The risk of cardiovascular disease in systemic sclerosis: a population-based cohort study.

abstract：:The main goal of traditional treatment of idiopathic retroperitoneal fibrosis is limitation of morbidity, and surgery of already formed fibrous masses has been the main therapeutic approach. More recently, the knowledge that the disorder may be the result of an allergic reaction to atherosclerotic lipids has prompted ...

journal_title：Annals of the rheumatic diseases

authors： Marzano A,Trapani A,Leone N,Actis GC,Rizzetto M

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To assess associations between joint-specific hand symptoms and self-reported and performance-based functional status. METHODS:Participants were from the population-based Johnston County Osteoarthritis Project. Symptoms in the distal interphalangeal (DIP), proximal interphalangeal (PIP), first carpometacarpa...

journal_title：Annals of the rheumatic diseases

authors： Elliott AL,Kraus VB,Fang F,Renner JB,Schwartz TA,Salazar A,Huguenin T,Hochberg MC,Helmick CG,Jordan JM

更新日期：2007-12-01 00:00:00

abstract：:The effect of two gold(I) compounds on stability of lysosomes in vitro was studied. Lysosomes from homogenates of rat kidney cortex were isolated by differential centrifugation. These lysosomes were incubated at 37 degrees C with widely varied concentrations of sodium aurothiomalate and sodium aurothiosulphate for 5, ...

journal_title：Annals of the rheumatic diseases

authors： Graabaek PM,Pedersen SM

更新日期：1988-06-01 00:00:00

abstract：:Serum C2 activity was measured in 135 individuals drawn from a panel of 418 tissue-typed blood donors. The study group included all donors with HLA antigens A10 and B18. Heterozygote C2 deficiency (C2Dhet) was defined by reference to the range of C2 activity in previously studied obligate heterozygotes. Five donors we...

journal_title：Annals of the rheumatic diseases

authors： Rynes RI,Britten AF,Pickering RJ

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in patients with active, refractory systemic lupus erythematosus (SLE). METHODS:Twelve patients received a median of two (range 1-4) 21-day cycles of i...

journal_title：Annals of the rheumatic diseases

authors： Alexander T,Sarfert R,Klotsche J,Kühl AA,Rubbert-Roth A,Lorenz HM,Rech J,Hoyer BF,Cheng Q,Waka A,Taddeo A,Wiesener M,Schett G,Burmester GR,Radbruch A,Hiepe F,Voll RE

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of interleukin 6 (IL-6) in the pathogenesis of bilateral erosive sacroiliitis in human tumour necrosis factor transgenic (hTNFtg) mice, an animal model of ankylosing spondylitis (AS). METHODS:Histological sections of the sacroiliac joints from hTNFtg and IL-6(-/-)hTNFtg mice were evaluat...

journal_title：Annals of the rheumatic diseases

authors： Hayer S,Niederreiter B,Nagelreiter I,Smolen J,Redlich K

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:We assessed the impact of tocilizumab (TCZ), a humanised monoclonal anti-interleukin-6 receptor antibody, on antibody response following administration of the 23-valent pneumococcal polysaccharide vaccine (PPV23). METHODS:A total of 190 patients with rheumatoid arthritis (RA) received PPV23. Patients were c...

journal_title：Annals of the rheumatic diseases

authors： Mori S,Ueki Y,Akeda Y,Hirakata N,Oribe M,Shiohira Y,Hidaka T,Oishi K

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To investigate the production of the matrix metalloproteinase (MMP), collagenase (MMP-1), and its natural inhibitor, the tissue inhibitor of metalloproteinases (TIMP) by diseased human tendon samples in organ culture. METHODS:Portions of tendons were excised from the shoulders of patients undergoing shoulder...

journal_title：Annals of the rheumatic diseases

authors： Dalton S,Cawston TE,Riley GP,Bayley IJ,Hazleman BL

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVES:To examine the long term prognosis in patients with fibromyalgia (FM). METHODS:Forty five of 70 patients who had participated in a three week trial six years earlier completed again the same questionnaires used previously. RESULTS:Most symptoms had remained stable. Pain had increased, but some aspects of q...

