Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography.

abstract：:An explant method for the isolation of fibroblasts from adult human tendon is described. Cells were successfully isolated from 22 out of 27 common biceps tendons obtained from cadaveric donors (age range 11-83 years). The fibroblasts could be maintained in culture using standard methods and morphologically resembled t...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Wright JK,Hazleman BL

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:To investigate the rate of incident diabetes mellitus (DM) in patients with rheumatoid arthritis (RA) and the impact of disease-modifying antirheumatic drug (DMARD) and statin treatments. METHODS:We studied patients with RA and ≥1 year participation in the National Data Bank for Rheumatic Diseases without ba...

journal_title：Annals of the rheumatic diseases

authors： Ozen G,Pedro S,Holmqvist ME,Avery M,Wolfe F,Michaud K

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To determine whether the humoral anti-chlamydia antibody response might be related to the ineffective bacterial elimination seen in patients with Chlamydia trachomatis reactive arthritis, particularly in men, who have a higher prevalence of the disease than women. METHODS:The number and specificity of the an...

journal_title：Annals of the rheumatic diseases

authors： Bas S,Scieux C,Vischer TL

更新日期：2001-06-01 00:00:00

abstract：:A novel explanation for the natural history of joint destruction in the early phase of ankylosing spondylitis is proposed on the basis of the clinical history, x-ray appearance, operative findings, and histopathology of a young patient believed to be suffering from the peripheral form of this disease. ...

journal_title：Annals of the rheumatic diseases

authors： Pasion EG,Goodfellow JW

更新日期：1975-02-01 00:00:00

abstract：OBJECTIVES:Lipid profiles are altered by active disease in patients with rheumatoid arthritis (RA) and may be further modified by treatment with Janus kinase inhibitors and other disease-modifying antirheumatic drugs. METHODS:Lipid data were analysed from phase II and III studies of 4 mg (n=997) and 2 mg (n=479) oral ...

journal_title：Annals of the rheumatic diseases

authors： Taylor PC,Kremer JM,Emery P,Zuckerman SH,Ruotolo G,Zhong J,Chen L,Witt S,Saifan C,Kurzawa M,Otvos JD,Connelly MA,Macias WL,Schlichting DE,Rooney TP,de Bono S,McInnes IB

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the elastic properties of the ascending aorta in untreated patients with giant cell arteritis compared with age and sex matched normal controls. METHODS:Distensibility of the ascending aorta and aortic strain were measured in 22 patients with a recent diagnosis of giant cell arteritis (documen...

journal_title：Annals of the rheumatic diseases

authors： Margos PN,Moyssakis IE,Tzioufas AG,Zintzaras E,Moutsopoulos HM

更新日期：2005-02-01 00:00:00

abstract：:The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas...

journal_title：Annals of the rheumatic diseases

authors： Clarke AK,Vernon-Roberts B,Currey HL

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:A great deal of evidence has shown that non-human leucocyte antigen (HLA)-B27 genes may play crucial roles in the aetiology of ankylosing spondylitis (AS), but there is little evidence of a relationship with tumour necrosis factor (TNF)alpha gene variation. One functional single-nucleotide polymorphism (SNP)...

journal_title：Annals of the rheumatic diseases

authors： Zhu X,Wang Y,Sun L,Song Y,Sun F,Tang L,Huo Z,Li J,Yang Z

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. METHODS:Three independent sets of case-con...

journal_title：Annals of the rheumatic diseases

authors： Kochi Y,Thabet MM,Suzuki A,Okada Y,Daha NA,Toes RE,Huizinga TW,Myouzen K,Kubo M,Yamada R,Nakamura Y,Yamamoto K

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To compare levels of disability of people with and without hip and knee arthroplasty in a random national sample. METHODS:In 1999 a screening questionnaire to classify people into groups of increasing probabilities of disability was sent to 417 500 people; response rate 86%. The study population was obtaine...

