A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses.

abstract：OBJECTIVE:To evaluate the ability of ultrasound (US) to detect the presence and change of Achilles erosions in spondyloarthritis (SpA). METHODS:A blind prospective two-dimensional (2D) and three-dimensional (3D) US study of Achilles enthesis erosions in early SpA was undertaken. US examinations were performed at basel...

journal_title：Annals of the rheumatic diseases

authors： de Miguel E,Falcao S,Castillo C,Plasencia C,García M,Branco JC,Martín-Mola E

更新日期：2011-11-01 00:00:00

abstract：:Two patients are described with severe and progressive rheumatoid arthritis in whom methotrexate was reintroduced despite previous methotrexate related pneumonitis. In both patients a marked improvement in disease control occurred without a recurrence of the pneumonitis. ...

journal_title：Annals of the rheumatic diseases

authors： Cook NJ,Carroll GJ

更新日期：1992-02-01 00:00:00

abstract：:A patient with rheumatoid arthritis (RA), vasculitis, and aortic valve incompetence of the histologically nonspecific type is described. Valve replacement was undertaken, and an excellent haemodynamic result was achieved. Both arthritis and vasculitis subsequently remitted. Valve replacement can be successfully perfor...

journal_title：Annals of the rheumatic diseases

authors： Liew M,Wilson D,Horton D,Fleming A

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:Previous studies have reported an interaction between ever cigarette smoking and the presence of the human leukocyte antigen (HLA)-DRB1 shared epitope (SE) genotype and rheumatoid arthritis (RA) risk. To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the...

journal_title：Annals of the rheumatic diseases

authors： Karlson EW,Chang SC,Cui J,Chibnik LB,Fraser PA,De Vivo I,Costenbader KH

更新日期：2010-01-01 00:00:00

abstract：:Neutrophil chemiluminescence was determined in patients with active rheumatoid arthritis. Twelve patients were randomly assigned either to a diet high in polyunsaturated fatty acids supplemented with eicosapentaenoic and docosahexaenoic acids or to a diet high in saturated fatty acids. A correlation with clinical and ...

journal_title：Annals of the rheumatic diseases

authors： Magaro M,Altomonte L,Zoli A,Mirone L,De Sole P,Di Mario G,Lippa S,Oradei A

更新日期：1988-10-01 00:00:00

abstract：:A patient with systemic lupus erythematosus was first diagnosed after she had developed the Budd-Chiari syndrome. We believe that the Budd-Chiari syndrome was part of her tendency for thrombosis, induced by the presence of a lupus anticoagulant. The association between enhanced thrombosis and the lupus anticoagulant i...

journal_title：Annals of the rheumatic diseases

authors： Averbuch M,Levo Y

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor alpha (ORalpha) in patients with systemic lupus erythematosus (SLE) in Korea. METHODS:Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and ...

journal_title：Annals of the rheumatic diseases

authors： Lee YJ,Shin KS,Kang SW,Lee CK,Yoo B,Cha HS,Koh EM,Yoon SJ,Lee J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To study the associations between structural abnormalities on ultrasound (US) or conventional x-rays (CR) and pain in hand osteoarthritis (HOA). METHODS:In 55 consecutive patients with HOA (mean age 61 years, 86% women) fulfilling the American College of Rheumatology criteria, pain in 30 separate hand joints...

journal_title：Annals of the rheumatic diseases

authors： Kortekaas MC,Kwok WY,Reijnierse M,Huizinga TW,Kloppenburg M

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of a switch from oral methotrexate (MTX) to subcutaneous MTX (scMTX) or adding ciclosporin to oral MTX with a simultaneous reduction of the MTX dose, in case of adverse events (AE) or insufficient effect (IE) in rheumatoid arthritis (RA). METHODS:The tight control treatment arm of ...

journal_title：Annals of the rheumatic diseases

authors： Bakker MF,Jacobs JW,Welsing PM,van der Werf JH,Linn-Rasker SP,van der Veen MJ,Lafeber FP,Bijlsma JW,Utrecht Arthritis Cohort Study Group.

更新日期：2010-10-01 00:00:00

abstract：:A 60-year-old man with destructive rheumatoid disease, multiple nodules, and vasculitis developed a facial rash with ulceration and scarring. Histology showed granulomatous vasculitis. The rash was rapidly controlled with oral corticosteroids. Granulomatous vasculitis has not previously been reported as causing this c...

journal_title：Annals of the rheumatic diseases

authors： White R,Wegman A,Bulpitt P,Wood G,Fleming A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an...

journal_title：Annals of the rheumatic diseases

authors： Möller I,Janta I,Backhaus M,Ohrndorf S,Bong DA,Martinoli C,Filippucci E,Sconfienza LM,Terslev L,Damjanov N,Hammer HB,Sudol-Szopinska I,Grassi W,Balint P,Bruyn GAW,D'Agostino MA,Hollander D,Siddle HJ,Supp G,Schmidt W

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of tumour necrosis factor alpha (TNFalpha) blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX). METHODS:Participants were consecutive patients with RA and PsA who had undergone MTX treatment...

journal_title：Annals of the rheumatic diseases

authors： Seitz M,Reichenbach S,Möller B,Zwahlen M,Villiger PM,Dufour JF

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS:A web-based exercise and subsequent patien...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Scirè CA,Adinolfi A,Damjanov NS,Carrara G,Bruyn GAW,Cazenave T,D'Agostino MA,Delle Sedie A,Di Sabatino V,Diaz Cortes ME,Filippucci E,Gandjbakhch F,Gutierrez M,Maccarter DK,Micu M,Möller Parera I,Mouterde G,

