Familial Felty's syndrome.

abstract：:The case presented is of a patient with migratory polyarthritis and serological evidence of a recent streptococcal infection, consistent with the diagnosis of acute rheumatic fever, who in addition had multisystem disease manifestations. This case supports the concept that the sequelae of streptococcal infection can e...

journal_title：Annals of the rheumatic diseases

authors： Livneh A,Sharma K,Sewell KL,Keiser HD

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of incident myocardial infarction (MI), stroke and peripheral vascular disease (PVD) in individuals with systemic sclerosis (SSc) in a general population context. METHODS:We conducted a cohort study using a UK primary care database containing records from 1986 to 2011. SSc diagnoses, ou...

journal_title：Annals of the rheumatic diseases

authors： Man A,Zhu Y,Zhang Y,Dubreuil M,Rho YH,Peloquin C,Simms RW,Choi HK

更新日期：2013-07-01 00:00:00

abstract：:A 33-year-old male with definite Behçet's disease had rheumatoid-like nodules at his elbows. This finding, we believe, represents another manifestation of vasculitis in Behçet's disease. ...

journal_title：Annals of the rheumatic diseases

authors： Yurdakul S,Yazici H,Tüzüner N,Aytac S,Müftüoğlu AU

更新日期：1981-04-01 00:00:00

abstract：OBJECTIVE:To elucidate the clinical importance of the anti-signal recognition particle (SRP) autoantibody in patients with myositis. METHODS:Retrospective systematic assessment of the clinical, laboratory and histological characteristics of 23 anti-SRP-positive patients from six European centres. Data were compared wi...

journal_title：Annals of the rheumatic diseases

authors： Hengstman GJ,ter Laak HJ,Vree Egberts WT,Lundberg IE,Moutsopoulos HM,Vencovsky J,Doria A,Mosca M,van Venrooij WJ,van Engelen BG

更新日期：2006-12-01 00:00:00

abstract：:In the World Health Organisation's supplementary classification of the consequences of disease a distinction is made between impairments, such as are related to the site and nature of joint involvement, and any disabilities in everyday activities to which these may give rise. This paper considers the application of th...

journal_title：Annals of the rheumatic diseases

authors： Badley EM,Wagstaff S,Wood PH

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVES:Factors contributing to the development of systemic lupus erythematosus (SLE) remain largely unknown although are likely to include both environmental and genetic components. Studies on murine lupus have indicated a role for an antibody that blocks binding of cytotoxic T lymphocyte associated-4 (CTLA-4) to B...

journal_title：Annals of the rheumatic diseases

authors： Heward J,Gordon C,Allahabadia A,Barnett AH,Franklyn JA,Gough SC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:Genetic variation at the type II deiodinase (D2) gene (DIO2) was previously identified as osteoarthritis (OA) risk factor. To investigate mechanisms possibly underlying this association, we assessed D2 protein in healthy and OA-affected cartilage and investigated allelic balance of the OA risk polymorphism rs...

journal_title：Annals of the rheumatic diseases

authors： Bos SD,Bovée JV,Duijnisveld BJ,Raine EV,van Dalen WJ,Ramos YF,van der Breggen R,Nelissen RG,Slagboom PE,Loughlin J,Meulenbelt I

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:To determine the probability of drug continuation in a large cohort of methotrexate treated rheumatoid arthritis (RA) patients, the reasons for discontinuation of methotrexate, the overall survival of the members of this cohort, and the causes of death in these patients. METHODS:Yearly follow up was conduct...

journal_title：Annals of the rheumatic diseases

authors： Alarcón GS,Tracy IC,Strand GM,Singh K,Macaluso M

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVES:To determine the accuracy of ultrasonography (US) for bone erosion detection in different areas of rheumatoid arthritis (RA) metacarpophalangeal (MCP) joints with multislice CT as the reference method. Second, to establish the necessary bone volume loss on CT for US to reliably detect it as an erosion, and f...

journal_title：Annals of the rheumatic diseases

authors： Døhn UM,Terslev L,Szkudlarek M,Hansen MS,Hetland ML,Hansen A,Madsen OR,Hasselquist M,Møller J,Ostergaard M

