The evolving role of the rheumatologist in the management of immune-related adverse events (irAEs) caused by cancer immunotherapy.

abstract：:Three aspects of polymorphonuclear leucocyte (PMN) function were studied in 19 patients with Behçet's syndrome (BS). By 2 different techniques directed motility was found to be increased. This increase was largely due to the subgroup of patients with ocular involvement. Counts of absolute numbers of cells migrating hi...

journal_title：Annals of the rheumatic diseases

authors： Fordham JN,Davies PG,Kirk A,Currey HL

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported. AIM:To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to l...

journal_title：Annals of the rheumatic diseases

authors： Hoberg M,Rudert M,Pap T,Klein G,Gay S,Aicher WK

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To formulate EULAR recommendations for the management of early arthritis. METHODS:In accordance with EULAR's "standardised operating procedures", the task force pursued an evidence based approach and an approach based on expert opinion. A steering group comprised of 14 rheumatologists representing 10 Europea...

journal_title：Annals of the rheumatic diseases

authors： Combe B,Landewe R,Lukas C,Bolosiu HD,Breedveld F,Dougados M,Emery P,Ferraccioli G,Hazes JM,Klareskog L,Machold K,Martin-Mola E,Nielsen H,Silman A,Smolen J,Yazici H

更新日期：2007-01-01 00:00:00

abstract：:Articular cartilage is avascular. Nutrients are transported to the cells mainly by diffusion from the synovial fluid. Nutrient transport is also sometimes thought to be assisted by movement of fluid in and out of cartilage in response to cyclic loading of the tissue ('pumping'). The influence of pumping on transport o...

journal_title：Annals of the rheumatic diseases

authors： O'Hara BP,Urban JP,Maroudas A

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Collagen-induced arthritis (CIA) is the most commonly used model of rheumatoid arthritis (RA). In both CIA and RA there is an increase in the cellular content of the synovium, this being dominated by macrophages. OBJECTIVE:To assess the impact of etoposide, a topoisomerase II antagonist known to induce mono...

journal_title：Annals of the rheumatic diseases

authors： Verdrengh M,Jonsson IM,Zaether O,Bajtner E,Holmdahl R,Tarkowski A

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low birth weight (LBW) and spontaneous abortion associated with leflunomide exposure during pregnancy in humans. METHODS:F...

journal_title：Annals of the rheumatic diseases

authors： Bérard A,Zhao JP,Shui I,Colilla S

更新日期：2018-04-01 00:00:00

abstract：:On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by...

journal_title：Annals of the rheumatic diseases

authors： Marshall JL,Fraser JR,Muirden KD

更新日期：1977-04-01 00:00:00

abstract：:One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is unclear, but has been suggested to be a lipoprotein. Sera from patients with (1) systemic necrotising arteritis (polyarter...

journal_title：Annals of the rheumatic diseases

authors： Blake DR,Winyard P,Scott DG,Brailsford S,Blann A,Lunec J

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVES:Little data are available regarding the rate and predicting factors of serious infections in patients with rheumatoid arthritis (RA) treated with abatacept (ABA) in daily practice. We therefore addressed this issue using real-life data from the Orencia and Rheumatoid Arthritis (ORA) registry. METHODS:ORA is...

journal_title：Annals of the rheumatic diseases

authors： Salmon JH,Gottenberg JE,Ravaud P,Cantagrel A,Combe B,Flipo RM,Schaeverbeke T,Houvenagel E,Gaudin P,Loeuille D,Rist S,Dougados M,Sibilia J,Le Loët X,Meyer O,Solau-Gervais E,Marcelli C,Bardin T,Pane I,Baron G,Perrod

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Pregnant women with systemic sclerosis (SSc; scleroderma) have an increased risk of premature delivery and small full-term infants. During placental development, angiogenesis and vascular remodelling are essential for a successful pregnancy outcome. An analysis was made of the pathological changes and express...

journal_title：Annals of the rheumatic diseases

authors： Ibba-Manneschi L,Manetti M,Milia AF,Miniati I,Benelli G,Guiducci S,Mecacci F,Mello G,Di Lollo S,Matucci-Cerinic M

