Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide.

abstract：:Orally bioavailable compounds that target key intracellular signalling molecules are receiving increasing attention for the treatment of rheumatic diseases. The mitogen activated protein (MAP) kinases are especially attractive because they regulate both cytokine production and cytokine action. The MAP kinases are expr...

journal_title：Annals of the rheumatic diseases

authors： Sweeney SE,Firestein GS

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Human osteoarthritic (OA) chondrocytes were previously classified into L (low)- and H (high)-OA according to matrix metalloproteinase-13 (MMP-13) basal levels and interleukin 1beta (IL1beta) inducibility. In H-OA chondrocytes, the regulatory proteins p130(cas) and nuclear matrix protein 4 (NMP4) acting on th...

journal_title：Annals of the rheumatic diseases

authors： Fan Z,Tardif G,Hum D,Duval N,Pelletier JP,Martel-Pelletier J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To describe granuloma annulare (GA) skin lesion development in patients during anti-tumour necrosis factor (TNF) therapy. METHODS:199 patients with rheumatoid arthritis and 127 suffering from spondyloarthropathies treated with anti-TNF antagonists were analysed to identify skin lesions suggesting GA. RESULT...

journal_title：Annals of the rheumatic diseases

authors： Voulgari PV,Markatseli TE,Exarchou SA,Zioga A,Drosos AA

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:To investigate the sympathetic and parasympathetic cardiovascular function in primary Sjögren's syndrome (SS) and to investigate the possible relation with ocular dryness. METHODS:41 (40 women) patients with primary SS, mean age 50 years (range 20-80) with a mean disease duration of eight years (range 1-30),...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van Den Meiracker AH,Markusse HM,Tulen JH,Boomsma F,van Der Heijde GL,Veld AJ

更新日期：1999-12-01 00:00:00

abstract：:Six measurements of joint mobility were made in a group of 446 normal adolescents. A method of measuring hip and knee rotation is presented. All these data are normally distributed, and would suggest that joint hypermobility lies at the end of the normal spectrum. There was a weak but significant correlation between e...

journal_title：Annals of the rheumatic diseases

authors： Fairbank JC,Pynsent PB,Phillips H

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVES:To study the prevalence of remission and its effect on damage and quality of life (QOL) in Chinese patients with systemic lupus erythematosus (SLE). METHODS:Patients who fulfilled ≥4 American College of Rheumatology criteria for SLE were identified. Their remission status at last clinic visits was determine...

journal_title：Annals of the rheumatic diseases

authors： Mok CC,Ho LY,Tse SM,Chan KL

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. METHODS:Three independent sets of case-con...

journal_title：Annals of the rheumatic diseases

authors： Kochi Y,Thabet MM,Suzuki A,Okada Y,Daha NA,Toes RE,Huizinga TW,Myouzen K,Kubo M,Yamada R,Nakamura Y,Yamamoto K

更新日期：2011-03-01 00:00:00

abstract：:A six month controlled study of 5-fluorouracil in the treatment of scleroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually respond...

journal_title：Annals of the rheumatic diseases

authors： Casas JA,Saway PA,Villarreal I,Nolte C,Menajovsky BL,Escudero EE,Blackburn WD,Alarcón GS,Subauste CP

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVES:To assess the long-term effect of bariatric surgery on the incidence of gout and hyperuricaemia in participants of the Swedish Obese Subjects (SOS) study. METHODS:This report includes 1982 subjects who underwent bariatric surgery and 1999 obese controls from the SOS study, a prospective intervention trial d...

journal_title：Annals of the rheumatic diseases

authors： Maglio C,Peltonen M,Neovius M,Jacobson P,Jacobsson L,Rudin A,Carlsson LM

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:To compare the validity, responsiveness to change, and user friendliness of four self completed, shoulder-specific questionnaires in primary care. METHODS:A cross sectional assessment of validity and a longitudinal assessment of responsiveness to change of four shoulder questionnaires was carried out: the D...

