Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis.


OBJECTIVE:To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. METHODS:Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 with longstanding RA (LSRA)) and from 248 gender-matched controls from the same geographical area. Clinical and immunological characteristics were recorded for all the patients. RESULTS:The percentage of the 2/2 genotype was higher in patients with ERA (27.0%), and in patients with LSRA (34.2%), than in controls (14.9%) (ERA: OR = 2.11 (95% CI 1.20 to 3.70) vs controls; LSRA: OR = 2.96 (95% CI 1.76 to 5.00) vs controls). A lower representation of allele *3 was present in patients with ERA (2.0%) than in controls (6.0%; OR = 0.32 (95% CI 0.11 to 0.91)). No significant associations were found between polymorphisms and autoantibodies positivity. CONCLUSION:The HS1,2A allele *2 associates with early and longstanding RA.


Ann Rheum Dis


Tolusso B,Frezza D,Mattioli C,Fedele AL,Bosello S,Faustini F,Peluso G,Giambra V,Pietrapertosa D,Morelli A,Gremese E,De Santis M,Ferraccioli GF




Has Abstract


2009-03-01 00:00:00














  • Terminal complement component deficiencies and rheumatic disease: development of a rheumatic syndrome and anticomplementary activity in a patient with complete C6 deficiency.

    abstract::Hereditary deficiencies of early complement components have usually been associated with the development of rheumatic diseases like systemic lupus erythematosus (SLE), while terminal component deficiency is well known to predispose to recurrent neisserial infection. In contrast, only recently have patients been report...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wisnieski JJ,Naff GB,Pensky J,Sorin SB

    更新日期:1985-10-01 00:00:00

  • Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells.

    abstract:OBJECTIVES:The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS:B6, B6.MyD88(-/-), B6.TLR7(-/-) and B6.TLR9(-/-) mice were subcutaneou...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Pan ZJ,Maier S,Schwarz K,Azbill J,Akira S,Uematsu S,Farris AD

    更新日期:2010-06-01 00:00:00

  • A comparison of four shoulder-specific questionnaires in primary care.

    abstract:OBJECTIVES:To compare the validity, responsiveness to change, and user friendliness of four self completed, shoulder-specific questionnaires in primary care. METHODS:A cross sectional assessment of validity and a longitudinal assessment of responsiveness to change of four shoulder questionnaires was carried out: the D...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Paul A,Lewis M,Shadforth MF,Croft PR,Van Der Windt DA,Hay EM

    更新日期:2004-10-01 00:00:00

  • Occurrence and risk factors for falls in rheumatoid arthritis.

    abstract:OBJECTIVES:To determine the one year period prevalence of falls by age and sex in patients with rheumatoid arthritis and the influence of concurrent medical treatment and disability on the occurrence of falls in this group. METHODS:A consecutive series of rheumatoid patients aged 35 years and over, attending hospital ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Armstrong C,Swarbrick CM,Pye SR,O'Neill TW

    更新日期:2005-11-01 00:00:00

  • Parasympathetic failure does not contribute to ocular dryness in primary Sjögren's syndrome.

    abstract:OBJECTIVE:To investigate the sympathetic and parasympathetic cardiovascular function in primary Sjögren's syndrome (SS) and to investigate the possible relation with ocular dryness. METHODS:41 (40 women) patients with primary SS, mean age 50 years (range 20-80) with a mean disease duration of eight years (range 1-30),...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Barendregt PJ,van Den Meiracker AH,Markusse HM,Tulen JH,Boomsma F,van Der Heijde GL,Veld AJ

    更新日期:1999-12-01 00:00:00

  • A randomised placebo controlled trial of delipidated, deglycolipidated Mycobacterium vaccae as immunotherapy for psoriatic arthritis.

    abstract:OBJECTIVES:To test the hypothesis that PVAC, delipidated, deglycolipidated heat killed Mycobacterium vaccae, is an effective and safe treatment for psoriatic arthritis (PsA). This treatment has shown promising results in psoriasis. METHODS:36 patients with PsA in two centres were studied in this double blind, placebo ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Dalbeth N,Yeoman S,Dockerty JL,Highton J,Robinson E,Tan PL,Herman D,McQueen FM

