Feverfew in rheumatoid arthritis: a double blind, placebo controlled study.

abstract：OBJECTIVE:To assess the expression of ICAM1, VCAM1, E-selectin, CD44, and TNF alpha in labial salivary glands of patients with rheumatoid vasculitis. METHODS:Labial salivary glands from six patients with rheumatoid vasculitis before and after treatment, six aged matched rheumatoid arthritis patients without clinical e...

journal_title：Annals of the rheumatic diseases

authors： Flipo RM,Cardon T,Copin MC,Vandecandelaere M,Duquesnoy B,Janin A

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To estimate the effects of biological drugs on the risk of demyelinating events in rheumatoid arthritis (RA). METHODS:Case-control analyses nested in an administrative database cohort. RESULTS:Initially the risk of demyelinating events appeared to be increased after exposure to anakinra and decreased after ...

journal_title：Annals of the rheumatic diseases

authors： Bernatsky S,Renoux C,Suissa S

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Preliminary clinical criteria based on age, inflammation, and immobility have been proposed to identify which patients with rheumatoid arthritis (RA) should be examined by dual energy x ray absorptiometry (DXA) to diagnose osteoporosis. The three item criteria have not been evaluated in male patients with RA...

journal_title：Annals of the rheumatic diseases

authors： Haugeberg G,Ørstavik RE,Uhlig T,Falch JA,Halse JI,Kvien TK

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:There is increased cardiovascular disease mortality in rheumatoid arthritis. This may reflect an increased prevalence of cardiovascular disease or an increased case fatality in patients with rheumatoid arthritis. OBJECTIVES:To examine whether rheumatoid patients with disease onset in the 1980s-1990s have in...

journal_title：Annals of the rheumatic diseases

authors： Goodson N,Marks J,Lunt M,Symmons D

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares. METHODS:We conducted an online case-crossover...

journal_title：Annals of the rheumatic diseases

authors： Yokose C,McCormick N,Chen C,Neogi T,Chaisson C,Terkeltaub R,Hunter DJ,Zhang Y,Choi H

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:Etanercept monotherapy has been studied and approved for treatment of polyarticular juvenile idiopathic arthritis (JIA). The following study evaluates the safety and efficacy of combination therapy of etanercept and methotrexate compared to etanercept monotherapy in JIA. METHODS:We perfomed an open, non-rand...

journal_title：Annals of the rheumatic diseases

authors： Horneff G,De Bock F,Foeldvari I,Girschick HJ,Michels H,Moebius D,Schmeling H,German and Austrian Paediatric Rheumatology Collaborative Study Group.

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVES:An abnormal CD4+ T cell subset related to inflammation exposure (inflammation-related cells, IRC) has been identified in rheumatoid arthritis (RA). Patients with inflammatory and non-inflammatory diseases were used to examine the relationship between inflammation and this T cell subset in vivo. METHODS:Bloo...

journal_title：Annals of the rheumatic diseases

authors： Burgoyne CH,Field SL,Brown AK,Hensor EM,English A,Bingham SL,Verburg R,Fearon U,Lawson CA,Hamlin PJ,Straszynski L,Veale D,Conaghan P,Hull MA,van Laar JM,Tennant A,Emery P,Isaacs JD,Ponchel F

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:There are no agreed criteria for osteoarthritis (OA) of the knee in population studies. The radiographic scoring system of Kellgren and Lawrence has been the system most used in the past and although other methods have been developed, comparisons have not been performed. Therefore these grading systems were ...

journal_title：Annals of the rheumatic diseases

authors： Spector TD,Hart DJ,Byrne J,Harris PA,Dacre JE,Doyle DV

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:Recent animal studies have revealed critical roles of interleukin (IL)17, which is produced by a newly identified subset of helper T cells, Th17 cells, in the development of autoimmune diseases including arthritis. However, in human rheumatoid arthritis (RA), detailed characteristics and the prevalence of Th...

journal_title：Annals of the rheumatic diseases

authors： Yamada H,Nakashima Y,Okazaki K,Mawatari T,Fukushi JI,Kaibara N,Hori A,Iwamoto Y,Yoshikai Y

