Circulating immune complexes containing secretory IgA in jejunoileal bypass disease.

Abstract:

:Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associated with intraluminal IgA, in significantly higher levels in patients with arthritis. Analytical ultracentrifugation showed complexes of approximately 10 X 8S, consistent with the size of secretory IgA. Arthritis after JIB appears to be associated with circulating immune complexes containing secretory IgA.

journal_name

Ann Rheum Dis

authors

Clegg DO,Zone JJ,Samuelson CO Jr,Ward JR

doi

10.1136/ard.44.4.239

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

239-44

issue

4

eissn

0003-4967

issn

1468-2060

journal_volume

44

pub_type

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