Abstract:
OBJECTIVE:To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. METHODS:Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4; Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. RESULTS:In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (OR(allele) 1.39; 95% CI 1.10 to 1.76; p(trend)=0.0054) than in women and in ever-smokers (OR(allele) 1.25; 95% CI 1.02 to 1.53; p(trend)=0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (OR(allele) 1.46; 95% CI 1.12 to 1.90; p(trend)=0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. CONCLUSION:PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.
journal_name
Ann Rheum Disjournal_title
Annals of the rheumatic diseasesauthors
Kochi Y,Thabet MM,Suzuki A,Okada Y,Daha NA,Toes RE,Huizinga TW,Myouzen K,Kubo M,Yamada R,Nakamura Y,Yamamoto Kdoi
10.1136/ard.2010.130526subject
Has Abstractpub_date
2011-03-01 00:00:00pages
512-5issue
3eissn
0003-4967issn
1468-2060pii
ard.2010.130526journal_volume
70pub_type
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journal_title:Annals of the rheumatic diseases
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,meta分析
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更新日期:2010-04-01 00:00:00
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