Cartilage degradation by polymorphonuclear leucocytes: in vitro assessment of the pathogenic mechanisms.

abstract：OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission rec...

journal_title：Annals of the rheumatic diseases

authors： Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of tumour necrosis factor alpha (TNFalpha) blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX). METHODS:Participants were consecutive patients with RA and PsA who had undergone MTX treatment...

journal_title：Annals of the rheumatic diseases

authors： Seitz M,Reichenbach S,Möller B,Zwahlen M,Villiger PM,Dufour JF

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:This prospective study was designed to clarify the frequency, causes, and clinical course of renal disease in patients with early rheumatoid arthritis (RA). METHODS:235 patients (185 women, mean age 49.4 years) with early RA of less than one year's duration were enrolled and assessed monthly. Proteinuria wa...

journal_title：Annals of the rheumatic diseases

authors： Koseki Y,Terai C,Moriguchi M,Uesato M,Kamatani N

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Human leucocyte antigen shared epitope (SE) alleles are associated with joint destruction, the presence of anticitrullinated protein antibodies (ACPA) and the ACPA fine specificity repertoire in rheumatoid arthritis (RA). A large variation in joint destruction is seen within the ACPA-positive patient populat...

journal_title：Annals of the rheumatic diseases

authors： Scherer HU,van der Woude D,Willemze A,Trouw LA,Knevel R,Syversen SW,van der Linden MP,Lie B,Huizinga TW,van der Heijde DM,van der Helm-van Mil AH,Kvien TK,Toes RE

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations of RA monocytes in bone marrow (BM), blood and inflamed joints. METHODS:CD14+ cells from BM and peripheral blood (PB) of patients with RA and osteoarthritis (OA) were profil...

journal_title：Annals of the rheumatic diseases

authors： Smiljanovic B,Radzikowska A,Kuca-Warnawin E,Kurowska W,Grün JR,Stuhlmüller B,Bonin M,Schulte-Wrede U,Sörensen T,Kyogoku C,Bruns A,Hermann S,Ohrndorf S,Aupperle K,Backhaus M,Burmester GR,Radbruch A,Grützkau A,Maslinski

更新日期：2018-02-01 00:00:00

abstract：:We report two cases of osteomyelitis secondary to staphylococcal septicaemia, presenting with large sterile effusions in adjacent joints. In both cases the clinical features were suggestive of septic arthritis. Multiple joints were involved in each patient. Initial radiographs showed no abnormalities. ...

journal_title：Annals of the rheumatic diseases

authors： Platt PN,Griffiths ID

更新日期：1984-08-01 00:00:00

abstract：:Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in...

journal_title：Annals of the rheumatic diseases

authors： Klimiuk PS,Taylor L,Baker RD,Jayson MI

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVES:To determine the probability of drug continuation in a large cohort of methotrexate treated rheumatoid arthritis (RA) patients, the reasons for discontinuation of methotrexate, the overall survival of the members of this cohort, and the causes of death in these patients. METHODS:Yearly follow up was conduct...

journal_title：Annals of the rheumatic diseases

authors： Alarcón GS,Tracy IC,Strand GM,Singh K,Macaluso M

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Persistent fibroblast activation initiated by transforming growth factor β (TGF-β) is a fundamental event in the pathogenesis of systemic sclerosis, and its pharmacological inhibition represents a potential therapeutic strategy. The nuclear receptor, peroxisome proliferator-activated receptor γ (PPAR-γ), exe...

journal_title：Annals of the rheumatic diseases

authors： Wei J,Zhu H,Komura K,Lord G,Tomcik M,Wang W,Doniparthi S,Tamaki Z,Hinchcliff M,Distler JH,Varga J

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether methotrexate or tumour necrosis factor inhibitors (TNFi) affect osteophyte formation in patients with psoriatic arthritis (PsA). METHODS:41 patients with PsA were examined for the presence of osteophytes and erosions at the metacarpophalangeal joints by high-resolution micro-CT imagin...

journal_title：Annals of the rheumatic diseases

authors： Finzel S,Kraus S,Schmidt S,Hueber A,Rech J,Engelke K,Englbrecht M,Schett G

