Cost effectiveness of two therapeutic regimens of infliximab in ankylosing spondylitis: economic evaluation within a randomised controlled trial.

abstract：:The prevalence of mild and severe radiological osteoarthritis was investigated in a random sample of 6585 inhabitants of a Dutch village. Radiographs were graded 0-4 according to the criteria described by Kellgren and Lawrence. The prevalence of radiological osteoarthritis increased strongly with age and was highest f...

journal_title：Annals of the rheumatic diseases

authors： van Saase JL,van Romunde LK,Cats A,Vandenbroucke JP,Valkenburg HA

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:A number of tumour necrosis factor α (TNFα) antagonists (anti-TNFα) are available to treat rheumatoid arthritis. All of these have demonstrated considerable efficacy in placebo controlled trials, but few head-to-head comparisons exist to date. This work's objective is to estimate the relative efficacy among ...

journal_title：Annals of the rheumatic diseases

authors： Schmitz S,Adams R,Walsh CD,Barry M,FitzGerald O

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Etanercept monotherapy has been studied and approved for treatment of polyarticular juvenile idiopathic arthritis (JIA). The following study evaluates the safety and efficacy of combination therapy of etanercept and methotrexate compared to etanercept monotherapy in JIA. METHODS:We perfomed an open, non-rand...

journal_title：Annals of the rheumatic diseases

authors： Horneff G,De Bock F,Foeldvari I,Girschick HJ,Michels H,Moebius D,Schmeling H,German and Austrian Paediatric Rheumatology Collaborative Study Group.

更新日期：2009-04-01 00:00:00

abstract：:Joint damage in rheumatoid arthritis is assessed radiologically. Previous studies have not examined in detail its long term progression. We evaluated the overall changes of peripheral joint damage radiologically in 50 rheumatoid patients followed up at one rheumatology centre for 10 years. All peripheral joints were s...

journal_title：Annals of the rheumatic diseases

authors： Scott DL,Coulton BL,Popert AJ

更新日期：1986-05-01 00:00:00

abstract：:An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

journal_title：Annals of the rheumatic diseases

authors： Gibson T,Burry HC,Poswillo D,Glass J

更新日期：1977-02-01 00:00:00

abstract：:Heart disease is a rare but important complication of polymyositis. Diagnosis of myocardial disease is usually based on non-specific clinical, electrocardiographic, and echocardiographic data. This paper reports a case of polymyositis with myocardial disease diagnosed by myocardial imaging with radiolabelled antibody ...

journal_title：Annals of the rheumatic diseases

authors： Le Guludec D,Lhote F,Weinmann P,Royer I,Jarrousse B,Caillat-Vigneron N,Guillevin L,Moretti JL

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Based upon findings in juvenile idiopathic arthritis, the genetic contribution of the VTCN1 region to rheumatoid arthritis (RA) susceptibility and anticitrullinated protein antibody (ACPA) status was investigated. VTCN1 is known to play a pivotal role in regulation of the immune system and, in soluble form, h...

journal_title：Annals of the rheumatic diseases

authors： Daha NA,Lie BA,Trouw LA,Stoeken G,Schonkeren JJ,Ding B,Kvien TK,Schilham MW,Padyukov L,Huizinga TW,Toes R

更新日期：2012-04-01 00:00:00

abstract：:An investigation of cell-mediated cytotoxicity in 22 patients with systemic lupus erythematosus (SLE), using both whole blood and purified peripheral blood mononuclear cells (PBM) to measure antibody-dependent (ADCC) and phytohaemagglutinin (PHA)-induced lymphocyte cytotoxicity for Chang liver cells, has revealed 2 di...

journal_title：Annals of the rheumatic diseases

authors： Wright JK,Hughes P,Gelsthorpe K,Ward AM,Rowell NR

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of adding sulfasalazine to leflunomide treatment compared with switching to sulfasalazine alone in patients with RA with an inadequate response to leflunomide monotherapy. METHODS:Patients with active RA ((DAS28) >3.2) who were enrolled in the first open label phase of the...

journal_title：Annals of the rheumatic diseases

authors： Dougados M,Emery P,Lemmel EM,Zerbini CA,Brin S,van Riel P

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:C-C chemokine receptor type 5 (CCR5), a chemokine receptor expressed on T cells and macrophages, and its ligands are found in inflamed synovial tissue (ST) of patients with rheumatoid arthritis (RA). The rationale for testing CCR5 blockade in patients with RA was supported by the effects of a CCR5 antagonist ...

journal_title：Annals of the rheumatic diseases

authors： van Kuijk AW,Vergunst CE,Gerlag DM,Bresnihan B,Gomez-Reino JJ,Rouzier R,Verschueren PC,van der Leij C,Maas M,Kraan MC,Tak PP

