The ACPA recognition profile and subgrouping of ACPA-positive RA patients.


OBJECTIVE:Anticitrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). Epitope spreading towards more citrullinated epitopes occurs before the onset of RA. Here, the authors investigated whether specific epitope recognition allows the identification of specific RA subgroups and whether it is associated with clinical features of RA. METHODS:The reactivity of 661 patients with RA from the Leiden Early Arthritis Clinic against several citrullinated antigens was determined by ELISA. Cluster analyses were performed to identify subgroups of patients on the basis of their ACPA recognition profile. The association of the specific reactivities with clinical characteristics was studied. RESULTS:ACPA-positive patients displayed a heterogeneous ACPA recognition profile. After performing cluster analyses, no apparent clustering of patients was found, and on the basis of the reactivities analysed, 64 different subgroups could already be identified. The extent of epitope recognition was associated with anticyclic citrullinated peptide-2 levels. The recognition of specific citrullinated epitopes was not associated with baseline characteristics. Likewise, patients with an extended fine specificity repertoire did not display differences in baseline characteristics or joint damage after 7 years of follow-up using cyclic citrullinated peptide-2 levels as a proxy, compared to ACPA-positive patients recognising fewer peptides. CONCLUSION:These data show that the ACPA response is highly diverse with respect to recognition of specific citrullinated epitopes. Furthermore, the authors' data indicate that clinical correlates in established ACPA-positive RA are independent from the specific (group of) citrullinated peptides recognised.


Ann Rheum Dis


Willemze A,Böhringer S,Knevel R,Levarht EW,Stoeken-Rijsbergen G,Houwing-Duistermaat JJ,van der Helm-van Mil AH,Huizinga TW,Toes RE,Trouw LA




Has Abstract


2012-02-01 00:00:00














  • Combined intravenous methotrexate and cyclophosphamide for refractory childhood lupus nephritis.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of combining monthly intravenous methotrexate (IV MTX) with monthly IV cyclophosphamide (CYTX; given on the same day) for the treatment of children who develop recurrent diffuse proliferative glomerulonephritis secondary to systemic lupus erythematosus during or after the s...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Lehman TJ,Edelheit BS,Onel KB

    更新日期:2004-03-01 00:00:00

  • Subacute bacterial endocarditis in a patient with ankylosing spondylitis.

    abstract::A 57 year old white man with aortic insufficiency and previously undiagnosed ankylosing spondylitis, who developed subacute bacterial endocarditis (SBE), is described. Emergency aortic valve replacement was necessary, and the aortic valve pathology showed diffusely fibrosed and thickened valve leaflets with bacterial ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Hoppmann RA,Wise CM,Challa VR,Peacock JE

    更新日期:1988-05-01 00:00:00

  • Pneumococcal epiglottitis in systemic lupus erythematosus on high-dose corticosteroids.

    abstract::A patient with systemic lupus erythematosus who developed pneumococcal epiglottitis is described and the literature reviewed. This infection is extremely rare in adults, and only 10 cases, none of them with SLE, have so far been reported. Epiglottitis is usually caused by Haemophilus influenzae. However, in immunocomp...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Shalit M,Gross DJ,Levo Y

    更新日期:1982-12-01 00:00:00

  • Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout.

    abstract:OBJECTIVES:Advanced imaging studies have demonstrated that urate deposition in periarticular structures, such as tendons, is common in gout. The aim of this study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on tenocyte viability and function. METHODS:The histological appearance of ten...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Chhana A,Callon KE,Dray M,Pool B,Naot D,Gamble GD,Coleman B,McCarthy G,McQueen FM,Cornish J,Dalbeth N

    更新日期:2014-09-01 00:00:00

  • Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF).

    abstract:OBJECTIVE:To develop widely accepted international severity score for children and adult patients with familial Mediterranean fever (FMF) that can be easily applied, in research and clinical practice. METHODS:Candidate severity criteria were suggested by several FMF expert physicians. After three rounds of Delphi surv...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Demirkaya E,Acikel C,Hashkes P,Gattorno M,Gul A,Ozdogan H,Turker T,Karadag O,Livneh A,Ben-Chetrit E,Ozen S,FMF Arthritis Vasculitis and Orphan disease Research in pediatric rheumatology (FAVOR).

    更新日期:2016-06-01 00:00:00

  • Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages.

    abstract:BACKGROUND:Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for rheumatoid arthritis (RA). Peptidylcitrulline can be generated by post-translational conversion of arginine residues. This process, citrullination, is catalysed by a group of calcium dependent peptid...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Vossenaar ER,Radstake TR,van der Heijden A,van Mansum MA,Dieteren C,de Rooij DJ,Barrera P,Zendman AJ,van Venrooij WJ

    更新日期:2004-04-01 00:00:00

  • Multisystem disease in post-streptococcal arthritis.

    abstract::The case presented is of a patient with migratory polyarthritis and serological evidence of a recent streptococcal infection, consistent with the diagnosis of acute rheumatic fever, who in addition had multisystem disease manifestations. This case supports the concept that the sequelae of streptococcal infection can e...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Livneh A,Sharma K,Sewell KL,Keiser HD