更新日期：2008-09-01 00:00:00

abstract：:A previous infection of C3H mice with viable Mycoplasma pulmonis organisms protected them from arthritis induced by intravenous inoculation of these organisms, whether or not their initial arthritis had resolved at the time of challenge. Although spleen cells obtained from such animals conferred resistance to acute ar...

journal_title：Annals of the rheumatic diseases

authors： Taylor G,Taylor-Robinson D

更新日期：1977-06-01 00:00:00

abstract：:The main goal of traditional treatment of idiopathic retroperitoneal fibrosis is limitation of morbidity, and surgery of already formed fibrous masses has been the main therapeutic approach. More recently, the knowledge that the disorder may be the result of an allergic reaction to atherosclerotic lipids has prompted ...

journal_title：Annals of the rheumatic diseases

authors： Marzano A,Trapani A,Leone N,Actis GC,Rizzetto M

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:The heteropolymer technology was developed to remove pathogens from the circulation. OBJECTIVES:To evaluate the safety and tolerability of a single administration and to establish proof of principle for ETI-104 in normal healthy volunteers (NHV) and patients with systemic lupus erythematosus (SLE) METHODS: ...

journal_title：Annals of the rheumatic diseases

authors： Iking-Konert C,Stocks S,Weinsberg F,Engelbrecht R,Bleck E,Perniok A,Fischer-Betz R,Pincus S,Nardone L,Schneider M

更新日期：2004-09-01 00:00:00

abstract：:The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose...

journal_title：Annals of the rheumatic diseases

authors： Godfrey DG,Stimson WH,Watson J,Belch JF,Sturrock RD

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

journal_title：Annals of the rheumatic diseases

authors： Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To estimate the incidence and consultation rate of lower extremity complaints in general practice. METHODS:Data were obtained from the Second Dutch National Survey of General Practice, in which 195 general practitioners (GPs) in 104 practices recorded all contacts with patients during 12 consecutive months i...

journal_title：Annals of the rheumatic diseases

authors： van der Waal JM,Bot SD,Terwee CB,van der Windt DA,Schellevis FG,Bouter LM,Dekker J

更新日期：2006-06-01 00:00:00

abstract：:A three phase study was designed to define further the sensitivity and specificity of symptomatic salicylate ototoxicity (primarily tinnitus) for serum salicylate concentrations. In phase one 260 patients with osteoarthritis and 112 with rheumatoid arthritis, none taking salicylates, were interviewed about their ear s...

journal_title：Annals of the rheumatic diseases

authors： Halla JT,Atchison SL,Hardin JG

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset. METHODS:We recruited cases with psoriasis and an onset of IA within the past 5 years. Controls were patients who had psoriasis but no arthritis. We ass...

journal_title：Annals of the rheumatic diseases

authors： Pattison E,Harrison BJ,Griffiths CE,Silman AJ,Bruce IN

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE:To study associations betwee...

journal_title：Annals of the rheumatic diseases

authors： Claessen KM,Kloppenburg M,Kroon HM,Bijsterbosch J,Pereira AM,Romijn JA,van der Straaten T,Nelissen RG,Hofman A,Uitterlinden AG,Duijnisveld BJ,Lakenberg N,Beekman M,van Meurs JB,Slagboom PE,Biermasz NR,Meulenbelt I

更新日期：2014-02-01 00:00:00

abstract：:To identify the local factors in cartilage that are responsible for the induction of pannus invasion, a 14 day organ culture study in which rheumatoid synovium was grown in contact with cartilage pieces was carried out. Rheumatoid synovium preferentially extended over hyaluronidase treated cartilage pieces, but detach...

journal_title：Annals of the rheumatic diseases

authors： Shiozawa S,Yoshihara R,Kuroki Y,Fujita T,Shiozawa K,Imura S

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis is associated with an unexplained increased risk of cardiovascular disease (CVD). Antibodies against human 60 kDa heat shock protein (anti-HSP60) are associated with the presence and severity of CVD. OBJECTIVES:To investigate whether anti-HSP60 antibodies are associated with prevalent C...

journal_title：Annals of the rheumatic diseases

authors： van Halm VP,Slot MC,Nurmohamed MT,Tervaert JW,Dijkmans BA,Voskuyl AE

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Patients with rheumatoid arthritis (RA) are at increased risk of myocardial infarction (MI) compared with subjects without RA, with the increased risk driven potentially by inflammation. Tumour necrosis factor inhibitors (TNFi) may modulate the risk and severity of MI. We compared the risk and severity of MI...

journal_title：Annals of the rheumatic diseases

authors： Low AS,Symmons DP,Lunt M,Mercer LK,Gale CP,Watson KD,Dixon WG,Hyrich KL,British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA) and the BSRBR Control Centre Consortium.

