MICL controls inflammation in rheumatoid arthritis.

abstract：OBJECTIVE:Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular cartilage structure predict knee replacement, and to establish their utility as outcomes in cli...

journal_title：Annals of the rheumatic diseases

authors： Eckstein F,Kwoh CK,Boudreau RM,Wang Z,Hannon MJ,Cotofana S,Hudelmaier MI,Wirth W,Guermazi A,Nevitt MC,John MR,Hunter DJ,OAI investigators.

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Increasing age at onset has been associated with worse outcome in rheumatoid arthritis, although there are few data from unselected inception cohorts. HYPOTHESIS:Increasing age is associated with a higher risk of erosions at presentation, and this increase is not explained by age-related disease confounders...

journal_title：Annals of the rheumatic diseases

authors： Bukhari M,Lunt M,Barton A,Bunn D,Silman A,Symmons D

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:There are no agreed criteria for osteoarthritis (OA) of the knee in population studies. The radiographic scoring system of Kellgren and Lawrence has been the system most used in the past and although other methods have been developed, comparisons have not been performed. Therefore these grading systems were ...

journal_title：Annals of the rheumatic diseases

authors： Spector TD,Hart DJ,Byrne J,Harris PA,Dacre JE,Doyle DV

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:To estimate the incidence and consultation rate of lower extremity complaints in general practice. METHODS:Data were obtained from the Second Dutch National Survey of General Practice, in which 195 general practitioners (GPs) in 104 practices recorded all contacts with patients during 12 consecutive months i...

journal_title：Annals of the rheumatic diseases

authors： van der Waal JM,Bot SD,Terwee CB,van der Windt DA,Schellevis FG,Bouter LM,Dekker J

更新日期：2006-06-01 00:00:00

abstract：:Three patients presented with septal fasciitis and panniculitis, associated with clinical and laboratory features which precluded straight-forward classification into eosinophilic fasciitis, localised scleroderma, or lupus erythematosus profundus. Treatment with cimetidine caused the remission of cutaneous manifestati...

journal_title：Annals of the rheumatic diseases

authors： Naschitz JE,Yeshurun D,Rosner I,Abrahamson JE,Misselevitch I,Boss JH

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

journal_title：Annals of the rheumatic diseases

authors： Akiyama S,Hamdeh S,Micic D,Sakuraba A

更新日期：2020-10-13 00:00:00

abstract：OBJECTIVES:To compare the prevalence and pattern of neuropsychiatric (NP) syndromes observed in systemic lupus erythematosus (SLE) to patients with Primary Sjögren syndrome (PSS) using the American College of Rheumatology (ACR) criteria for the 19 NP syndromes seen in SLE. METHODS:A population-based study was conducte...

journal_title：Annals of the rheumatic diseases

authors： Harboe E,Tjensvoll AB,Maroni S,Gøransson LG,Greve OJ,Beyer MK,Herigstad A,Kvaløy JT,Omdal R

更新日期：2009-10-01 00:00:00

abstract：:Osteotomies on 101 knees in 79 patients were assessed either prospectively or retrospectively. High tibial osteotomy was performed in 54 knees (27 with rheumatoid arthritis (RA) and 27 with osteoarthrosis (OA)) and double (tibiofemoral) osteotomy in 47 knees (25 RA and 22 OA), and were assessed prospectively in 46 and...

journal_title：Annals of the rheumatic diseases

authors： Iveson JM,Longton EB,Wright V

更新日期：1977-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of canakinumab to treat patients with colchicine-resistant familial Mediterranean fever (crFMF) during Epoch 4 (weeks 41 to 113) of the CLUSTER study. METHODS:Patients received open-label canakinumab 150 or 300 mg, every 4 or 8 weeks during a 72-week period. We ...

journal_title：Annals of the rheumatic diseases

authors： Ozen S,Ben-Cherit E,Foeldvari I,Amarilyo G,Ozdogan H,Vanderschueren S,Marzan K,Kahlenberg JM,Dekker E,De Benedetti F,Koné-Paut I

