Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study.

Abstract:

OBJECTIVE:To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis. DESIGN:Cohort study. SETTING:Population based. PARTICIPANTS:3585 people aged > or =55 years were selected from the Rotterdam Study, on the basis of the availability of radiographs of baseline and follow-up. MAIN OUTCOME MEASURES:Incidence of knee or hip osteoarthritis was defined as minimally grade 2 at follow-up and grade 0 or 1 at baseline. The progression of osteoarthritis was defined as a decrease in joint space width. METHODS:x Rays of the knee and hip at baseline and follow-up (mean follow-up of 6.6 years) were evaluated. BMI was measured at baseline. RESULTS:A high BMI (>27 kg/m(2)) at baseline was associated with incident knee osteoarthritis (odds ratio (OR) 3.3), but not with incident hip osteoarthritis. A high BMI was also associated with progression of knee osteoarthritis (OR 3.2). For the hip, a significant association between progression of osteoarthritis and BMI was not found. CONCLUSION:On the basis of these results, we conclude that BMI is associated with the incidence and progression of knee osteoarthritis. Furthermore, it seems that BMI is not associated with the incidence and progression of hip osteoarthritis.

journal_name

Ann Rheum Dis

authors

Reijman M,Pols HA,Bergink AP,Hazes JM,Belo JN,Lievense AM,Bierma-Zeinstra SM

doi

10.1136/ard.2006.053538

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

158-62

issue

2

eissn

0003-4967

issn

1468-2060

pii

ard.2006.053538

journal_volume

66

pub_type

杂志文章
  • Premature development of erosive osteoarthritis of hands in patients with chronic renal failure.

    abstract::The prevalence of grade III or IV osteoarthritis was determined in 210 patients with chronic renal failure, of whom 94 were receiving chronic haemodialysis and 116 had functioning renal transplants. The prevalence of grade III or IV osteoarthritis was three times greater in patients under 65 than in a control populati...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.49.6.378

    authors: Duncan IJ,Hurst NP,Sebben R,Milazzo SC,Disney A

    更新日期:1990-06-01 00:00:00

  • Lumiracoxib is effective in the treatment of osteoarthritis of the knee: a 13 week, randomised, double blind study versus placebo and celecoxib.

    abstract:OBJECTIVES:To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis OA in a 13 week, multicentre, randomised, double blind study. METHODS:After a 37 day washout period for nonsteroidal antiinflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/ard.2003.015974

    authors: Tannenbaum H,Berenbaum F,Reginster JY,Zacher J,Robinson J,Poor G,Bliddal H,Uebelhart D,Adami S,Navarro F,Lee A,Moore A,Gimona A

    更新日期:2004-11-01 00:00:00

  • Maternal age influences risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice.

    abstract:OBJECTIVE:To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE. METHODS:The relationship between maternal age at littering and frequency of AE was analy...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.54.9.754

    authors: Weinreich S,Hoebe B,Ivanyi P

    更新日期:1995-09-01 00:00:00

  • Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.

    abstract::The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9....

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.40.5.462

    authors: Tokunaga M,Ohuchi K,Yoshizawa S,Tsurufuji S,Rikimaru A,Wakamatsu E

    更新日期:1981-10-01 00:00:00

  • Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes.

    abstract:OBJECTIVES:Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low birth weight (LBW) and spontaneous abortion associated with leflunomide exposure during pregnancy in humans. METHODS:F...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2017-212078

    authors: Bérard A,Zhao JP,Shui I,Colilla S

    更新日期:2018-04-01 00:00:00

  • Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature.

    abstract:OBJECTIVES:To review systematically the available literature on the optimal dosage and route of administration of methotrexate in patients with rheumatoid arthritis (RA), as an evidence base for generating clinical practice recommendations. METHODS:A systematic literature search was carried out in MEDLINE, EMBASE, Coc...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/ard.2008.092668

    authors: Visser K,van der Heijde D

    更新日期:2009-07-01 00:00:00

  • Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis.

    abstract:OBJECTIVES:To assess the association of body mass index (BMI) with modifiable cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA). METHODS:BMI, disease activity, selected CVD risk factors and CVD medication were assessed in 378 (276 women) patients with RA. Patients exceeding accepted ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2008.095596

    authors: Stavropoulos-Kalinoglou A,Metsios GS,Panoulas VF,Douglas KM,Nevill AM,Jamurtas AZ,Kita M,Koutedakis Y,Kitas GD

