Facial rash with scarring due to granulomatous vasculitis in rheumatoid disease.

abstract：:Chondromalacia patellae is difficult to diagnosis clinically with accuracy. In order to clarify the relevant symptoms and signs, 78 patients presenting with a clinical diagnosis of chondromalacia were examined by arthroscopy. In 49% of the knees no abnormalities were found. Presenting symptoms were similar in the norm...

journal_title：Annals of the rheumatic diseases

authors： Leslie IJ,Bentley G

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor alpha (ORalpha) in patients with systemic lupus erythematosus (SLE) in Korea. METHODS:Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and ...

journal_title：Annals of the rheumatic diseases

authors： Lee YJ,Shin KS,Kang SW,Lee CK,Yoo B,Cha HS,Koh EM,Yoon SJ,Lee J

更新日期：2004-10-01 00:00:00

abstract：:Monoclonal antibodies have proved to be extremely valuable additions to conventional treatment for rheumatic diseases. However, despite the general trend towards "humanisation", these drugs remain immunogenic in clinical settings, baffling drug developers. In principle, humanised and fully human monoclonal antibodies ...

journal_title：Annals of the rheumatic diseases

authors： Scott DW,De Groot AS

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:(a)To determine the accuracy and reliability of arthroscopic measurements of cartilage lesion diameter in an artificial right knee model; (b) to determine whether the use of a set of variable angle elongated probes improves performance; and (c) to identify other sources of variability. METHODS:Ovoid "lesion...

journal_title：Annals of the rheumatic diseases

authors： Oakley SP,Portek I,Szomor Z,Turnbull A,Murrell GA,Kirkham BW,Lassere MN

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

journal_title：Annals of the rheumatic diseases

authors： Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

更新日期：2009-10-01 00:00:00

abstract：:In a double blind, single observer, 48 week study the effects of sulphasalazine (2 g daily) and hydroxychloroquine (400 mg daily months 0-6, thereafter 200 mg daily) were compared in 60 patients with definite or classical rheumatoid arthritis. They had not been treated previously with second line drugs. The onset of r...

journal_title：Annals of the rheumatic diseases

authors： Nuver-Zwart IH,van Riel PL,van de Putte LB,Gribnau FW

更新日期：1989-05-01 00:00:00

abstract：:We report 2 contrasting cases of a seronegative polyarthritis associated with angioimmunoblastic lymphadenopathy (AILD). Both cases were nonerosive, with symmetrical involvement of the elbows, wrists, knees, and ankles. In one the arthritis appeared concurrently with the main systemic manifestations of AILD. The secon...

journal_title：Annals of the rheumatic diseases

authors： Davies PG,Fordham JN

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVES:Previous evidence suggests the role of psychological stress in triggering the onset of autoimmunity. We aimed to investigate whether stress following major and minor life events could precede the onset of primary Sjögren's syndrome (pSS). The role of coping strategies and social support, as compensating buff...

journal_title：Annals of the rheumatic diseases

authors： Karaiskos D,Mavragani CP,Makaroni S,Zinzaras E,Voulgarelis M,Rabavilas A,Moutsopoulos HM

更新日期：2009-01-01 00:00:00

abstract：:Two patients (one male, one female) with ankylosing spondylitis (AS) and IgA nephropathy are described. The female patient is the first reported case to have AS and IgA nephropathy concurrently. Contrary to previously reported cases, her renal manifestation preceded her rheumatic symptoms. It is suggested that women w...

journal_title：Annals of the rheumatic diseases

authors： Lai KN,Li PK,Hawkins B,Lai FM

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:The British Society for Rheumatology Biologics Register (BSRBR) has collected data on adverse events including pregnancies in patients with rheumatoid arthritis treated with anti-tumour necrosis factor (anti-TNF) therapy. The purpose of this report is to summarise the pregnancy outcomes in women treated with ...

journal_title：Annals of the rheumatic diseases

authors： Verstappen SM,King Y,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium, BSR Biologics Register.

