Scleromyxoedema with features of systemic sclerosis.


:The case is described of a patient with scleromyxoedema with features typical of systemic sclerosis. The features were so characteristic that the disease was misdiagnosed as systemic sclerosis. A brief review of the association of the two diseases is given.


Ann Rheum Dis


Verma UN,Singh RR,Misra R,Naik S,Agarwal SS




Has Abstract


1992-10-01 00:00:00












  • A six year prospective study of a cohort of patients with fibromyalgia.

    abstract:OBJECTIVES:To examine the long term prognosis in patients with fibromyalgia (FM). METHODS:Forty five of 70 patients who had participated in a three week trial six years earlier completed again the same questionnaires used previously. RESULTS:Most symptoms had remained stable. Pain had increased, but some aspects of q...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Baumgartner E,Finckh A,Cedraschi C,Vischer TL

    更新日期:2002-07-01 00:00:00

  • The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases.

    abstract:BACKGROUND AND OBJECTIVES:The Fc receptor-like 3 (FCRL3) gene -169T>C single nucleotide polymorphism (SNP) has been reported to be associated with several autoimmune diseases (AIDs) in Japanese populations. However, association results in other populations have been conflicting. Therefore, we investigated this SNP in a...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Eike MC,Nordang GB,Karlsen TH,Boberg KM,Vatn MH,IBSEN study group.,Dahl-Jørgensen K,Rønningen KS,Joner G,Flatø B,Bergquist A,Thorsby E,Førre O,Kvien TK,Undlien DE,Lie BA

    更新日期:2008-09-01 00:00:00

  • Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies.

    abstract:OBJECTIVE:A study was undertaken to investigate the in vivo pathogenic role of Toll-like receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying the thrombogenic antiphospholipid (aPL) activity in lipopolysaccharide (LPS) non-responsive (LPS-/-) mice and the association between tlr4 gene polymorphisms and...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Pierangeli SS,Vega-Ostertag ME,Raschi E,Liu X,Romay-Penabad Z,De Micheli V,Galli M,Moia M,Tincani A,Borghi MO,Nguyen-Oghalai T,Meroni PL

    更新日期:2007-10-01 00:00:00

  • Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.

    abstract:OBJECTIVE:Genetic variation at the type II deiodinase (D2) gene (DIO2) was previously identified as osteoarthritis (OA) risk factor. To investigate mechanisms possibly underlying this association, we assessed D2 protein in healthy and OA-affected cartilage and investigated allelic balance of the OA risk polymorphism rs...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Bos SD,Bovée JV,Duijnisveld BJ,Raine EV,van Dalen WJ,Ramos YF,van der Breggen R,Nelissen RG,Slagboom PE,Loughlin J,Meulenbelt I

    更新日期:2012-07-01 00:00:00

  • Evaluation of the effect of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure.

    abstract::A new method is described for separating free 35SO4-- from 35SO4 labelled proteoglycans synthesised by rabbit articular chondrocytes cultured in the presence of excess 35SO4--. The procedure uses the low solubility product of barium sulphate to remove, by precipitation, free 35SO4-- from culture medium. Optimum recove...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Collier S,Ghosh P

    更新日期:1989-05-01 00:00:00

  • The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis.

    abstract:OBJECTIVES:Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously t...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Bergmann C,Brandt A,Merlevede B,Hallenberger L,Dees C,Wohlfahrt T,Pötter S,Zhang Y,Chen CW,Mallano T,Liang R,Kagwiria R,Kreuter A,Pantelaki I,Bozec A,Abraham D,Rieker R,Ramming A,Distler O,Schett G,Distler JHW

    更新日期:2018-01-01 00:00:00

  • Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.

    abstract:OBJECTIVE:Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α). This study was aimed at investigating the role of PGRN in degradat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Zhao YP,Liu B,Tian QY,Wei JL,Richbourgh B,Liu CJ

    更新日期:2015-12-01 00:00:00

  • Anticardiolipin antibodies in patients from Malaysia with systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is highly prevalent in Malaysia, which has a mixed population of Malays, Chinese, and Indians. A quantitative enzyme linked immunosorbent assay (ELISA) was used to determine anticardiolipin antibody (aCL) levels (total immunoglobulin, IgG, and IgM) in 200 patients with SLE (164 Chine...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Jones HW,Ireland R,Senaldi G,Wang F,Khamashta M,Bellingham AJ,Veerapan K,Hughes GR,Vergani D

    更新日期:1991-03-01 00:00:00

  • Polymorphisms of the mannose binding lectin gene in patients with Sjögren's syndrome.

    abstract:OBJECTIVE:To investigate polymorphisms of both codon 54 allele and promoter variants of the mannose binding lectin (MBL) gene in patients with primary Sjögren's syndrome (SS). METHODS:Polymorphisms of codon 54 allele and promoter variants of the MBL gene in 104 patients with SS and 143 healthy controls were determined...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wang ZY,Morinobu A,Kanagawa S,Kumagai S