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To maintain and optimise the quality of care provided by health professionals in rheumatology (HPRs), adequate educational offerings are needed. This task force (TF) aimed to develop evidence-based recommendations for the generic core competences of HPRs, with specific reference to nurses, physica...

journal_title：Annals of the rheumatic diseases

authors： Edelaar L,Nikiphorou E,Fragoulis GE,Iagnocco A,Haines C,Bakkers M,Barbosa L,Cikes N,Ndosi M,Primdahl J,Prior Y,Pchelnikova P,Ritschl V,Schäfer VS,Smucrova H,Storrønning I,Testa M,Wiek D,Vliet Vlieland TPM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported. AIM:To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to l...

journal_title：Annals of the rheumatic diseases

authors： Hoberg M,Rudert M,Pap T,Klein G,Gay S,Aicher WK

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To examine the effects of smoking on cartilage loss and pain at the knee in individuals with knee osteoarthritis. METHODS:159 men with symptomatic knee osteoarthritis who participated in a 30-month, prospective, natural history study of knee osteoarthritis were examined. The more symptomatic knee was imaged ...

journal_title：Annals of the rheumatic diseases

authors： Amin S,Niu J,Guermazi A,Grigoryan M,Hunter DJ,Clancy M,LaValley MP,Genant HK,Felson DT

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Antibodies directed against citrullinated proteins (eg anti-cyclic citrullinated peptide (CCP)) have excellent diagnostic and good prognostic potential for rheumatoid arthritis. Type 1 autoimmune hepatitis (AIH-1) is a chronic liver disease characterised by a variety of serum autoantibodies. Recently, in a l...

journal_title：Annals of the rheumatic diseases

authors： Vannini A,Cheung K,Fusconi M,Stammen-Vogelzangs J,Drenth JP,Dall'Aglio AC,Bianchi FB,Bakker-Jonges LE,van Venrooij WJ,Pruijn GJ,Zendman AJ

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:There is a need to identify effective treatments for rheumatic diseases, and while genetic studies have been successful it is unclear which genes contribute to the disease. Using our existing Capture Hi-C data on three rheumatic diseases, we can identify potential causal genes which are targets for existing ...

journal_title：Annals of the rheumatic diseases

authors： Martin P,Ding J,Duffus K,Gaddi VP,McGovern A,Ray-Jones H,Yarwood A,Worthington J,Barton A,Orozco G

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of interleukin 6 (IL-6) in the pathogenesis of bilateral erosive sacroiliitis in human tumour necrosis factor transgenic (hTNFtg) mice, an animal model of ankylosing spondylitis (AS). METHODS:Histological sections of the sacroiliac joints from hTNFtg and IL-6(-/-)hTNFtg mice were evaluat...

journal_title：Annals of the rheumatic diseases

authors： Hayer S,Niederreiter B,Nagelreiter I,Smolen J,Redlich K

更新日期：2010-07-01 00:00:00

abstract：:The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This artic...

journal_title：Annals of the rheumatic diseases

authors： Flossmann O,Bacon P,de Groot K,Jayne D,Rasmussen N,Seo P,Westman K,Luqmani R

更新日期：2007-03-01 00:00:00

abstract：:T lymphocytes expressing the gamma/delta T cell receptor and B lymphocytes expressing CD5 are known to occur in expanded numbers in the peripheral blood of patients with primary Sjögren's syndrome. The cellular infiltrates for the surface phenotypic markers for alpha/beta and gamma/delta T cell receptors, CD4, CD8, CD...

journal_title：Annals of the rheumatic diseases

authors： Zumla A,Mathur M,Stewart J,Wilkinson L,Isenberg D

更新日期：1991-10-01 00:00:00

abstract：:The first biological therapeutics in rheumatology are approaching patent expiration, encouraging development of 'follow-on' versions, known as 'biosimilars'. Biological agents range from simple replacement hormones to complex monoclonal antibodies and soluble receptors: large, intricate proteins with unique tertiary a...

journal_title：Annals of the rheumatic diseases

authors： Dörner T,Strand V,Castañeda-Hernández G,Ferraccioli G,Isaacs JD,Kvien TK,Martin-Mola E,Mittendorf T,Smolen JS,Burmester GR

更新日期：2013-03-01 00:00:00

abstract：:CTLA-4 is a regulator of co-stimulation and inhibits the activation of T cells through interfering with the interaction of CD80/86 on antigen-presenting cells with CD28 on T cells. CTLA-4 binds to the surface of antigen-presenting cells, such as dendritic cells and monocytes through CD80/86. Monocytes can differentiat...

journal_title：Annals of the rheumatic diseases

authors： Axmann R,Herman S,Zaiss M,Franz S,Polzer K,Zwerina J,Herrmann M,Smolen J,Schett G

