Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?

Abstract:

:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA, ACPA enhances arthritis. Furthermore, in vitro generated immune complexes with ACPA can activate macrophages and the complement system in the human system. Recently, a direct functional and specific response of FcεRI+ immune cells towards citrullinated proteins was demonstrated. Basophils of ACPA+ RA patients are activated by citrullinated proteins that cross link the FcεRI receptor via IgE-ACPA, physiologically bound to the receptor. In addition, synovial mast cells from ACPA+ RA patients show a more activated phenotype than mast cells from ACPA- patients. These findings underline the suggestion that ACPA+ and ACPA- RA are two different disease entities and point to a possible functional role of ACPA and FcεRI+ cells in the pathogenesis of RA.

journal_name

Ann Rheum Dis

authors

Suurmond J,Schuerwegh AJ,Toes RE

doi

10.1136/ard.2010.138032

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

i55-8

eissn

0003-4967

issn

1468-2060

pii

70/Suppl_1/i55

journal_volume

70 Suppl 1

pub_type

杂志文章,收录出版,评审
  • Familial inflammatory inclusion body myositis.

    abstract:OBJECTIVE:To compare familial inflammatory inclusion body myositis (IBM) with hereditary inclusion body myopathies and sporadic IBM. PATIENTS AND METHODS:Clinical, biological, MRI, and histological data were analysed in two siblings with inflammatory IBM and compared with those of patients with sporadic and hereditary...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/ard.2004.025494

    authors: Ranque-Francois B,Maisonobe T,Dion E,Piette JC,Chauveheid MP,Amoura Z,Papo T

    更新日期:2005-04-01 00:00:00

  • Relationship between erythrocyte sedimentation rate and serum C-reactive protein in rheumatoid arthritis.

    abstract::Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship bet...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.38.4.362

    authors: Walsh L,Davies P,McConkey B

    更新日期:1979-08-01 00:00:00

  • Epistasis between the MHC and the RCA alpha block in primary Sjögren syndrome.

    abstract:OBJECTIVE:The RCA alpha block (Regulators of Complement Activation, 1q32) contains critical complement regulatory genes such as CR1 and MCP. This study examined RCA alpha block haplotype associations with both disease susceptibility and diversification of the anti-Ro/La autoantibody response in primary Sjögren syndrome...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2007.075044

    authors: Lester S,McLure C,Williamson J,Bardy P,Rischmueller M,Dawkins RL

    更新日期:2008-06-01 00:00:00

  • Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA).

    abstract:BACKGROUND:PATIENTS with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. OBJECTIVES:To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. METHODS: STUDY DESIGN:international, cross-sectional. PATIENTS:consecutiv...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2013-204223

    authors: Dougados M,Soubrier M,Antunez A,Balint P,Balsa A,Buch MH,Casado G,Detert J,El-Zorkany B,Emery P,Hajjaj-Hassouni N,Harigai M,Luo SF,Kurucz R,Maciel G,Mola EM,Montecucco CM,McInnes I,Radner H,Smolen JS,Song YW,Von

    更新日期:2014-01-01 00:00:00

  • Opportunistic infections and biologic therapies in immune-mediated inflammatory diseases: consensus recommendations for infection reporting during clinical trials and postmarketing surveillance.

    abstract::No consensus has previously been formed regarding the types and presentations of infectious pathogens to be considered as 'opportunistic infections' (OIs) within the setting of biologic therapy. We systematically reviewed published literature reporting OIs in the setting of biologic therapy for inflammatory diseases. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/annrheumdis-2015-207841

    authors: Winthrop KL,Novosad SA,Baddley JW,Calabrese L,Chiller T,Polgreen P,Bartalesi F,Lipman M,Mariette X,Lortholary O,Weinblatt ME,Saag M,Smolen J

    更新日期:2015-12-01 00:00:00

  • Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis.

    abstract:OBJECTIVES:To assess the association of body mass index (BMI) with modifiable cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA). METHODS:BMI, disease activity, selected CVD risk factors and CVD medication were assessed in 378 (276 women) patients with RA. Patients exceeding accepted ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2008.095596

    authors: Stavropoulos-Kalinoglou A,Metsios GS,Panoulas VF,Douglas KM,Nevill AM,Jamurtas AZ,Kita M,Koutedakis Y,Kitas GD

