Anti-citrullinated protein antibodies in rheumatoid arthritis: a functional role for mast cells and basophils?

abstract：BACKGROUND:Bone erosion is a common manifestation of chronic tophaceous gout. OBJECTIVES:To investigate the effects of monosodium urate monohydrate (MSU) crystals on osteoblast viability and function. METHODS:The MTT assay and flow cytometry were used to assess osteoblast cell viability in the MC3T3-E1 and ST2 osteob...

journal_title：Annals of the rheumatic diseases

authors： Chhana A,Callon KE,Pool B,Naot D,Watson M,Gamble GD,McQueen FM,Cornish J,Dalbeth N

更新日期：2011-09-01 00:00:00

abstract：:Thirty patients with classical or definite rheumatoid disease (RD) with foot pain and radiologically demonstrated erosions were studied electrodiagnostically to ascertain the frequency of the tarsal tunnel syndrome and peripheral neuropathy. Four patients (13.3%) had evidence of the tarsal tunnel syndrome. The electri...

journal_title：Annals of the rheumatic diseases

authors： McGuigan L,Burke D,Fleming A

更新日期：1983-04-01 00:00:00

abstract：:Decreased immunoglobulin production in pokeweed mitogen driven lymphocyte cultures has been reported in rheumatoid arthritis (RA). Here various activators and experimental designs have been used to determine the contribution of B cells, T cells, or monocytes to this low response. Sixty patients with RA and paired cont...

journal_title：Annals of the rheumatic diseases

authors： Jokinen I,Poikonen K,Möttönen T,Hannonen P,Oka M,Ilonen J,Surcel HM,Karttunen R,Arvilommi H

更新日期：1990-07-01 00:00:00

abstract：:Cultures of synovial cells obtained at surgery from patients with rheumatoid arthritis produced a protein which inhibits the mitosis of normal rabbit and human synovial cells, and of human lung fibroblasts. This mitotic inhibitory effect can be transferred to rabbit synovial cells by intra-articular injection of the a...

journal_title：Annals of the rheumatic diseases

authors： Smith CA

更新日期：1978-04-01 00:00:00

abstract：OBJECTIVE:To assess survival and identify predictors of survival in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated in the Scleroderma Lung Studies (SLS) I and II. METHODS:SLS I randomised 158 patients with SSc-ILD to 1  year of oral cyclophosphamide (CYC) vs placebo. SLS II rando...

journal_title：Annals of the rheumatic diseases

authors： Volkmann ER,Tashkin DP,Sim M,Li N,Goldmuntz E,Keyes-Elstein L,Pinckney A,Furst DE,Clements PJ,Khanna D,Steen V,Schraufnagel DE,Arami S,Hsu V,Roth MD,Elashoff RM,Sullivan KM,SLS I and SLS II study groups.

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To study the ability of low-cost low-field dedicated extremity magnetic resonance imaging (E-MRI) to assess and predict erosive joint damage in the wrist and metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis. METHODS:24 previously untreated patients with rheumatoid arthritis with j...

journal_title：Annals of the rheumatic diseases

authors： Lindegaard HM,Vallø J,Hørslev-Petersen K,Junker P,Østergaard M

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:To study the risk of a second malignant neoplasm (SMN) and mortality in patients with rheumatoid arthritis (RA) with a history of a primary cancer diagnosis and treated with biological disease-modifying antirheumatic drugs (bDMARD). METHODS:Among patients with RA (n=15 286) registered in the DANBIO Register ...

journal_title：Annals of the rheumatic diseases

authors： Dreyer L,Cordtz RL,Hansen IMJ,Kristensen LE,Hetland ML,Mellemkjaer L

更新日期：2018-04-01 00:00:00

abstract：:One hundred acute geriatric inpatients were assessed to investigate the prevalence of shoulder disorders; 21 had symptoms due to shoulder disease. Conditions included supraspinatus tendinitis (five), chronic rotator cuff rupture (seven), frozen shoulder (two), glenohumeral osteoarthritis (two), apatite related shoulde...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Hazleman BL