journal_title：Annals of the rheumatic diseases

authors： Paul A,Lewis M,Shadforth MF,Croft PR,Van Der Windt DA,Hay EM

更新日期：2004-10-01 00:00:00

abstract：:Overdiagnosis is a term coined by experts in cancer screening to point to indolent cancers detected by screening that would have never led to manifest health problems. Overdiagnosis leads to unnecessary medical care (overtreatment), anxiety and cost. In rheumatology overdiagnosis and overtreatment are hardly discussed...

journal_title：Annals of the rheumatic diseases

authors： Landewé RBM

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To describe presentation and outcome of patients with scleroderma renal crisis (SRC). METHODS:SRC was defined as rapidly progressive oliguric renal insufficiency and/or rapidly progressive arterial hypertension occurring during the course of systemic sclerosis (SSc). Chronic dialysis-free survival was analy...

journal_title：Annals of the rheumatic diseases

authors： Teixeira L,Mouthon L,Mahr A,Berezné A,Agard C,Mehrenberger M,Noël LH,Trolliet P,Frances C,Cabane J,Guillevin L,Group Français de Recherche sur le Sclérodermie (GFRS).

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:While new treatments for rheumatoid arthritis (RA) have markedly improved disease control by targeting immune/inflammatory pathways, current treatments rarely induce remission, underscoring the need for therapies that target other aspects of the disease. Little is known about the regulation of disease severi...

journal_title：Annals of the rheumatic diseases

authors： Laragione T,Brenner M,Lahiri A,Gao E,Harris C,Gulko PS

更新日期：2018-11-01 00:00:00

abstract：:A three phase study was designed to define further the sensitivity and specificity of symptomatic salicylate ototoxicity (primarily tinnitus) for serum salicylate concentrations. In phase one 260 patients with osteoarthritis and 112 with rheumatoid arthritis, none taking salicylates, were interviewed about their ear s...

journal_title：Annals of the rheumatic diseases

authors： Halla JT,Atchison SL,Hardin JG

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVES:MRI is recommended in the diagnostic process of rheumatoid arthritis (RA) to detect joint damage early. MRI-detected erosions are also present in symptom-free controls, especially at older age. It is unclear if RA-specific MRI-detected erosions can be distinguished from 'physiological' erosions in symptom-fr...

journal_title：Annals of the rheumatic diseases

authors： Boeters DM,Nieuwenhuis WP,van Steenbergen HW,Reijnierse M,Landewé RBM,van der Helm-van Mil AHM

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To assess pooled golimumab safety up to year 3 of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) trials. METHODS:Golimumab 50 and 100 mg, administered subcutaneously (SC) every 4 weeks (q4wk), were assessed in patients with active RA (methotrexate-naïve, methotrexate-exp...

journal_title：Annals of the rheumatic diseases

authors： Kay J,Fleischmann R,Keystone E,Hsia EC,Hsu B,Mack M,Goldstein N,Braun J,Kavanaugh A

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and suppressive capacity of regulatory T cells (T(reg)) and their association with clinical parameters in patients with systemic scleroderma (SSc). METHODS:Peripheral blood from 25 patients with SSc, 15 patients with localised scleroderma (LS) and 29 healthy controls (HC) was studi...

journal_title：Annals of the rheumatic diseases

authors： Klein S,Kretz CC,Ruland V,Stumpf C,Haust M,Hartschuh W,Hartmann M,Enk A,Suri-Payer E,Oberle N,Krammer PH,Kuhn A

更新日期：2011-08-01 00:00:00

abstract：:Mild iron deficiency induced by treatment with the iron chelator desferrioxamine reduced the incidence and severity of joint inflammation associated with adjuvant disease in rats but did not alter the local primary inflammatory response or the systemic sequelae. Both rats treated with desferrioxamine and control rats ...

journal_title：Annals of the rheumatic diseases

authors： Andrews FJ,Morris CJ,Kondratowicz G,Blake DR

更新日期：1987-04-01 00:00:00

abstract：:Thirty patients with classical or definite rheumatoid disease (RD) with foot pain and radiologically demonstrated erosions were studied electrodiagnostically to ascertain the frequency of the tarsal tunnel syndrome and peripheral neuropathy. Four patients (13.3%) had evidence of the tarsal tunnel syndrome. The electri...

