Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.

abstract：:Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Roberts-Thomson PJ

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVES:Rheumatoid arthritis (RA) is less common among men than women, and sex hormones have been suggested to play a part in the pathogenesis. Lower levels of testosterone have been demonstrated in men with RA, but it is not known if these changes precede the disease. METHODS:In a nested case-control study, using ...

journal_title：Annals of the rheumatic diseases

authors： Pikwer M,Giwercman A,Bergström U,Nilsson JÅ,Jacobsson LT,Turesson C

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE. METHODS:The relationship between maternal age at littering and frequency of AE was analy...

journal_title：Annals of the rheumatic diseases

authors： Weinreich S,Hoebe B,Ivanyi P

更新日期：1995-09-01 00:00:00

abstract：:The response of synovial lymphocytes from a 65-year-old lady with persistent polyarthritis, to rubella antigen and a number of other microbial agents was studied over a period of 11 months by [3H]thymidine incorporation. The results were correlated with the ability to isolate rubella virus from both peripheral blood a...

journal_title：Annals of the rheumatic diseases

authors： Chantler JK,da Roza DM,Bonnie ME,Reid GD,Ford DK

更新日期：1985-08-01 00:00:00

abstract：INTRODUCTION:Psoriasis susceptibility locus 4 (PSORS4) is a susceptibility locus for psoriasis vulgaris (PsV), a common inflammatory, hyperproliferative skin disorder. Recently, a deletion of 2 late cornified envelope (LCE) genes within epidermal differentiation complex on chromosome 1 was shown to be enriched in 1426 ...

journal_title：Annals of the rheumatic diseases

authors： Hüffmeier U,Estivill X,Riveira-Munoz E,Traupe H,Wendler J,Lohmann J,Böhm B,Burkhardt H,Reis A

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Hyperplasia of synovial fibroblasts, infiltration with lymphocytes and tissue hypoxia are major characteristics of rheumatoid arthritis (RA). Extensive data support a key role for toll-like receptors (TLRs) in RA. Little is known regarding the impact of hypoxia on TLR-induced inflammation in RA. The aim of t...

journal_title：Annals of the rheumatic diseases

authors： Hu F,Mu R,Zhu J,Shi L,Li Y,Liu X,Shao W,Li G,Li M,Su Y,Cohen PL,Qiu X,Li Z

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To investigate the inflammatory response in giant cell arteritis (GCA) by characterising the DNA methylation pattern within the temporal artery microenvironment. METHODS:Twelve patients with non-equivocal histological evidence for GCA and 12 age-matched, sex-matched and ethnicity-matched controls with normal...

journal_title：Annals of the rheumatic diseases

authors： Coit P,De Lott LB,Nan B,Elner VM,Sawalha AH

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:The effect of adalimumab on hand osteoporosis was examined and related to radiographic joint damage in the three treatment arms of the PREMIER study: adalimumab plus methotrexate, adalimumab and methotrexate monotherapy. Predictors of hand bone loss were also searched for. METHODS:768 patients (537 fulfilled...

journal_title：Annals of the rheumatic diseases

authors： Hoff M,Kvien TK,Kälvesten J,Elden A,Haugeberg G

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Evidence was sought for genetic anticipation (disease occurring at an earlier age in subsequent generations, with increasing severity) in nodal osteoarthritis (NOA). METHODS:Age at symptom onset and disease severity was compared within 30 parent/offspring pairs with NOA. Correlation between the offspring age...

journal_title：Annals of the rheumatic diseases

authors： Wright GD,Regan M,Deighton CM,Wallis G,Doherty M

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVES:Although shared decision making (SDM) is advocated in rheumatoid arthritis (RA) treatment, it is largely unclear when, how and to what extent SDM is applied in routine clinical care of patients with RA. This study aimed to investigate the level of SDM in RA treatment from an observer perspective and to asses...

journal_title：Annals of the rheumatic diseases

authors： Mathijssen EGE,Vriezekolk JE,Popa CD,van den Bemt BJF

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To characterise renal tissue metabolic pathway gene expression in different forms of glomerulonephritis. METHODS:Patients with nephrotic syndrome (NS), antineutrophil cytoplasmic antibody-associated vasculitis (AAV), systemic lupus erythematosus (SLE) and healthy living donors (LD) were studied. Clinically ...

