Anti-TNF therapies and pregnancy: outcome of 130 pregnancies in the British Society for Rheumatology Biologics Register.


OBJECTIVE:The British Society for Rheumatology Biologics Register (BSRBR) has collected data on adverse events including pregnancies in patients with rheumatoid arthritis treated with anti-tumour necrosis factor (anti-TNF) therapy. The purpose of this report is to summarise the pregnancy outcomes in women treated with anti-TNF in the BSRBR. METHODS:Patients were categorised according to anti-TNF exposure as follows: (1) exposure to anti-TNF and to methotrexate (MTX) and/or leflunomide (LEF) at conception (n=21 pregnancies); (2) exposure to anti-TNF at conception (n=50); (3) exposure to anti-TNF prior to conception (n=59); (4) no exposure to anti-TNF (control group; n=10). RESULTS:Eighty-eight live births in a total of 130 pregnancies were reported in patients who received anti-TNF before or during pregnancy. The rate of spontaneous abortion was highest among patients exposed to anti-TNF at the time of conception (with MTX/LEF 33% and without MTX/LEF 24%). This compared with 17% spontaneous abortions in those with prior exposure to anti-TNF and 10% spontaneous abortions in the control group. Ten terminations were performed. CONCLUSION:Although the results to date have been promising, no firm conclusions can be drawn about the safety of anti-TNF during pregnancy and, without further evidence, guidelines which suggest these drugs should be avoided at the time of conception cannot yet be changed.


Ann Rheum Dis


Verstappen SM,King Y,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium, BSR Biologics Register.




Has Abstract


2011-05-01 00:00:00














  • Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?

    abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA,...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,收录出版,评审


    authors: Suurmond J,Schuerwegh AJ,Toes RE

    更新日期:2011-03-01 00:00:00

  • Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome.

    abstract:BACKGROUND:Primary Sjögren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocri...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Appel S,Le Hellard S,Bruland O,Brun JG,Omdal R,Kristjansdottir G,Theander E,Nordmark G,Kvarnström M,Eriksson P,Rönnblom L,Wahren-Herlenius M,Jonsson R

    更新日期:2011-07-01 00:00:00

  • Psoriatic arthritis. Follow-up study.

    abstract::227 patients with psoriasis and various forms of arthritis have been kept under review. Psoriasis and inflammatory arthropathy was present in 168 patients, of whom 94 have been followed up for more than 10 years. An arthritis indistinguishable from rheumatoid disease was present in 78%, distal joint arthritis in 16-6%...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Roberts ME,Wright V,Hill AG,Mehra AC

    更新日期:1976-06-01 00:00:00

  • The unclosing premature mortality gap in gout: a general population-based study.

    abstract:OBJECTIVE:Gout, the most common inflammatory arthritis, is associated with premature mortality. Whether this mortality gap has improved over time, as observed in rheumatoid arthritis (RA), is unknown. METHODS:Using an electronic medical record database representative of the UK general population, we identified inciden...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Fisher MC,Rai SK,Lu N,Zhang Y,Choi HK

    更新日期:2017-07-01 00:00:00

  • Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages.

    abstract:OBJECTIVES:To investigate the disease-modifying effects of phosphodiesterase 4 (PDE4) inhibition in preclinical models of systemic sclerosis (SSc). METHODS:We studied the effects of PDE4 inhibition in a prevention and a treatment model of bleomycin-induced skin fibrosis, in the topoisomerase mouse model as well as in ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Maier C,Ramming A,Bergmann C,Weinkam R,Kittan N,Schett G,Distler JHW,Beyer C

    更新日期:2017-06-01 00:00:00

  • Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement.

    abstract:OBJECTIVE:We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). METHODS:Fifty-eight forearm biopsies were evaluated from 26 individuals with dcSSc in two clinical trials. Histologic/immunophenotypic assessments of glob...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Showalter K,Spiera R,Magro C,Agius P,Martyanov V,Franks JM,Sharma R,Geiger H,Wood TA,Zhang Y,Hale CR,Finik J,Whitfield ML,Orange DE,Gordon JK

