinolone), in combination with insuli...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,Postma NS,Verbunt J,van den Berg WB

更新日期：1993-10-01 00:00:00

abstract：:Pulmonary hypertension in systemic lupus erythematosus (SLE) is rare in the absence of parenchymal lung disease. We report such a case, which was complicated by the subsequent development of a left recurrent laryngeal nerve palsy, and in which there was a strong family history of SLE. ...

journal_title：Annals of the rheumatic diseases

authors： Aszkenasy OM,Clarke TJ,Hickling P,Marshall AJ

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVES:The differential diagnosis of seronegative rheumatoid arthritis (negRA) and psoriasis arthritis (PsA) is often difficult due to the similarity of symptoms and the unavailability of reliable clinical markers. Since chronic inflammation induces major changes in the serum metabolome and lipidome, we tested whet...

journal_title：Annals of the rheumatic diseases

authors： Souto-Carneiro M,Tóth L,Behnisch R,Urbach K,Klika KD,Carvalho RA,Lorenz HM

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. METHODS:A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres partic...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Sakellariou G,Scirè CA,Carrara G,Rumi F,Bellis E,Adinolfi A,Batticciotto A,Bortoluzzi A,Cagnotto G,Caprioli M,Canzoni M,Cavatorta FP,De Lucia O,Di Sabatino V,Draghessi A,Farina I,Focherini MC,Gabba A,Guti

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To examine the expression of the natural killer (NK) antigen CD56, and T cell receptor delta chain antigen (TCR delta), expressed on the gamma delta T cell subset, in patients with scleroderma, and to correlate levels of expression with clinical characteristics. METHODS:Peripheral blood mononuclear cells (P...

journal_title：Annals of the rheumatic diseases

authors： Holcombe RF,Baethge BA,Wolf RE,Betzing KW,Stewart RM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of Janus kinase inhibitors (Jakinibs) on cardiovascular risk in adult patients with rheumatoid arthritis (RA) via a meta-analysis of randomised controlled trials (RCTs). METHODS:PubMed, Embase and Cochrane library were thoroughly searched for RCTs reporting safety issues in patient...

journal_title：Annals of the rheumatic diseases

authors： Xie W,Huang Y,Xiao S,Sun X,Fan Y,Zhang Z

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Serum leptin measures are associated with radiographic knee osteoarthritis, but no studies have examined leptin levels with respect to different measures of knee joint damage from MRI. METHODS:Participants in the Michigan Study of Women's Health Across the Nation underwent bilateral knee MRIs ...

journal_title：Annals of the rheumatic diseases

authors： Karvonen-Gutierrez CA,Harlow SD,Jacobson J,Mancuso P,Jiang Y

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To compare median nerve conduction velocity measured using a new, portable electroneurometer with measurements made using conventional hospital nerve conduction apparatus. METHODS:Twenty five patients were studied who were consecutively referred to a hospital neurophysiology department with a clinical diagno...

journal_title：Annals of the rheumatic diseases

authors： Dunne CA,Thompson PW,Cole J,Dunning J,Martyn CN,Coggon D,Cooper C

更新日期：1996-06-01 00:00:00

abstract：:OBJECTIVE: To examine the risk of major cardiovascular disease associated with non-steroidal anti-inflammatory drugs (NSAIDs) in a large 'real-world' contemporary rheumatoid arthritis (RA) cohort. METHODS: A longitudinal cohort study was conducted with use of Danish nationwide individual-level registry data on inpat...

journal_title：Annals of the rheumatic diseases

authors： Lindhardsen J,Gislason GH,Jacobsen S,Ahlehoff O,Olsen AM,Madsen OR,Torp-Pedersen C,Hansen PR

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Although shared decision making (SDM) is advocated in rheumatoid arthritis (RA) treatment, it is largely unclear when, how and to what extent SDM is applied in routine clinical care of patients with RA. This study aimed to investigate the level of SDM in RA treatment from an observer perspective and to asses...

journal_title：Annals of the rheumatic diseases

authors： Mathijssen EGE,Vriezekolk JE,Popa CD,van den Bemt BJF

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:A prospective randomised trial to compare two different durations of maintenance immunosuppressive therapy for the prevention of relapse in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). METHODS:Patients with AAV were recruited 18-24 months after diagnosis if they were in stable ...

journal_title：Annals of the rheumatic diseases

authors： Karras A,Pagnoux C,Haubitz M,Groot K,Puechal X,Tervaert JWC,Segelmark M,Guillevin L,Jayne D,European Vasculitis Society.