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Preliminary clinical criteria based on age, inflammation, and immobility have been proposed to identify which patients with rheumatoid arthritis (RA) should be examined by dual energy x ray absorptiometry (DXA) to diagnose osteoporosis. The three item criteria have not been evaluated in male patients with RA...

journal_title：Annals of the rheumatic diseases

authors： Haugeberg G,Ørstavik RE,Uhlig T,Falch JA,Halse JI,Kvien TK

更新日期：2002-12-01 00:00:00

abstract：:Arthro-osteitis at the anterior chest wall was found in 12 (9.4%) out of 128 consecutive patients with pustulosis palmaris et plantaris. This finding indicates that the concomitance of arthro-osteitis with PPP is not incidental but is based on some common aetiological factor. We propose a term ;pustulotic arthro-ostei...

journal_title：Annals of the rheumatic diseases

authors： Sonozaki H,Kawashima M,Hongo O,Yaoita H,Ikeno M,Matsuura M,Okai K,Azuma A

更新日期：1981-12-01 00:00:00

abstract：:The success of anti-tumour necrosis factor (TNF) treatment, either using antibodies or soluble receptors, has defined TNF as a major factor of the inflammatory response in rheumatoid arthritis (RA). As a result of this success, much attention has been devoted to understanding the molecular mechanisms by which TNF expr...

journal_title：Annals of the rheumatic diseases

authors： Foxwell BM,Bondeson J,Brennan F,Feldmann M

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:Over 50% of patients with rheumatoid arthritis (RA) harbour a variety of anti-modified protein antibodies (AMPA) against different post-translationally modified (PTM) proteins, including anti-carbamylated protein (anti-CarP) antibodies. At present, it is unknown how AMPA are generated and how autoreactive B ...

journal_title：Annals of the rheumatic diseases

authors： Dekkers JS,Verheul MK,Stoop JN,Liu B,Ioan-Facsinay A,van Veelen PA,de Ru AH,Janssen GMC,Hegen M,Rapecki S,Huizinga TWJ,Trouw LA,Toes REM

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate the association between MRI findings (cartilage defects, bone marrow lesions (BML), osteophytes, meniscal lesion, effusion/synovitis, ligamentous abnormalities, subchondral cysts and bone attrition) and pain in patients with knee osteoarthritis (OA) in order to establish the relevan...

journal_title：Annals of the rheumatic diseases

authors： Yusuf E,Kortekaas MC,Watt I,Huizinga TW,Kloppenburg M

更新日期：2011-01-01 00:00:00

abstract：:Ten patients (8 female, 2 male) with systemic lupus erythematosus (SLE) were entered into an open trial with the anabolic steroid 19-nortestosterone (19-nor). Their clinical condition did not improve, nor were significant changes observed in the majority of laboratory data. However, overall the platelet count rose, an...

journal_title：Annals of the rheumatic diseases

authors： Hazelton RA,McCruden AB,Sturrock RD,Stimson WH

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVES:Nicotinamide phosphoribosyltransferase (NAMPT)/pre-B-cell colony-enhancing factor/visfatin exerts multiple functions and has been implicated in the pathogenesis of rheumatoid arthritis. To gain insight into its role in arthritis and given that NAMPT is identified as a novel mediator of innate immunity, we ad...

journal_title：Annals of the rheumatic diseases

authors： Présumey J,Courties G,Louis-Plence P,Escriou V,Scherman D,Pers YM,Yssel H,Pène J,Kyburz D,Gay S,Jorgensen C,Apparailly F

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS:A total of 116 patients with SSc were classifi...

journal_title：Annals of the rheumatic diseases

authors： Frezza D,Giambra V,Tolusso B,De Santis M,Bosello S,Vettori S,Triolo G,Valentini G,Ferraccioli G

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:While new treatments for rheumatoid arthritis (RA) have markedly improved disease control by targeting immune/inflammatory pathways, current treatments rarely induce remission, underscoring the need for therapies that target other aspects of the disease. Little is known about the regulation of disease severi...

journal_title：Annals of the rheumatic diseases

authors： Laragione T,Brenner M,Lahiri A,Gao E,Harris C,Gulko PS

更新日期：2018-11-01 00:00:00

abstract：:Polymorphonuclear leucocytes (PMNs), which predominate in inflammatory synovial fluid, can degrade cartilage. This was measured by a novel in vitro model; PMNs were incubated for up to one hour with 2 or 3 microns sections of cartilage and the glycosaminoglycan loss determined by microdensitometry after alcian blue st...

journal_title：Annals of the rheumatic diseases

authors： Moore AR,Iwamura H,Larbre JP,Scott DL,Willoughby DA

更新日期：1993-01-01 00:00:00