    更新日期:2021-02-01 00:00:00

  • Immunoglobulin phagocytosis by granulocytes from sera and synovial fluids in various rheumatoid and nonrheumatoid diseases.

    abstract::(1) The phagocytosis of human IgG, IgM, and C3 by granulocytes from various rheumatoid and nonrheumatoid sera and synovial fluids (SF) was investigated by direct examination of the patient's leucocytes and indirect testing by incubation of normal donor leucocytes with various sera and SF. (2) In rheumatoid arthritis (...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Cats A,Lafeber GJ,Klein F

    更新日期:1975-04-01 00:00:00

  • Increased incidence of cardiovascular disease in patients with rheumatoid arthritis: results from a community based study.

    abstract:OBJECTIVE:To investigate the first-ever incidence of acute myocardial infarction and stroke in a community based RA cohort compared with the general population. METHODS:The RA cohort consisted of all patients in a local RA register in Malmö, Sweden (n = 1022). The patients were recruited from private and hospital base...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Turesson C,Jarenros A,Jacobsson L

    更新日期:2004-08-01 00:00:00

  • Septic arthritis due to Histoplasma capsulatum in a leukaemic patient.

    abstract::A case of septic, histoplasmal monoarthritis of the knee in a leukaemic patient is described. Ketoconazole therapy failed to eliminate the infection, but after histoplasmosis was diagnosed prolonged therapy with amphotericin B was curative. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Jones PG,Rolston K,Hopfer RL

    更新日期:1985-02-01 00:00:00

  • Risk of diabetes mellitus associated with disease-modifying antirheumatic drugs and statins in rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the rate of incident diabetes mellitus (DM) in patients with rheumatoid arthritis (RA) and the impact of disease-modifying antirheumatic drug (DMARD) and statin treatments. METHODS:We studied patients with RA and ≥1 year participation in the National Data Bank for Rheumatic Diseases without ba...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Ozen G,Pedro S,Holmqvist ME,Avery M,Wolfe F,Michaud K

    更新日期:2017-05-01 00:00:00

  • Pulmonary involvement in ankylosing spondylitis.

    abstract::Thirty two patients with ankylosing spondylitis were investigated with a set of pulmonary function tests and the results compared with those for a control population. The patients had no complaints about lung symptoms and their chest radiographs were normal. The main pathological findings were reduced lung volumes, a ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Feltelius N,Hedenström H,Hillerdal G,Hällgren R

    更新日期:1986-09-01 00:00:00

  • Monosodium urate monohydrate crystals inhibit osteoblast viability and function: implications for development of bone erosion in gout.

    abstract:BACKGROUND:Bone erosion is a common manifestation of chronic tophaceous gout. OBJECTIVES:To investigate the effects of monosodium urate monohydrate (MSU) crystals on osteoblast viability and function. METHODS:The MTT assay and flow cytometry were used to assess osteoblast cell viability in the MC3T3-E1 and ST2 osteob...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Chhana A,Callon KE,Pool B,Naot D,Watson M,Gamble GD,McQueen FM,Cornish J,Dalbeth N

    更新日期:2011-09-01 00:00:00

  • The faux profil (oblique view) of the hip in the standing position. Contribution to the evaluation of osteoarthritis of the adult hip.

    abstract:OBJECTIVE:The technique and results of a special oblique radiograph of the hip called the "faux profil" (FP) of the hip are described. The FP was evaluated for the detection of joint space narrowing in incipient osteoarthritis of the hip (OAH) as compared with the anteroposterior (AP) radiograph. METHODS:58 hips with ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Lequesne MG,Laredo JD

    更新日期:1998-11-01 00:00:00

  • The "X-Ray RheumaCoach" software: a novel tool for enhancing the efficacy and accelerating radiological quantification in rheumatoid arthritis.

    abstract:BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

    更新日期:2003-06-01 00:00:00

  • Patients' needs and expectations with regard to rheumatology nursing care: results of multicentre focus group interviews.

