Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis.

abstract：:Polymorphonuclear leucocytes (PMNs), which predominate in inflammatory synovial fluid, can degrade cartilage. This was measured by a novel in vitro model; PMNs were incubated for up to one hour with 2 or 3 microns sections of cartilage and the glycosaminoglycan loss determined by microdensitometry after alcian blue st...

journal_title：Annals of the rheumatic diseases

authors： Moore AR,Iwamura H,Larbre JP,Scott DL,Willoughby DA

更新日期：1993-01-01 00:00:00

abstract：:HLA types, especially HLA-DR3, are associated with the development of toxic reactions in patients with rheumatoid arthritis after treatment with gold or D-penicillamine. In this study, after treatment with sulphasalazine, leucopenia was observed in three patients, who all had a history of leucopenia after previous gol...

journal_title：Annals of the rheumatic diseases

authors： Bliddal H,Eiberg B,Helin P,Svejgaard A

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of monotherapy with adalimumab in patients with RA for whom previous DMARD treatment has failed. METHODS:In a 26 week, double blind, placebo controlled, phase III trial, 544 patients with RA were randomised to monotherapy with adalimumab 20 mg every other week, 20 mg weekl...

journal_title：Annals of the rheumatic diseases

authors： van de Putte LB,Atkins C,Malaise M,Sany J,Russell AS,van Riel PL,Settas L,Bijlsma JW,Todesco S,Dougados M,Nash P,Emery P,Walter N,Kaul M,Fischkoff S,Kupper H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Soluble E-selectin (sE-selectin) is a marker of activation of vascular endothelium. OBJECTIVE:To examine serum levels of sE-selectin in a cohort of 85 patients with early rheumatoid arthritis (RA) followed up for five years. METHODS:sE-selectin levels were assessed annually using an enzyme linked immunosor...

journal_title：Annals of the rheumatic diseases

authors： Kuuliala A,Eberhardt K,Takala A,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2002-03-01 00:00:00

abstract：:We have compared the distribution of histocompatibility antigens of 22 Turkish and 14 British patients with Behçet's disease with those of their respective controls. There was a strong association of B5, specifically its Bw51 split, with the disease. A modest increase in the incidence of HLA B27 was noted in British p...

journal_title：Annals of the rheumatic diseases

authors： Yazici H,Chamberlain MA,Schreuder I,D'Amaro J,Muftuoglu M

更新日期：1980-08-01 00:00:00

abstract：:Today, patients' functioning is a central issue in medicine. Concepts, classifications, and measurements of functioning and health, such as the International Classification of Functioning, Disability and Health (ICF) are of prime importance in clinical practice, teaching, and research. This report compares the content...

journal_title：Annals of the rheumatic diseases

authors： Stucki G,Cieza A

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To determine the significance of quantitative levels of antibodies to cyclic citrullinated peptides (anti-CCP) in a population of patients with rheumatoid arthritis (RA). METHODS:A total of 241 consecutive sera from patients with RA sent from a large rheumatology clinic for laboratory testing were selected f...

journal_title：Annals of the rheumatic diseases

authors： Lee DM,Phillips R,Hagan EM,Chibnik LB,Costenbader KH,Schur PH

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:There is emerging evidence that the development and progression of osteoarthritis (OA) is associated with inflammation. C reactive protein (CRP), a systemic marker for inflammation, may be elevated in OA patients but the evidence is conflicting. OBJECTIVE:To systematically review the literature for the rela...

journal_title：Annals of the rheumatic diseases

authors： Jin X,Beguerie JR,Zhang W,Blizzard L,Otahal P,Jones G,Ding C

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Genetic variation at the type II deiodinase (D2) gene (DIO2) was previously identified as osteoarthritis (OA) risk factor. To investigate mechanisms possibly underlying this association, we assessed D2 protein in healthy and OA-affected cartilage and investigated allelic balance of the OA risk polymorphism rs...

journal_title：Annals of the rheumatic diseases

authors： Bos SD,Bovée JV,Duijnisveld BJ,Raine EV,van Dalen WJ,Ramos YF,van der Breggen R,Nelissen RG,Slagboom PE,Loughlin J,Meulenbelt I