更新日期：2017-10-01 00:00:00

abstract：:Two cases of acute monarthritis secondary to asymptomatic renal cell carcinoma are described. This association has not previously been reported. The patients were initially thought to have a septic arthritis, but hot spots were seen on isotope bone scans and biopsy samples showed secondary neoplasms, which were later ...

journal_title：Annals of the rheumatic diseases

authors： Chakravarty KK,Webley M

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:High rheumatoid arthritis (RA) disease activity during pregnancy is associated with a lower birth weight. Active RA is characterised by high circulating levels of cytokines, which can mediate placental growth and remodelling. OBJECTIVES:To assess the influence of maternal serum cytokine levels on birth weig...

journal_title：Annals of the rheumatic diseases

authors： de Steenwinkel FD,Hokken-Koelega AC,de Man YA,de Rijke YB,de Ridder MA,Hazes JM,Dolhain RJ

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Reduced caveolin-1 levels in lung fibroblasts from patients with scleroderma and the lungs of bleomycin-treated mice promote collagen overexpression and lung fibrosis. This study was undertaken to determine whether caveolin-1 is deficient in leucocytes from bleomycin-treated mice and patients with scleroderm...

journal_title：Annals of the rheumatic diseases

authors： Tourkina E,Richard M,Oates J,Hofbauer A,Bonner M,Gööz P,Visconti R,Zhang J,Znoyko S,Hatfield CM,Silver RM,Hoffman S

更新日期：2010-06-01 00:00:00

abstract：:Reproducibility along a vertical 10 cm visual analogue scale (VAS) was investigated. Eight normal volunteers attempted to duplicate a set of marked VAS. There was a tendency to estimate too high on the scale, and reproducibility was found to be variable along its length. This indicates that the error involved in the u...

journal_title：Annals of the rheumatic diseases

authors： Dixon JS,Bird HA

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:To determine if a new inhibitor, esculetin (EST), can block resorption of cartilage. METHODS:Interleukin 1alpha (IL1alpha, 0.04-5 ng/ml) and oncostatin M (OSM, 0.4-50 ng/ml) were used to stimulate the release of proteoglycan and collagen from bovine nasal cartilage and human articular cartilage in explant cu...

journal_title：Annals of the rheumatic diseases

authors： Elliott S,Rowan AD,Carrère S,Koshy P,Catterall JB,Cawston TE

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of golimumab over 104 weeks in patients with active ankylosing spondylitis. METHODS:At baseline, patients with active ankylosing spondylitis (n=356) were randomly assigned (1:1.8:1.8) to subcutaneous injections of placebo (group 1), golimumab 50 mg (group 2) or golimumab 100...

journal_title：Annals of the rheumatic diseases

authors： Braun J,Deodhar A,Inman RD,van der Heijde D,Mack M,Xu S,Hsu B

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not b...

journal_title：Annals of the rheumatic diseases

authors： Belkhir R,Burel SL,Dunogeant L,Marabelle A,Hollebecque A,Besse B,Leary A,Voisin AL,Pontoizeau C,Coutte L,Pertuiset E,Mouterde G,Fain O,Lambotte O,Mariette X

更新日期：2017-10-01 00:00:00

abstract：:A 62 year old woman taking L-tryptophan developed eosinophilic fasciitis shortly after starting an exercise class. She received prednisone without benefit but improved after azathioprine treatment was started and L-tryptophan was discontinued. As products containing L-tryptophan have recently been implicated in develo...

journal_title：Annals of the rheumatic diseases

authors： Hamilton ME

更新日期：1991-01-01 00:00:00

abstract：:A previously normal 58-year-old woman developed a widespread psoriatic rash and asymmetrical peripheral polyarthritis a week after beginning treatment with oxprenolol for hypertension. Skin and joint disease resolved simultaneously after drug withdrawal and have not recurred. ...

journal_title：Annals of the rheumatic diseases

authors： Macfarlane DG,Settas L

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVE:We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). METHODS:Fifty-eight forearm biopsies were evaluated from 26 individuals with dcSSc in two clinical trials. Histologic/immunophenotypic assessments of glob...

journal_title：Annals of the rheumatic diseases

authors： Showalter K,Spiera R,Magro C,Agius P,Martyanov V,Franks JM,Sharma R,Geiger H,Wood TA,Zhang Y,Hale CR,Finik J,Whitfield ML,Orange DE,Gordon JK

更新日期：2021-02-01 00:00:00

abstract：:Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid ar...

journal_title：Annals of the rheumatic diseases

authors： O'Dell JR,Lemley-Gillespie S,Palmer WR,Weaver AL,Moore GF,Klassen LW

更新日期：1991-06-01 00:00:00

abstract：:Synovial fluid isolated from 16 patients with rheumatoid arthritis activated luminol dependent chemiluminescence in bloodstream neutrophils, and the maximal activity stimulated varied over a 50-fold range. In contrast, these same fluids only activated a much lower range (two- to threefold) of maximal rates of lucigeni...

journal_title：Annals of the rheumatic diseases

authors： Nurcombe HL,Bucknall RC,Edwards SW

更新日期：1991-04-01 00:00:00