    更新日期:2009-02-01 00:00:00

  • 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis.

    abstract::This paper presents the second update of the Assessment in SpondyloArthritis international Society (ASAS) consensus statement on the use of anti-tumour necrosis factor (anti-TNF) agents in patients with axial spondyloarthritis (SpA). A major change from the previous recommendations is that patients fulfilling the ASAS...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章

    doi:10.1136/ard.2011.151563

    authors: van der Heijde D,Sieper J,Maksymowych WP,Dougados M,Burgos-Vargas R,Landewé R,Rudwaleit M,Braun J,Assessment of SpondyloArthritis international Society.

    更新日期:2011-06-01 00:00:00

  • Neuropsychiatric syndromes in patients with systemic lupus erythematosus and primary Sjögren syndrome: a comparative population-based study.

    abstract:OBJECTIVES:To compare the prevalence and pattern of neuropsychiatric (NP) syndromes observed in systemic lupus erythematosus (SLE) to patients with Primary Sjögren syndrome (PSS) using the American College of Rheumatology (ACR) criteria for the 19 NP syndromes seen in SLE. METHODS:A population-based study was conducte...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2008.098301

    authors: Harboe E,Tjensvoll AB,Maroni S,Gøransson LG,Greve OJ,Beyer MK,Herigstad A,Kvaløy JT,Omdal R

    更新日期:2009-10-01 00:00:00

  • Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritis.

    abstract:OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2003.010942

    authors: Majeed M,McQueen F,Yeoman S,McLean L

    更新日期:2004-09-01 00:00:00

  • Association between the IL-1 family gene cluster and spondyloarthritis.

    abstract:OBJECTIVE:Spondyloarthritis is a group of articular disorders sharing a genetic background. Polymorphisms in the IL-1 gene cluster have previously been associated with ankylosing spondylitis (AS), a subset of spondyloarthritis. This study examined the association between several of these polymorphisms and the whole spo...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2011-200439

    authors: Monnet D,Kadi A,Izac B,Lebrun N,Letourneur F,Zinovieva E,Said-Nahal R,Chiocchia G,Breban M

    更新日期:2012-06-01 00:00:00

  • Impact of Janus kinase inhibitors on risk of cardiovascular events in patients with rheumatoid arthritis: systematic review and meta-analysis of randomised controlled trials.

    abstract:OBJECTIVES:To investigate the effect of Janus kinase inhibitors (Jakinibs) on cardiovascular risk in adult patients with rheumatoid arthritis (RA) via a meta-analysis of randomised controlled trials (RCTs). METHODS:PubMed, Embase and Cochrane library were thoroughly searched for RCTs reporting safety issues in patient...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析

    doi:10.1136/annrheumdis-2018-214846

    authors: Xie W,Huang Y,Xiao S,Sun X,Fan Y,Zhang Z

    更新日期:2019-08-01 00:00:00

  • Interleukin 6 is not a crucial regulator in an animal model of tumour necrosis factor-mediated bilateral sacroiliitis.

    abstract:OBJECTIVE:To evaluate the role of interleukin 6 (IL-6) in the pathogenesis of bilateral erosive sacroiliitis in human tumour necrosis factor transgenic (hTNFtg) mice, an animal model of ankylosing spondylitis (AS). METHODS:Histological sections of the sacroiliac joints from hTNFtg and IL-6(-/-)hTNFtg mice were evaluat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2010.129148

    authors: Hayer S,Niederreiter B,Nagelreiter I,Smolen J,Redlich K

    更新日期:2010-07-01 00:00:00

  • High disease activity is associated with an increased risk of infection in patients with rheumatoid arthritis.

    abstract:OBJECTIVE:To determine the relationship of disease activity to infections in patients with rheumatoid arthritis (RA). METHODS:From the CORRONA database, the incidence of physician-reported infections in RA patients on stable disease-modifying antirheumatic drug, biological, and corticosteroid therapy for at least 6 mo...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1136/ard.2010.128637

    authors: Au K,Reed G,Curtis JR,Kremer JM,Greenberg JD,Strand V,Furst DE,CORRONA Investigators.

