Estimation of IgM rheumatoid factors by fluorimetry.

abstract：:A 49 year old white woman with systemic lupus erythematosus and bronchiolitis obliterans was treated with prednisone (1 mg/kg daily), which led to a transitory improvement in pulmonary status. Cyclophosphamide was then added--4 mg/kg daily intravenously for five days, then 2 mg/kg daily orally--and this was followed b...

journal_title：Annals of the rheumatic diseases

authors： Godeau B,Cormier C,Menkes CJ

更新日期：1991-12-01 00:00:00

abstract：:The effect of auranofin on human neutrophil (PMN) 5-lipoxygenase activity and leucotriene B4 (LTB4) chemotaxis was investigated. [1-14C]Arachidonic acid was incorporated into the purified cells until steady state conditions were obtained. After preincubations with serial dilutions of auranofin arachidonic acid release...

journal_title：Annals of the rheumatic diseases

authors： Elmgreen J,Ahnfelt-Rønne I,Nielsen OH

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Entheseal fibrocartilage (EF) derangement is hypothesised to be pivotal to the pathogenesis of spondyloarthritis. Ultrasound is useful for visualisation of the enthesis but its role in EF visualisation is uncertain. This work aimed to demonstrate face and content validity of ultrasound for EF visualisation b...

journal_title：Annals of the rheumatic diseases

authors： Aydin SZ,Bas E,Basci O,Filippucci E,Wakefield RJ,Celikel C,Karahan M,Atagunduz P,Benjamin M,Direskeneli H,McGonagle D

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Anticitrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). Epitope spreading towards more citrullinated epitopes occurs before the onset of RA. Here, the authors investigated whether specific epitope recognition allows the identification of spe...

journal_title：Annals of the rheumatic diseases

authors： Willemze A,Böhringer S,Knevel R,Levarht EW,Stoeken-Rijsbergen G,Houwing-Duistermaat JJ,van der Helm-van Mil AH,Huizinga TW,Toes RE,Trouw LA

更新日期：2012-02-01 00:00:00

abstract：:We have identified regular thermal patterns over normal knee, ankle, and elbow joints and demonstrate how synovitis affecting these joints may be identified by alteration or loss of the thermal pattern. Sixty healthy volunteers were thermographed on a total of 190 occasions, and 614 out of 618 joints conformed to the ...

journal_title：Annals of the rheumatic diseases

authors： Salisbury RS,Parr G,De Silva M,Hazleman BL,Page-Thomas DP

更新日期：1983-10-01 00:00:00

abstract：:Two cases of acute monarthritis secondary to asymptomatic renal cell carcinoma are described. This association has not previously been reported. The patients were initially thought to have a septic arthritis, but hot spots were seen on isotope bone scans and biopsy samples showed secondary neoplasms, which were later ...

journal_title：Annals of the rheumatic diseases

authors： Chakravarty KK,Webley M

更新日期：1992-05-01 00:00:00

abstract：:Pulmonary hypertension in systemic lupus erythematosus (SLE) is rare in the absence of parenchymal lung disease. We report such a case, which was complicated by the subsequent development of a left recurrent laryngeal nerve palsy, and in which there was a strong family history of SLE. ...

journal_title：Annals of the rheumatic diseases

authors： Aszkenasy OM,Clarke TJ,Hickling P,Marshall AJ

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVES:To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS:Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA...

journal_title：Annals of the rheumatic diseases

authors： Glinatsi D,Baker JF,Hetland ML,Hørslev-Petersen K,Ejbjerg BJ,Stengaard-Pedersen K,Junker P,Ellingsen T,Lindegaard HM,Hansen I,Lottenburger T,Møller JM,Ørnbjerg L,Vestergaard A,Jurik AG,Thomsen HS,Torfing T,Møller-Bisgaa

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To investigate the association of a recently described classification of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid factors (RF) and anti-cyclic citrullinated peptide (CCP) production and radiological severity in rheumatoid arthritis (RA). METHODS:Patients with RA (n = 962) wer...

journal_title：Annals of the rheumatic diseases

authors： Mewar D,Marinou I,Coote AL,Moore DJ,Akil M,Smillie D,Dickson MC,Binks MH,Montgomery DS,Wilson AG