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To investigate polymorphisms of both codon 54 allele and promoter variants of the mannose binding lectin (MBL) gene in patients with primary Sjögren's syndrome (SS). METHODS:Polymorphisms of codon 54 allele and promoter variants of the MBL gene in 104 patients with SS and 143 healthy controls were determined...

journal_title：Annals of the rheumatic diseases

authors： Wang ZY,Morinobu A,Kanagawa S,Kumagai S

更新日期：2001-05-01 00:00:00

abstract：:Human extensor tendons of the hand were pulled to rupture, and the torn ends, when observed in the scanning electron microscope, appeared to be knotted, possibly owing to the denaturation of the collagen. This confirmed by fluorimetry assays of both the ruptured ends and the middle unbroken sections of the same tendon...

journal_title：Annals of the rheumatic diseases

authors： Minns RJ,Steven FS

更新日期：1980-04-01 00:00:00

abstract：OBJECTIVE:To analyse fibronectin (FN) gene polymorphisms in type II mixed cryoglobulinemic syndrome (MCsn), an immune-complex mediated systemic vasculitis linked to hepatitis C virus (HCV) infection and characterised by rheumatoid factor (RF) positive B-cell proliferation at high risk for the progression into non-Hodgk...

journal_title：Annals of the rheumatic diseases

authors： Fabris M,Quartuccio L,Salvin S,Pozzato G,De Re V,Mazzaro C,Ferri C,Baldini C,De Vita S

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functio...

journal_title：Annals of the rheumatic diseases

authors： Bocelli-Tyndall C,Trella E,Frachet A,Zajac P,Pfaff D,Geurts J,Heiler S,Barbero A,Mumme M,Resink TJ,Schaeren S,Spagnoli GC,Tyndall A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To examine the expression of the natural killer (NK) antigen CD56, and T cell receptor delta chain antigen (TCR delta), expressed on the gamma delta T cell subset, in patients with scleroderma, and to correlate levels of expression with clinical characteristics. METHODS:Peripheral blood mononuclear cells (P...

journal_title：Annals of the rheumatic diseases

authors： Holcombe RF,Baethge BA,Wolf RE,Betzing KW,Stewart RM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA). METHODS:A randomised, double-blind, placebo-controlled, dose-e...

journal_title：Annals of the rheumatic diseases

authors： Burmester GR,Feist E,Sleeman MA,Wang B,White B,Magrini F

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To investigate the activation of NF-kappaB in the carrageenan rat air pouch model of inflammation in a time course experiment, and the effect of dexamethasone on NF-kappaB activation. METHODS:Air pouch tissue treated with carrageenan (inflamed tissue) was obtained from rats killed at days 1, 2, 3, 6, 14, 21,...

journal_title：Annals of the rheumatic diseases

authors： Ellis L,Gilston V,Soo CC,Morris CJ,Kidd BL,Winyard PG

更新日期：2000-04-01 00:00:00

abstract：:The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and...

journal_title：Annals of the rheumatic diseases

authors： Gale R,Bertouch JV,Bradley J,Roberts-Thomson PJ

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Poor adherence to treatment is difficult to diagnose accurately. Hydroxychloroquine (HCQ) has a long elimination half-life and its concentration in whole blood can be measured easily. OBJECTIVE:To evaluate the utility of a very low blood HCQ concentration as a marker of poor compliance in patients with syst...

journal_title：Annals of the rheumatic diseases

authors： Costedoat-Chalumeau N,Amoura Z,Hulot JS,Aymard G,Leroux G,Marra D,Lechat P,Piette JC

更新日期：2007-06-01 00:00:00

abstract：:Chemotactic migration of leucocytes largely depends on adhesive interaction with the substratum and recognition of a chemoattractant gradient. Both aspects, cell adhesion and chemotaxis, are regulated by members of the family of chemotactic cytokines (chemokines) comprising structurally related and secreted proteins o...

journal_title：Annals of the rheumatic diseases

authors： Moser B,Willimann K

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Optimal treatment for rheumatoid arthritis (RA) after inadequate response (IR) to tumour necrosis factor α inhibitors (TNFi) remains uncertain. OBJECTIVE:To compare the efficacy and safety of biological agents after TNFi-IR. METHODS:A systematic literature search was carried out using Medline and Cochrane ...

