当前位置： SCI文献检索 > ANNALS OF THE RHEUMATIC DISEASES期刊下所有文献 > Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham heart study.

Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham heart study.

Abstract：

OBJECTIVES:To study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed. METHODS:We examined whether symptomatic (≥1 joint(s) with radiographic OA and pain in the same joint) and radiographic hand OA (≥1 joint(s) with radiographic OA without pain) were associated with mortality and incident cardiovascular events (coronary heart disease, congestive heart failure and/or atherothrombotic brain infarction) using Cox proportional hazards models. In the adjusted models, we included possible confounding factors from baseline (eg, metabolic factors, medication use, smoking/alcohol). We also adjusted for the number of painful joints in the lower limb and physical inactivity. RESULTS:We evaluated 1348 participants (53.8% women) with mean (SD) age of 62.2 (8.2) years, of whom 540 (40.1%) and 186 (13.8%) had radiographic and symptomatic hand OA, respectively. There was no association between hand OA and mortality. Although there was no significant relation to incident cardiovascular events overall or a relation of radiographic hand OA with events, we found a significant association between symptomatic hand OA and incident coronary heart disease (myocardial infarction/coronary insufficiency syndrome) (HR 2.26, 95% CI 1.22 to 4.18). The association remained after additional adjustment for pain in the lower limb or physical inactivity. CONCLUSIONS:Symptomatic hand OA, but not radiographic hand OA, was associated with an increased risk of coronary heart disease events. The results suggest an effect of pain, which may be a possible marker of inflammation.

journal_name

Ann Rheum Dis

journal_title

Annals of the rheumatic diseases

authors

Haugen IK,Ramachandran VS,Misra D,Neogi T,Niu J,Yang T,Zhang Y,Felson DT

doi

10.1136/annrheumdis-2013-203789

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

74-81

issue

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2013-203789

journal_volume

pub_type

杂志文章

在线工具

Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham heart study.