    更新日期:2009-02-01 00:00:00

  • Pulmonary involvement in ankylosing spondylitis.

    abstract::Thirty two patients with ankylosing spondylitis were investigated with a set of pulmonary function tests and the results compared with those for a control population. The patients had no complaints about lung symptoms and their chest radiographs were normal. The main pathological findings were reduced lung volumes, a ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.45.9.736

    authors: Feltelius N,Hedenström H,Hillerdal G,Hällgren R

    更新日期:1986-09-01 00:00:00

  • Physical trauma recorded in primary care is associated with the onset of psoriatic arthritis among patients with psoriasis.

    abstract:OBJECTIVES:To evaluate the risk of psoriatic arthritis (PsA) among patients with psoriasis exposed to physical trauma. METHODS:A matched cohort study was performed using data from The Health Improvement Network (THIN). Patients with psoriasis exposed to trauma were randomly matched to up to five unexposed psoriasis co...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2016-209334

    authors: Thorarensen SM,Lu N,Ogdie A,Gelfand JM,Choi HK,Love TJ

    更新日期:2017-03-01 00:00:00

  • Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis.

    abstract:OBJECTIVES:To study the short term effects of a single dose of D2E7, a fully human anti-tumour necrosis factor (TNFalpha) monoclonal antibody (mAb), on the local and systemic homeostasis of interleukin 1beta (IL1beta) and TNFalpha in patients with rheumatoid arthritis (RA). METHODS:All patients with RA enrolled in a p...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/ard.60.7.660

    authors: Barrera P,Joosten LA,den Broeder AA,van de Putte LB,van Riel PL,van den Berg WB

    更新日期:2001-07-01 00:00:00

  • Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2.

    abstract:OBJECTIVE:Notch signalling pathways are critical for angiogenesis and endothelial cell (EC) fate; however the mechanisms regulating these processes in the inflamed joint remain to be elucidated. Here, we examine whether Notch signalling mediates vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2)-induce...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2012-201978

    authors: Gao W,Sweeney C,Walsh C,Rooney P,McCormick J,Veale DJ,Fearon U

    更新日期:2013-06-01 00:00:00

  • The "X-Ray RheumaCoach" software: a novel tool for enhancing the efficacy and accelerating radiological quantification in rheumatoid arthritis.

    abstract:BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.62.6.579

    authors: Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

    更新日期:2003-06-01 00:00:00

  • Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Rheumatoid arthritis is associated with an unexplained increased risk of cardiovascular disease (CVD). Antibodies against human 60 kDa heat shock protein (anti-HSP60) are associated with the presence and severity of CVD. OBJECTIVES:To investigate whether anti-HSP60 antibodies are associated with prevalent C...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2005.038828

    authors: van Halm VP,Slot MC,Nurmohamed MT,Tervaert JW,Dijkmans BA,Voskuyl AE

    更新日期:2006-05-01 00:00:00

  • Ankylosing hyperostosis: a study of HLA A, B, and C antigens.

    abstract::HLA A, B, and C antigens were studied in 25 patients with ankylosing hyperostosis. There was no evidence of an increased frequency of any antigen in association with the condition itself. However, a high frequency of several antigens was found, reflecting the predominance of Jewish patients in the series. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.38.1.72

    authors: Perry JD,Wolf H,Festenstein H,Storey GO

    更新日期:1979-02-01 00:00:00

  • Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review.

    abstract:OBJECTIVE:To systematically evaluate the association between MRI findings (cartilage defects, bone marrow lesions (BML), osteophytes, meniscal lesion, effusion/synovitis, ligamentous abnormalities, subchondral cysts and bone attrition) and pain in patients with knee osteoarthritis (OA) in order to establish the relevan...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/ard.2010.131904

    authors: Yusuf E,Kortekaas MC,Watt I,Huizinga TW,Kloppenburg M

    更新日期:2011-01-01 00:00:00

  • Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis.