    更新日期:2004-06-01 00:00:00

  • Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone.

    abstract:OBJECTIVES:Examine whether osteoarthritis (OA) progression can be delayed by halofuginone in anterior cruciate ligament transection (ACLT) rodent models. METHODS:3-month-old male C57BL/6J (wild type; WT) mice and Lewis rats were randomised to sham-operated, ACLT-operated, treated with vehicle, or ACLT-operated, treate...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Cui Z,Crane J,Xie H,Jin X,Zhen G,Li C,Xie L,Wang L,Bian Q,Qiu T,Wan M,Xie M,Ding S,Yu B,Cao X

    更新日期:2016-09-01 00:00:00

  • Major improvements in health-related quality of life during the use of etanercept in patients with previously refractory juvenile idiopathic arthritis.

    abstract:OBJECTIVE:To evaluate changes in health-related quality of life (HRQoL) in patients with refractory juvenile idiopathic arthritis (JIA) who are being treated with etanercept. METHODS:53 patients with JIA from seven Dutch centres were included. HRQoL was measured by the Childhood Health Assessment Questionnaire (CHAQ),...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Prince FH,Geerdink LM,Borsboom GJ,Twilt M,van Rossum MA,Hoppenreijs EP,Cate RT,Koopman-Keemink Y,van Santen-Hoeufft M,Raat H,van Suijlekom-Smit LW

    更新日期:2010-01-01 00:00:00

  • Absence of chromosome damage in human lymphocytes exposed to allopurinol and oxipurinol.

    abstract::The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Stevenson AC,Silcock SR,Scott JT

    更新日期:1976-04-01 00:00:00

  • Conventional treatments for ankylosing spondylitis.

    abstract::Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease. To date, no intervention is available that alters the underlying mechanism of inflammation in AS. Currently available conventional treatments are palliative at best, and often fail to control symptoms in the long term. Cu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Dougados M,Dijkmans B,Khan M,Maksymowych W,van der Linden S,Brandt J

    更新日期:2002-12-01 00:00:00

  • Rapid and sustained health utility gain in anti-tumour necrosis factor-treated inflammatory arthritis: observational data during 7 years in southern Sweden.

    abstract:BACKGROUND:Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other spondylarthritides impose a great impact on the individual in addition to the costs on society, which may be reduced by effective pharmacological treatment. Industry-independent health economic studies should complement studies sponsored by indus...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Gülfe A,Kristensen LE,Saxne T,Jacobsson LT,Petersson IF,Geborek P

    更新日期:2010-02-01 00:00:00

  • Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis.

    abstract:OBJECTIVE:Calprotectin is a major leucocyte protein, shown to correlate well with laboratory and clinical assessments in several inflammatory rheumatic diseases, and large concentrations of calprotectin have been found in synovial fluid from patients with rheumatoid arthritis (RA). The objective of the present study wa...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Hammer HB,Odegard S,Fagerhol MK,Landewé R,van der Heijde D,Uhlig T,Mowinckel P,Kvien TK

    更新日期:2007-08-01 00:00:00

  • Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF).

    abstract:OBJECTIVE:To develop widely accepted international severity score for children and adult patients with familial Mediterranean fever (FMF) that can be easily applied, in research and clinical practice. METHODS:Candidate severity criteria were suggested by several FMF expert physicians. After three rounds of Delphi surv...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Demirkaya E,Acikel C,Hashkes P,Gattorno M,Gul A,Ozdogan H,Turker T,Karadag O,Livneh A,Ben-Chetrit E,Ozen S,FMF Arthritis Vasculitis and Orphan disease Research in pediatric rheumatology (FAVOR).