    abstract:OBJECTIVE:The contribution of rheumatology nurses to improved patient outcomes is increasingly recognised but more research is needed about the effects of interventions. The patient's role in deciding about healthcare quality is considered pivotal and therefore patients' opinions and expectations should be directional ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: van Eijk-Hustings Y,Ammerlaan J,Voorneveld-Nieuwenhuis H,Maat B,Veldhuizen C,Repping-Wuts H

    更新日期:2013-06-01 00:00:00

  • Ultrasound and operative evaluation of arthritic shoulder joints.

    abstract:OBJECTIVE:To assess the diagnostic value of ultrasonography (US) in the evaluation of arthritic shoulder joints. METHODS:Twenty shoulders of 20 inpatients with arthritis were evaluated by US one day before the shoulder operation. Changes in the subacromial-subdeltoid bursa, biceps tendon and tendon sheath, rotatof cuf...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章


    authors: Alasaarela E,Leppilahti J,Hakala M

    更新日期:1998-06-01 00:00:00

  • Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.

    abstract:OBJECTIVES:IKZF1 and IKZF3 (encoding transcription factors Ikaros and Aiolos) are susceptibility loci for systemic lupus erythematosus (SLE). The pharmacology of iberdomide (CC-220), a cereblon (CRBN) modulator targeting Ikaros and Aiolos, was studied in SLE patient cells and in a phase 1 healthy volunteer study. METH...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验


    authors: Schafer PH,Ye Y,Wu L,Kosek J,Ringheim G,Yang Z,Liu L,Thomas M,Palmisano M,Chopra R

    更新日期:2018-10-01 00:00:00

  • A diagnostic algorithm for persistence of very early inflammatory arthritis: the utility of power Doppler ultrasound when added to conventional assessment tools.

    abstract:OBJECTIVES:The aim of this study was to assess the value of power Doppler ultrasound (PDUS) in combination with routine management in a cohort of patients with very early inflammatory arthritis (IA). METHODS:50 patients with < or =12 weeks of inflammatory symptoms with or without signs had clinical, laboratory and ima...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Freeston JE,Wakefield RJ,Conaghan PG,Hensor EM,Stewart SP,Emery P

    更新日期:2010-02-01 00:00:00

  • Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis.

    abstract:BACKGROUND:Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). OBJECTIVE:To investigate whether the recognition of citrullinated epitopes changes during disease onset or progression, by studying the fine specificity of ACPA in serum samples coll...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van der Woude D,Rantapää-Dahlqvist S,Ioan-Facsinay A,Onnekink C,Schwarte CM,Verpoort KN,Drijfhout JW,Huizinga TW,Toes RE,Pruijn GJ

    更新日期:2010-08-01 00:00:00

  • The role of non-invasive cardiovascular imaging in the assessment of cardiovascular risk in rheumatoid arthritis: where we are and where we need to be.

    abstract::This review assesses the risk assessment of cardiovascular disease (CVD) in rheumatoid arthritis (RA) and how non-invasive imaging modalities may improve risk stratification in future. RA is common and patients are at greater risk of CVD than the general population. Cardiovascular (CV) risk stratification is recommend...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Fent GJ,Greenwood JP,Plein S,Buch MH

    更新日期:2017-07-01 00:00:00

  • The B lymphocyte stimulator receptor-ligand system in hepatitis C virus-induced B cell clonal disorders.

    abstract:OBJECTIVE:The study aim was to examine the B lymphocyte stimulator (BLyS) receptor-ligand system in hepatitis C virus (HCV)-induced B lymphocyte clonal disorders. METHODS:94 patients with chronic HCV (including 35 with HCV+ mixed cryoglobulinaemia (MC)-vasculitis and nine with HCV+ B cell non-Hodgkin's lymphoma (B-NHL...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Landau DA,Rosenzwajg M,Saadoun D,Klatzmann D,Cacoub P

    更新日期:2009-03-01 00:00:00

  • Hypochlorhydria and hypergastrinaemia in rheumatoid arthritis.

