Osteoarthritis and articular chondrocalcinosis in the elderly.

abstract：BACKGROUND:Oxidative stress in RA synovial tissue can cause DNA damage and suppress the DNA mismatch repair (MMR) system in cultured synoviocytes. This mechanism includes two enzyme complexes, hMutSalpha (hMSH2/hMSH6) and hMutSbeta (hMSH2/hMSH3). OBJECTIVE:To examine the expression and distribution of MMR enzymes in s...

journal_title：Annals of the rheumatic diseases

authors： Simelyte E,Boyle DL,Firestein GS

更新日期：2004-12-01 00:00:00

abstract：:Eighty-one patients with 116 osteoarthritic knees were seen by the author at the University College Hospital (UCH), Ibadan in six years. Below the age of 50 the disease was significantly commoner among Nigerians than Caucasians; 39.5% of our patients were less than 50 years old, compared with 1.1% of Caucasians. In co...

journal_title：Annals of the rheumatic diseases

authors： Ebong WW

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:To assess the association of body mass index (BMI) with modifiable cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA). METHODS:BMI, disease activity, selected CVD risk factors and CVD medication were assessed in 378 (276 women) patients with RA. Patients exceeding accepted ...

journal_title：Annals of the rheumatic diseases

authors： Stavropoulos-Kalinoglou A,Metsios GS,Panoulas VF,Douglas KM,Nevill AM,Jamurtas AZ,Kita M,Koutedakis Y,Kitas GD

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjögren's syndrome (SS). METHODS:A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice...

journal_title：Annals of the rheumatic diseases

authors： Tsifetaki N,Kitsos G,Paschides CA,Alamanos Y,Eftaxias V,Voulgari PV,Psilas K,Drosos AA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:To determine the diagnostic value of beta 2 microglobulin in parotid saliva, its concentration in relation to salivary flow was determined in 29 patients with primary Sjögren's syndrome and in 30 normal controls. The specific secretion rate of beta 2 microglobulin was calculated. METHODS:Parotid saliva samp...

journal_title：Annals of the rheumatic diseases

authors： van der Geest SA,Markusse HM,Swaak AJ

更新日期：1993-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA,...

journal_title：Annals of the rheumatic diseases

authors： Suurmond J,Schuerwegh AJ,Toes RE

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:The contribution of rheumatology nurses to improved patient outcomes is increasingly recognised but more research is needed about the effects of interventions. The patient's role in deciding about healthcare quality is considered pivotal and therefore patients' opinions and expectations should be directional ...

journal_title：Annals of the rheumatic diseases

authors： van Eijk-Hustings Y,Ammerlaan J,Voorneveld-Nieuwenhuis H,Maat B,Veldhuizen C,Repping-Wuts H

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Previous studies have reported an interaction between ever cigarette smoking and the presence of the human leukocyte antigen (HLA)-DRB1 shared epitope (SE) genotype and rheumatoid arthritis (RA) risk. To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the...

journal_title：Annals of the rheumatic diseases

authors： Karlson EW,Chang SC,Cui J,Chibnik LB,Fraser PA,De Vivo I,Costenbader KH

更新日期：2010-01-01 00:00:00

abstract：:In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune...

journal_title：Annals of the rheumatic diseases

authors： French MA,Harrison G,Penning CA,Cunningham J,Hughes P,Rowell NR

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with arthritis demonstrated tyrosine hydroxylase-positive (TH(+)) cells in arthritic synovium and parallel loss of sympathetic nerve fibres. The exact function of TH(+) cells and mode of TH induction are not known. METHODS:Synovial cells of ...

journal_title：Annals of the rheumatic diseases

authors： Jenei-Lanzl Z,Capellino S,Kees F,Fleck M,Lowin T,Straub RH

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:To characterise renal tissue metabolic pathway gene expression in different forms of glomerulonephritis. METHODS:Patients with nephrotic syndrome (NS), antineutrophil cytoplasmic antibody-associated vasculitis (AAV), systemic lupus erythematosus (SLE) and healthy living donors (LD) were studied. Clinically ...