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:For our understanding of the pathogenesis of rheumatoid arthritis (RA), it is important to elucidate the mechanisms underlying early stages of synovitis. Here, synovial cytokine production was investigated in patients with very early arthritis. METHODS:Synovial biopsies were obtained from pat...

journal_title：Annals of the rheumatic diseases

authors： Yeo L,Adlard N,Biehl M,Juarez M,Smallie T,Snow M,Buckley CD,Raza K,Filer A,Scheel-Toellner D

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To investigate the relation between anatomic changes of the synovium, the bone, the bone marrow and the cartilage to biochemical properties of the cartilage in patients with rheumatoid arthritis (RA). METHODS:33 patients with RA received 3-T MRI scans of the metacarpophalangeal joints. Two independent metho...

journal_title：Annals of the rheumatic diseases

authors： Herz B,Albrecht A,Englbrecht M,Welsch GH,Uder M,Renner N,Schlechtweg P,Paul D,Lauer L,Engelke K,Janka R,Rech J,Schett G,Finzel S

更新日期：2014-06-01 00:00:00

abstract：AIM:To assess the prevalence and the nature of autonomic neuropathy (AN) in 17 patients with inactive or mild active systemic lupus erythematosus (SLE). METHODS:Patients were tested using questionnaires related to possible AN symptoms, and four non invasive cardiovascular autonomic function tests at rest, during lying...

journal_title：Annals of the rheumatic diseases

authors： Lioté F,Osterland CK

更新日期：1994-10-01 00:00:00

abstract：:There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proli...

journal_title：Annals of the rheumatic diseases

authors： Niedbala W,Cai B,Liew FY

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:Hand osteoarthritis is a prevalent disease with limited treatment options. Since joint inflammation is often present, we investigated tumour necrosis factor (TNF) as treatment target in patients with proven joint inflammation in a proof-of-concept study. METHODS:This 1-year, double-blind, randomised, multice...

journal_title：Annals of the rheumatic diseases

authors： Kloppenburg M,Ramonda R,Bobacz K,Kwok WY,Elewaut D,Huizinga TWJ,Kroon FPB,Punzi L,Smolen JS,Vander Cruyssen B,Wolterbeek R,Verbruggen G,Wittoek R

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To analyse tender and swollen joint counts in three cohorts of patients with rheumatoid arthritis (RA), with a focus on the proportions of patients who had fewer than 6-12 tender or swollen joints, as possible evidence based information toward more generalisable inclusion criteria for current and future RA cl...

journal_title：Annals of the rheumatic diseases

authors： Pincus T,Sokka T,Chung CP,Cawkwell G

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:Assess golimumab's long-term efficacy/safety in psoriatic arthritis (PsA). METHODS:Adults with active PsA (≥3 swollen and tender joints, active psoriasis) were randomly assigned to subcutaneous placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks (q4wks) through wk20. All patients received golimumab ...

journal_title：Annals of the rheumatic diseases

authors： Kavanaugh A,McInnes IB,Mease P,Krueger GG,Gladman D,van der Heijde D,Zhou Y,Lu J,Leu JH,Goldstein N,Beutler A

更新日期：2014-09-01 00:00:00

abstract：:A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other t...

journal_title：Annals of the rheumatic diseases

authors： Allard SA,King RH,Thomas PK,Bourke BE

更新日期：1991-11-01 00:00:00

abstract：:The relation between the basal and stimulated gastric acid secretion, plasma gastrin, and the gastric microflora was examined in 45 patients with rheumatoid arthritis. Sixteen patients (36%) had basal achlorhydria, and of these, 10 (22%) had achlorhydria or hypochlorhydria after stimulation with pentagastrin. The peak...

journal_title：Annals of the rheumatic diseases

authors： Henriksson K,Uvnäs-Moberg K,Nord CE,Johansson C,Gullberg R

更新日期：1986-06-01 00:00:00