Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?


:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA, ACPA enhances arthritis. Furthermore, in vitro generated immune complexes with ACPA can activate macrophages and the complement system in the human system. Recently, a direct functional and specific response of FcεRI+ immune cells towards citrullinated proteins was demonstrated. Basophils of ACPA+ RA patients are activated by citrullinated proteins that cross link the FcεRI receptor via IgE-ACPA, physiologically bound to the receptor. In addition, synovial mast cells from ACPA+ RA patients show a more activated phenotype than mast cells from ACPA- patients. These findings underline the suggestion that ACPA+ and ACPA- RA are two different disease entities and point to a possible functional role of ACPA and FcεRI+ cells in the pathogenesis of RA.


Ann Rheum Dis


Suurmond J,Schuerwegh AJ,Toes RE




Has Abstract


2011-03-01 00:00:00










70 Suppl 1


  • Prevalence of rheumatoid arthritis in France: 2001.

    abstract:BACKGROUND:Prevalence estimates of rheumatoid arthritis (RA) vary across Europe. Recent estimates in southern European countries showed a lower prevalence than in northern countries. OBJECTIVES:To estimate the prevalence of RA in France in a multiregional representative sample in the year 2001. METHODS:A two stage ra...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Guillemin F,Saraux A,Guggenbuhl P,Roux CH,Fardellone P,Le Bihan E,Cantagrel A,Chary-Valckenaere I,Euller-Ziegler L,Flipo RM,Juvin R,Behier JM,Fautrel B,Masson C,Coste J

    更新日期:2005-10-01 00:00:00

  • Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.

    abstract:BACKGROUND:Certain sequences present in the hypervariable region of human leucocyte antigen (HLA)-DRB1 known as the shared epitope (SE) are hypothesised to increase the risk of rheumatoid arthritis (RA), whereas alleles encoding aspartic acid at position 70 (D70 alleles) may have a protective effect. METHODS:Patient H...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Shadick NA,Heller JE,Weinblatt ME,Maher NE,Cui J,Ginsburg G,Coblyn J,Anderson R,Solomon DH,Roubenoff R,Parker A

    更新日期:2007-11-01 00:00:00

  • Predicting the onset of knee pain: results from a 2-year prospective study of new workers.

    abstract:OBJECTIVE:To determine the relative contribution of work-related mechanical (injury) factors and psychosocial factors to the onset of a new episode of knee pain, in a cohort of newly employed workers. METHODS:A prospective cohort study of newly employed workers from 12 diverse occupational settings in England (The New...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Jones GT,Harkness EF,Nahit ES,McBeth J,Silman AJ,Macfarlane GJ

    更新日期:2007-03-01 00:00:00

  • False positive results for antibody to HIV in two men with systemic lupus erythematosus.

    abstract::False positive results were obtained for HIV tests in two men with active systemic lupus erythematosus (SLE) who were suspected of being infected with HIV because of fever, weight loss, lymphadenopathy, and inflammatory myopathy. Enzyme linked immunosorbent assays (ELISAs) for HIV were twice positive when tested three...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Esteva MH,Blasini AM,Ogly D,Rodríguez MA

    更新日期:1992-09-01 00:00:00

  • Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse.

    abstract:OBJECTIVES:An abnormal CD4+ T cell subset related to inflammation exposure (inflammation-related cells, IRC) has been identified in rheumatoid arthritis (RA). Patients with inflammatory and non-inflammatory diseases were used to examine the relationship between inflammation and this T cell subset in vivo. METHODS:Bloo...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Burgoyne CH,Field SL,Brown AK,Hensor EM,English A,Bingham SL,Verburg R,Fearon U,Lawson CA,Hamlin PJ,Straszynski L,Veale D,Conaghan P,Hull MA,van Laar JM,Tennant A,Emery P,Isaacs JD,Ponchel F