更新日期：2010-02-01 00:00:00

abstract：:The effect of auranofin on human neutrophil (PMN) 5-lipoxygenase activity and leucotriene B4 (LTB4) chemotaxis was investigated. [1-14C]Arachidonic acid was incorporated into the purified cells until steady state conditions were obtained. After preincubations with serial dilutions of auranofin arachidonic acid release...

journal_title：Annals of the rheumatic diseases

authors： Elmgreen J,Ahnfelt-Rønne I,Nielsen OH

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:To perform a prospective long term follow up study comparing conventional radiography (CR), ultrasonography (US), and magnetic resonance imaging (MRI) in the detection of bone erosions and synovitis in rheumatoid arthritis (RA) finger joints. METHODS:The metacarpophalangeal and proximal interphalangeal joint...

journal_title：Annals of the rheumatic diseases

authors： Scheel AK,Hermann KG,Ohrndorf S,Werner C,Schirmer C,Detert J,Bollow M,Hamm B,Müller GA,Burmester GR,Backhaus M

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To measure gelatinase activities in paired synovial fluid (SF) and serum of patients with juvenile idiopathic arthritis (JIA), and to assess how these activities relate to clinical and laboratory measures of disease activity. METHODS:A quantitative protein substrate zymography method was adapted and validate...

journal_title：Annals of the rheumatic diseases

authors： Peake NJ,Foster HE,Khawaja K,Cawston TE,Rowan AD

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Advances in health measurement have led to the application of Rasch Item Response Theory (IRT) analysis (Rasch analysis) to evaluate instruments measuring health status and quality of life of patients, including the Health Assessment Questionnaire and SF-36. This study investigated the extent to which the Wes...

journal_title：Annals of the rheumatic diseases

authors： Wolfe F,Kong SX

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease, mediated by disrupted B cell quiescence and typically treated with glucocorticoids. We studied whether B cells in SLE are regulated by the glucocorticoid-induced leucine zipper (GILZ) protein, an endogenous mediator of anti-infla...

journal_title：Annals of the rheumatic diseases

authors： Jones SA,Toh AE,Odobasic D,Oudin MA,Cheng Q,Lee JP,White SJ,Russ BE,Infantino S,Light A,Tarlinton DM,Harris J,Morand EF

更新日期：2016-04-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is not a disease, but an exclusion diagnosis that encompasses all forms of arthritis that begin before the age of 16 years, persist for more than 6 weeks, and are of unknown origin. This heterogeneous group of chronic arthritides has been classified on clinical and laboratory ground...

journal_title：Annals of the rheumatic diseases

authors： Martini A

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular ...

journal_title：Annals of the rheumatic diseases

authors： Urano W,Taniguchi A,Anzai N,Inoue E,Kanai Y,Yamanaka M,Endou H,Kamatani N,Yamanaka H

更新日期：2010-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA,...

journal_title：Annals of the rheumatic diseases

authors： Suurmond J,Schuerwegh AJ,Toes RE

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To review systematically the available literature on the optimal dosage and route of administration of methotrexate in patients with rheumatoid arthritis (RA), as an evidence base for generating clinical practice recommendations. METHODS:A systematic literature search was carried out in MEDLINE, EMBASE, Coc...

journal_title：Annals of the rheumatic diseases

authors： Visser K,van der Heijde D

更新日期：2009-07-01 00:00:00

abstract：:Two British secondary schools (one a specialist music school) were surveyed to assess the prevalence of upper limb pain among specialist music students compared with students in a regular school setting. Female students tended to report pain more often than male students, but for both significantly higher prevalence w...

journal_title：Annals of the rheumatic diseases

authors： Fry HJ,Rowley GL

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVES:To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. METHODS:322 Finnish patients with rheumatoid arthritis were typed for ...

journal_title：Annals of the rheumatic diseases

authors： Laivoranta-Nyman S,Möttönen T,Hermann R,Tuokko J,Luukkainen R,Hakala M,Hannonen P,Korpela M,Yli-Kerttula U,Toivanen A,Ilonen J,FIN-RACo Trial Group.

