Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not?

abstract：BACKGROUND:We report on a workshop on ethical and legal constraints on data sharing between countries in multinational epidemiologic research in Europe that was held in January 2007 in Potsdam, Germany. The participants were experienced epidemiologic and clinical researchers from eight European countries. The aim of th...

journal_title：Annals of the rheumatic diseases

authors： Zink A,Silman AJ

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis (SSc). METHODS:Fifty-two consecutive patients with SSc underwent cardiac MRI to determine morphological, functional, perfusion at rest and delayed enhancement abnormal...

journal_title：Annals of the rheumatic diseases

authors： Hachulla AL,Launay D,Gaxotte V,de Groote P,Lamblin N,Devos P,Hatron PY,Beregi JP,Hachulla E

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:To determine the relative contribution of work-related mechanical (injury) factors and psychosocial factors to the onset of a new episode of knee pain, in a cohort of newly employed workers. METHODS:A prospective cohort study of newly employed workers from 12 diverse occupational settings in England (The New...

journal_title：Annals of the rheumatic diseases

authors： Jones GT,Harkness EF,Nahit ES,McBeth J,Silman AJ,Macfarlane GJ

更新日期：2007-03-01 00:00:00

abstract：:Persistent infectious polyarthritis caused by Ureaplasma urealyticum in a patient with common variable hypogammaglobulinaemia is described. The patient developed a symmetrical, destructive polyarthritis and tenosynovitis associated with a markedly depressed synovial fluid glucose concentration and characteristic soft ...

journal_title：Annals of the rheumatic diseases

authors： Lehmer RR,Andrews BS,Robertson JA,Stanbridge EJ,de la Maza L,Friou GJ

更新日期：1991-08-01 00:00:00

abstract：:The relation between common rheumatic diseases such as osteoarthrosis, arthralgia without definite signs of osteoarthrosis, subacromial shoulder pain, different forms of tendinitis, low back pain and neck pain, and the level of formal education, occupational workload and some lifestyle factors were examined in 502 of ...

journal_title：Annals of the rheumatic diseases

authors： Jacobsson L,Lindgärde F,Manthorpe R,Ohlsson K

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses t...

journal_title：Annals of the rheumatic diseases

authors： Malik MH,Jury F,Bayat A,Ollier WE,Kay PR

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:In a prospective observational study, we investigated whether patients with active systemic lupus erythematosus (SLE) had higher indices of endothelial damage and dysfunction than healthy controls and whether improved disease control was associated with improvement in these indices. METHODS:Twenty-seven pat...

journal_title：Annals of the rheumatic diseases

authors： Parker B,Al-Husain A,Pemberton P,Yates AP,Ho P,Gorodkin R,Teh LS,Alexander MY,Bruce IN

更新日期：2014-06-01 00:00:00

abstract：:Animals were injected intra-articularly with antigen after prior immunization with that antigen in Freund's incomplete adjuvant in order to precipitate immune complexes in the surfaces of menisci, ligaments, and cartilage. On reimmunization with antigen in Freund's complete adjuvant 10 weeks later, generally an arthri...

journal_title：Annals of the rheumatic diseases

authors： Fox A,Glynn LE

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVES:To compare the effects of etanercept (ETN) 50 mg once weekly plus methotrexate (MTX) versus MTX alone on patient-reported outcomes (PROs) and the relationship between remission and PRO improvement. METHODS:In this double-blind, randomised clinical trial (COMET), PROs included: the Health Assessment Question...

journal_title：Annals of the rheumatic diseases

authors： Kekow J,Moots RJ,Emery P,Durez P,Koenig A,Singh A,Pedersen R,Robertson D,Freundlich B,Sato R

更新日期：2010-01-01 00:00:00

abstract：:The synovial surface in rabbit knees was examined by scanning electron microscopy (SEM) to define normal surface contour, cell shape, and interstitial exposure. Comparison was made between specimens excised before immersion fixation (I), fixed in situ by vascular perfusion (V) before excision, or fixed in situ under a...