    更新日期:2008-06-01 00:00:00

  • Autonomic neuropathy in systemic sclerosis: a case report and evaluation of six patients.

    abstract::We describe a case of systemic sclerosis with sympathetic and parasympathetic neuropathy and detail autonomic testing in six further patients. Of these six patients, three showed early parasympathetic damage. None of the patients had evidence of peripheral neuropathy, and there was no correlation between the presence ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Sonnex C,Paice E,White AG

    更新日期:1986-11-01 00:00:00

  • Severe alterations in expression and localisation of {alpha}6{beta}4 integrin in salivary gland acini from patients with Sjogren syndrome.

    abstract:OBJECTIVES:In salivary glands from patients with Sjögren syndrome, overexpression of laminins 1 and 5 and disorganisation of the acinar basal lamina have been reported. Laminin 5 mediates association of the basal lamina with epithelial cells by forming adhesion complexes upon interaction with alpha6beta4 integrin. In t...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Velozo J,Aguilera S,Alliende C,Ewert P,Molina C,Pérez P,Leyton L,Quest A,Brito M,González S,Leyton C,Hermoso M,Romo R,González MJ

    更新日期:2009-06-01 00:00:00

  • Interleukin 6 is not a crucial regulator in an animal model of tumour necrosis factor-mediated bilateral sacroiliitis.

    abstract:OBJECTIVE:To evaluate the role of interleukin 6 (IL-6) in the pathogenesis of bilateral erosive sacroiliitis in human tumour necrosis factor transgenic (hTNFtg) mice, an animal model of ankylosing spondylitis (AS). METHODS:Histological sections of the sacroiliac joints from hTNFtg and IL-6(-/-)hTNFtg mice were evaluat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Hayer S,Niederreiter B,Nagelreiter I,Smolen J,Redlich K

    更新日期:2010-07-01 00:00:00

  • Treatment with cimetidine of atypical fasciitis panniculitis syndrome.

    abstract::Three patients presented with septal fasciitis and panniculitis, associated with clinical and laboratory features which precluded straight-forward classification into eosinophilic fasciitis, localised scleroderma, or lupus erythematosus profundus. Treatment with cimetidine caused the remission of cutaneous manifestati...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Naschitz JE,Yeshurun D,Rosner I,Abrahamson JE,Misselevitch I,Boss JH

    更新日期:1990-10-01 00:00:00

  • Disease activity-guided dose optimisation of adalimumab and etanercept is a cost-effective strategy compared with non-tapering tight control rheumatoid arthritis care: analyses of the DRESS study.

    abstract:BACKGROUND:A disease activity-guided dose optimisation strategy of adalimumab or etanercept (TNFi (tumour necrosis factor inhibitors)) has shown to be non-inferior in maintaining disease control in patients with rheumatoid arthritis (RA) compared with usual care. However, the cost-effectiveness of this strategy is stil...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kievit W,van Herwaarden N,van den Hoogen FH,van Vollenhoven RF,Bijlsma JW,van den Bemt BJ,van der Maas A,den Broeder AA

    更新日期:2016-11-01 00:00:00

  • FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue.

    abstract:OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

    更新日期:2010-04-01 00:00:00

  • A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.

    abstract:OBJECTIVES:Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors, which regulate the production of proinflammatory cytokines. Polymorphisms in the IRF5 gene have been associated with susceptibility to systemic lupus erythaematosus (SLE) in Caucasian and Asian populations, but thei...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Shimane K,Kochi Y,Yamada R,Okada Y,Suzuki A,Miyatake A,Kubo M,Nakamura Y,Yamamoto K

    更新日期:2009-03-01 00:00:00

  • Subacute bacterial endocarditis in a patient with ankylosing spondylitis.

    abstract::A 57 year old white man with aortic insufficiency and previously undiagnosed ankylosing spondylitis, who developed subacute bacterial endocarditis (SBE), is described. Emergency aortic valve replacement was necessary, and the aortic valve pathology showed diffusely fibrosed and thickened valve leaflets with bacterial ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Hoppmann RA,Wise CM,Challa VR,Peacock JE