journal_title：Annals of the rheumatic diseases

authors： Grayson PC,Eddy S,Taroni JN,Lightfoot YL,Mariani L,Parikh H,Lindenmeyer MT,Ju W,Greene CS,Godfrey B,Cohen CD,Krischer J,Kretzler M,Merkel PA,Vasculitis Clinical Research Consortium, the European Renal cDNA Bank cohort, and th

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To evaluate concentrations of the platelet activation markers beta thromboglobulin (BTG) and platelet factor 4 (PF4) in bronchoalveolar lavage fluid (BALF) from patients with systemic sclerosis with and without scleroderma interstitial lung disease (SLD). METHODS:BTG and PF-4 were measured by enzyme immunoas...

journal_title：Annals of the rheumatic diseases

authors： Kowal-Bielecka O,Kowal K,Lewszuk A,Bodzenta-Lukaszyk A,Walecki J,Sierakowski S

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. METHODS:Three independent sets of case-con...

journal_title：Annals of the rheumatic diseases

authors： Kochi Y,Thabet MM,Suzuki A,Okada Y,Daha NA,Toes RE,Huizinga TW,Myouzen K,Kubo M,Yamada R,Nakamura Y,Yamamoto K

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and gastroduodenal safety of a fixed-dose combination of diclofenac sodium 50 mg and misoprostol 200 micrograms twice daily with those of piroxicam 10 mg twice daily and naproxen 375 mg twice daily in patients with osteoarthritis. METHODS:A 4 week, randomised, double-blind, parallel-...

journal_title：Annals of the rheumatic diseases

authors： Melo Gomes JA,Roth SH,Zeeh J,Bruyn GA,Woods EM,Geis GS

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by aberrant B cell hyperactivation, whose mechanism is partially understood. METHODS:We performed whole transcriptome sequencing of B cells from three pSS patients and three matched healthy controls (HC). Differentially expressi...

journal_title：Annals of the rheumatic diseases

authors： Sun JL,Zhang HZ,Liu SY,Lian CF,Chen ZL,Shao TH,Zhang S,Zhao LL,He CM,Wang M,Zhang W,Chen H,Zhang FC

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjögren's syndrome (SS). METHODS:A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice...

journal_title：Annals of the rheumatic diseases

authors： Tsifetaki N,Kitsos G,Paschides CA,Alamanos Y,Eftaxias V,Voulgari PV,Psilas K,Drosos AA

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Collagen-induced arthritis (CIA) is the most commonly used model of rheumatoid arthritis (RA). In both CIA and RA there is an increase in the cellular content of the synovium, this being dominated by macrophages. OBJECTIVE:To assess the impact of etoposide, a topoisomerase II antagonist known to induce mono...

journal_title：Annals of the rheumatic diseases

authors： Verdrengh M,Jonsson IM,Zaether O,Bajtner E,Holmdahl R,Tarkowski A

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functio...

journal_title：Annals of the rheumatic diseases

authors： Bocelli-Tyndall C,Trella E,Frachet A,Zajac P,Pfaff D,Geurts J,Heiler S,Barbero A,Mumme M,Resink TJ,Schaeren S,Spagnoli GC,Tyndall A

更新日期：2015-01-01 00:00:00

abstract：:Three aspects of polymorphonuclear leucocyte (PMN) function were studied in 19 patients with Behçet's syndrome (BS). By 2 different techniques directed motility was found to be increased. This increase was largely due to the subgroup of patients with ocular involvement. Counts of absolute numbers of cells migrating hi...

journal_title：Annals of the rheumatic diseases

authors： Fordham JN,Davies PG,Kirk A,Currey HL

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVES:Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential therapeutic approach for the treatment of osteoporosis in preclinical models. METHODS:Systemic bone loss was induced in mice by gluc...

journal_title：Annals of the rheumatic diseases

authors： Lin NY,Chen CW,Kagwiria R,Liang R,Beyer C,Distler A,Luther J,Engelke K,Schett G,Distler JH

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To compare familial inflammatory inclusion body myositis (IBM) with hereditary inclusion body myopathies and sporadic IBM. PATIENTS AND METHODS:Clinical, biological, MRI, and histological data were analysed in two siblings with inflammatory IBM and compared with those of patients with sporadic and hereditary...