    更新日期:2016-06-01 00:00:00

  • Performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: a systematic literature review.

    abstract:BACKGROUND:The 2010 ACR/EULAR classification criteria for rheumatoid arthritis (RA) were developed to improve the identification of individuals for studies of RA. We aimed to summarise the performance of the criteria based on the published literature. METHODS:We performed a systematic literature search to identify all...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Radner H,Neogi T,Smolen JS,Aletaha D

    更新日期:2014-01-01 00:00:00

  • Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Rheumatoid arthritis is associated with an unexplained increased risk of cardiovascular disease (CVD). Antibodies against human 60 kDa heat shock protein (anti-HSP60) are associated with the presence and severity of CVD. OBJECTIVES:To investigate whether anti-HSP60 antibodies are associated with prevalent C...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van Halm VP,Slot MC,Nurmohamed MT,Tervaert JW,Dijkmans BA,Voskuyl AE

    更新日期:2006-05-01 00:00:00

  • Treatment of idiopathic retroperitoneal fibrosis using cyclosporin.

    abstract::The main goal of traditional treatment of idiopathic retroperitoneal fibrosis is limitation of morbidity, and surgery of already formed fibrous masses has been the main therapeutic approach. More recently, the knowledge that the disorder may be the result of an allergic reaction to atherosclerotic lipids has prompted ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Marzano A,Trapani A,Leone N,Actis GC,Rizzetto M

    更新日期:2001-04-01 00:00:00

  • Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.

    abstract:OBJECTIVES:Leri's pleonosteosis (LP) is an autosomal dominant rheumatic condition characterised by flexion contractures of the interphalangeal joints, limited motion of multiple joints, and short broad metacarpals, metatarsals and phalanges. Scleroderma-like skin thickening can be seen in some individuals with LP. We u...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Banka S,Cain SA,Carim S,Daly SB,Urquhart JE,Erdem G,Harris J,Bottomley M,Donnai D,Kerr B,Kingston H,Superti-Furga A,Unger S,Ennis H,Worthington J,Herrick AL,Merry CL,Yue WW,Kielty CM,Newman WG

    更新日期:2015-06-01 00:00:00

  • Modification and validation of the Birmingham Vasculitis Activity Score (version 3).

    abstract:BACKGROUND:Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a need to revise the instrument. The previous version of BVAS has been revised, according to usage and reviewed by an exper...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Mukhtyar C,Lee R,Brown D,Carruthers D,Dasgupta B,Dubey S,Flossmann O,Hall C,Hollywood J,Jayne D,Jones R,Lanyon P,Muir A,Scott D,Young L,Luqmani RA

    更新日期:2009-12-01 00:00:00

  • Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritis.

    abstract:OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Majeed M,McQueen F,Yeoman S,McLean L

    更新日期:2004-09-01 00:00:00

  • Productivity costs among patients with rheumatoid arthritis: the influence of methods and sources to value loss of productivity.

    abstract:OBJECTIVE:To assess productivity costs incurred by rheumatoid arthritis, comprising paid as well as household productivity costs, from a societal perspective, using different methods. METHODS:A questionnaire on productivity, including items of the Health and Labour Questionnaire, was completed by 576 patients with rhe...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Verstappen SM,Boonen A,Verkleij H,Bijlsma JW,Buskens E,Jacobs JW,Utrecht Rheumatoid Arthritis Cohort Study Group.

    更新日期:2005-12-01 00:00:00

  • Validation of the Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire and its potential as a single-item outcome measure in clinical practice.

    abstract:OBJECTIVES:The Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire is a recently developed patient-reported outcome measure (PROM) of disease impact in psoriatic arthritis (PsA). We set out to assess the validity in an independent cohort of patients, estimate the minimally important difference for improvement a...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Holland R,Tillett W,Korendowych E,Cavill C,Waldron N,Brooke M,McHugh NJ

    更新日期:2018-03-01 00:00:00

  • Economic aspects of treatment options in rheumatoid arthritis: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis.

    abstract:OBJECTIVE:To review the cost effectiveness of rheumatoid arthritis (RA) treatments and inform the clinical recommendations by the European League Against Rheumatism. METHODS:A systematic literature search and review of the health economic evidence on RA treatment options was performed. RESULTS:Despite diverse methodo...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Schoels M,Wong J,Scott DL,Zink A,Richards P,Landewé R,Smolen JS,Aletaha D