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:To investigate whether patients with primary Sjögren's syndrome (pSS) have an increased tendency to develop other autoimmune diseases. METHODS:A retrospective case note review was carried out on 114 patients in whom a diagnosis of pSS had been made in a department of rheumatology from 1979 onwards. The year...

journal_title：Annals of the rheumatic diseases

authors： Lazarus MN,Isenberg DA

更新日期：2005-07-01 00:00:00

abstract：:A method is described for evaluating the progress of patients with back pain. Various symptoms were scored on analogue scales and spinal motion was measured by various techniques. These data were integrated to make subjective and objective indices respectively. Reasonable reproducibility of the measurements was obtain...

journal_title：Annals of the rheumatic diseases

authors： Million R,Nilsen KH,Jayson MI,Baker RD

更新日期：1981-10-01 00:00:00

abstract：OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

journal_title：Annals of the rheumatic diseases

authors： Majeed M,McQueen F,Yeoman S,McLean L

更新日期：2004-09-01 00:00:00

abstract：:Chemotactic migration of leucocytes largely depends on adhesive interaction with the substratum and recognition of a chemoattractant gradient. Both aspects, cell adhesion and chemotaxis, are regulated by members of the family of chemotactic cytokines (chemokines) comprising structurally related and secreted proteins o...

journal_title：Annals of the rheumatic diseases

authors： Moser B,Willimann K

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/C...

journal_title：Annals of the rheumatic diseases

authors： Raghu H,Lepus CM,Wang Q,Wong HH,Lingampalli N,Oliviero F,Punzi L,Giori NJ,Goodman SB,Chu CR,Sokolove JB,Robinson WH

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Rice bodies can occur in the joints in many rheumatic conditions, but they are most common in rheumatoid arthritis. They are generally believed to occur rarely in patients with osteoarthritis, but one study reported rice bodies with apatite crystals. OBJECTIVE:To report on a series of joint fluids with rice...

journal_title：Annals of the rheumatic diseases

authors： Li-Yu J,Clayburne GM,Sieck MS,Walker SE,Athreya BH,DeHoratius RJ,Schumacher HR Jr

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:The humoral immune response against a broad spectrum of cartilage antigens (cellular and matrix antigens) was studied in a group of patients who showed resorption and/or rejection of transplanted cartilage in nasal surgery. METHODS:Sera were obtained from patients with successful and unsuccessful cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Bujia J,Alsalameh S,Naumann A,Wilmes E,Sittinger M,Burmester GR

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of innovator infliximab (INX) and CT-P13, an INX biosimilar, in active rheumatoid arthritis patients with inadequate response to methotrexate (MTX) treatment. METHODS:Phase III randomised, double-blind, multicentre, multinational, parallel-group study. Patients with active...

journal_title：Annals of the rheumatic diseases

authors： Yoo DH,Hrycaj P,Miranda P,Ramiterre E,Piotrowski M,Shevchuk S,Kovalenko V,Prodanovic N,Abello-Banfi M,Gutierrez-Ureña S,Morales-Olazabal L,Tee M,Jimenez R,Zamani O,Lee SJ,Kim H,Park W,Müller-Ladner U

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To study immunological markers and compare these markers with standard measures for the clinical and immunological follow up of vasculitis activity in hepatitis C virus (HCV) associated cryoglobulinaemic vasculitis (CV). METHODS:Serial serum samples from eight patients with newly diagnosed HCV associated CV ...

journal_title：Annals of the rheumatic diseases

authors： Lamprecht P,Moosig F,Gause A,Herlyn K,Csernok E,Hansen H,Gross WL

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence and clinical associations of autoantibodies to myeloperoxidase (MPO) in an unselected series of well-characterised outpatients with rheumatoid arthritis (RA) and to compare the distribution of IgG subclasses of anti-MPO antibodies in these patients with that in patients with syste...

journal_title：Annals of the rheumatic diseases

authors： Cambridge G,Williams M,Leaker B,Corbett M,Smith CR

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To investigate the sympathetic and parasympathetic cardiovascular function in primary Sjögren's syndrome (SS) and to investigate the possible relation with ocular dryness. METHODS:41 (40 women) patients with primary SS, mean age 50 years (range 20-80) with a mean disease duration of eight years (range 1-30),...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van Den Meiracker AH,Markusse HM,Tulen JH,Boomsma F,van Der Heijde GL,Veld AJ