    更新日期:2001-05-01 00:00:00

  • Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout.

    abstract:OBJECTIVES:Advanced imaging studies have demonstrated that urate deposition in periarticular structures, such as tendons, is common in gout. The aim of this study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on tenocyte viability and function. METHODS:The histological appearance of ten...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Chhana A,Callon KE,Dray M,Pool B,Naot D,Gamble GD,Coleman B,McCarthy G,McQueen FM,Cornish J,Dalbeth N

    更新日期:2014-09-01 00:00:00

  • Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: longitudinal results from two randomised controlled trials

    abstract:OBJECTIVES:To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS:Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Glinatsi D,Baker JF,Hetland ML,Hørslev-Petersen K,Ejbjerg BJ,Stengaard-Pedersen K,Junker P,Ellingsen T,Lindegaard HM,Hansen I,Lottenburger T,Møller JM,Ørnbjerg L,Vestergaard A,Jurik AG,Thomsen HS,Torfing T,Møller-Bisgaa

    更新日期:2017-10-01 00:00:00

  • Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome.

    abstract::Eye disease, arthritis, folliculitis, and thrombophlebitis were more common among males, and erythema nodosum among females, in 297 patients with Behćet syndrome (BS) at their first visit despite an identical disease duration. Younger males and females (age of onset 24 years or less) had a higher prevalence of eye dis...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Yazici H,Tüzün Y,Pazarli H,Yurdakul S,Ozyazgan Y,Ozdoğan H,Serdaroğlu S,Ersanli M,Ulkü BY,Müftüoğlu AU

    更新日期:1984-12-01 00:00:00

  • Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid.

    abstract::The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Gale R,Bertouch JV,Bradley J,Roberts-Thomson PJ

    更新日期:1983-04-01 00:00:00

  • Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis.

    abstract:OBJECTIVES:Human leucocyte antigen shared epitope (SE) alleles are associated with joint destruction, the presence of anticitrullinated protein antibodies (ACPA) and the ACPA fine specificity repertoire in rheumatoid arthritis (RA). A large variation in joint destruction is seen within the ACPA-positive patient populat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Scherer HU,van der Woude D,Willemze A,Trouw LA,Knevel R,Syversen SW,van der Linden MP,Lie B,Huizinga TW,van der Heijde DM,van der Helm-van Mil AH,Kvien TK,Toes RE

    更新日期:2011-08-01 00:00:00

  • Environmental risk factors for the development of psoriatic arthritis: results from a case-control study.

    abstract:OBJECTIVE:To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset. METHODS:We recruited cases with psoriasis and an onset of IA within the past 5 years. Controls were patients who had psoriasis but no arthritis. We ass...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Pattison E,Harrison BJ,Griffiths CE,Silman AJ,Bruce IN

    更新日期:2008-05-01 00:00:00

  • The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus.

    abstract:OBJECTIVES:To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in patients with active, refractory systemic lupus erythematosus (SLE). METHODS:Twelve patients received a median of two (range 1-4) 21-day cycles of i...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Alexander T,Sarfert R,Klotsche J,Kühl AA,Rubbert-Roth A,Lorenz HM,Rech J,Hoyer BF,Cheng Q,Waka A,Taddeo A,Wiesener M,Schett G,Burmester GR,Radbruch A,Hiepe F,Voll RE

    更新日期:2015-07-01 00:00:00

  • Real world experience with antiphospholipid antibody tests: how stable are results over time?

    abstract:OBJECTIVE:To determine the stability and the degree of variation of antiphospholipid antibody (aPL) results over time in a large cohort of well evaluated aPL positive patients; and to analyse factors contributing to aPL variation and the validity of aPL in a real world setting in which aPL tests are done in multiple la...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Erkan D,Derksen WJ,Kaplan V,Sammaritano L,Pierangeli SS,Roubey R,Lockshin MD

    更新日期:2005-09-01 00:00:00

  • Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity.

    abstract:OBJECTIVE:To investigate if the increased concentrations of stromelysin (MMP-3) found in the synovial fluid (SF) of patients with various arthritides reflect the concentrations in the circulation. METHODS:Using a double antibody ELISA, we have measured proMMP-3 concentrations in sera from these patient groups and in o...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Taylor DJ,Cheung NT,Dawes PT

    更新日期:1994-11-01 00:00:00

  • Nutritional status in patients with rheumatoid arthritis.

    abstract::A nutritional assessment of 50 patients with rheumatoid arthritis (RA) showed evidence of malnutrition in 13 (26%), while all 50 control subjects had normal nutritional status. Of the anthropometric measurements the body-mass index and triceps skinfold thickness values in men and women were significantly reduced in RA...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Helliwell M,Coombes EJ,Moody BJ,Batstone GF,Robertson JC

    更新日期:1984-06-01 00:00:00

  • Antibody-dependent and phytohaemagglutinin-induced lymphocyte cytotoxicity in systemic lupus erythematosus.