    更新日期:1991-05-01 00:00:00

  • Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus.

    abstract:OBJECTIVE:To evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor alpha (ORalpha) in patients with systemic lupus erythematosus (SLE) in Korea. METHODS:Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Lee YJ,Shin KS,Kang SW,Lee CK,Yoo B,Cha HS,Koh EM,Yoon SJ,Lee J

    更新日期:2004-10-01 00:00:00

  • Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.

    abstract:BACKGROUND:Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA). OBJECTIVE:To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Britsemmer K,Ursum J,Gerritsen M,van Tuyl LH,van Schaardenburg D

    更新日期:2011-08-01 00:00:00

  • The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?

    abstract::Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment. A new era in rheumatoid arthritis (RA) and related chronic autoimmune/inflammatory diseases is now beginning, with a variety of anti-TNFalpha treatments licensed for use in both RA and Crohn's disease. The rationale f...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Feldmann M,Bondeson J,Brennan FM,Foxwell BM,Maini RN

    更新日期:1999-11-01 00:00:00

  • Hsp90{beta} and p130(cas): novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes.

    abstract:BACKGROUND:Human osteoarthritic (OA) chondrocytes were previously classified into L (low)- and H (high)-OA according to matrix metalloproteinase-13 (MMP-13) basal levels and interleukin 1beta (IL1beta) inducibility. In H-OA chondrocytes, the regulatory proteins p130(cas) and nuclear matrix protein 4 (NMP4) acting on th...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Fan Z,Tardif G,Hum D,Duval N,Pelletier JP,Martel-Pelletier J

    更新日期:2009-06-01 00:00:00

  • Incidence of arthro-osteitis in patients with pustulosis palmaris et plantaris.

    abstract::Arthro-osteitis at the anterior chest wall was found in 12 (9.4%) out of 128 consecutive patients with pustulosis palmaris et plantaris. This finding indicates that the concomitance of arthro-osteitis with PPP is not incidental but is based on some common aetiological factor. We propose a term ;pustulotic arthro-ostei...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Sonozaki H,Kawashima M,Hongo O,Yaoita H,Ikeno M,Matsuura M,Okai K,Azuma A

    更新日期:1981-12-01 00:00:00

  • Activation of the transcription factor NF-kappaB in the rat air pouch model of inflammation.

    abstract:OBJECTIVE:To investigate the activation of NF-kappaB in the carrageenan rat air pouch model of inflammation in a time course experiment, and the effect of dexamethasone on NF-kappaB activation. METHODS:Air pouch tissue treated with carrageenan (inflamed tissue) was obtained from rats killed at days 1, 2, 3, 6, 14, 21,...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Ellis L,Gilston V,Soo CC,Morris CJ,Kidd BL,Winyard PG

    更新日期:2000-04-01 00:00:00

  • Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet.

    abstract:OBJECTIVE:To measure Proteus mirabilis and Escherichia coli antibody levels in patients with rheumatoid arthritis (RA) during treatment by vegetarian diet. METHODS:Sera were collected from 53 RA patients who took part in a controlled clinical trial of fasting and a one year vegetarian diet. P mirabilis and E coli anti...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kjeldsen-Kragh J,Rashid T,Dybwad A,Sioud M,Haugen M,Førre O,Ebringer A

    更新日期:1995-03-01 00:00:00

  • Attempt to classify patients with arthritis of the hip suitable for prosthetic replacement, and their femoral heads.

    abstract::Using clinical, radiological, and morbid anatomical data about patients with arthritis of the hip and their femoral heads resected during total hip replacement, an attempt has been made first, to classify patients and femoral heads by a cluster analysis technique, and secondly and more realistically, to use existing c...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Byers PD,Roper BA,Glennie B

    更新日期:1975-08-01 00:00:00

  • Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.

    abstract:OBJECTIVES:Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional r...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Tong W,Zeng Y,Chow DHK,Yeung W,Xu J,Deng Y,Chen S,Zhao H,Zhang X,Ho KK,Qin L,Mak KK

    更新日期:2019-04-01 00:00:00

  • Cellular targets of interleukin-18 in rheumatoid arthritis.

    abstract::Recent data are presented which indicate a critical role for interleukin (IL)-18 in rheumatoid arthritis (RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL-18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of I...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Dai SM,Shan ZZ,Xu H,Nishioka K

    更新日期:2007-11-01 00:00:00

  • Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome.

    abstract::Eye disease, arthritis, folliculitis, and thrombophlebitis were more common among males, and erythema nodosum among females, in 297 patients with Behćet syndrome (BS) at their first visit despite an identical disease duration. Younger males and females (age of onset 24 years or less) had a higher prevalence of eye dis...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Yazici H,Tüzün Y,Pazarli H,Yurdakul S,Ozyazgan Y,Ozdoğan H,Serdaroğlu S,Ersanli M,Ulkü BY,Müftüoğlu AU

    更新日期:1984-12-01 00:00:00

  • IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.