journal_title：Annals of the rheumatic diseases

authors： Ranque-Francois B,Maisonobe T,Dion E,Piette JC,Chauveheid MP,Amoura Z,Papo T

更新日期：2005-04-01 00:00:00

abstract：:Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease. To date, no intervention is available that alters the underlying mechanism of inflammation in AS. Currently available conventional treatments are palliative at best, and often fail to control symptoms in the long term. Cu...

journal_title：Annals of the rheumatic diseases

authors： Dougados M,Dijkmans B,Khan M,Maksymowych W,van der Linden S,Brandt J

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To assess the intra and interobserver reproducibility of musculoskeletal ultrasonography (US) among rheumatologists in detecting destructive and inflammatory shoulder abnormalities in patients with rheumatoid arthritis (RA) and to determine the overall agreement between US and MRI. METHODS:A total of 14 obse...

journal_title：Annals of the rheumatic diseases

authors： Bruyn GA,Naredo E,Möller I,Moragues C,Garrido J,de Bock GH,d'Agostino MA,Filippucci E,Iagnocco A,Backhaus M,Swen WA,Balint P,Pineda C,Milutinovic S,Kane D,Kaeley G,Narvaez FJ,Wakefield RJ,Narvaez JA,de Augustin J,

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:To study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed. METHODS:We examined whether symptomatic (≥1 joint(s) with radio...

journal_title：Annals of the rheumatic diseases

authors： Haugen IK,Ramachandran VS,Misra D,Neogi T,Niu J,Yang T,Zhang Y,Felson DT

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of combining monthly intravenous methotrexate (IV MTX) with monthly IV cyclophosphamide (CYTX; given on the same day) for the treatment of children who develop recurrent diffuse proliferative glomerulonephritis secondary to systemic lupus erythematosus during or after the s...

journal_title：Annals of the rheumatic diseases

authors： Lehman TJ,Edelheit BS,Onel KB

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Upadacitinib is a Janus kinase inhibitor under evaluation for the treatment of psoriatic arthritis (PsA). We evaluated upadacitinib in patients with PsA and prior inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD). METHODS:In this 24-week randomised, pla...

journal_title：Annals of the rheumatic diseases

authors： Mease PJ,Lertratanakul A,Anderson JK,Papp K,Van den Bosch F,Tsuji S,Dokoupilova E,Keiserman M,Wang X,Zhong S,McCaskill RM,Zueger P,Pangan AL,Tillett W

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease. OBJECTIVE:To combine hrMRI and cadaveric histological studie...

journal_title：Annals of the rheumatic diseases

authors： Tan AL,Toumi H,Benjamin M,Grainger AJ,Tanner SF,Emery P,McGonagle D

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Compare the radiographic progression of ankylosing spondylitis (AS) patients treated with infliximab (INF) versus historical controls (Herne cohort, HC) never treated with tumour necrosis factor (TNF)-blockers over 8 years. METHODS:Patients were selected based on the availability of lateral cervical and lumb...

journal_title：Annals of the rheumatic diseases

authors： Baraliakos X,Haibel H,Listing J,Sieper J,Braun J

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of septic arthritis (SA) in patients with rheumatoid arthritis (RA) treated with anti-tumour necrosis factor (TNF) therapy. METHODS:Using data from the British Society for Rheumatology Biologics Register, a prospective observational study, the authors compared the risk of SA between 11 ...

journal_title：Annals of the rheumatic diseases

authors： Galloway JB,Hyrich KL,Mercer LK,Dixon WG,Ustianowski AP,Helbert M,Watson KD,Lunt M,Symmons DP,BSR Biologics Register.

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Previous data have shown that etanercept levels are associated with clinical response in rheumatoid arthritis. However, for ankylosing spondylitis (AS), data regarding this topic are inconclusive. OBJECTIVES:To investigate the relationship between etanercept levels and clinical response in patients with AS....

journal_title：Annals of the rheumatic diseases

authors： Kneepkens EL,Krieckaert CL,van der Kleij D,Nurmohamed MT,van der Horst-Bruinsma IE,Rispens T,Wolbink GJ

更新日期：2015-10-01 00:00:00