更新日期：2012-07-01 00:00:00

abstract：:The prevalence of anticardiolipin antibodies was evaluated in 70 children with juvenile chronic arthritis (JCA), in 25 adult patients with rheumatoid arthritis, in 42 healthy children and in 40 adult controls. Thirty seven (53%) patients with JCA were positive for IgG or IgM anticardiolipin antibodies, or both, and 30...

journal_title：Annals of the rheumatic diseases

authors： Caporali R,Ravelli A,De Gennaro F,Neirotti G,Montecucco C,Martini A

更新日期：1991-09-01 00:00:00

abstract：:A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other t...

journal_title：Annals of the rheumatic diseases

authors： Allard SA,King RH,Thomas PK,Bourke BE

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:To assess pooled golimumab safety up to year 3 of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) trials. METHODS:Golimumab 50 and 100 mg, administered subcutaneously (SC) every 4 weeks (q4wk), were assessed in patients with active RA (methotrexate-naïve, methotrexate-exp...

journal_title：Annals of the rheumatic diseases

authors： Kay J,Fleischmann R,Keystone E,Hsia EC,Hsu B,Mack M,Goldstein N,Braun J,Kavanaugh A

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:To report the results of a pilot study using rituximab combined with Peg-interferon (IFN) alpha2b-ribavirin in severe refractory hepatitis C virus (HCV) related mixed cryoglobulinaemia (MC) vasculitis. METHODS:Sixteen consecutive patients with severe HCV-MC vasculitis that were resistant (n = 11) or relapse...

journal_title：Annals of the rheumatic diseases

authors： Saadoun D,Resche-Rigon M,Sene D,Perard L,Karras A,Cacoub P

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:To study the short term effects of a single dose of D2E7, a fully human anti-tumour necrosis factor (TNFalpha) monoclonal antibody (mAb), on the local and systemic homeostasis of interleukin 1beta (IL1beta) and TNFalpha in patients with rheumatoid arthritis (RA). METHODS:All patients with RA enrolled in a p...

journal_title：Annals of the rheumatic diseases

authors： Barrera P,Joosten LA,den Broeder AA,van de Putte LB,van Riel PL,van den Berg WB

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:An increased proportion of circulating follicular helper T (Tfh) cells was reported in rheumatoid arthritis (RA), but it remains uncertain how Tfh cells affect antibody hyposialylation. We investigated the regulation of autoantibody hyposialylation by Tfh cells in RA using murine model. METHODS:Behaviours of...

journal_title：Annals of the rheumatic diseases

authors： Kurata I,Matsumoto I,Ohyama A,Osada A,Ebe H,Kawaguchi H,Kaneko S,Kondo Y,Tsuboi H,Tomioka A,Kaji H,Sumida T

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:To compare the effect of a single infusion of zoledronic acid (ZA) with placebo on knee pain and bone marrow lesions (BMLs). METHODS:Adults aged 50-80 years (n=59) with clinical knee osteoarthritis and knee BMLs were randomised to receive either ZA (5 mg/100 ml) or placebo. BMLs were determined using proton...

journal_title：Annals of the rheumatic diseases

authors： Laslett LL,Doré DA,Quinn SJ,Boon P,Ryan E,Winzenberg TM,Jones G

更新日期：2012-08-01 00:00:00

abstract：:The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming growth factor beta (TGF-beta) was investigated in vitro and in vivo. In vitro TGF-beta (400 pmol/l) had no effect on basal proteoglycan degradation. Proteoglycan degradation induced by IL-1, ho...

journal_title：Annals of the rheumatic diseases

authors： van Beuningen HM,van der Kraan PM,Arntz OJ,van den Berg WB

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To determine the incremental cost-effectiveness ratios (ICERs) of two therapeutic regimens of infliximab for ankylosing spondylitis (AS). METHODS:230 patients with active AS who were participating in a randomised controlled trial comparing two infliximab infusion modalities-every 6 weeks (Q6) and on demand (...

journal_title：Annals of the rheumatic diseases

authors： Fautrel B,Benhamou M,Breban M,Roy C,Lenoir C,Trape G,Baleydier A,Ravaud P,Dougados M