journal_title：Annals of the rheumatic diseases

authors： Baumgartner E,Finckh A,Cedraschi C,Vischer TL

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Mast cells have been implicated in the pathogenesis of arthritis, but elucidation of their precise role has been hampered by a lack of efficient and selective inhibitors of their function. OBJECTIVE:To elucidate the role of mast cells in the pathogenesis of rheumatoid arthritis (RA) and to assess whether ap...

journal_title：Annals of the rheumatic diseases

authors： Juurikivi A,Sandler C,Lindstedt KA,Kovanen PT,Juutilainen T,Leskinen MJ,Mäki T,Eklund KK

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:To investigate whether type II collagen (CII) is recognised by oligoclonally expanded synovial T cells of patients with rheumatoid arthritis (RA). METHODS:Peripheral blood mononuclear cells (PBMC) from 15 RA patients were stimulated with CII in vitro. T cell clones expanded by such stimulation were compared ...

journal_title：Annals of the rheumatic diseases

authors： Sekine T,Kato T,Masuko-Hongo K,Nakamura H,Yoshino S,Nishioka K,Yamamoto K

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Treatment with tumour necrosis factor inhibitors (TNF-i) plus methotrexate (MTX), but not MTX monotherapy alone, inhibits joint damage progression even at higher levels of disease activity. Such disassociation of disease activity and structural damage has not been shown for biological agents other than TNF-i...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Avila JC,Aletaha D

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

journal_title：Annals of the rheumatic diseases

authors： Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:To determine whether hormonal dysfunction involving the hypothalamic-pituitary-adrenal (HPA) axis, prolactin (PRL) secretion, and sex hormone status contribute to development of systemic lupus erythematosus (SLE). METHODS:11 patients with SLE and 9 healthy controls were tested for their total anterior pitui...

journal_title：Annals of the rheumatic diseases

authors： Köller MD,Templ E,Riedl M,Clodi M,Wagner O,Smolen JS,Luger A

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Pregnant women with systemic sclerosis (SSc; scleroderma) have an increased risk of premature delivery and small full-term infants. During placental development, angiogenesis and vascular remodelling are essential for a successful pregnancy outcome. An analysis was made of the pathological changes and express...

journal_title：Annals of the rheumatic diseases

authors： Ibba-Manneschi L,Manetti M,Milia AF,Miniati I,Benelli G,Guiducci S,Mecacci F,Mello G,Di Lollo S,Matucci-Cerinic M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Human osteoarthritic (OA) chondrocytes were previously classified into L (low)- and H (high)-OA according to matrix metalloproteinase-13 (MMP-13) basal levels and interleukin 1beta (IL1beta) inducibility. In H-OA chondrocytes, the regulatory proteins p130(cas) and nuclear matrix protein 4 (NMP4) acting on th...

journal_title：Annals of the rheumatic diseases

authors： Fan Z,Tardif G,Hum D,Duval N,Pelletier JP,Martel-Pelletier J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Millions of patients worldwide are treated with therapeutic monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss of response. Fully human biological agents, such as the anti-tumour necrosis factor α (anti-TNFα) antibody adalimu...

journal_title：Annals of the rheumatic diseases

authors： van Schouwenburg PA,van de Stadt LA,de Jong RN,van Buren EE,Kruithof S,de Groot E,Hart M,van Ham SM,Rispens T,Aarden L,Wolbink GJ,Wouters D

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) may be an important mediator of insulin resistance. Infliximab is a chimeric monoclonal, high affinity antibody against the soluble and transmembrane TNFalpha, which can reduce markedly the biological activity of circulating and tissue TNFalpha and is used to treat var...

journal_title：Annals of the rheumatic diseases

authors： Kiortsis DN,Mavridis AK,Vasakos S,Nikas SN,Drosos AA

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To determine if serum urate concentration is associated with development of hypertension in young adults. METHODS:Retrospective cohort analysis from 4752 participants with available serum urate and without hypertension at baseline from the Coronary Artery Risk Development in Young Adults (CARDIA) study; a mi...

journal_title：Annals of the rheumatic diseases

authors： Gaffo AL,Jacobs DR Jr,Sijtsma F,Lewis CE,Mikuls TR,Saag KG

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission rec...

journal_title：Annals of the rheumatic diseases

authors： Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.