    abstract::In order to evaluate the incidence and aetiology of hypergastrinaemia 53 patients with seropositive rheumatoid arthritis were examined for gastric acid secretion, fasting serum gastrin concentration, circulating parietal cell antibodies, and some parameters of the activity of inflammation of rheumatoid arthritis. The ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: de Witte TJ,Geerdink PJ,Lamers CB,Boerbooms AM,van der Korst JK

    更新日期:1979-02-01 00:00:00

  • Absence of chromosome damage in human lymphocytes exposed to allopurinol and oxipurinol.

    abstract::The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Stevenson AC,Silcock SR,Scott JT

    更新日期:1976-04-01 00:00:00

  • Sialometry and sialochemistry: a non-invasive approach for diagnosing Sjögren's syndrome.

    abstract:BACKGROUND:Analysis of salivary variables has frequently been proposed as a diagnostic tool for Sjögren's syndrome (SS). Because univocal salivary reference values are lacking, it is currently rather difficult to use sialometry and sialochemistry for diagnosing SS unless major changes have occurred in salivary secretio...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Kalk WW,Vissink A,Stegenga B,Bootsma H,Nieuw Amerongen AV,Kallenberg CG

    更新日期:2002-02-01 00:00:00

  • Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab.

    abstract:OBJECTIVES:In a post-hoc analysis, we aimed to validate the Lupus Low Disease Activity State (LLDAS) definition as an endpoint in an systemic lupus erythematosus (SLE) Phase IIb randomised controlled trial (RCT) (MUSE [NCT01438489]) and then utilize LLDAS to discriminate between anifrolumab and placebo. METHODS:Patien...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验


    authors: Morand EF,Trasieva T,Berglind A,Illei GG,Tummala R

    更新日期:2018-05-01 00:00:00

  • Local denaturation of collagen fibres during the mechanical rupture of collagenous fibrous tissue.

    abstract::Human extensor tendons of the hand were pulled to rupture, and the torn ends, when observed in the scanning electron microscope, appeared to be knotted, possibly owing to the denaturation of the collagen. This confirmed by fluorimetry assays of both the ruptured ends and the middle unbroken sections of the same tendon...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Minns RJ,Steven FS

    更新日期:1980-04-01 00:00:00

  • Anti-tumour necrosis factor (TNF) alpha treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13.

    abstract:OBJECTIVE:To measure interleukin (IL)18 serum concentrations in patients with rheumatoid arthritis (RA) undergoing infliximab treatment (tumour necrosis factor (TNF) alpha blockade) and to evaluate the concomitant modification of IL12 and IL13 serum concentrations, two cytokines belonging to the Th1 and Th2 profile res...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Pittoni V,Bombardieri M,Spinelli FR,Scrivo R,Alessandri C,Conti F,Spadaro A,Valesini G

    更新日期:2002-08-01 00:00:00

  • Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T cells and macrophages predominate in early and active sacroiliitis- cellularity correlates with the degree of enhancement detected by magnetic resonance imaging.

    abstract:OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

    更新日期:2000-02-01 00:00:00

  • Blood hyperviscosity with reduced skin blood flow in scleroderma.

    abstract::The vascular complications of scleroderma have previously been attributed to the progressive obliteration of small vessels. Our study was carried out to determine whether abnormalities of blood viscosity occur in this disease, thereby contributing to the ischaemic process. Blood viscosity was measured in 20 patients u...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: McGrath MA,Peek R,Penny R

    更新日期:1977-12-01 00:00:00

  • Autonomic neuropathy in systemic lupus erythematosus: cardiovascular autonomic function assessment.

    abstract:AIM:To assess the prevalence and the nature of autonomic neuropathy (AN) in 17 patients with inactive or mild active systemic lupus erythematosus (SLE). METHODS:Patients were tested using questionnaires related to possible AN symptoms, and four non invasive cardiovascular autonomic function tests at rest, during lying...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Lioté F,Osterland CK

    更新日期:1994-10-01 00:00:00