    abstract:OBJECTIVE:High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNα production by activating endosomal Toll-like receptors and interferon regulatory factors (IRFs), including IRF5. Genetic variat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Niewold TB,Kelly JA,Kariuki SN,Franek BS,Kumar AA,Kaufman KM,Thomas K,Walker D,Kamp S,Frost JM,Wong AK,Merrill JT,Alarcón-Riquelme ME,Tikly M,Ramsey-Goldman R,Reveille JD,Petri MA,Edberg JC,Kimberly RP,Alarcón GS,

    更新日期:2012-03-01 00:00:00

  • Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae.

    abstract::The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine patellae was studied. Exogenously added TGF beta up to a concentration of 200 pmol/l had no effect on proteoglycan synthesis in intact articular cartilage. Neutralisat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: van der Kraan PM,Vitters EL,van den Berg WB

    更新日期:1992-05-01 00:00:00

  • Evaluation of low back pain and assessment of lumbar corsets with and without back supports.

    abstract::A method is described for evaluating the progress of patients with back pain. Various symptoms were scored on analogue scales and spinal motion was measured by various techniques. These data were integrated to make subjective and objective indices respectively. Reasonable reproducibility of the measurements was obtain...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Million R,Nilsen KH,Jayson MI,Baker RD

    更新日期:1981-10-01 00:00:00

  • Use of statins is associated with an increased risk of rheumatoid arthritis.

    abstract:OBJECTIVES:Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether statin use was associated with an increased risk of dev...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: de Jong HJ,Klungel OH,van Dijk L,Vandebriel RJ,Leufkens HG,van der Laan JW,Cohen Tervaert JW,van Loveren H

    更新日期:2012-05-01 00:00:00

  • Inhibition of human neutrophils by auranofin: chemotaxis and metabolism of arachidonate via the 5-lipoxygenase pathway.

    abstract::The effect of auranofin on human neutrophil (PMN) 5-lipoxygenase activity and leucotriene B4 (LTB4) chemotaxis was investigated. [1-14C]Arachidonic acid was incorporated into the purified cells until steady state conditions were obtained. After preincubations with serial dilutions of auranofin arachidonic acid release...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Elmgreen J,Ahnfelt-Rønne I,Nielsen OH

    更新日期:1989-02-01 00:00:00

  • Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis.

    abstract:OBJECTIVE:To examine the effects of smoking on cartilage loss and pain at the knee in individuals with knee osteoarthritis. METHODS:159 men with symptomatic knee osteoarthritis who participated in a 30-month, prospective, natural history study of knee osteoarthritis were examined. The more symptomatic knee was imaged ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Amin S,Niu J,Guermazi A,Grigoryan M,Hunter DJ,Clancy M,LaValley MP,Genant HK,Felson DT

    更新日期:2007-01-01 00:00:00

  • Oral pilocarpine for the treatment of ocular symptoms in patients with Sjögren's syndrome: a randomised 12 week controlled study.

    abstract:OBJECTIVE:To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjögren's syndrome (SS). METHODS:A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tsifetaki N,Kitsos G,Paschides CA,Alamanos Y,Eftaxias V,Voulgari PV,Psilas K,Drosos AA

    更新日期:2003-12-01 00:00:00

  • Reproductive history, hormonal factors and the incidence of hip and knee replacement for osteoarthritis in middle-aged women.

    abstract:OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission rec...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.

    更新日期:2009-07-01 00:00:00

  • ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.

    abstract:BACKGROUND:Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). OBJECTIVE:To test the validity and the mechanism of this association between α1AT and AAV. METHODS:The distribution of α1AT deficiency alleles Z and S was co...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Morris H,Morgan MD,Wood AM,Smith SW,Ekeowa UI,Herrmann K,Holle JU,Guillevin L,Lomas DA,Perez J,Pusey CD,Salama AD,Stockley R,Wieczorek S,McKnight AJ,Maxwell AP,Miranda E,Williams J,Savage CO,Harper L

    更新日期:2011-10-01 00:00:00

  • Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritis.

    abstract:OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Majeed M,McQueen F,Yeoman S,McLean L

    更新日期:2004-09-01 00:00:00

  • Isolation and analysis of immune complexes from sera of patients with polymyalgia rheumatica and giant cell arteritis.

    abstract::Serum samples were obtained from patients with polymyalgia rheumatica (PMR: n = 10) or giant cell arteritis (GCA; n = 7), or both. Samples were taken either before treatment or within one week of starting prednisolone. Immune complexes (IC) were concentrated by polyethylene glycol (PEG) precipitation then purified wit...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Smith AJ,Kyle V,Cawston TE,Hazleman BL

    更新日期:1987-06-01 00:00:00

  • Morphological evidence that activated polymorphs circulate in the peripheral blood of patients with rheumatoid arthritis.

    abstract::Purified peripheral blood polymorphonuclear leucocytes (PMNs) from patients with rheumatoid arthritis (RA) have been found to differ from purified PMNs from normal subjects in ways that are consistent with their prior activation. However, it is currently contentious whether activated PMNs really circulate in patients ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章


    authors: McCarthy DA,Bernhagen J,Taylor MJ,Hamblin AS,James I,Thompson PW,Perry JD

    更新日期:1992-01-01 00:00:00