更新日期：2020-10-01 00:00:00

abstract：:The circulating levels of hyaluronate were determined in 36 patients with scleroderma and in 36 control subjects matched for age and sex. The mean serum hyaluronate concentration in patients with progressive systemic sclerosis (n = 25) was 131 +/- 67 (SD) microgram/l and significantly greater (p less than 0.001) than ...

journal_title：Annals of the rheumatic diseases

authors： Engström-Laurent A,Feltelius N,Hällgren R,Wasteson A

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:To investigate the possibility of drug-free remission in patients with psoriatic arthritis (PsA) in continuous remission. METHODS:Prospective observational study in disease-modifying antirheumatic drug (DMARD)-treated PsA patients in continuous disease remission (no musculoskeletal symptoms, no or minimal sk...

journal_title：Annals of the rheumatic diseases

authors： Araujo EG,Finzel S,Englbrecht M,Schreiber DA,Faustini F,Hueber A,Nas K,Rech J,Schett G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Despite the lower prevalence of obesity (a known risk factor for osteoarthritis (OA)), the prevalence of lateral tibiofemoral OA is higher in Chinese communities compared with Caucasian communities. One potential explanation is the difference in knee alignment between the two populations. We measured various ...

journal_title：Annals of the rheumatic diseases

authors： Harvey WF,Niu J,Zhang Y,McCree PI,Felson DT,Nevitt M,Xu L,Aliabadi P,Hunter DJ

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjögren syndrome. METHODS:Cryostat sections of labial salivary glands from 15 patients with primary Sjögren syndrome were examined by an indirect immunoperoxidase technique and monoclonal antibodies to a pa...

journal_title：Annals of the rheumatic diseases

authors： Aziz KE,McCluskey PJ,Wakefield D

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To examine the effects of smoking on cartilage loss and pain at the knee in individuals with knee osteoarthritis. METHODS:159 men with symptomatic knee osteoarthritis who participated in a 30-month, prospective, natural history study of knee osteoarthritis were examined. The more symptomatic knee was imaged ...

journal_title：Annals of the rheumatic diseases

authors： Amin S,Niu J,Guermazi A,Grigoryan M,Hunter DJ,Clancy M,LaValley MP,Genant HK,Felson DT

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. METHODS:TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical c...

journal_title：Annals of the rheumatic diseases

authors： Pettipher C,Benitha R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To study long term utility of early, continual, and serial use of disease modifying antirheumatic drugs (DMARDs) in early rheumatoid arthritis (RA) in clinical setting. METHODS:A total of 135 patients with early RA were treated according to the "sawtooth" strategy and prospectively followed up to 15 years. ...

journal_title：Annals of the rheumatic diseases

authors： Sokka T,Hannonen P

更新日期：1999-10-01 00:00:00

abstract：:The incidence of exacerbations in the disease course was investigated in 110 patients with systemic lupus erythematosus (SLE) who were studied prospectively at our institute for lupus research. At the time of disease onset and diagnosis the male patients were much older than the female patients (about 10 years); exace...

journal_title：Annals of the rheumatic diseases

authors： Swaak AJ,Nossent JC,Bronsveld W,van Rooyen A,Nieuwenhuys EJ,Theuns L,Smeenk RJ

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Rheumatoid factors (RFs) and antibodies against cyclic citrullinated peptides (CCPs) of IgG, IgA and IgM isotype have been shown to precede disease onset by years. OBJECTIVE:To evaluate serological risk markers in first-degree relatives from multicase families in relation to genetic and environmental risk f...

journal_title：Annals of the rheumatic diseases

authors： Ärlestig L,Mullazehi M,Kokkonen H,Rocklöv J,Rönnelid J,Dahlqvist SR

更新日期：2012-06-01 00:00:00

abstract：:Sheep red cells coated with rabbit IgG antibody may be used to detect IgM rheumatoid factors either by agglutination or microscopically by the fluorescence of antihuman IgM antibody conjugate bound to rheumatoid factors on the cell surface. By substituting for red cells the plastic surface of a filter disc coated with...