journal_title：Annals of the rheumatic diseases

authors： Boutron I,Poiraudeau S,Ravaud JF,Baron G,Revel M,Nizard R,Dougados M,Ravaud P

更新日期：2003-08-01 00:00:00

abstract：:A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. Magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient ...

journal_title：Annals of the rheumatic diseases

authors： Peh WC,Shek TW,Ip WY

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To compare responsiveness of the Harris Hip Score with generic measures (that is, the Short Form-36 (SF-36), and a test of walking speed and pain during walking) in patients with osteoarthritis (OA) of the hip. METHOD:The first 75 cases within the population of a randomised clinical trial on manual therapy a...

journal_title：Annals of the rheumatic diseases

authors： Hoeksma HL,Van Den Ende CH,Ronday HK,Heering A,Breedveld FC

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To confirm and extend the immunopathological evidence of effects of infliximab on the synovium in active spondyloarthropathy. METHODS:Synovial biopsies obtained in patients with spondyloarthropathy at baseline and week 12 were stained and scored by two independent observers. Two study populations were evalua...

journal_title：Annals of the rheumatic diseases

authors： Kruithof E,Baeten D,Van den Bosch F,Mielants H,Veys EM,De Keyser F

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To determine if serum urate concentration is associated with development of hypertension in young adults. METHODS:Retrospective cohort analysis from 4752 participants with available serum urate and without hypertension at baseline from the Coronary Artery Risk Development in Young Adults (CARDIA) study; a mi...

journal_title：Annals of the rheumatic diseases

authors： Gaffo AL,Jacobs DR Jr,Sijtsma F,Lewis CE,Mikuls TR,Saag KG

更新日期：2013-08-01 00:00:00

abstract：:Twenty-five patients (22 males and 3 females) are described who had 'unclassifiable' seronegative peripheral arthritis affecting mainly the large joints of the lower limbs with other typical features of spondyloarthropathies such as heel pain, low back pain, and mucosal ulcers. But their disorders could not be diagnos...

journal_title：Annals of the rheumatic diseases

authors： Prakash S,Mehra NK,Bhargava S,Malaviya AN

更新日期：1983-12-01 00:00:00

abstract：:Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in...

journal_title：Annals of the rheumatic diseases

authors： Klimiuk PS,Taylor L,Baker RD,Jayson MI

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To assess the value of advanced imaging techniques in the detection of hand osteoarthritis (OA) and hand OA progression. METHODS:PubMed/Medline and Embase were searched until April 2012 for studies on imaging of hand OA that presented quantitative data on validity, reliability or responsiveness. Articles pre...

journal_title：Annals of the rheumatic diseases

authors： Saltzherr MS,Selles RW,Bierma-Zeinstra SM,Muradin GS,Coert JH,van Neck JW,Luime JJ

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:The influence of dexamethasone on interleukin 10 (IL10) production and the type 1 (T1)/type 2 (T2) T cell balance found in rheumatoid arthritis (RA) was studied. METHODS:Peripheral blood mononuclear cells (PB MNC) were isolated from 14 RA patients both before and 7 and 42 days after high dose dexamethasone ...

journal_title：Annals of the rheumatic diseases

authors： Verhoef CM,van Roon JA,Vianen ME,Lafeber FP,Bijlsma JW

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:There is increased cardiovascular disease mortality in rheumatoid arthritis. This may reflect an increased prevalence of cardiovascular disease or an increased case fatality in patients with rheumatoid arthritis. OBJECTIVES:To examine whether rheumatoid patients with disease onset in the 1980s-1990s have in...

journal_title：Annals of the rheumatic diseases

authors： Goodson N,Marks J,Lunt M,Symmons D

更新日期：2005-11-01 00:00:00

abstract：:Antibody production in response to the primary immunogen bacteriophage phi X174 was investigated in 14 patients with previous yersinia arthritis (YA) and in 15 controls. HLA-B27 occurred in 10 patients with YA and in three controls. After primary and secondary immunisation the antibody responses were essentially simil...