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To study the long term effectiveness of intravenous immunoglobulin and plasmapheresis associated with prednisone and cyclophosphamide in Churg-Strauss syndrome. SUBJECTS:and methods: We studied 18 subjects with new onset Churg-Strauss syndrome. All received the "standard" treatment based on prednisone (1 mg/...

journal_title：Annals of the rheumatic diseases

authors： Danieli MG,Cappelli M,Malcangi G,Logullo F,Salvi A,Danieli G

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE:To study associations betwee...

journal_title：Annals of the rheumatic diseases

authors： Claessen KM,Kloppenburg M,Kroon HM,Bijsterbosch J,Pereira AM,Romijn JA,van der Straaten T,Nelissen RG,Hofman A,Uitterlinden AG,Duijnisveld BJ,Lakenberg N,Beekman M,van Meurs JB,Slagboom PE,Biermasz NR,Meulenbelt I

更新日期：2014-02-01 00:00:00

abstract：:After in vitro incubation with 3H-thymidine, the proliferation of synovial lining cells and fibroblasts was investigated in surgically-removed articular tissue. Under normal conditions, in nonrheumatoid arthritis and in osteoarthrosis, low proliferation rates for both cell types were observed. In rheumatoid arthritis,...

journal_title：Annals of the rheumatic diseases

authors： Mohr W,Beneke G,Mohing W

更新日期：1975-06-01 00:00:00

abstract：:The effects of fasting for 7 days were investigated in 13 patients with rheumatoid arthritis (RA) in comparison with a control regimen in a cross-over trial. The effects of fasting on clinical performance and blood neutrophil functions were studied. During fasting, with a mean weight loss of 5.1 kg, clinical inflammat...

journal_title：Annals of the rheumatic diseases

authors： Udén AM,Trang L,Venizelos N,Palmblad J

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVES:A prospective, open study of corticosteroid hip injection (CHI) was performed to determine if different radiological patterns of arthritis vary in their response. METHODS:Forty five patients (15 with rheumatoid arthritis, 27 with osteoarthritis, and three with anklyosing spondylitis) underwent hip injection...

journal_title：Annals of the rheumatic diseases

authors： Plant MJ,Borg AA,Dziedzic K,Saklatvala J,Dawes PT

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint cartilage tissue homeostasis and the modulating effect herein of Dio2 deficiency. METHODS:Wild-type and C57BL/6-Dio2(-/-) -mice were s...

journal_title：Annals of the rheumatic diseases

authors： Bomer N,Cornelis FM,Ramos YF,den Hollander W,Storms L,van der Breggen R,Lakenberg N,Slagboom PE,Meulenbelt I,Lories RJ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an...

journal_title：Annals of the rheumatic diseases

authors： Möller I,Janta I,Backhaus M,Ohrndorf S,Bong DA,Martinoli C,Filippucci E,Sconfienza LM,Terslev L,Damjanov N,Hammer HB,Sudol-Szopinska I,Grassi W,Balint P,Bruyn GAW,D'Agostino MA,Hollander D,Siddle HJ,Supp G,Schmidt W

更新日期：2017-12-01 00:00:00

abstract：:In this retrospective study of 57 patients with primary hyperparathyroidism who underwent parathyroidectomy, the overall incidence of chondrocalcinosis was 40%. Neither joint symptoms nor chondrocalcinosis regressed after the operation. In several patients the condition appeared to deteriorate both clinically and radi...

journal_title：Annals of the rheumatic diseases

authors： Glass JS,Grahame R

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Soluble E-selectin (sE-selectin) is a marker of activation of vascular endothelium. OBJECTIVE:To examine serum levels of sE-selectin in a cohort of 85 patients with early rheumatoid arthritis (RA) followed up for five years. METHODS:sE-selectin levels were assessed annually using an enzyme linked immunosor...

journal_title：Annals of the rheumatic diseases

authors： Kuuliala A,Eberhardt K,Takala A,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of upregulation of interferon (IFN) type I inducible genes, the so called 'IFN type I signature', in CD14 monocytes in 69 patients with primary Sjögren's syndrome (pSS) and 44 healthy controls (HC) and correlate it with disease manifestations and expression of B cell activating fac...