journal_title：Annals of the rheumatic diseases

authors： Lea DJ,Ward DJ

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate the role of CD8 cell subsets in the pathogenesis of rheumatoid arthritis (RA) and the phenotypes of T cells adherent or non-adherent to the target cells (endothelial cells and synovial cells) pre-treated with IL-1 beta. METHODS:The expression of S6F1 on CD8 cells and that of an activation mark...

journal_title：Annals of the rheumatic diseases

authors： Ueki Y,Eguchi K,Miyake S,Nagataki S,Tominaga Y

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

journal_title：Annals of the rheumatic diseases

authors： Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

更新日期：2020-11-04 00:00:00

abstract：:Four patients with Neisseria meningitidis infection complicated by arthritis are described. Three patients had an acute polyarthritis which responded quickly to antimicrobial therapy. A fourth patient developed a prolonged arthritis which occurred after the initial infection had been successfully treated. Tenosynoviti...

journal_title：Annals of the rheumatic diseases

authors： Kidd BL,Hart HH,Grigor RR

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA). METHODS:A randomised, double-blind, placebo-controlled, dose-e...

journal_title：Annals of the rheumatic diseases

authors： Burmester GR,Feist E,Sleeman MA,Wang B,White B,Magrini F

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Etanercept monotherapy has been studied and approved for treatment of polyarticular juvenile idiopathic arthritis (JIA). The following study evaluates the safety and efficacy of combination therapy of etanercept and methotrexate compared to etanercept monotherapy in JIA. METHODS:We perfomed an open, non-rand...

journal_title：Annals of the rheumatic diseases

authors： Horneff G,De Bock F,Foeldvari I,Girschick HJ,Michels H,Moebius D,Schmeling H,German and Austrian Paediatric Rheumatology Collaborative Study Group.

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Notch signalling pathways are critical for angiogenesis and endothelial cell (EC) fate; however the mechanisms regulating these processes in the inflamed joint remain to be elucidated. Here, we examine whether Notch signalling mediates vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2)-induce...

journal_title：Annals of the rheumatic diseases

authors： Gao W,Sweeney C,Walsh C,Rooney P,McCormick J,Veale DJ,Fearon U

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To investigate the contribution of red blood cell (RBC) methotrexate polyglutamates (MTX PGs), RBC folate polyglutamates (folate PGs), and a pharmacogenetic index to the clinical status of patients with rheumatoid arthritis treated with MTX. METHODS:226 adult patients treated with weekly MTX for more than 3 ...

journal_title：Annals of the rheumatic diseases

authors： Dervieux T,Furst D,Lein DO,Capps R,Smith K,Caldwell J,Kremer J

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:To assess the impact of certolizumab pegol (CZP) on patient-reported outcomes (PROs) in rheumatoid arthritis (RA), and to interpret these results using number needed to treat (NNT), and associations between PRO responses and longer term outcomes. METHODS:A total of 619 patients with active RA were randomised...

journal_title：Annals of the rheumatic diseases

authors： Strand V,Smolen JS,van Vollenhoven RF,Mease P,Burmester GR,Hiepe F,Khanna D,Nikaï E,Coteur G,Schiff M

更新日期：2011-06-01 00:00:00

abstract：:The case is reported of a 27 year old woman who had mixed connective tissue disease (MCTD) associated with chronic active hepatitis and thyroiditis. Although hepatomegaly is sometimes observed in MCTD, only four cases of MCTD and chronic active hepatitis have been described. It is thought that this is the first report...

journal_title：Annals of the rheumatic diseases

authors： Tomsic M,Ferlan-Marolt V,Kveder T,Hojker S,Rozman B

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

journal_title：Annals of the rheumatic diseases

authors： Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

更新日期：2003-06-01 00:00:00