journal_title：Annals of the rheumatic diseases

authors： Grayson PC,Eddy S,Taroni JN,Lightfoot YL,Mariani L,Parikh H,Lindenmeyer MT,Ju W,Greene CS,Godfrey B,Cohen CD,Krischer J,Kretzler M,Merkel PA,Vasculitis Clinical Research Consortium, the European Renal cDNA Bank cohort, and th

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not b...

journal_title：Annals of the rheumatic diseases

authors： Belkhir R,Burel SL,Dunogeant L,Marabelle A,Hollebecque A,Besse B,Leary A,Voisin AL,Pontoizeau C,Coutte L,Pertuiset E,Mouterde G,Fain O,Lambotte O,Mariette X

更新日期：2017-10-01 00:00:00

abstract：:On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by...

journal_title：Annals of the rheumatic diseases

authors： Marshall JL,Fraser JR,Muirden KD

更新日期：1977-04-01 00:00:00

abstract：:We report two cases of osteomyelitis secondary to staphylococcal septicaemia, presenting with large sterile effusions in adjacent joints. In both cases the clinical features were suggestive of septic arthritis. Multiple joints were involved in each patient. Initial radiographs showed no abnormalities. ...

journal_title：Annals of the rheumatic diseases

authors： Platt PN,Griffiths ID

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVES:Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential therapeutic approach for the treatment of osteoporosis in preclinical models. METHODS:Systemic bone loss was induced in mice by gluc...

journal_title：Annals of the rheumatic diseases

authors： Lin NY,Chen CW,Kagwiria R,Liang R,Beyer C,Distler A,Luther J,Engelke K,Schett G,Distler JH

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To investigate the membrane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens in human keratinocytes under the influence of an important mediator of inflammation, TNF alpha. METHODS:Keratinocytes, isolated from human skins obtained at circumcision and identified using monoclonal antibodies, were treate...

journal_title：Annals of the rheumatic diseases

authors： Dörner T,Hucko M,Mayet WJ,Trefzer U,Burmester GR,Hiepe F

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Despite the importance of timely management of patients with inflammatory arthritis (IA), delays exist in its diagnosis and treatment. OBJECTIVE:To perform a systematic literature review to identify strategies addressing these delays to inform an American College of Rheumatology (ACR)/European League Agains...

journal_title：Annals of the rheumatic diseases

authors： Villeneuve E,Nam JL,Bell MJ,Deighton CM,Felson DT,Hazes JM,McInnes IB,Silman AJ,Solomon DH,Thompson AE,White PH,Bykerk VP,Emery P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA). OBJECTIVE:/st> To develop recommendations for achieving optimal therapeutic outcomes in RA. METHODS:A task force of rheuma...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Aletaha D,Bijlsma JW,Breedveld FC,Boumpas D,Burmester G,Combe B,Cutolo M,de Wit M,Dougados M,Emery P,Gibofsky A,Gomez-Reino JJ,Haraoui B,Kalden J,Keystone EC,Kvien TK,McInnes I,Martin-Mola E,Montecucco C,

更新日期：2010-04-01 00:00:00

abstract：:A three phase study was designed to define further the sensitivity and specificity of symptomatic salicylate ototoxicity (primarily tinnitus) for serum salicylate concentrations. In phase one 260 patients with osteoarthritis and 112 with rheumatoid arthritis, none taking salicylates, were interviewed about their ear s...

journal_title：Annals of the rheumatic diseases

authors： Halla JT,Atchison SL,Hardin JG

更新日期：1991-10-01 00:00:00

abstract：:Adult human articular cartilage has been maintained in organ culture for 8 days, and the culture medium, which was changed on alternate days, was pooled. Normal and rheumatoid cartilage was obtained from patients and 4 types of culture were prepared: (1) cartilage alone; (2) cartilage + D-penicillamine; (3) cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Jacoby RK

更新日期：1980-02-01 00:00:00

abstract：OBJECTIVE:The study aim was to examine the B lymphocyte stimulator (BLyS) receptor-ligand system in hepatitis C virus (HCV)-induced B lymphocyte clonal disorders. METHODS:94 patients with chronic HCV (including 35 with HCV+ mixed cryoglobulinaemia (MC)-vasculitis and nine with HCV+ B cell non-Hodgkin's lymphoma (B-NHL...

