Development of comprehensive disease assessment in systemic vasculitis.


:The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.


Ann Rheum Dis


Flossmann O,Bacon P,de Groot K,Jayne D,Rasmussen N,Seo P,Westman K,Luqmani R




Has Abstract


2007-03-01 00:00:00














  • Dual energy computed tomography in tophaceous gout.

    abstract:OBJECTIVE:To evaluate the potential utility of a dual energy CT (DECT) scan in assessing urate deposits among patients with tophaceous gout, and obtain computerised quantification of tophus volume in peripheral joints. METHODS:20 consecutive patients with tophaceous gout and 10 control patients with other arthritic co...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Choi HK,Al-Arfaj AM,Eftekhari A,Munk PL,Shojania K,Reid G,Nicolaou S

    更新日期:2009-10-01 00:00:00

  • IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.

    abstract:OBJECTIVE:The first genome-wide association study (GWAS) of systemic sclerosis (SSc) demonstrated three non-major histocompatibility complex (MHC) susceptibility loci. The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc. METHODS...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Sharif R,Mayes MD,Tan FK,Gorlova OY,Hummers LK,Shah AA,Furst DE,Khanna D,Martin J,Bossini-Castillo L,Gonzalez EB,Ying J,Draeger HT,Agarwal SK,Reveille JD,Arnett FC,Wigley FM,Assassi S

    更新日期:2012-07-01 00:00:00

  • Naproxen in juvenile chronic polyarthritis.

    abstract::Naproxen at 10 mg per kg body weight was compared with aspirin at 80 mg per kg body weight in children suffering from juvenile chronic polyarthritis. It was found to be as effective as aspirin, with certainly no more and possibly fewer gastrointestinal side effects. A long-term tolerance study up to 12 months confirme...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章


    authors: Moran H,Hanna DB,Ansell BM,Hall M,Engler C

    更新日期:1979-04-01 00:00:00

  • Combined intravenous methotrexate and cyclophosphamide for refractory childhood lupus nephritis.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of combining monthly intravenous methotrexate (IV MTX) with monthly IV cyclophosphamide (CYTX; given on the same day) for the treatment of children who develop recurrent diffuse proliferative glomerulonephritis secondary to systemic lupus erythematosus during or after the s...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Lehman TJ,Edelheit BS,Onel KB

    更新日期:2004-03-01 00:00:00

  • Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint.

    abstract:OBJECTIVE:Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations of RA monocytes in bone marrow (BM), blood and inflamed joints. METHODS:CD14+ cells from BM and peripheral blood (PB) of patients with RA and osteoarthritis (OA) were profil...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Smiljanovic B,Radzikowska A,Kuca-Warnawin E,Kurowska W,Grün JR,Stuhlmüller B,Bonin M,Schulte-Wrede U,Sörensen T,Kyogoku C,Bruns A,Hermann S,Ohrndorf S,Aupperle K,Backhaus M,Burmester GR,Radbruch A,Grützkau A,Maslinski

    更新日期:2018-02-01 00:00:00

  • Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy.

    abstract:OBJECTIVE:To elucidate the clinical importance of the anti-signal recognition particle (SRP) autoantibody in patients with myositis. METHODS:Retrospective systematic assessment of the clinical, laboratory and histological characteristics of 23 anti-SRP-positive patients from six European centres. Data were compared wi...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Hengstman GJ,ter Laak HJ,Vree Egberts WT,Lundberg IE,Moutsopoulos HM,Vencovsky J,Doria A,Mosca M,van Venrooij WJ,van Engelen BG

    更新日期:2006-12-01 00:00:00

  • Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees.

    abstract:OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Belcher C,Yaqub R,Fawthrop F,Bayliss M,Doherty M

    更新日期:1997-05-01 00:00:00

  • Clinical features of meningococcal arthritis: a report of four cases.

    abstract::Four patients with Neisseria meningitidis infection complicated by arthritis are described. Three patients had an acute polyarthritis which responded quickly to antimicrobial therapy. A fourth patient developed a prolonged arthritis which occurred after the initial infection had been successfully treated. Tenosynoviti...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Kidd BL,Hart HH,Grigor RR

    更新日期:1985-11-01 00:00:00

  • D-penicillamine and immune complex deposition.

    abstract::Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Kirby JD,Dieppe PA,Huskisson EC,Smith B

    更新日期:1979-08-01 00:00:00

  • Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.