更新日期：2004-11-01 00:00:00

abstract：:A study of the walking activities of 243 individuals was carried out. The individuals came from four different occupations and had an age range of 17-83 years. The survey carried out in this investigation showed surprisingly little correlation between variables such as age, height, and weight of individuals and their ...

journal_title：Annals of the rheumatic diseases

authors： Seedhom BB,Wallbridge NC

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNα production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including IRF5. Genetic variat...

journal_title：Annals of the rheumatic diseases

authors： Niewold TB,Kelly JA,Kariuki SN,Franek BS,Kumar AA,Kaufman KM,Thomas K,Walker D,Kamp S,Frost JM,Wong AK,Merrill JT,Alarcón-Riquelme ME,Tikly M,Ramsey-Goldman R,Reveille JD,Petri MA,Edberg JC,Kimberly RP,Alarcón GS,

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether statin use was associated with an increased risk of dev...

journal_title：Annals of the rheumatic diseases

authors： de Jong HJ,Klungel OH,van Dijk L,Vandebriel RJ,Leufkens HG,van der Laan JW,Cohen Tervaert JW,van Loveren H

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:To compare the validity, responsiveness to change, and user friendliness of four self completed, shoulder-specific questionnaires in primary care. METHODS:A cross sectional assessment of validity and a longitudinal assessment of responsiveness to change of four shoulder questionnaires was carried out: the D...

journal_title：Annals of the rheumatic diseases

authors： Paul A,Lewis M,Shadforth MF,Croft PR,Van Der Windt DA,Hay EM

更新日期：2004-10-01 00:00:00

abstract：:Thirty-three patients with early peripheral synovitis were followed up for two to four years in order to study the relationship between fluctuations in rheumatoid factor (RF) levels and indices of clinical activity. Twenty-eight of these patients developed classical/definite rheumatoid arthritis (RA). Seventeen patien...

journal_title：Annals of the rheumatic diseases

authors： Withrington RH,Teitsson I,Valdimarsson H,Seifert MH

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVES:To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis (SSc). METHODS:Fifty-two consecutive patients with SSc underwent cardiac MRI to determine morphological, functional, perfusion at rest and delayed enhancement abnormal...

journal_title：Annals of the rheumatic diseases

authors： Hachulla AL,Launay D,Gaxotte V,de Groote P,Lamblin N,Devos P,Hatron PY,Beregi JP,Hachulla E

更新日期：2009-12-01 00:00:00

abstract：:Pain in the neck and upper limb is common and contributes considerably to absence from work due to sickness. Evidence suggest that prolonged abnormal posture and repetition contribute to such conditions. Psychosocial risk factors may also play a part in the aetiology of upper limb disorders. ...

journal_title：Annals of the rheumatic diseases

authors： Walker-Bone K,Cooper C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Upadacitinib is a Janus kinase inhibitor under evaluation for the treatment of psoriatic arthritis (PsA). We evaluated upadacitinib in patients with PsA and prior inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD). METHODS:In this 24-week randomised, pla...

journal_title：Annals of the rheumatic diseases

authors： Mease PJ,Lertratanakul A,Anderson JK,Papp K,Van den Bosch F,Tsuji S,Dokoupilova E,Keiserman M,Wang X,Zhong S,McCaskill RM,Zueger P,Pangan AL,Tillett W

更新日期：2020-12-03 00:00:00

abstract：OBJECTIVE:To evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR). METHODS:In total, 67 patients were randomised to receive weekly subcutaneous doses of 120 mg ...

journal_title：Annals of the rheumatic diseases

authors： Visvanathan S,Daniluk S,Ptaszyński R,Müller-Ladner U,Ramanujam M,Rosenstock B,Eleftheraki AG,Vinisko R,Petříková A,Kellner H,Dokoupilova E,Kwiatkowska B,Alten R,Schwabe C,Baum P,Joseph D,Fine JS,Padula SJ,Steffgen J

更新日期：2019-06-01 00:00:00