    abstract:OBJECTIVE:To define the mechanisms whereby methotrexate (MTX) manifests its effects in patients with rheumatoid arthritis. METHODS:T and B cells from peripheral blood and rheumatoid synovial tissues, synovial adherent cells, and the human fibrosarcoma cell line HT1080 and its mutant (defective in an enzyme in the nucl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.55.4.237

    authors: Nakajima A,Hakoda M,Yamanaka H,Kamatani N,Kashiwazaki S

    更新日期:1996-04-01 00:00:00

  • Management of Behçet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behçet disease.

    abstract:OBJECTIVES:To present and analyse the literature sources regarding the management of Behçet disease (BD) identified during the systematic literature research, which formed the basis for the European League Against Rheumatism (EULAR) evidence-based recommendations for the management of BD. METHODS:Problem areas and rel...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/ard.2008.087957

    authors: Hatemi G,Silman A,Bang D,Bodaghi B,Chamberlain AM,Gul A,Houman MH,Kötter I,Olivieri I,Salvarani C,Sfikakis PP,Siva A,Stanford MR,Stübiger N,Yurdakul S,Yazici H

    更新日期:2009-10-01 00:00:00

  • Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout.

    abstract:OBJECTIVES:Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2008.106856

    authors: Urano W,Taniguchi A,Anzai N,Inoue E,Kanai Y,Yamanaka M,Endou H,Kamatani N,Yamanaka H

    更新日期:2010-06-01 00:00:00

  • Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.

    abstract:OBJECTIVES:This integrated analysis presents the safety profile of upadacitinib, a Janus kinase inhibitor, at 15 mg and 30 mg once daily in patients with moderately to severely active rheumatoid arthritis (RA). METHODS:Treatment-emergent adverse events (TEAEs) and laboratory data from five randomised, placebo- or acti...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218510

    authors: Cohen SB,van Vollenhoven RF,Winthrop KL,Zerbini CAF,Tanaka Y,Bessette L,Zhang Y,Khan N,Hendrickson B,Enejosa JV,Burmester GR

    更新日期:2020-10-28 00:00:00

  • Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s.

    abstract:BACKGROUND:There is increased cardiovascular disease mortality in rheumatoid arthritis. This may reflect an increased prevalence of cardiovascular disease or an increased case fatality in patients with rheumatoid arthritis. OBJECTIVES:To examine whether rheumatoid patients with disease onset in the 1980s-1990s have in...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1136/ard.2004.034777

    authors: Goodson N,Marks J,Lunt M,Symmons D

    更新日期:2005-11-01 00:00:00

  • Changes in estimated right ventricular systolic pressure predict mortality and pulmonary hypertension in a cohort of scleroderma patients.

    abstract:OBJECTIVES:Annual echocardiography screening is widely used in scleroderma, but the utility of longitudinal assessment is unknown. We evaluated whether change in right ventricular systolic pressure (RVSP) was a risk factor for mortality and development of pulmonary arterial hypertension (PAH) in a cohort of scleroderma...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2012-201861

    authors: Shah AA,Chung SE,Wigley FM,Wise RA,Hummers LK

    更新日期:2013-07-01 00:00:00

  • Increment of CD8S6F1 cells in synovial fluid from patients with rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the role of CD8 cell subsets in the pathogenesis of rheumatoid arthritis (RA) and the phenotypes of T cells adherent or non-adherent to the target cells (endothelial cells and synovial cells) pre-treated with IL-1 beta. METHODS:The expression of S6F1 on CD8 cells and that of an activation mark...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.53.12.816

    authors: Ueki Y,Eguchi K,Miyake S,Nagataki S,Tominaga Y

    更新日期:1994-12-01 00:00:00

  • Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women.

    abstract:BACKGROUND:Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE:To study associations betwee...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2012-202713

    authors: Claessen KM,Kloppenburg M,Kroon HM,Bijsterbosch J,Pereira AM,Romijn JA,van der Straaten T,Nelissen RG,Hofman A,Uitterlinden AG,Duijnisveld BJ,Lakenberg N,Beekman M,van Meurs JB,Slagboom PE,Biermasz NR,Meulenbelt I

    更新日期:2014-02-01 00:00:00

  • Development of patient-centred standards of care for osteoarthritis in Europe: the eumusc.net-project.