更新日期：2009-07-01 00:00:00

abstract：:There is no agreement as to which variable best mirrors disease activity in rheumatoid arthritis (RA) and no studies have been performed on the validity of disease activity variables. In this study the validity of 10 commonly used single variables and three composite indices was tested. All patients participated in a ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde DM,van't Hof MA,van Riel PL,van Leeuwen MA,van Rijswijk MH,van de Putte LB

更新日期：1992-02-01 00:00:00

abstract：:Articular cartilage is avascular. Nutrients are transported to the cells mainly by diffusion from the synovial fluid. Nutrient transport is also sometimes thought to be assisted by movement of fluid in and out of cartilage in response to cyclic loading of the tissue ('pumping'). The influence of pumping on transport o...

journal_title：Annals of the rheumatic diseases

authors： O'Hara BP,Urban JP,Maroudas A

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Increased apoptosis may induce autoimmune conditions. Apoptosis is induced by binding of death receptor ligands, members of the tumour necrosis factor (TNF) superfamily, to their cognate receptors. The Fas-Fas ligand pathway has been studied extensively in relation to systemic lupus erythematosus (SLE). Howe...

journal_title：Annals of the rheumatic diseases

authors： Lub-de Hooge MN,de Vries EG,de Jong S,Bijl M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis. DESIGN:Cohort study. SETTING:Population based. PARTICIPANTS:3585 people aged > or =55 years were selected from the Rotterdam Study, on the basi...

journal_title：Annals of the rheumatic diseases

authors： Reijman M,Pols HA,Bergink AP,Hazes JM,Belo JN,Lievense AM,Bierma-Zeinstra SM

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence up...

journal_title：Annals of the rheumatic diseases

authors： Schaefer CJ,Lawrence WD,Wooley PH

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Osteoarthritis is the most frequent chronic joint disease causing pain and disability. Besides biomechanical mechanisms, the pathogenesis of osteoarthritis may involve inflammation, vascular alterations and dysregulation of lipid metabolism. As statins are able to modulate many of these processes, this study...

journal_title：Annals of the rheumatic diseases

authors： Clockaerts S,Van Osch GJ,Bastiaansen-Jenniskens YM,Verhaar JA,Van Glabbeek F,Van Meurs JB,Kerkhof HJ,Hofman A,Stricker BH,Bierma-Zeinstra SM

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:In patients with systemic sclerosis (scleroderma, SSc), impaired hand function greatly contributes to disability and reduced quality of life, and is insufficiently relieved by currently available therapies. Adipose tissue-derived stromal vascular fraction (SVF) is increasingly recognised as an easily accessi...

journal_title：Annals of the rheumatic diseases

authors： Granel B,Daumas A,Jouve E,Harlé JR,Nguyen PS,Chabannon C,Colavolpe N,Reynier JC,Truillet R,Mallet S,Baiada A,Casanova D,Giraudo L,Arnaud L,Veran J,Sabatier F,Magalon G

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To report the efficacy of conservative treatment with cervical traction and immobilisation with a Halo vest, in two consecutive rheumatoid arthritis patients with progressive cervical myelopathy caused by subaxial subluxation. METHODS:Description of neurological symptoms and signs and findings in plain radio...

journal_title：Annals of the rheumatic diseases

authors： Oostveen JC,van de Laar MA,Geelen JA,de Graaff R

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Entheseal fibrocartilage (EF) derangement is hypothesised to be pivotal to the pathogenesis of spondyloarthritis. Ultrasound is useful for visualisation of the enthesis but its role in EF visualisation is uncertain. This work aimed to demonstrate face and content validity of ultrasound for EF visualisation b...

journal_title：Annals of the rheumatic diseases

authors： Aydin SZ,Bas E,Basci O,Filippucci E,Wakefield RJ,Celikel C,Karahan M,Atagunduz P,Benjamin M,Direskeneli H,McGonagle D

更新日期：2010-12-01 00:00:00

abstract：:To identify the local factors in cartilage that are responsible for the induction of pannus invasion, a 14 day organ culture study in which rheumatoid synovium was grown in contact with cartilage pieces was carried out. Rheumatoid synovium preferentially extended over hyaluronidase treated cartilage pieces, but detach...

journal_title：Annals of the rheumatic diseases

authors： Shiozawa S,Yoshihara R,Kuroki Y,Fujita T,Shiozawa K,Imura S

更新日期：1992-07-01 00:00:00