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To investigate the activation of NF-kappaB in the carrageenan rat air pouch model of inflammation in a time course experiment, and the effect of dexamethasone on NF-kappaB activation. METHODS:Air pouch tissue treated with carrageenan (inflamed tissue) was obtained from rats killed at days 1, 2, 3, 6, 14, 21,...

journal_title：Annals of the rheumatic diseases

authors： Ellis L,Gilston V,Soo CC,Morris CJ,Kidd BL,Winyard PG

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVES:To study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed. METHODS:We examined whether symptomatic (≥1 joint(s) with radio...

journal_title：Annals of the rheumatic diseases

authors： Haugen IK,Ramachandran VS,Misra D,Neogi T,Niu J,Yang T,Zhang Y,Felson DT

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:High rheumatoid arthritis (RA) disease activity during pregnancy is associated with a lower birth weight. Active RA is characterised by high circulating levels of cytokines, which can mediate placental growth and remodelling. OBJECTIVES:To assess the influence of maternal serum cytokine levels on birth weig...

journal_title：Annals of the rheumatic diseases

authors： de Steenwinkel FD,Hokken-Koelega AC,de Man YA,de Rijke YB,de Ridder MA,Hazes JM,Dolhain RJ

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

journal_title：Annals of the rheumatic diseases

authors： Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Endoplasmic reticulum aminopeptidase-1 (ERAP1) protein is highly polymorphic with numerous missense amino acid variants. We sought to determine the naturally occurring ERAP1 protein allotypes and their contribution to Behçet's disease. METHODS:Genotypes of all reported missense ERAP1 gene variants with 10...

journal_title：Annals of the rheumatic diseases

authors： Takeuchi M,Ombrello MJ,Kirino Y,Erer B,Tugal-Tutkun I,Seyahi E,Özyazgan Y,Watts NR,Gül A,Kastner DL,Remmers EF

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:To compare the effects of etanercept (ETN) 50 mg once weekly plus methotrexate (MTX) versus MTX alone on patient-reported outcomes (PROs) and the relationship between remission and PRO improvement. METHODS:In this double-blind, randomised clinical trial (COMET), PROs included: the Health Assessment Question...

journal_title：Annals of the rheumatic diseases

authors： Kekow J,Moots RJ,Emery P,Durez P,Koenig A,Singh A,Pedersen R,Robertson D,Freundlich B,Sato R

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR). METHODS:In total, 67 patients were randomised to receive weekly subcutaneous doses of 120 mg ...

journal_title：Annals of the rheumatic diseases

authors： Visvanathan S,Daniluk S,Ptaszyński R,Müller-Ladner U,Ramanujam M,Rosenstock B,Eleftheraki AG,Vinisko R,Petříková A,Kellner H,Dokoupilova E,Kwiatkowska B,Alten R,Schwabe C,Baum P,Joseph D,Fine JS,Padula SJ,Steffgen J

更新日期：2019-06-01 00:00:00

abstract：:The immune response against two herpesviruses has been determined in sera and matched synovial fluids of patients with rheumatoid arthritis (RA) and compared with that of a healthy control population. The increased level of antibody to Epstein-Barr virus (EBV) induced antigens in patients with RA resembles the antibod...

journal_title：Annals of the rheumatic diseases

authors： Musiani M,Zerbini M,Ferri S,Plazzi M,Gentilomi G,La Placa M

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset. METHODS:We recruited cases with psoriasis and an onset of IA within the past 5 years. Controls were patients who had psoriasis but no arthritis. We ass...

journal_title：Annals of the rheumatic diseases

authors： Pattison E,Harrison BJ,Griffiths CE,Silman AJ,Bruce IN

更新日期：2008-05-01 00:00:00

abstract：:Overdiagnosis is a term coined by experts in cancer screening to point to indolent cancers detected by screening that would have never led to manifest health problems. Overdiagnosis leads to unnecessary medical care (overtreatment), anxiety and cost. In rheumatology overdiagnosis and overtreatment are hardly discussed...

journal_title：Annals of the rheumatic diseases

authors： Landewé RBM

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjögren's syndrome (SS). METHODS:A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice...