journal_title：Annals of the rheumatic diseases

authors： Schoels M,Aletaha D,Smolen JS,Wong JB

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

journal_title：Annals of the rheumatic diseases

authors： Akiyama S,Hamdeh S,Micic D,Sakuraba A

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses t...

journal_title：Annals of the rheumatic diseases

authors： Malik MH,Jury F,Bayat A,Ollier WE,Kay PR

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS:A total of 116 patients with SSc were classifi...

journal_title：Annals of the rheumatic diseases

authors： Frezza D,Giambra V,Tolusso B,De Santis M,Bosello S,Vettori S,Triolo G,Valentini G,Ferraccioli G

更新日期：2007-09-01 00:00:00

abstract：:Two cases of bilateral shoulder-hand syndrome and symmetrical arthralgia are described in patients with tubo-ovarian carcinoma. Swelling and contracture of the hands continued to develop despite oral corticosteroid therapy, and one patient underwent surgery in an attempt to prevent the development of further deformity...

journal_title：Annals of the rheumatic diseases

authors： Taggart AJ,Iveson JM,Wright V

更新日期：1984-06-01 00:00:00

abstract：QUESTION:Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)? METHODS:In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive patients with JIA, three treatment-strategies were compared: (1) sequential DMARD-monotherapy (sulfas...

journal_title：Annals of the rheumatic diseases

authors： Hissink Muller P,Brinkman DMC,Schonenberg-Meinema D,van den Bosch WB,Koopman-Keemink Y,Brederije ICJ,Bekkering PW,Kuijpers TW,Van Rossum M,van Suijlekom-Smit LWA,van den Berg JM,Boehringer S,Allaart CF,Ten Cate R

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:MRI is recommended in the diagnostic process of rheumatoid arthritis (RA) to detect joint damage early. MRI-detected erosions are also present in symptom-free controls, especially at older age. It is unclear if RA-specific MRI-detected erosions can be distinguished from 'physiological' erosions in symptom-fr...

journal_title：Annals of the rheumatic diseases

authors： Boeters DM,Nieuwenhuis WP,van Steenbergen HW,Reijnierse M,Landewé RBM,van der Helm-van Mil AHM

更新日期：2018-06-01 00:00:00

abstract：:Quantitative isotype specific enzyme linked immunosorbent assay (ELISA) was used to determine the distribution of immunoglobulin isotypes and phospholipid specificities of anticardiolipin (anti-CL) antibodies in 40 patients with one or more of the following 'antiphospholipid (anti-PL) antibody associated clinical comp...

journal_title：Annals of the rheumatic diseases

authors： Gharavi AE,Harris EN,Asherson RA,Hughes GR

更新日期：1987-01-01 00:00:00

abstract：:This review focuses on the contribution of genetic markers to the severity of radiological damage in rheumatoid arthritis (RA). Currently available biomarkers of more severe disease include elevated erythrocyte sedimentation rates or C-reactive protein levels and rheumatoid factor (RF) or anticyclic citrullinated prot...

journal_title：Annals of the rheumatic diseases

authors： Marinou I,Maxwell JR,Wilson AG

更新日期：2010-03-01 00:00:00

abstract：:An acute inflammatory arthritis has been induced in 76% of rats injected intradermally with native bovine type II collagen emulsified in Freund's complete (CFA) or incomplete (ICFA) adjuvant. The arthritis became chronic in 14 out of 31 rats, and ear and tail lesions were noted in some rats. No arthritis was induced b...

journal_title：Annals of the rheumatic diseases

authors： Morgan K,Clague RB,Shaw MJ,Holt PJ

更新日期：1980-06-01 00:00:00

abstract：:Symptomatic osteonecrosis occurred in 8 out of 68 patients with systemic lupus erythematosus. Multiple joints were involved in 3 patients, and weight-bearing joints were most frequently affected. Osteonecrosis tended to occur early in the disease, and the patients had all received corticosteroids. Symptoms tended to o...

journal_title：Annals of the rheumatic diseases

authors： Griffiths ID,Maini RN,Scott JT

更新日期：1979-10-01 00:00:00