journal_title：Annals of the rheumatic diseases

authors： Landau DA,Rosenzwajg M,Saadoun D,Klatzmann D,Cacoub P

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Human osteoarthritic (OA) chondrocytes were previously classified into L (low)- and H (high)-OA according to matrix metalloproteinase-13 (MMP-13) basal levels and interleukin 1beta (IL1beta) inducibility. In H-OA chondrocytes, the regulatory proteins p130(cas) and nuclear matrix protein 4 (NMP4) acting on th...

journal_title：Annals of the rheumatic diseases

authors： Fan Z,Tardif G,Hum D,Duval N,Pelletier JP,Martel-Pelletier J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis (RA) in populations of Northern European descent. The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (I...

journal_title：Annals of the rheumatic diseases

authors： Naseem H,Thomson W,Silman A,Worthington J,Symmons D,Barton A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). OBJECTIVE:To test the validity and the mechanism of this association between α1AT and AAV. METHODS:The distribution of α1AT deficiency alleles Z and S was co...

journal_title：Annals of the rheumatic diseases

authors： Morris H,Morgan MD,Wood AM,Smith SW,Ekeowa UI,Herrmann K,Holle JU,Guillevin L,Lomas DA,Perez J,Pusey CD,Salama AD,Stockley R,Wieczorek S,McKnight AJ,Maxwell AP,Miranda E,Williams J,Savage CO,Harper L

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:To determine if the presence of low percentages of CD8 positive cells or high levels of soluble interleukin-2 receptors (sIL-2R) define a subgroup of patients with more severe polymyalgia rheumatica and giant cell arteritis (PMR/GCA). METHODS:38 PMR/GCA patients were followed up prospectively. Serum levels ...

journal_title：Annals of the rheumatic diseases

authors： Salvarani C,Boiardi L,Macchioni P,Rossi F,Tartoni P,Casadei Maldini M,Mancini R,Beltrandi E,Portioli I

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:There are no agreed criteria for osteoarthritis (OA) of the knee in population studies. The radiographic scoring system of Kellgren and Lawrence has been the system most used in the past and although other methods have been developed, comparisons have not been performed. Therefore these grading systems were ...

journal_title：Annals of the rheumatic diseases

authors： Spector TD,Hart DJ,Byrne J,Harris PA,Dacre JE,Doyle DV

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The Health Assessment Questionnaire Disability Index (HAQ-DI) is the most widely used measure of function in rheumatoid arthritis (RA). OBJECTIVE:To evaluate individualised forms of the HAQ-DI and thus enhance the incorporation of patients' views in outcome assessment. PATIENTS AND METHODS:HAQ-DI data were...

journal_title：Annals of the rheumatic diseases

authors： Seror R,Tubach F,Baron G,Guillemin F,Ravaud P

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether statin use was associated with an increased risk of dev...

journal_title：Annals of the rheumatic diseases

authors： de Jong HJ,Klungel OH,van Dijk L,Vandebriel RJ,Leufkens HG,van der Laan JW,Cohen Tervaert JW,van Loveren H

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:This randomised, double-blind, parallel-group, phase 3 study compared monotherapy with sirukumab, an anti-interleukin-6 cytokine monoclonal antibody, with adalimumab monotherapy in patients with rheumatoid arthritis (RA). METHODS:Biologic-naïve patients with active RA who were inadequate responders or were i...

journal_title：Annals of the rheumatic diseases

authors： Taylor PC,Schiff MH,Wang Q,Jiang Y,Zhuang Y,Kurrasch R,Daga S,Rao R,Tak PP,Hsu B

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Antibodies directed against citrullinated proteins (eg anti-cyclic citrullinated peptide (CCP)) have excellent diagnostic and good prognostic potential for rheumatoid arthritis. Type 1 autoimmune hepatitis (AIH-1) is a chronic liver disease characterised by a variety of serum autoantibodies. Recently, in a l...

journal_title：Annals of the rheumatic diseases

authors： Vannini A,Cheung K,Fusconi M,Stammen-Vogelzangs J,Drenth JP,Dall'Aglio AC,Bianchi FB,Bakker-Jonges LE,van Venrooij WJ,Pruijn GJ,Zendman AJ

更新日期：2007-04-01 00:00:00