journal_title：Annals of the rheumatic diseases

authors： Tsifetaki N,Kitsos G,Paschides CA,Alamanos Y,Eftaxias V,Voulgari PV,Psilas K,Drosos AA

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:To see if a group course delivered by rheumatology teams using cognitive-behavioural approaches, plus usual care, reduced RA fatigue impact more than usual care alone. METHODS:Multicentre, 2-year randomised controlled trial in RA adults (fatigue severity>6/10, no recent major medication changes). RAFT (Redu...

journal_title：Annals of the rheumatic diseases

authors： Hewlett S,Almeida C,Ambler N,Blair PS,Choy EH,Dures E,Hammond A,Hollingworth W,Kadir B,Kirwan JR,Plummer Z,Rooke C,Thorn J,Turner N,Pollock J,RAFT Study Group.

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It is unknown whether this relation is linear, referring to a common 'the-earlier-the-better principle', or whether a transient time frame in which the disease is more suscep...

journal_title：Annals of the rheumatic diseases

authors： van Nies JA,Tsonaka R,Gaujoux-Viala C,Fautrel B,van der Helm-van Mil AH

更新日期：2015-05-01 00:00:00

abstract：:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management. The objective of this report is to produce evidence-based recommendations to guide rheumatologists and other health professionals in the treatment and follow-u...

journal_title：Annals of the rheumatic diseases

authors： Ozen S,Demirkaya E,Erer B,Livneh A,Ben-Chetrit E,Giancane G,Ozdogan H,Abu I,Gattorno M,Hawkins PN,Yuce S,Kallinich T,Bilginer Y,Kastner D,Carmona L

更新日期：2016-04-01 00:00:00

abstract：:A new method is described for separating free 35SO4-- from 35SO4 labelled proteoglycans synthesised by rabbit articular chondrocytes cultured in the presence of excess 35SO4--. The procedure uses the low solubility product of barium sulphate to remove, by precipitation, free 35SO4-- from culture medium. Optimum recove...

journal_title：Annals of the rheumatic diseases

authors： Collier S,Ghosh P

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. METHODS:Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 ...

journal_title：Annals of the rheumatic diseases

authors： Tolusso B,Frezza D,Mattioli C,Fedele AL,Bosello S,Faustini F,Peluso G,Giambra V,Pietrapertosa D,Morelli A,Gremese E,De Santis M,Ferraccioli GF

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To better understand the characteristics of synoviocytes located in the rheumatoid arthritis (RA) pannus. METHODS:One cell line, termed PSC, was cloned from RA pannus lesions. Phenotypic analysis was done by contrast microscopy, indirect immunostaining, and safranin O staining. Transcription of several proto...

journal_title：Annals of the rheumatic diseases

authors： Xue C,Takahashi M,Hasunuma T,Aono H,Yamamoto K,Yoshino S,Sumida T,Nishioka K

更新日期：1997-04-01 00:00:00

abstract：:An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

journal_title：Annals of the rheumatic diseases

authors： Gibson T,Burry HC,Poswillo D,Glass J

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVES:To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using coronary CT angiography (CCTA). METHODS:Ninety consecutive patients with PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls (male: 137(57.1%); 49.6±10.7 years) without known cardiovasc...

journal_title：Annals of the rheumatic diseases

authors： Shen J,Wong KT,Cheng IT,Shang Q,Li EK,Wong P,Kun EW,Law MY,Yip R,Yim I,Ying S,Li M,Li TK,Wong CK,Zhu TY,Lee JJ,Chang M,Lee AP,Tam LS

更新日期：2017-07-01 00:00:00

abstract：:This paper looks at the problem confronting a doctor evaluating a patient with anticentromere antibody who does not have evidence of disease along the spectrum from CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) to progressive systemic sclerosis. Of 33 people with anti...

journal_title：Annals of the rheumatic diseases

authors： Goldman JA

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:Few studies have addressed the natural course of, or prognostic factors for the salivary and lacrimal function in primary Sjögren syndrome (SS). Except for the early stages, glandular function has been seemingly stable, and SS A antigen (SSA) seropositivity and hypocomplementemia may predict a decline in the...

journal_title：Annals of the rheumatic diseases

authors： Haldorsen K,Moen K,Jacobsen H,Jonsson R,Brun JG

更新日期：2008-07-01 00:00:00