    更新日期:2011-05-01 00:00:00

  • Comparison of the immune response to Epstein-Barr virus and cytomegalovirus in sera and synovial fluids of patients with rheumatoid arthritis.

    abstract::The immune response against two herpesviruses has been determined in sera and matched synovial fluids of patients with rheumatoid arthritis (RA) and compared with that of a healthy control population. The increased level of antibody to Epstein-Barr virus (EBV) induced antigens in patients with RA resembles the antibod...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.46.11.837

    authors: Musiani M,Zerbini M,Ferri S,Plazzi M,Gentilomi G,La Placa M

    更新日期:1987-11-01 00:00:00

  • Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles.

    abstract:OBJECTIVES:To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis. METHODS:From incident cases of arthritis (n = 1305), patients who did not fulfil any classification criteria (undifferentiated arthritis (n...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2005.041079

    authors: Linn-Rasker SP,van der Helm-van Mil AH,van Gaalen FA,Kloppenburg M,de Vries RR,le Cessie S,Breedveld FC,Toes RE,Huizinga TW

    更新日期:2006-03-01 00:00:00

  • Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort.

    abstract:OBJECTIVE:To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. METH...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2013-203845

    authors: Rasmussen A,Ice JA,Li H,Grundahl K,Kelly JA,Radfar L,Stone DU,Hefner KS,Anaya JM,Rohrer M,Gopalakrishnan R,Houston GD,Lewis DM,Chodosh J,Harley JB,Hughes P,Maier-Moore JS,Montgomery CG,Rhodus NL,Farris AD,Segal BM

    更新日期:2014-01-01 00:00:00

  • Tolerising cellular therapies: what is their promise for autoimmune disease?

    abstract::The current management of autoimmunity involves the administration of immunosuppressive drugs coupled to symptomatic and functional interventions such as anti-inflammatory therapies and hormone replacement. Given the chronic nature of autoimmunity, however, the ideal therapeutic strategy would be to reinduce self-tole...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/annrheumdis-2018-214024

    authors: Mosanya CH,Isaacs JD

    更新日期:2019-03-01 00:00:00

  • Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery.

    abstract:OBJECTIVES:To determine whether continued methotrexate treatment increases the risk of postoperative infections or of surgical complications in patients with rheumatoid arthritis (RA) within one year of elective orthopaedic surgery. DESIGN:A prospective randomised study of postoperative infection or surgical complicat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/ard.60.3.214

    authors: Grennan DM,Gray J,Loudon J,Fear S

    更新日期:2001-03-01 00:00:00

  • Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis.

    abstract:OBJECTIVE:To define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA). METHODS:Citrullinated autoantigens were identified by immunoblotting control and ionomycin-activated human primary neutrophil lysate with RA sera. Autoantigen ide...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2011.151712

    authors: Darrah E,Rosen A,Giles JT,Andrade F

    更新日期:2012-01-01 00:00:00

  • Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of monotherapy with adalimumab in patients with RA for whom previous DMARD treatment has failed. METHODS:In a 26 week, double blind, placebo controlled, phase III trial, 544 patients with RA were randomised to monotherapy with adalimumab 20 mg every other week, 20 mg weekl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/ard.2003.013052

    authors: van de Putte LB,Atkins C,Malaise M,Sany J,Russell AS,van Riel PL,Settas L,Bijlsma JW,Todesco S,Dougados M,Nash P,Emery P,Walter N,Kaul M,Fischkoff S,Kupper H

    更新日期:2004-05-01 00:00:00

  • Budd-Chiari syndrome as the major thrombotic complication of systemic lupus erythematosus with the lupus anticoagulant.

    abstract::A patient with systemic lupus erythematosus was first diagnosed after she had developed the Budd-Chiari syndrome. We believe that the Budd-Chiari syndrome was part of her tendency for thrombosis, induced by the presence of a lupus anticoagulant. The association between enhanced thrombosis and the lupus anticoagulant i...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.45.5.435

    authors: Averbuch M,Levo Y

    更新日期:1986-05-01 00:00:00

  • Serum concanavalin-A binding in rheumatoid arthritis.

    abstract::A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in p...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.41.2.133

    authors: Martin MF,Dieppe PA,Jones HE,Warren C,Whicher J,Kohn J

    更新日期:1982-04-01 00:00:00

  • A vascular endothelial growth factor deficiency characterises scleroderma lung disease.