更新日期：2010-02-01 00:00:00

abstract：:A previous report that C3 activation products are demonstrable in the plasma of subjects with rheumatoid arthritis was reinvestigated using 2-dimensional immunoelectrophoresis. Initially it seemed that results were in agreement, but the occurrence of similar patterns in normal sera and poor reproducibility of results ...

journal_title：Annals of the rheumatic diseases

authors： Shadforth MF,McNaughton DC

更新日期：1978-02-01 00:00:00

abstract：:Two patients are described with severe and progressive rheumatoid arthritis in whom methotrexate was reintroduced despite previous methotrexate related pneumonitis. In both patients a marked improvement in disease control occurred without a recurrence of the pneumonitis. ...

journal_title：Annals of the rheumatic diseases

authors： Cook NJ,Carroll GJ

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. METHODS:TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical c...

journal_title：Annals of the rheumatic diseases

authors： Pettipher C,Benitha R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

journal_title：Annals of the rheumatic diseases

authors： Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:In the present work, the frequency of inherited polymorphisms of the beta2 adrenergic receptor (beta2AR) gene and their association with rheumatoid arthritis (RA) as well as human leukocyte antigen (HLA)-DRB1 alleles was examined. METHODS:An allele-specific polymerase chain reaction was used to determine the...

journal_title：Annals of the rheumatic diseases

authors： Malysheva O,Pierer M,Wagner U,Wahle M,Wagner U,Baerwald CG

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To maintain and optimise the quality of care provided by health professionals in rheumatology (HPRs), adequate educational offerings are needed. This task force (TF) aimed to develop evidence-based recommendations for the generic core competences of HPRs, with specific reference to nurses, physica...

journal_title：Annals of the rheumatic diseases

authors： Edelaar L,Nikiphorou E,Fragoulis GE,Iagnocco A,Haines C,Bakkers M,Barbosa L,Cikes N,Ndosi M,Primdahl J,Prior Y,Pchelnikova P,Ritschl V,Schäfer VS,Smucrova H,Storrønning I,Testa M,Wiek D,Vliet Vlieland TPM

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS:In the population based, nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener's granulomatosis, 1969-95, was identified. Through linkage with...

journal_title：Annals of the rheumatic diseases

authors： Knight A,Askling J,Granath F,Sparen P,Ekbom A

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

journal_title：Annals of the rheumatic diseases

authors： Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

更新日期：2010-04-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is not a disease, but an exclusion diagnosis that encompasses all forms of arthritis that begin before the age of 16 years, persist for more than 6 weeks, and are of unknown origin. This heterogeneous group of chronic arthritides has been classified on clinical and laboratory ground...

journal_title：Annals of the rheumatic diseases

authors： Martini A

更新日期：2012-09-01 00:00:00

abstract：:Premature death has been long recognised as a manifestation of rheumatoid arthritis (RA). Three lines of evidence can explain why patients with RA die prematurely and why the mortality gap between patients with RA and the general population appears to widening. First, patients with RA have a higher risk of several ser...

journal_title：Annals of the rheumatic diseases

authors： Gabriel SE

更新日期：2008-12-01 00:00:00

abstract：:A 49 year old white woman with systemic lupus erythematosus and bronchiolitis obliterans was treated with prednisone (1 mg/kg daily), which led to a transitory improvement in pulmonary status. Cyclophosphamide was then added--4 mg/kg daily intravenously for five days, then 2 mg/kg daily orally--and this was followed b...

journal_title：Annals of the rheumatic diseases

authors： Godeau B,Cormier C,Menkes CJ

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:To determine the relationship of disease activity to infections in patients with rheumatoid arthritis (RA). METHODS:From the CORRONA database, the incidence of physician-reported infections in RA patients on stable disease-modifying antirheumatic drug, biological, and corticosteroid therapy for at least 6 mo...

journal_title：Annals of the rheumatic diseases

authors： Au K,Reed G,Curtis JR,Kremer JM,Greenberg JD,Strand V,Furst DE,CORRONA Investigators.

更新日期：2011-05-01 00:00:00