    更新日期:1988-05-01 00:00:00

  • Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood.

    abstract:OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

    更新日期:2015-06-01 00:00:00

  • Extent and distribution of CPP deposits in patients affected by calcium pyrophosphate dihydrate deposition disease: an ultrasonographic study.

    abstract:OBJECTIVE:To assess the extent of calcium pyrophosphate dihydrate (CPP) crystal deposition and the distribution of affected sites, using ultrasonography (US), in patients affected by CPP deposition disease (CPPD). PATIENTS AND METHODS:42 consecutive patients affected by definite CPPD according to the McCarty criteria ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Filippou G,Filippucci E,Tardella M,Bertoldi I,Di Carlo M,Adinolfi A,Grassi W,Frediani B

    更新日期:2013-11-01 00:00:00

  • The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STA

    abstract:OBJECTIVE:To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. METHODS:A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres partic...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Filippou G,Sakellariou G,Scirè CA,Carrara G,Rumi F,Bellis E,Adinolfi A,Batticciotto A,Bortoluzzi A,Cagnotto G,Caprioli M,Canzoni M,Cavatorta FP,De Lucia O,Di Sabatino V,Draghessi A,Farina I,Focherini MC,Gabba A,Guti

    更新日期:2018-09-01 00:00:00

  • Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative.

    abstract:OBJECTIVE:Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular cartilage structure predict knee replacement, and to establish their utility as outcomes in cli...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Eckstein F,Kwoh CK,Boudreau RM,Wang Z,Hannon MJ,Cotofana S,Hudelmaier MI,Wirth W,Guermazi A,Nevitt MC,John MR,Hunter DJ,OAI investigators.

    更新日期:2013-05-01 00:00:00

  • Bacterial and viral superantigens: roles in autoimmunity?

    abstract::Superantigens are bacterial, viral, or retroviral proteins which can activate specifically a large proportion of T cells. In contrast with classical peptide antigen recognition, superantigens do not require processing to small peptides but act as complete or partially processed proteins. They can bind to major histoco...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Acha-Orbea H

    更新日期:1993-03-01 00:00:00

  • Acute tropical polyarthritis in Zimbabwe: a prospective search for a gonococcal aetiology.

    abstract::Fifteen consecutive patients with acute arthritis were studied. Careful culture and microscopy of swabs from mucosal sites were performed to examine the hypothesis that the acute tropical polyarthritis commonly seen in Zimbabwe is due to undiagnosed gonococcal infection. Rheumatic fever and Reiter's disease accounted ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Stein CM,Hanly MG

    更新日期:1987-12-01 00:00:00

  • Incidences of overall and site specific cancers in TNFα inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry.

    abstract:OBJECTIVES:To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I). METHODS:Arthritis patients from the DANBIO database were followed-up for cancer in the Danish Cancer Registry during 2000-2008. RESULTS:Hazard ratio for cancer overall was 1.02 (95% confidence inte...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Dreyer L,Mellemkjær L,Andersen AR,Bennett P,Poulsen UE,Juulsgaard Ellingsen T,Hansen TH,Jensen DV,Linde L,Lindegaard HM,Loft AG,Nordin H,Omerovic E,Rasmussen C,Schlemmer A,Tarp U,Hetland ML

    更新日期:2013-01-01 00:00:00

  • Measurement of plasma DNA by a physiochemical method: relevance in SLE.

    abstract::Plasma DNA has been measured by a new physiochemical approach based on fluorimetric analysis of phenol extracted nucleic acids electrophoresed on polyacrylamide gels. This method is specific for native double-stranded DNA of molecular weight greater than 5 x 10(6). The use of plasma rigorously freed of leucocytes is e...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Klemp P,Meyers OL,Harley EH