journal_title：Annals of the rheumatic diseases

authors： Bucknall R,Leirisalo-Repo M,Laitinen O,Jones JV

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：:The vascular complications of scleroderma have previously been attributed to the progressive obliteration of small vessels. Our study was carried out to determine whether abnormalities of blood viscosity occur in this disease, thereby contributing to the ischaemic process. Blood viscosity was measured in 20 patients u...

journal_title：Annals of the rheumatic diseases

authors： McGrath MA,Peek R,Penny R

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint cartilage tissue homeostasis and the modulating effect herein of Dio2 deficiency. METHODS:Wild-type and C57BL/6-Dio2(-/-) -mice were s...

journal_title：Annals of the rheumatic diseases

authors： Bomer N,Cornelis FM,Ramos YF,den Hollander W,Storms L,van der Breggen R,Lakenberg N,Slagboom PE,Meulenbelt I,Lories RJ

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To study the associations between structural abnormalities on ultrasound (US) or conventional x-rays (CR) and pain in hand osteoarthritis (HOA). METHODS:In 55 consecutive patients with HOA (mean age 61 years, 86% women) fulfilling the American College of Rheumatology criteria, pain in 30 separate hand joints...

journal_title：Annals of the rheumatic diseases

authors： Kortekaas MC,Kwok WY,Reijnierse M,Huizinga TW,Kloppenburg M

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Evidence was sought for genetic anticipation (disease occurring at an earlier age in subsequent generations, with increasing severity) in nodal osteoarthritis (NOA). METHODS:Age at symptom onset and disease severity was compared within 30 parent/offspring pairs with NOA. Correlation between the offspring age...

journal_title：Annals of the rheumatic diseases

authors： Wright GD,Regan M,Deighton CM,Wallis G,Doherty M

更新日期：1998-09-01 00:00:00

abstract：:The capacity of monocytes from patients with rheumatoid arthritis to generate superoxide anion in vitro after stimulation with serum treated zymosan (STZ) or IgG treated zymosan (IgTZ) was studied before and during therapy with penicillamine (n = 9) or sodium aurothiomalate (AuTM) (n = 12). Significant increases in ra...

journal_title：Annals of the rheumatic diseases

authors： Hurst NP,Bell AL,Nuki G

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To assess the interobserver agreement on the diagnostic classification of shoulder disorders, based on history taking and physical examination, and to identify the determinants of diagnostic disagreement. METHODS:Consecutive eligible patients with shoulder pain were recruited in various health care settings...

journal_title：Annals of the rheumatic diseases

authors： de Winter AF,Jans MP,Scholten RJ,Devillé W,van Schaardenburg D,Bouter LM

更新日期：1999-05-01 00:00:00

abstract：:Naproxen at 10 mg per kg body weight was compared with aspirin at 80 mg per kg body weight in children suffering from juvenile chronic polyarthritis. It was found to be as effective as aspirin, with certainly no more and possibly fewer gastrointestinal side effects. A long-term tolerance study up to 12 months confirme...

journal_title：Annals of the rheumatic diseases

authors： Moran H,Hanna DB,Ansell BM,Hall M,Engler C

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:To assess the usefulness of high resolution computed tomography (HRCT) of the lungs in patients with rheumatoid arthritis (RA) with and without respiratory symptoms. PATIENTS AND METHODS:Eighty eight RA patients with a mean duration of disease 12 (SD 8) years were evaluated. Eleven patients were excluded bec...

journal_title：Annals of the rheumatic diseases

authors： Cortet B,Flipo RM,Rémy-Jardin M,Coquerelle P,Duquesnoy B,Rêmy J,Delcambre B

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential therapeutic approach for the treatment of osteoporosis in preclinical models. METHODS:Systemic bone loss was induced in mice by gluc...

journal_title：Annals of the rheumatic diseases

authors： Lin NY,Chen CW,Kagwiria R,Liang R,Beyer C,Distler A,Luther J,Engelke K,Schett G,Distler JH

更新日期：2016-06-01 00:00:00