    abstract:OBJECTIVES:Vascular endothelial growth factor (VEGF) is thought to play an important role in systemic sclerosis (SSc) pathogenesis. It was found to be upregulated in the serum and in the affected skin of scleroderma patients. However, its involvement in scleroderma lung disease is not clear. This study aimed to evaluat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2011-200657

    authors: De Santis M,Bosello SL,Capoluongo E,Inzitari R,Peluso G,Lulli P,Zizzo G,Bocci M,Tolusso B,Zuppi C,Castagnola M,Ferraccioli G

    更新日期:2012-09-01 00:00:00

  • Periodontal disease in patients with ankylosing spondylitis.

    abstract:OBJECTIVE:Ankylosing spondylitis (AS) and periodontal disease (PD) are characterised by dysregulation of the host inflammatory response, resulting in soft and hard connective tissue destruction. AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with infl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2008.097212

    authors: Pischon N,Pischon T,Gülmez E,Kröger J,Purucker P,Kleber BM,Landau H,Jost-Brinkmann PG,Schlattmann P,Zernicke J,Burmester GR,Bernimoulin JP,Buttgereit F,Detert J

    更新日期:2010-01-01 00:00:00

  • Successful reintroduction of methotrexate after pneumonitis in two patients with rheumatoid arthritis.

    abstract::Two patients are described with severe and progressive rheumatoid arthritis in whom methotrexate was reintroduced despite previous methotrexate related pneumonitis. In both patients a marked improvement in disease control occurred without a recurrence of the pneumonitis. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.51.2.272

    authors: Cook NJ,Carroll GJ

    更新日期:1992-02-01 00:00:00

  • The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology.

    abstract:BACKGROUND:In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,实务指引

    doi:10.1136/annrheumdis-2017-211585

    authors: Möller I,Janta I,Backhaus M,Ohrndorf S,Bong DA,Martinoli C,Filippucci E,Sconfienza LM,Terslev L,Damjanov N,Hammer HB,Sudol-Szopinska I,Grassi W,Balint P,Bruyn GAW,D'Agostino MA,Hollander D,Siddle HJ,Supp G,Schmidt W

    更新日期:2017-12-01 00:00:00

  • PRINTO/PRES international website for families of children with rheumatic diseases: www.pediatric-rheumatology.printo.it.

    abstract:OBJECTIVE:To prepare a website for families and health professionals containing up to date information about paediatric rheumatic diseases (PRD). METHODS:Firstly, paediatric rheumatology centres and family self help associations were surveyed to characterise current clinical practice of physicians providing care for c...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2004.030221

    authors: Ruperto N,Garcia-Munitis P,Villa L,Pesce M,Aggarwal A,Fasth A,Avcin T,Bae SC,Balogh Z,Li C,De Inocencio J,Dibra M,Dolezalova P,El Miedany Y,Flato B,Harjacek M,Huppertz HI,Kanakoudi-Tsakalidou F,Wulffraat N,Lahdenne

    更新日期:2005-07-01 00:00:00

  • Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: longitudinal results from two randomised controlled trials

    abstract:OBJECTIVES:To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS:Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/annrheumdis-2017-211315

    authors: Glinatsi D,Baker JF,Hetland ML,Hørslev-Petersen K,Ejbjerg BJ,Stengaard-Pedersen K,Junker P,Ellingsen T,Lindegaard HM,Hansen I,Lottenburger T,Møller JM,Ørnbjerg L,Vestergaard A,Jurik AG,Thomsen HS,Torfing T,Møller-Bisgaa

    更新日期:2017-10-01 00:00:00

  • Anti-TNF therapies and pregnancy: outcome of 130 pregnancies in the British Society for Rheumatology Biologics Register.

    abstract:OBJECTIVE:The British Society for Rheumatology Biologics Register (BSRBR) has collected data on adverse events including pregnancies in patients with rheumatoid arthritis treated with anti-tumour necrosis factor (anti-TNF) therapy. The purpose of this report is to summarise the pregnancy outcomes in women treated with ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2010.140822

    authors: Verstappen SM,King Y,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium, BSR Biologics Register.

    更新日期:2011-05-01 00:00:00