journal_title：Annals of the rheumatic diseases

authors： McGuigan L,Burke D,Fleming A

更新日期：1983-04-01 00:00:00

abstract：:The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

journal_title：Annals of the rheumatic diseases

authors： Stevenson AC,Silcock SR,Scott JT

更新日期：1976-04-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate the association between MRI findings (cartilage defects, bone marrow lesions (BML), osteophytes, meniscal lesion, effusion/synovitis, ligamentous abnormalities, subchondral cysts and bone attrition) and pain in patients with knee osteoarthritis (OA) in order to establish the relevan...

journal_title：Annals of the rheumatic diseases

authors： Yusuf E,Kortekaas MC,Watt I,Huizinga TW,Kloppenburg M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To estimate the incidence of postinfectious joint complaints after Campylobacter jejuni/coli enteritis compared with enteritis caused by enterotoxigenic E coli (ETEC). To compare gastrointestinal symptoms, antibiotic treatment, and antibody levels among patients with and without joint symptoms. METHOD:Quest...

journal_title：Annals of the rheumatic diseases

authors： Locht H,Krogfelt KA

更新日期：2002-05-01 00:00:00

abstract：:Twenty seven patients with primary or possible Sjögren's syndrome with neurological manifestations were compared immunologically with 21 patients with Sjögren's syndrome with an intact nervous system. Patients with Sjögren's syndrome were divided into seropositive and seronegative subgroups with respect to the occurre...

journal_title：Annals of the rheumatic diseases

authors： Hietaharju A,Korpela M,Ilonen J,Frey H

更新日期：1992-04-01 00:00:00

abstract：:One hundred consecutive admissions to an acute geriatric unit were examined for clinical and radiographic evidence of osteoarthritis (OA) and articular chondrocalcinosis (ACC). Thirty-four patients had ACC. This was age related, the prevalence rising from 15% in patients aged 65-74 years to 44% in patients over 84 yea...

journal_title：Annals of the rheumatic diseases

authors： Wilkins E,Dieppe P,Maddison P,Evison G

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:To improve the understanding of the pathogenesis of rheumatoid arthritis (RA) by identifying novel, disease specific autoantibodies. METHODS:Total protein preparations from synovial membranes were separated electrophoretically and immunoblotted. Sera from RA patients were screened for predominant immunoreact...

journal_title：Annals of the rheumatic diseases

authors： Bläss S,Specker C,Lakomek HJ,Schneider EM,Schwochau M

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVES:To determine whether hormonal dysfunction involving the hypothalamic-pituitary-adrenal (HPA) axis, prolactin (PRL) secretion, and sex hormone status contribute to development of systemic lupus erythematosus (SLE). METHODS:11 patients with SLE and 9 healthy controls were tested for their total anterior pitui...

journal_title：Annals of the rheumatic diseases

authors： Köller MD,Templ E,Riedl M,Clodi M,Wagner O,Smolen JS,Luger A

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Rice bodies can occur in the joints in many rheumatic conditions, but they are most common in rheumatoid arthritis. They are generally believed to occur rarely in patients with osteoarthritis, but one study reported rice bodies with apatite crystals. OBJECTIVE:To report on a series of joint fluids with rice...

journal_title：Annals of the rheumatic diseases

authors： Li-Yu J,Clayburne GM,Sieck MS,Walker SE,Athreya BH,DeHoratius RJ,Schumacher HR Jr

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...

journal_title：Annals of the rheumatic diseases

authors： Belcher C,Yaqub R,Fawthrop F,Bayliss M,Doherty M

更新日期：1997-05-01 00:00:00

abstract：:A family with features of the mucocutaneous ocular syndrome is described. A 4-generation study reveals that the condition has been inherited as an autosomal dominant trait with variable expressivity. Psychiatric symptoms and myalgia have been prominent features peculiar to our patients. ...

journal_title：Annals of the rheumatic diseases

authors： Berman L,Trappler B,Jenkins T

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α). This study was aimed at investigating the role of PGRN in degradat...

journal_title：Annals of the rheumatic diseases

authors： Zhao YP,Liu B,Tian QY,Wei JL,Richbourgh B,Liu CJ

更新日期：2015-12-01 00:00:00