    更新日期:1981-12-01 00:00:00

  • Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli.

    abstract::The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Clarke AK,Vernon-Roberts B,Currey HL

    更新日期:1975-08-01 00:00:00

  • Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review.

    abstract:OBJECTIVE:To systematically evaluate the association between MRI findings (cartilage defects, bone marrow lesions (BML), osteophytes, meniscal lesion, effusion/synovitis, ligamentous abnormalities, subchondral cysts and bone attrition) and pain in patients with knee osteoarthritis (OA) in order to establish the relevan...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Yusuf E,Kortekaas MC,Watt I,Huizinga TW,Kloppenburg M

    更新日期:2011-01-01 00:00:00

  • Successful valve replacement for aortic incompetence in rheumatoid arthritis with vasculitis.

    abstract::A patient with rheumatoid arthritis (RA), vasculitis, and aortic valve incompetence of the histologically nonspecific type is described. Valve replacement was undertaken, and an excellent haemodynamic result was achieved. Both arthritis and vasculitis subsequently remitted. Valve replacement can be successfully perfor...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Liew M,Wilson D,Horton D,Fleming A

    更新日期:1979-10-01 00:00:00

  • Ethical and legal constraints on data sharing between countries in multinational epidemiological studies in Europe report from a joint workshop of the European League Against Rheumatism standing committee on epidemiology with the "AutoCure" project.

    abstract:BACKGROUND:We report on a workshop on ethical and legal constraints on data sharing between countries in multinational epidemiologic research in Europe that was held in January 2007 in Potsdam, Germany. The participants were experienced epidemiologic and clinical researchers from eight European countries. The aim of th...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章


    authors: Zink A,Silman AJ

    更新日期:2008-07-01 00:00:00

  • Music related upper limb pain in schoolchildren.

    abstract::Two British secondary schools (one a specialist music school) were surveyed to assess the prevalence of upper limb pain among specialist music students compared with students in a regular school setting. Female students tended to report pain more often than male students, but for both significantly higher prevalence w...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Fry HJ,Rowley GL

    更新日期:1989-12-01 00:00:00

  • A seroepidemiological study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome.

    abstract::Antibodies to cytomegalovirus (CMV) and Epstein-Barr virus capsid antigen (EBVCA) were examined in 41 patients with rheumatoid arthritis (RA), 26 patients with primary sicca syndrome, and 26 healthy subjects of similar age and sex. IgG antibody titres to EBVCA and CMV were similar in all three groups, apart from a tri...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Venables PJ,Ross MG,Charles PJ,Melsom RD,Griffiths PD,Maini RN

    更新日期:1985-11-01 00:00:00

  • IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.

    abstract:OBJECTIVE:The first genome-wide association study (GWAS) of systemic sclerosis (SSc) demonstrated three non-major histocompatibility complex (MHC) susceptibility loci. The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc. METHODS...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Sharif R,Mayes MD,Tan FK,Gorlova OY,Hummers LK,Shah AA,Furst DE,Khanna D,Martin J,Bossini-Castillo L,Gonzalez EB,Ying J,Draeger HT,Agarwal SK,Reveille JD,Arnett FC,Wigley FM,Assassi S

    更新日期:2012-07-01 00:00:00

  • Systemic and mucosal antibodies to Klebsiella in patients with ankylosing spondylitis and Crohn's disease.

    abstract::Whole gut lavage fluid is a useful source of material for the study of intestinal immunity and inflammation in humans. Systemic and mucosal antibodies to Klebsiella pneumoniae were measured by enzyme linked immunosorbent assay (ELISA) in serum samples and whole gut lavage fluid from 14 patients with ankylosing spondyl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: O'Mahony S,Anderson N,Nuki G,Ferguson A

    更新日期:1992-12-01 00:00:00

  • Growing wrist mass.

    abstract::A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. Magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Peh WC,Shek TW,Ip WY

    更新日期:2001-06-01 00:00:00