Abstract:
OBJECTIVES:To evaluate the risk of septic arthritis (SA) in patients with rheumatoid arthritis (RA) treated with anti-tumour necrosis factor (TNF) therapy. METHODS:Using data from the British Society for Rheumatology Biologics Register, a prospective observational study, the authors compared the risk of SA between 11 881 anti-TNF-treated and 3673 non-biological disease-modifying antirheumatic drug (nbDMARD)-treated patients. RESULTS:199 patients had at least one episode of SA (anti-TNF: 179, nbDMARD: 20). Incidence rates were: anti-TNF 4.2/1000 patient years (pyrs) follow-up (95% CI 3.6 to 4.8), nbDMARD 1.8/1000 pyrs (95% CI 1.1 to 2.7). The adjusted HR for SA in the anti-TNF cohort was 2.3 (95% CI 1.2 to 4.4). The risk did not differ significantly between the three agents: adalimumab, etanercept and infliximab. The risk was highest in the early months of therapy. The patterns of reported organisms differed in the anti-TNF cohort. Prior joint replacement surgery was a risk factor for SA in all patients. The rate of postoperative joint infection (within 90 days of surgery) was 0.7%. This risk was not significantly influenced by anti-TNF therapy. CONCLUSIONS:Anti-TNF therapy use in RA is associated with a doubling in the risk of SA. Physicians and surgeons assessing the RA patient should be aware of this potentially life-threatening complication.
journal_name
Ann Rheum Disjournal_title
Annals of the rheumatic diseasesauthors
Galloway JB,Hyrich KL,Mercer LK,Dixon WG,Ustianowski AP,Helbert M,Watson KD,Lunt M,Symmons DP,BSR Biologics Register.doi
10.1136/ard.2011.152769subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1810-4issue
10eissn
0003-4967issn
1468-2060pii
ard.2011.152769journal_volume
70pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...
journal_title:Annals of the rheumatic diseases
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doi:10.1136/ard.56.5.299
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doi:10.1136/ard.56.3.176
更新日期:1997-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.60.4.385
更新日期:2001-04-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2003.017210
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2007.085480
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/annrheumdis-2015-208444
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1136/annrheumdis-2015-207841
更新日期:2015-12-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1136/annrheumdis-2015-207362
更新日期:2016-06-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/annrheumdis-2018-214644
更新日期:2019-05-01 00:00:00
abstract::Three hundred and twenty-one synovial fluids from the knees of patients with six different inflammatory arthropathies have been examined for the presence of cytophagocytic monocytes (CPM) and mast cells. Both cell types were seen independently in many of the fluids examined but were found together only in those patien...
journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.44.5.312
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2008.101279
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2004.030221
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2007.080341
更新日期:2008-09-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/annrheumdis-2011-200981
更新日期:2012-07-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
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更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章,实务指引
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.61.8.723
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.48.12.998
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journal_title:Annals of the rheumatic diseases
pub_type: 临床试验,杂志文章
doi:10.1136/ard.2006.052092
更新日期:2006-12-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.35.6.521
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.53.1.24
更新日期:1994-01-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.46.9.684
更新日期:1987-09-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1136/ard.2008.095653
更新日期:2009-07-01 00:00:00
abstract::A new method is described for separating free 35SO4-- from 35SO4 labelled proteoglycans synthesised by rabbit articular chondrocytes cultured in the presence of excess 35SO4--. The procedure uses the low solubility product of barium sulphate to remove, by precipitation, free 35SO4-- from culture medium. Optimum recove...
journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.48.5.372
更新日期:1989-05-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.44.4.239
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVES:To review systematically the available literature on the optimal dosage and route of administration of methotrexate in patients with rheumatoid arthritis (RA), as an evidence base for generating clinical practice recommendations. METHODS:A systematic literature search was carried out in MEDLINE, EMBASE, Coc...
journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1136/ard.2008.092668
更新日期:2009-07-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2007.083782
更新日期:2008-12-01 00:00:00