    abstract:OBJECTIVES:Millions of patients worldwide are treated with therapeutic monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss of response. Fully human biological agents, such as the anti-tumour necrosis factor α (anti-TNFα) antibody adalimu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van Schouwenburg PA,van de Stadt LA,de Jong RN,van Buren EE,Kruithof S,de Groot E,Hart M,van Ham SM,Rispens T,Aarden L,Wolbink GJ,Wouters D

    更新日期:2013-01-01 00:00:00

  • Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid.

    abstract::The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Gale R,Bertouch JV,Bradley J,Roberts-Thomson PJ

    更新日期:1983-04-01 00:00:00

  • Behçet's syndrome: a family study and the elucidation of a genetic role.

    abstract::A family with features of the mucocutaneous ocular syndrome is described. A 4-generation study reveals that the condition has been inherited as an autosomal dominant trait with variable expressivity. Psychiatric symptoms and myalgia have been prominent features peculiar to our patients. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Berman L,Trappler B,Jenkins T

    更新日期:1979-04-01 00:00:00

  • IFN-α kinoid in systemic lupus erythematosus: results from a phase IIb, randomised, placebo-controlled study.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of the immunotherapeutic vaccine interferon-α kinoid (IFN-K) in a 36-week (W) phase IIb, randomised, double-blind, placebo (PBO)-controlled trial in adults with active systemic lupus erythematosus (SLE) despite standard of care. METHODS:Patients with SLE (185) with moderat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Houssiau FA,Thanou A,Mazur M,Ramiterre E,Gomez Mora DA,Misterska-Skora M,Perich-Campos RA,Smakotina SA,Cerpa Cruz S,Louzir B,Croughs T,Tee ML

    更新日期:2020-03-01 00:00:00

  • Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity.

    abstract::Thirty-three patients with early peripheral synovitis were followed up for two to four years in order to study the relationship between fluctuations in rheumatoid factor (RF) levels and indices of clinical activity. Twenty-eight of these patients developed classical/definite rheumatoid arthritis (RA). Seventeen patien...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Withrington RH,Teitsson I,Valdimarsson H,Seifert MH

    更新日期:1984-10-01 00:00:00

  • A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: the PLANETRA study.

    abstract:OBJECTIVES:To compare the efficacy and safety of innovator infliximab (INX) and CT-P13, an INX biosimilar, in active rheumatoid arthritis patients with inadequate response to methotrexate (MTX) treatment. METHODS:Phase III randomised, double-blind, multicentre, multinational, parallel-group study. Patients with active...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Yoo DH,Hrycaj P,Miranda P,Ramiterre E,Piotrowski M,Shevchuk S,Kovalenko V,Prodanovic N,Abello-Banfi M,Gutierrez-Ureña S,Morales-Olazabal L,Tee M,Jimenez R,Zamani O,Lee SJ,Kim H,Park W,Müller-Ladner U

    更新日期:2013-10-01 00:00:00

  • Bronchiolitis obliterans in systemic lupus erythematosus: beneficial effect of intravenous cyclophosphamide.

    abstract::A 49 year old white woman with systemic lupus erythematosus and bronchiolitis obliterans was treated with prednisone (1 mg/kg daily), which led to a transitory improvement in pulmonary status. Cyclophosphamide was then added--4 mg/kg daily intravenously for five days, then 2 mg/kg daily orally--and this was followed b...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Godeau B,Cormier C,Menkes CJ

    更新日期:1991-12-01 00:00:00

  • Effect of iron chelation on inflammatory joint disease.

    abstract::Mild iron deficiency induced by treatment with the iron chelator desferrioxamine reduced the incidence and severity of joint inflammation associated with adjuvant disease in rats but did not alter the local primary inflammatory response or the systemic sequelae. Both rats treated with desferrioxamine and control rats ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Andrews FJ,Morris CJ,Kondratowicz G,Blake DR

    更新日期:1987-04-01 00:00:00

  • Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?

    abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA,...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,收录出版,评审


    authors: Suurmond J,Schuerwegh AJ,Toes RE

    更新日期:2011-03-01 00:00:00

  • Detection of immune deposits in skin lesions of patients with Wegener's granulomatosis.

    abstract:BACKGROUND:Wegener's granulomatosis (WG) is considered a pauci-immune systemic vasculitis based on the absence of immune deposits in renal biopsies of patients with active disease. In animal models of antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis, immune deposits along the glomerular capillar...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Brons RH,de Jong MC,de Boer NK,Stegeman CA,Kallenberg CG,Tervaert JW

    更新日期:2001-12-01 00:00:00

  • EULAR recommendations for the management of familial Mediterranean fever.

    abstract::Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals in the treatment and follow-u...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Ozen S,Demirkaya E,Erer B,Livneh A,Ben-Chetrit E,Giancane G,Ozdogan H,Abu I,Gattorno M,Hawkins PN,Yuce S,Kallinich T,Bilginer Y,Kastner D,Carmona L

    更新日期:2016-04-01 00:00:00

  • Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.

    abstract::The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9....