journal_title：Annals of the rheumatic diseases

authors： McDonald JN,Levick JR

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Oxidative stress in RA synovial tissue can cause DNA damage and suppress the DNA mismatch repair (MMR) system in cultured synoviocytes. This mechanism includes two enzyme complexes, hMutSalpha (hMSH2/hMSH6) and hMutSbeta (hMSH2/hMSH3). OBJECTIVE:To examine the expression and distribution of MMR enzymes in s...

journal_title：Annals of the rheumatic diseases

authors： Simelyte E,Boyle DL,Firestein GS

更新日期：2004-12-01 00:00:00

abstract：:We report two cases of osteomyelitis secondary to staphylococcal septicaemia, presenting with large sterile effusions in adjacent joints. In both cases the clinical features were suggestive of septic arthritis. Multiple joints were involved in each patient. Initial radiographs showed no abnormalities. ...

journal_title：Annals of the rheumatic diseases

authors： Platt PN,Griffiths ID

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVES:To determine whether hormonal dysfunction involving the hypothalamic-pituitary-adrenal (HPA) axis, prolactin (PRL) secretion, and sex hormone status contribute to development of systemic lupus erythematosus (SLE). METHODS:11 patients with SLE and 9 healthy controls were tested for their total anterior pitui...

journal_title：Annals of the rheumatic diseases

authors： Köller MD,Templ E,Riedl M,Clodi M,Wagner O,Smolen JS,Luger A

更新日期：2004-12-01 00:00:00

abstract：:The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and...

journal_title：Annals of the rheumatic diseases

authors： Gale R,Bertouch JV,Bradley J,Roberts-Thomson PJ

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation may contribute to accelerated atherosclerosis and increased arterial stiffness in patients with rheumatoid arthritis (RA). In addition to lowering cholesterol, statins have immunomodulatory effects which may be especially beneficial in patients with RA who have systemic immune a...

journal_title：Annals of the rheumatic diseases

authors： Van Doornum S,McColl G,Wicks IP

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:To develop a questionnaire assessing the expectations of patients regarding management of osteoarthritis (OA of the knee. METHODS:A detailed document reporting on a qualitative analysis of interviews of patients with knee OA was sent to experts and a Delphi procedure was adopted for item generation. Eighty ...

journal_title：Annals of the rheumatic diseases

authors： Benhamou M,Boutron I,Dalichampt M,Baron G,Alami S,Rannou F,Ravaud P,Poiraudeau S

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS:Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA...

journal_title：Annals of the rheumatic diseases

authors： Glinatsi D,Baker JF,Hetland ML,Hørslev-Petersen K,Ejbjerg BJ,Stengaard-Pedersen K,Junker P,Ellingsen T,Lindegaard HM,Hansen I,Lottenburger T,Møller JM,Ørnbjerg L,Vestergaard A,Jurik AG,Thomsen HS,Torfing T,Møller-Bisgaa

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). OBJECTIVE:To test the validity and the mechanism of this association between α1AT and AAV. METHODS:The distribution of α1AT deficiency alleles Z and S was co...

journal_title：Annals of the rheumatic diseases

authors： Morris H,Morgan MD,Wood AM,Smith SW,Ekeowa UI,Herrmann K,Holle JU,Guillevin L,Lomas DA,Perez J,Pusey CD,Salama AD,Stockley R,Wieczorek S,McKnight AJ,Maxwell AP,Miranda E,Williams J,Savage CO,Harper L

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:People with spondyloarthritis (SpA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) have identified the importance of understanding how their disease and its treatment impacts on their social roles. This requires a reliable and valid standardised measure, and this study evaluates these measurement...

journal_title：Annals of the rheumatic diseases

authors： Davis AM,Palaganas MP,Badley EM,Gladman DD,Inman RD,Gignac MA

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To evaluate concentrations of the platelet activation markers beta thromboglobulin (BTG) and platelet factor 4 (PF4) in bronchoalveolar lavage fluid (BALF) from patients with systemic sclerosis with and without scleroderma interstitial lung disease (SLD). METHODS:BTG and PF-4 were measured by enzyme immunoas...

journal_title：Annals of the rheumatic diseases

authors： Kowal-Bielecka O,Kowal K,Lewszuk A,Bodzenta-Lukaszyk A,Walecki J,Sierakowski S