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and suppressive capacity of regulatory T cells (T(reg)) and their association with clinical parameters in patients with systemic scleroderma (SSc). METHODS:Peripheral blood from 25 patients with SSc, 15 patients with localised scleroderma (LS) and 29 healthy controls (HC) was studi...

journal_title：Annals of the rheumatic diseases

authors： Klein S,Kretz CC,Ruland V,Stumpf C,Haust M,Hartschuh W,Hartmann M,Enk A,Suri-Payer E,Oberle N,Krammer PH,Kuhn A

更新日期：2011-08-01 00:00:00

abstract：:Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are a marker of bone formation. Because bone demineralisation is a common finding in patients with rheumatoid arthritis (RA)...

journal_title：Annals of the rheumatic diseases

authors： Pietschmann P,Machold KP,Wolosczuk W,Smolen JS

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Oral glucosamine preparations are widely used as a treatment for osteoarthritis, purportedly functioning by a variety of mechanisms suggested by results of in vitro experiments, and generally using glucosamine concentrations well in excess of 100 micromol/l. OBJECTIVE:To use high performance liquid chromato...

journal_title：Annals of the rheumatic diseases

authors： Biggee BA,Blinn CM,McAlindon TE,Nuite M,Silbert JE

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). METHODS:Fifty-eight forearm biopsies were evaluated from 26 individuals with dcSSc in two clinical trials. Histologic/immunophenotypic assessments of glob...

journal_title：Annals of the rheumatic diseases

authors： Showalter K,Spiera R,Magro C,Agius P,Martyanov V,Franks JM,Sharma R,Geiger H,Wood TA,Zhang Y,Hale CR,Finik J,Whitfield ML,Orange DE,Gordon JK

更新日期：2021-02-01 00:00:00

abstract：:There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proli...

journal_title：Annals of the rheumatic diseases

authors： Niedbala W,Cai B,Liew FY

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To investigate the activation of NF-kappaB in the carrageenan rat air pouch model of inflammation in a time course experiment, and the effect of dexamethasone on NF-kappaB activation. METHODS:Air pouch tissue treated with carrageenan (inflamed tissue) was obtained from rats killed at days 1, 2, 3, 6, 14, 21,...

journal_title：Annals of the rheumatic diseases

authors： Ellis L,Gilston V,Soo CC,Morris CJ,Kidd BL,Winyard PG

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

journal_title：Annals of the rheumatic diseases

authors： Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of...

journal_title：Annals of the rheumatic diseases

authors： Kloppenburg M,Stamm T,Watt I,Kainberger F,Cawston TE,Birrell FN,Petersson IF,Saxne T,Kvien TK,Slatkowsky-Christensen B,Dougados M,Gossec L,Breedveld FC,Smolen JS

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate serum interleukin (IL) 12 concentration in patients with juvenile chronic arthritis (JCA), according to disease subtype, activity, and duration. IL12 has been demonstrated to prime the selective expansion of T helper (Th) cells with a Th1-type pattern of cytokine product...

journal_title：Annals of the rheumatic diseases

authors： Gattorno M,Picco P,Vignola S,Stalla F,Buoncompagni A,Pistoia V

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the presence of flow by Doppler ultrasound (DUS) in the wrist and finger joints (carpometacarpal 1 (CMC1), metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints) of healthy controls. METHODS:Twenty seven healthy volunteers (15 women, 12 men; mean age 45 years, range 18-93) with a t...

journal_title：Annals of the rheumatic diseases

authors： Terslev L,Torp-Pedersen S,Qvistgaard E,von der Recke P,Bliddal H

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:To develop and validate candidate sets of joints and tendons for assessment of ultrasound (US) joint inflammation in rheumatoid arthritis (RA). METHODS:Patients were included in one of two cohorts from 2010 to June 2013: disease-modifying antirheumatic drug naïve early RA or established RA starting/switchin...

journal_title：Annals of the rheumatic diseases

authors： Aga AB,Hammer HB,Olsen IC,Uhlig T,Kvien TK,van der Heijde D,Fremstad H,Madland TM,Lexberg ÅS,Haukeland H,Rødevand E,Høili C,Stray H,Bendvold AN,Soldal DM,Bakland G,Lie E,Haavardsholm EA