    更新日期:2010-06-01 00:00:00

  • An open label, single dose study to evaluate the safety, efficacy, and effects on CD25 expression of ciclosporin in patients with active rheumatoid arthritis despite treatment with methotrexate and infliximab.

    abstract:OBJECTIVE:To explore the safety, efficacy, and lymphocyte activation of a triple therapeutic regimen with infliximab, methotrexate (MTX), and ciclosporin A (CsA) by an open label, pilot study. PATIENTS AND METHODS:19 patients (mean age 52.9 years) with active rheumatoid arthritis (mean DAS28 7.3) after a mean of 16.8 ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章


    authors: Sidiropoulos PI,Siakka P,Raptopoulou A,Mamoulaki M,Choulaki C,Koutala H,Kouroumali H,Kritikos H,Boumpas DT

    更新日期:2006-04-01 00:00:00

  • HLA DR alloantigens in different subsets of patients with Sjögren's syndrome and in family members.

    abstract::Patients with Sjögren's syndrome alone (Ss), Sjögren's syndrome with rheumatoid arthritis (Ss-RA), and Sjögren's syndrome with Raynaud's phenomenon (Ss-RP) were typed for the HLA DR and MT antigens. Ss-RA patients had higher frequencies of HLA DR4 than did Ss patients. HLA-DR4 was also increased in frequency in patien...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Mann DL,Moutsopoulos HM

    更新日期:1983-10-01 00:00:00

  • Validation of ultrasound imaging for Achilles entheseal fibrocartilage in bovines and description of changes in humans with spondyloarthritis.

    abstract:BACKGROUND:Entheseal fibrocartilage (EF) derangement is hypothesised to be pivotal to the pathogenesis of spondyloarthritis. Ultrasound is useful for visualisation of the enthesis but its role in EF visualisation is uncertain. This work aimed to demonstrate face and content validity of ultrasound for EF visualisation b...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Aydin SZ,Bas E,Basci O,Filippucci E,Wakefield RJ,Celikel C,Karahan M,Atagunduz P,Benjamin M,Direskeneli H,McGonagle D

    更新日期:2010-12-01 00:00:00

  • The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association.

    abstract:BACKGROUND:An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well established, and accounts for an estimated 30% of the genetic component in RA. The MHC class II transactivator gene (MHC2TA) on chromosome 16p13 has re...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Bronson PG,Criswell LA,Barcellos LF

    更新日期:2008-07-01 00:00:00

  • Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling.

    abstract:OBJECTIVES:While new treatments for rheumatoid arthritis (RA) have markedly improved disease control by targeting immune/inflammatory pathways, current treatments rarely induce remission, underscoring the need for therapies that target other aspects of the disease. Little is known about the regulation of disease severi...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Laragione T,Brenner M,Lahiri A,Gao E,Harris C,Gulko PS

    更新日期:2018-11-01 00:00:00

  • Risk of gout flares after vaccination: a prospective case cross-over study.

    abstract:OBJECTIVES:The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares. METHODS:We conducted an online case-crossover...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Yokose C,McCormick N,Chen C,Neogi T,Chaisson C,Terkeltaub R,Hunter DJ,Zhang Y,Choi H

    更新日期:2019-11-01 00:00:00

  • Gastrin, gastric acid secretion, and gastric microflora in patients with rheumatoid arthritis.

    abstract::The relation between the basal and stimulated gastric acid secretion, plasma gastrin, and the gastric microflora was examined in 45 patients with rheumatoid arthritis. Sixteen patients (36%) had basal achlorhydria, and of these, 10 (22%) had achlorhydria or hypochlorhydria after stimulation with pentagastrin. The peak...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Henriksson K,Uvnäs-Moberg K,Nord CE,Johansson C,Gullberg R

    更新日期:1986-06-01 00:00:00

  • Olecranon nodules in a case of Behçet's disease.

    abstract::A 33-year-old male with definite Behçet's disease had rheumatoid-like nodules at his elbows. This finding, we believe, represents another manifestation of vasculitis in Behçet's disease. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Yurdakul S,Yazici H,Tüzüner N,Aytac S,Müftüoğlu AU

    更新日期:1981-04-01 00:00:00