    abstract:OBJECTIVE:The eumusc.net project is an initiative founded by the European Community and the European League Against Rheumatism. One aim of the project was to facilitate equal standards for musculoskeletal health across Europe. The aim of this work-package was to develop patient-centred and consensus based standards of ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,实务指引,评审

    doi:10.1136/annrheumdis-2014-206176

    authors: Stoffer MA,Smolen JS,Woolf A,Ambrozic A,Berghea F,Boonen A,Bosworth A,Carmona L,Dougados M,de Wit M,Erwin J,Fialka-Moser V,Ionescu R,Keenan AM,Loza E,Moe RH,Greiff R,Olejnik P,Petersson IF,Rat AC,Rozman B,Strömb

    更新日期:2015-06-01 00:00:00

  • Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I.

    abstract:OBJECTIVES:The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown, but growth factors and hormones probably play an important part. The effects of glucocorticosteroids (prednisolone and triamcinolone), in combination with insuli...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.52.10.734

    authors: van der Kraan PM,Vitters EL,Postma NS,Verbunt J,van den Berg WB

    更新日期:1993-10-01 00:00:00

  • Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus.

    abstract:OBJECTIVES:Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease, mediated by disrupted B cell quiescence and typically treated with glucocorticoids. We studied whether B cells in SLE are regulated by the glucocorticoid-induced leucine zipper (GILZ) protein, an endogenous mediator of anti-infla...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2015-207744

    authors: Jones SA,Toh AE,Odobasic D,Oudin MA,Cheng Q,Lee JP,White SJ,Russ BE,Infantino S,Light A,Tarlinton DM,Harris J,Morand EF

    更新日期:2016-04-01 00:00:00

  • Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma: placental findings.

    abstract:OBJECTIVE:Pregnant women with systemic sclerosis (SSc; scleroderma) have an increased risk of premature delivery and small full-term infants. During placental development, angiogenesis and vascular remodelling are essential for a successful pregnancy outcome. An analysis was made of the pathological changes and express...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2009.107623

    authors: Ibba-Manneschi L,Manetti M,Milia AF,Miniati I,Benelli G,Guiducci S,Mecacci F,Mello G,Di Lollo S,Matucci-Cerinic M

    更新日期:2010-02-01 00:00:00

  • Rasch analysis of the Western Ontario MacMaster questionnaire (WOMAC) in 2205 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia.

    abstract:OBJECTIVE:Advances in health measurement have led to the application of Rasch Item Response Theory (IRT) analysis (Rasch analysis) to evaluate instruments measuring health status and quality of life of patients, including the Health Assessment Questionnaire and SF-36. This study investigated the extent to which the Wes...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.58.9.563

    authors: Wolfe F,Kong SX

    更新日期:1999-09-01 00:00:00

  • ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis.

    abstract:OBJECTIVE:To assess the expression of ICAM1, VCAM1, E-selectin, CD44, and TNF alpha in labial salivary glands of patients with rheumatoid vasculitis. METHODS:Labial salivary glands from six patients with rheumatoid vasculitis before and after treatment, six aged matched rheumatoid arthritis patients without clinical e...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.56.1.41

    authors: Flipo RM,Cardon T,Copin MC,Vandecandelaere M,Duquesnoy B,Janin A

    更新日期:1997-01-01 00:00:00

  • The shape of the distal femur: a palaeopathological comparison of eburnated and non-eburnated femora.

    abstract:OBJECTIVES:To determine the difference in shape of the distal femur, viewed axially in two dimensions, between eburnated and non-eburnated femora. METHODS:A comparison of 52 non-eburnated and 16 eburnated femora drawn from a large archeological skeletal population. Eburnation was taken to indicate late stage osteoarth...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.58.2.72

    authors: Shepstone L,Rogers J,Kirwan J,Silverman B

    更新日期:1999-02-01 00:00:00

  • Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography.

    abstract:OBJECTIVE:To measure gelatinase activities in paired synovial fluid (SF) and serum of patients with juvenile idiopathic arthritis (JIA), and to assess how these activities relate to clinical and laboratory measures of disease activity. METHODS:A quantitative protein substrate zymography method was adapted and validate...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2005.039032

    authors: Peake NJ,Foster HE,Khawaja K,Cawston TE,Rowan AD

    更新日期:2006-04-01 00:00:00