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Tokunaga M,Ohuchi K,Yoshizawa S,Tsurufuji S,Rikimaru A,Wakamatsu E

    更新日期:1981-10-01 00:00:00

  • Severe alterations in expression and localisation of {alpha}6{beta}4 integrin in salivary gland acini from patients with Sjogren syndrome.

    abstract:OBJECTIVES:In salivary glands from patients with Sjögren syndrome, overexpression of laminins 1 and 5 and disorganisation of the acinar basal lamina have been reported. Laminin 5 mediates association of the basal lamina with epithelial cells by forming adhesion complexes upon interaction with alpha6beta4 integrin. In t...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Velozo J,Aguilera S,Alliende C,Ewert P,Molina C,Pérez P,Leyton L,Quest A,Brito M,González S,Leyton C,Hermoso M,Romo R,González MJ

    更新日期:2009-06-01 00:00:00

  • Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Rheumatoid arthritis is associated with an unexplained increased risk of cardiovascular disease (CVD). Antibodies against human 60 kDa heat shock protein (anti-HSP60) are associated with the presence and severity of CVD. OBJECTIVES:To investigate whether anti-HSP60 antibodies are associated with prevalent C...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van Halm VP,Slot MC,Nurmohamed MT,Tervaert JW,Dijkmans BA,Voskuyl AE

    更新日期:2006-05-01 00:00:00

  • Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis.

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    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Nakajima A,Hakoda M,Yamanaka H,Kamatani N,Kashiwazaki S

    更新日期:1996-04-01 00:00:00

  • Characterisation of the nasal microbiota in granulomatosis with polyangiitis.

    abstract:OBJECTIVES:Prior studies have suggested a potential link between nasal microbes and granulomatosis with polyangiitis (GPA; Wegener's), but these studies relied on culture-dependent methods. This study comprehensively examined the entire community of nasal microbiota (bacteria and fungi) in participants with GPA compare...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Rhee RL,Sreih AG,Najem CE,Grayson PC,Zhao C,Bittinger K,Collman RG,Merkel PA

    更新日期:2018-10-01 00:00:00

  • Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis.

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    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Tan AL,Toumi H,Benjamin M,Grainger AJ,Tanner SF,Emery P,McGonagle D

    更新日期:2006-10-01 00:00:00

  • Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor alpha mRNAs in a chondrocyte-like cell line.

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    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Takahashi K,Kubo T,Arai Y,Kitajima I,Takigawa M,Imanishi J,Hirasawa Y

    更新日期:1998-04-01 00:00:00

  • Epistasis between the MHC and the RCA alpha block in primary Sjögren syndrome.

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    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Lester S,McLure C,Williamson J,Bardy P,Rischmueller M,Dawkins RL

    更新日期:2008-06-01 00:00:00

  • Potential involvement of OX40 in the regulation of autoantibody sialylation in arthritis.

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    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Kurata I,Matsumoto I,Ohyama A,Osada A,Ebe H,Kawaguchi H,Kaneko S,Kondo Y,Tsuboi H,Tomioka A,Kaji H,Sumida T

    更新日期:2019-11-01 00:00:00

  • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs.

    abstract::Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear and consensual international recommendations on RA treatment are not available. In this paper recommendations for the treatment of RA with synthetic and biological disease-modifying antirheumatic drugs (DMARDs) and glucocortic...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章,评审


    authors: Smolen JS,Landewé R,Breedveld FC,Dougados M,Emery P,Gaujoux-Viala C,Gorter S,Knevel R,Nam J,Schoels M,Aletaha D,Buch M,Gossec L,Huizinga T,Bijlsma JW,Burmester G,Combe B,Cutolo M,Gabay C,Gomez-Reino J,Kouloumas M

    更新日期:2010-06-01 00:00:00