Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?

Abstract:

:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA, ACPA enhances arthritis. Furthermore, in vitro generated immune complexes with ACPA can activate macrophages and the complement system in the human system. Recently, a direct functional and specific response of FcεRI+ immune cells towards citrullinated proteins was demonstrated. Basophils of ACPA+ RA patients are activated by citrullinated proteins that cross link the FcεRI receptor via IgE-ACPA, physiologically bound to the receptor. In addition, synovial mast cells from ACPA+ RA patients show a more activated phenotype than mast cells from ACPA- patients. These findings underline the suggestion that ACPA+ and ACPA- RA are two different disease entities and point to a possible functional role of ACPA and FcεRI+ cells in the pathogenesis of RA.

journal_name

Ann Rheum Dis

authors

Suurmond J,Schuerwegh AJ,Toes RE

doi

10.1136/ard.2010.138032

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

i55-8

eissn

0003-4967

issn

1468-2060

pii

70/Suppl_1/i55

journal_volume

70 Suppl 1

pub_type

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