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To determine the significance of quantitative levels of antibodies to cyclic citrullinated peptides (anti-CCP) in a population of patients with rheumatoid arthritis (RA). METHODS:A total of 241 consecutive sera from patients with RA sent from a large rheumatology clinic for laboratory testing were selected f...

journal_title：Annals of the rheumatic diseases

authors： Lee DM,Phillips R,Hagan EM,Chibnik LB,Costenbader KH,Schur PH

更新日期：2009-02-01 00:00:00

abstract：:The clinical and laboratory data for an 8 year old girl with abdominal pain as a presenting manifestation of acute rheumatic fever are reported. An abdominal investigation with ultrasonography carried out at the same time showed free peritoneal fluid. These findings support the proposal that the abdominal pain classic...

journal_title：Annals of the rheumatic diseases

authors： Picard E,Gedalia A,Benmeir P,Zucker N,Barki Y

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Primary Sjögren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocri...

journal_title：Annals of the rheumatic diseases

authors： Appel S,Le Hellard S,Bruland O,Brun JG,Omdal R,Kristjansdottir G,Theander E,Nordmark G,Kvarnström M,Eriksson P,Rönnblom L,Wahren-Herlenius M,Jonsson R

更新日期：2011-07-01 00:00:00

abstract：:The pattern of joint involvement on conventional radiographs and the four hour gammacamera image of 99Tc HMDP bone scans were studied in 33 patients with generalised nodal osteoarthritis. Both techniques showed the predominant involvement of the distal interphalangeal, scaphotrapezial, and first carpometacarpal joints...

journal_title：Annals of the rheumatic diseases

authors： Hutton CW,Higgs ER,Jackson PC,Watt I,Dieppe PA

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVES:Recent observational studies have highlighted the beneficial role of dairy ingestion in gout prevention. The aims of this study were to determine the acute effects of milk ingestion on serum urate concentrations and examine the mechanisms of these effects. METHODS:This was a short-term randomised controlled...

journal_title：Annals of the rheumatic diseases

authors： Dalbeth N,Wong S,Gamble GD,Horne A,Mason B,Pool B,Fairbanks L,McQueen FM,Cornish J,Reid IR,Palmano K

更新日期：2010-09-01 00:00:00

abstract：:The 13 questions to which 173 rheumatic outpatients most frequently wished to know the answer were made the basis of a structured interview. Two lengths of interview were conducted in a controlled trial (short being of 2 minutes' duration, long ranging from 4 to 11 minutes). Sixty patients referred directly from their...

journal_title：Annals of the rheumatic diseases

authors： Wright V,Hopkins R,Burton K

更新日期：1982-06-01 00:00:00

abstract：:Two cases of acute monarthritis secondary to asymptomatic renal cell carcinoma are described. This association has not previously been reported. The patients were initially thought to have a septic arthritis, but hot spots were seen on isotope bone scans and biopsy samples showed secondary neoplasms, which were later ...

journal_title：Annals of the rheumatic diseases

authors： Chakravarty KK,Webley M

更新日期：1992-05-01 00:00:00

abstract：:The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

journal_title：Annals of the rheumatic diseases

authors： Stevenson AC,Silcock SR,Scott JT

更新日期：1976-04-01 00:00:00

abstract：:A method is described for evaluating the progress of patients with back pain. Various symptoms were scored on analogue scales and spinal motion was measured by various techniques. These data were integrated to make subjective and objective indices respectively. Reasonable reproducibility of the measurements was obtain...

journal_title：Annals of the rheumatic diseases

authors： Million R,Nilsen KH,Jayson MI,Baker RD

更新日期：1981-10-01 00:00:00

abstract：:Lornoxicam is a new non-steroidal anti-inflammatory agent (NSAID) with a similar pharmacological profile to other oxicams and a potency 10 times greater than piroxicam. A multicentre, randomised, double blind, parallel group study was undertaken to compare the efficacy and tolerance of four weeks' treatment with lorno...

journal_title：Annals of the rheumatic diseases

authors： Berry H,Bird HA,Black C,Blake DR,Freeman AM,Golding DN,Hamilton EB,Jayson MI,Kidd B,Kohn H

更新日期：1992-02-01 00:00:00