    abstract::An investigation of cell-mediated cytotoxicity in 22 patients with systemic lupus erythematosus (SLE), using both whole blood and purified peripheral blood mononuclear cells (PBM) to measure antibody-dependent (ADCC) and phytohaemagglutinin (PHA)-induced lymphocyte cytotoxicity for Chang liver cells, has revealed 2 di...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wright JK,Hughes P,Gelsthorpe K,Ward AM,Rowell NR

    更新日期:1981-02-01 00:00:00

  • The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.

    abstract:OBJECTIVE:To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint cartilage tissue homeostasis and the modulating effect herein of Dio2 deficiency. METHODS:Wild-type and C57BL/6-Dio2(-/-) -mice were s...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Bomer N,Cornelis FM,Ramos YF,den Hollander W,Storms L,van der Breggen R,Lakenberg N,Slagboom PE,Meulenbelt I,Lories RJ

    更新日期:2016-03-01 00:00:00

  • Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. METHODS:Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Tolusso B,Frezza D,Mattioli C,Fedele AL,Bosello S,Faustini F,Peluso G,Giambra V,Pietrapertosa D,Morelli A,Gremese E,De Santis M,Ferraccioli GF

    更新日期:2009-03-01 00:00:00

  • Hand osteoarthritis and MRI: development and first validation step of the proposed Oslo Hand Osteoarthritis MRI score.

    abstract:OBJECTIVES:MRI scoring systems for hand osteoarthritis (HOA) are currently not available. The present work proposes the Oslo HOA MRI (OHOA-MRI) score and examines the intrareader and inter-reader reliability. METHODS:Relevant HOA features were included in the initial version of the OHOA-MRI score after literature revi...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Haugen IK,Lillegraven S,Slatkowsky-Christensen B,Haavardsholm EA,Sesseng S,Kvien TK,van der Heijde D,Bøyesen P

    更新日期:2011-06-01 00:00:00

  • Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.

    abstract:BACKGROUND:Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE:To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the exp...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Yatabe T,Mochizuki S,Takizawa M,Chijiiwa M,Okada A,Kimura T,Fujita Y,Matsumoto H,Toyama Y,Okada Y

    更新日期:2009-06-01 00:00:00

  • A rheumatological dilemma: is it possible to modify the course of rheumatoid arthritis? Can we answer the question?

    abstract::The question 'Does the use of second-line therapy confer long-term benefit on outcome measures in rheumatoid arthritis?' remains unanswered. The major obstacle which prevents collection of the necessary data is the lack of a suitable control group. In this report experience with three 'second-line placebo groups' is d...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,评审


    authors: Pullar T,Capell HA

    更新日期:1985-02-01 00:00:00

  • Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.

    abstract:BACKGROUND:Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). OBJECTIVES:To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. METHODS:Male Sprague Dawley rats (140-260 g) were...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Sagar DR,Ashraf S,Xu L,Burston JJ,Menhinick MR,Poulter CL,Bennett AJ,Walsh DA,Chapman V

    更新日期:2014-08-01 00:00:00

  • Rasch analysis of the Western Ontario MacMaster questionnaire (WOMAC) in 2205 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia.

    abstract:OBJECTIVE:Advances in health measurement have led to the application of Rasch Item Response Theory (IRT) analysis (Rasch analysis) to evaluate instruments measuring health status and quality of life of patients, including the Health Assessment Questionnaire and SF-36. This study investigated the extent to which the Wes...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wolfe F,Kong SX

    更新日期:1999-09-01 00:00:00

  • Disease activity-guided dose optimisation of adalimumab and etanercept is a cost-effective strategy compared with non-tapering tight control rheumatoid arthritis care: analyses of the DRESS study.

    abstract:BACKGROUND:A disease activity-guided dose optimisation strategy of adalimumab or etanercept (TNFi (tumour necrosis factor inhibitors)) has shown to be non-inferior in maintaining disease control in patients with rheumatoid arthritis (RA) compared with usual care. However, the cost-effectiveness of this strategy is stil...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kievit W,van Herwaarden N,van den Hoogen FH,van Vollenhoven RF,Bijlsma JW,van den Bemt BJ,van der Maas A,den Broeder AA

    更新日期:2016-11-01 00:00:00

  • DNA methylation analysis of the temporal artery microenvironment in giant cell arteritis.

    abstract:OBJECTIVE:To investigate the inflammatory response in giant cell arteritis (GCA) by characterising the DNA methylation pattern within the temporal artery microenvironment. METHODS:Twelve patients with non-equivocal histological evidence for GCA and 12 age-matched, sex-matched and ethnicity-matched controls with normal...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Coit P,De Lott LB,Nan B,Elner VM,Sawalha AH

    更新日期:2016-06-01 00:00:00

  • Chloroquine retinopathy: is there a safe daily dose?

    abstract::Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less. Eleven cases of ocular toxicity attributed to chloroquine were report...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Marks JS

    更新日期:1982-02-01 00:00:00