更新日期：1999-12-01 00:00:00

abstract：:Biological therapies directed at proinflammatory cytokines have irrevocably changed the landscape of treatment of rheumatoid arthritis (RA) and other autoimmune diseases. With the advances in our knowledge in cytokine signalling, the question emerges whether targeting intracellular signalling might also be a safe and ...

journal_title：Annals of the rheumatic diseases

authors： O'Shea JJ,Kontzias A,Yamaoka K,Tanaka Y,Laurence A

更新日期：2013-04-01 00:00:00

abstract：:Superantigens are bacterial, viral, or retroviral proteins which can activate specifically a large proportion of T cells. In contrast with classical peptide antigen recognition, superantigens do not require processing to small peptides but act as complete or partially processed proteins. They can bind to major histoco...

journal_title：Annals of the rheumatic diseases

authors： Acha-Orbea H

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To better understand the characteristics of synoviocytes located in the rheumatoid arthritis (RA) pannus. METHODS:One cell line, termed PSC, was cloned from RA pannus lesions. Phenotypic analysis was done by contrast microscopy, indirect immunostaining, and safranin O staining. Transcription of several proto...

journal_title：Annals of the rheumatic diseases

authors： Xue C,Takahashi M,Hasunuma T,Aono H,Yamamoto K,Yoshino S,Sumida T,Nishioka K

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Cancellous bone from patients with osteoarthritis (OA) has been reported to be undermineralised and that from patients with osteoporosis (OP) is more liable to fracture. Changes in the mineral component might be implicated in these processes. OBJECTIVES:To investigate the thermal stability and the mineral s...

journal_title：Annals of the rheumatic diseases

authors： Mkukuma LD,Imrie CT,Skakle JM,Hukins DW,Aspden RM

更新日期：2005-02-01 00:00:00

abstract：:Feverfew, reputed by folklore to be effective in arthritis, has in vitro properties that could be beneficial in the control of inflammatory disease. Forty one female patients with symptomatic rheumatoid arthritis received either dried chopped feverfew (70-86 mg) or placebo capsules once daily for six weeks. Allocation...

journal_title：Annals of the rheumatic diseases

authors： Pattrick M,Heptinstall S,Doherty M

更新日期：1989-07-01 00:00:00

abstract：:Alefacept is a bioengineered fusion protein of soluble lymphocyte function antigen (LFA-3) with Fc fragments of IgG1. It is marketed in many countries for the treatment of moderate to severe psoriasis. This paper reviews the data supporting the use of alefacept in psoriasis and psoriatic arthritis. ...

journal_title：Annals of the rheumatic diseases

authors： Gottlieb AB

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:To assess the long-term effect of bariatric surgery on the incidence of gout and hyperuricaemia in participants of the Swedish Obese Subjects (SOS) study. METHODS:This report includes 1982 subjects who underwent bariatric surgery and 1999 obese controls from the SOS study, a prospective intervention trial d...

journal_title：Annals of the rheumatic diseases

authors： Maglio C,Peltonen M,Neovius M,Jacobson P,Jacobsson L,Rudin A,Carlsson LM

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS:The review included current disease activity using data from clinical assessment and...

journal_title：Annals of the rheumatic diseases

authors： Sokka T,Kautiainen H,Toloza S,Mäkinen H,Verstappen SM,Lund Hetland M,Naranjo A,Baecklund E,Herborn G,Rau R,Cazzato M,Gossec L,Skakic V,Gogus F,Sierakowski S,Bresnihan B,Taylor P,McClinton C,Pincus T,QUEST-RA Group.

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Mast cells have been implicated in the pathogenesis of arthritis, but elucidation of their precise role has been hampered by a lack of efficient and selective inhibitors of their function. OBJECTIVE:To elucidate the role of mast cells in the pathogenesis of rheumatoid arthritis (RA) and to assess whether ap...

journal_title：Annals of the rheumatic diseases

authors： Juurikivi A,Sandler C,Lindstedt KA,Kovanen PT,Juutilainen T,Leskinen MJ,Mäki T,Eklund KK

更新日期：2005-08-01 00:00:00