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:A number of tumour necrosis factor α (TNFα) antagonists (anti-TNFα) are available to treat rheumatoid arthritis. All of these have demonstrated considerable efficacy in placebo controlled trials, but few head-to-head comparisons exist to date. This work's objective is to estimate the relative efficacy among ...

journal_title：Annals of the rheumatic diseases

authors： Schmitz S,Adams R,Walsh CD,Barry M,FitzGerald O

更新日期：2012-02-01 00:00:00

abstract：:The cellular events underlying the pathogenesis of psoriatic arthritis (PsA) and psoriasis have not yet been fully elucidated. Nevertheless, some clues to these conditions are beginning to emerge. In particular, a growing body of data supports the role of proinflammatory cytokines, such as tumour necrosis factor (TNF)...

journal_title：Annals of the rheumatic diseases

authors： Mease PJ

更新日期：2001-11-01 00:00:00

abstract：:Recent data are presented which indicate a critical role for interleukin (IL)-18 in rheumatoid arthritis (RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL-18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of I...

journal_title：Annals of the rheumatic diseases

authors： Dai SM,Shan ZZ,Xu H,Nishioka K

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functio...

journal_title：Annals of the rheumatic diseases

authors： Bocelli-Tyndall C,Trella E,Frachet A,Zajac P,Pfaff D,Geurts J,Heiler S,Barbero A,Mumme M,Resink TJ,Schaeren S,Spagnoli GC,Tyndall A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To determine, using the method of adjusted indirect comparisons, whether there are differences in efficacy of tumour necrosis factor (TNF alpha) blocking agents, as measured by the rate ratios for American College of Rheumatology (ACR) 20, 50, and 70 responses, in patients with rheumatoid arthritis with an in...

journal_title：Annals of the rheumatic diseases

authors： Hochberg MC,Tracy JK,Hawkins-Holt M,Flores RH

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVES:Rheumatoid arthritis (RA) is less common among men than women, and sex hormones have been suggested to play a part in the pathogenesis. Lower levels of testosterone have been demonstrated in men with RA, but it is not known if these changes precede the disease. METHODS:In a nested case-control study, using ...

journal_title：Annals of the rheumatic diseases

authors： Pikwer M,Giwercman A,Bergström U,Nilsson JÅ,Jacobsson LT,Turesson C

更新日期：2014-03-01 00:00:00

abstract：:Four patients with Neisseria meningitidis infection complicated by arthritis are described. Three patients had an acute polyarthritis which responded quickly to antimicrobial therapy. A fourth patient developed a prolonged arthritis which occurred after the initial infection had been successfully treated. Tenosynoviti...

journal_title：Annals of the rheumatic diseases

authors： Kidd BL,Hart HH,Grigor RR

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:To study the association between the occurrence of peripheral arthritis and of acute anterior uveitis during the course of ankylosing spondylitis (AS). METHODS:Retrospective clinical follow up by both chart review and direct patient interview was performed on 271 individuals comprised of 222 local white and ...

journal_title：Annals of the rheumatic diseases

authors： Maksymowych WP,Chou CT,Russell AS

更新日期：1995-02-01 00:00:00

abstract：:The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of ea...

journal_title：Annals of the rheumatic diseases

authors： Garrett R,Manthey B,Vernon-Roberts B,Brooks PM

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:To analyse tender and swollen joint counts in three cohorts of patients with rheumatoid arthritis (RA), with a focus on the proportions of patients who had fewer than 6-12 tender or swollen joints, as possible evidence based information toward more generalisable inclusion criteria for current and future RA cl...

journal_title：Annals of the rheumatic diseases

authors： Pincus T,Sokka T,Chung CP,Cawkwell G

更新日期：2006-07-01 00:00:00

abstract：:One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is unclear, but has been suggested to be a lipoprotein. Sera from patients with (1) systemic necrotising arteritis (polyarter...

journal_title：Annals of the rheumatic diseases

authors： Blake DR,Winyard P,Scott DG,Brailsford S,Blann A,Lunec J

更新日期：1985-03-01 00:00:00