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

journal_title：Annals of the rheumatic diseases

authors： Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Advances in health measurement have led to the application of Rasch Item Response Theory (IRT) analysis (Rasch analysis) to evaluate instruments measuring health status and quality of life of patients, including the Health Assessment Questionnaire and SF-36. This study investigated the extent to which the Wes...

journal_title：Annals of the rheumatic diseases

authors： Wolfe F,Kong SX

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early antigen (EA). In ...

journal_title：Annals of the rheumatic diseases

authors： Jog NR,Young KA,Munroe ME,Harmon MT,Guthridge JM,Kelly JA,Kamen DL,Gilkeson GS,Weisman MH,Karp DR,Gaffney PM,Harley JB,Wallace DJ,Norris JM,James JA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：:We describe a case of systemic sclerosis with sympathetic and parasympathetic neuropathy and detail autonomic testing in six further patients. Of these six patients, three showed early parasympathetic damage. None of the patients had evidence of peripheral neuropathy, and there was no correlation between the presence ...

journal_title：Annals of the rheumatic diseases

authors： Sonnex C,Paice E,White AG

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:To determine the influence of TAP1 and TAP2 alleles in northwestern Colombian patients with systemic lupus erythematosus (SLE). METHODS:Unselected patients with SLE (n=140) and controls (n=120) matched for sex, age, and ethnicity were analysed. Clinical manifestations, clinical activity, and severity of dise...

journal_title：Annals of the rheumatic diseases

authors： Correa PA,Molina JF,Pinto LF,Arcos-Burgos M,Herrera M,Anaya JM

更新日期：2003-04-01 00:00:00

abstract：:An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

journal_title：Annals of the rheumatic diseases

authors： Gibson T,Burry HC,Poswillo D,Glass J

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy. CASE REPORTS:Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate. METHODS:Iliac crest biopsy samples were t...

journal_title：Annals of the rheumatic diseases

authors： Preston SJ,Diamond T,Scott A,Laurent MR

更新日期：1993-08-01 00:00:00

abstract：:Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial ...

journal_title：Annals of the rheumatic diseases

authors： Rudge SR,Perrett D,Swannell AJ

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of anti-tumour necrosis factor (TNF) treatments (given for rheumatological manifestations) in reducing uveitis flares in patients with spondylarthropathy in daily practice. METHODS:A retrospective observational study of all patients with spondylarthropathy with at least one uveitis f...

journal_title：Annals of the rheumatic diseases

authors： Guignard S,Gossec L,Salliot C,Ruyssen-Witrand A,Luc M,Duclos M,Dougados M

更新日期：2006-12-01 00:00:00

abstract：:Persistent infectious polyarthritis caused by Ureaplasma urealyticum in a patient with common variable hypogammaglobulinaemia is described. The patient developed a symmetrical, destructive polyarthritis and tenosynovitis associated with a markedly depressed synovial fluid glucose concentration and characteristic soft ...

journal_title：Annals of the rheumatic diseases

authors： Lehmer RR,Andrews BS,Robertson JA,Stanbridge EJ,de la Maza L,Friou GJ

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To explore the safety, efficacy, and lymphocyte activation of a triple therapeutic regimen with infliximab, methotrexate (MTX), and ciclosporin A (CsA) by an open label, pilot study. PATIENTS AND METHODS:19 patients (mean age 52.9 years) with active rheumatoid arthritis (mean DAS28 7.3) after a mean of 16.8 ...

journal_title：Annals of the rheumatic diseases

authors： Sidiropoulos PI,Siakka P,Raptopoulou A,Mamoulaki M,Choulaki C,Koutala H,Kouroumali H,Kritikos H,Boumpas DT

更新日期：2006-04-01 00:00:00

abstract：:Phenotypic and genotypic characteristics of the peripheral blood mononuclear cells in nine patients with Felty's syndrome have been examined. One patient had an increased number and percentage of peripheral blood mononuclear cells with the phenotype CD3+ Leu-7+ CD16+ and showed a clonal rearrangement of the T cell rec...

journal_title：Annals of the rheumatic diseases

authors： Ahern MJ,Roberts-Thomson PJ,Bradley J,Story C,Seshadri P

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:To define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA). METHODS:Citrullinated autoantigens were identified by immunoblotting control and ionomycin-activated human primary neutrophil lysate with RA sera. Autoantigen ide...

journal_title：Annals of the rheumatic diseases

authors： Darrah E,Rosen A,Giles JT,Andrade F

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To study the effect of meloxicam (MXC) and diclofenac (DCF) on the recruitment of leucocytes during acute experimental arthritis. METHODS:Rabbits with antigen-induced arthritis were treated with MXC, DCF, or not treated. After 48 hours, synovial fluid (SF) leucocyte influx and prostaglandin E(2) (PGE(2)) lev...

journal_title：Annals of the rheumatic diseases

authors： López-Armada MJ,Sánchez-Pernaute O,Largo R,Diez-Ortego I,Palacios I,Egido J,Herrero-Beaumont G

更新日期：2002-11-01 00:00:00

abstract：:A 33-year-old male with definite Behçet's disease had rheumatoid-like nodules at his elbows. This finding, we believe, represents another manifestation of vasculitis in Behçet's disease. ...

journal_title：Annals of the rheumatic diseases

authors： Yurdakul S,Yazici H,Tüzüner N,Aytac S,Müftüoğlu AU

更新日期：1981-04-01 00:00:00

abstract：OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

journal_title：Annals of the rheumatic diseases

authors： Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

更新日期：2010-04-01 00:00:00