journal_title：Annals of the rheumatic diseases

authors： Brkic Z,Maria NI,van Helden-Meeuwsen CG,van de Merwe JP,van Daele PL,Dalm VA,Wildenberg ME,Beumer W,Drexhage HA,Versnel MA

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Treatment of juvenile idiopathic arthritis (JIA) has changed dramatically since the introduction of biological agents in 1999. OBJECTIVE:To evaluate trends in prescription patterns of biological agents and the subsequent outcome of JIA. METHODS:The Arthritis and Biologics in Children register (multicentre ...

journal_title：Annals of the rheumatic diseases

authors： Otten MH,Anink J,Prince FH,Twilt M,Vastert SJ,ten Cate R,Hoppenreijs EP,Armbrust W,Gorter SL,van Pelt PA,Kamphuis SS,Dolman KM,Swart JF,van den Berg JM,Koopman-Keemink Y,van Rossum MA,Wulffraat NM,van Suijlekom-Smit LW

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To assess sensory function in skin overlying the joints of patients with rheumatoid arthritis, in relation to the pain and tenderness which commonly arises in structures not directly involved in the inflammatory process. METHODS:An intradermal injection of capsaicin 0.05 microgram in 10 microliters was made ...

journal_title：Annals of the rheumatic diseases

authors： Jolliffe VA,Anand P,Kidd BL

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:To determine whether abnormalities in the function of the autonomic nervous system are associated with oral and ocular dryness in rheumatoid arthritis. METHODS:Pupillography was done using an infrared light reflection method (IRIS) to measure both parasympathetic function (constriction latency and the latenc...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van der Heijde GL,Breedveld FC,Markusse HM

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The Health Assessment Questionnaire Disability Index (HAQ-DI) is the most widely used measure of function in rheumatoid arthritis (RA). OBJECTIVE:To evaluate individualised forms of the HAQ-DI and thus enhance the incorporation of patients' views in outcome assessment. PATIENTS AND METHODS:HAQ-DI data were...

journal_title：Annals of the rheumatic diseases

authors： Seror R,Tubach F,Baron G,Guillemin F,Ravaud P

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To investigate the inflammatory response in giant cell arteritis (GCA) by characterising the DNA methylation pattern within the temporal artery microenvironment. METHODS:Twelve patients with non-equivocal histological evidence for GCA and 12 age-matched, sex-matched and ethnicity-matched controls with normal...

journal_title：Annals of the rheumatic diseases

authors： Coit P,De Lott LB,Nan B,Elner VM,Sawalha AH

更新日期：2016-06-01 00:00:00

abstract：:One hundred acute geriatric inpatients were assessed to investigate the prevalence of shoulder disorders; 21 had symptoms due to shoulder disease. Conditions included supraspinatus tendinitis (five), chronic rotator cuff rupture (seven), frozen shoulder (two), glenohumeral osteoarthritis (two), apatite related shoulde...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Hazleman BL

更新日期：1987-09-01 00:00:00

abstract：:Platelet serotonin concentrations were measured in 43 patients with systemic sclerosis, in 11 patients with primary Raynaud's phenomenon, and in 38 normal controls. Patients with the CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) had significantly lower platele...

journal_title：Annals of the rheumatic diseases

authors： Klimiuk PS,Grennan A,Weinkove C,Jayson MI

更新日期：1989-07-01 00:00:00

abstract：:Ten patients (8 female, 2 male) with systemic lupus erythematosus (SLE) were entered into an open trial with the anabolic steroid 19-nortestosterone (19-nor). Their clinical condition did not improve, nor were significant changes observed in the majority of laboratory data. However, overall the platelet count rose, an...

journal_title：Annals of the rheumatic diseases

authors： Hazelton RA,McCruden AB,Sturrock RD,Stimson WH

更新日期：1983-04-01 00:00:00

abstract：:Adult human articular cartilage has been maintained in organ culture for 8 days, and the culture medium, which was changed on alternate days, was pooled. Normal and rheumatoid cartilage was obtained from patients and 4 types of culture were prepared: (1) cartilage alone; (2) cartilage + D-penicillamine; (3) cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Jacoby RK

更新日期：1980-02-01 00:00:00