Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis.

abstract：OBJECTIVES:Smoking increases the risk of developing rheumatoid arthritis (RA) and worsens the course of the disease. In the current study we analysed whether smoking can affect gene expression directly in the joints. METHODS:Synovial fibroblasts were incubated with 5% cigarette smoke extract and changes in gene expres...

journal_title：Annals of the rheumatic diseases

authors： Ospelt C,Camici GG,Engler A,Kolling C,Vogetseder A,Gay RE,Michel BA,Gay S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterised by flares of sterile arthritis with neutrophil infiltrate and the overproduction of interleukin (IL)-1β. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (N...

journal_title：Annals of the rheumatic diseases

authors： Mistry P,Carmona-Rivera C,Ombrello AK,Hoffmann P,Seto NL,Jones A,Stone DL,Naz F,Carlucci P,Dell'Orso S,Gutierrez-Cruz G,Sun HW,Kastner DL,Aksentijevich I,Kaplan MJ

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:While gout is associated with cardiovascular (CV)-metabolic comorbidities and their sequelae, the antioxidant effects of uric acid may have neuroprotective benefits. We evaluated the potential impact of incident gout on the risk of developing Alzheimer's disease (AD) in a general population context. METHODS:...

journal_title：Annals of the rheumatic diseases

authors： Lu N,Dubreuil M,Zhang Y,Neogi T,Rai SK,Ascherio A,Hernán MA,Choi HK

更新日期：2016-03-01 00:00:00

abstract：:Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associ...

journal_title：Annals of the rheumatic diseases

authors： Clegg DO,Zone JJ,Samuelson CO Jr,Ward JR

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate serum interleukin (IL) 12 concentration in patients with juvenile chronic arthritis (JCA), according to disease subtype, activity, and duration. IL12 has been demonstrated to prime the selective expansion of T helper (Th) cells with a Th1-type pattern of cytokine product...

journal_title：Annals of the rheumatic diseases

authors： Gattorno M,Picco P,Vignola S,Stalla F,Buoncompagni A,Pistoia V

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Human osteoarthritic (OA) chondrocytes were previously classified into L (low)- and H (high)-OA according to matrix metalloproteinase-13 (MMP-13) basal levels and interleukin 1beta (IL1beta) inducibility. In H-OA chondrocytes, the regulatory proteins p130(cas) and nuclear matrix protein 4 (NMP4) acting on th...

journal_title：Annals of the rheumatic diseases

authors： Fan Z,Tardif G,Hum D,Duval N,Pelletier JP,Martel-Pelletier J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:To examine the expression of the natural killer (NK) antigen CD56, and T cell receptor delta chain antigen (TCR delta), expressed on the gamma delta T cell subset, in patients with scleroderma, and to correlate levels of expression with clinical characteristics. METHODS:Peripheral blood mononuclear cells (P...

journal_title：Annals of the rheumatic diseases

authors： Holcombe RF,Baethge BA,Wolf RE,Betzing KW,Stewart RM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To determine, using the method of adjusted indirect comparisons, whether there are differences in efficacy of tumour necrosis factor (TNF alpha) blocking agents, as measured by the rate ratios for American College of Rheumatology (ACR) 20, 50, and 70 responses, in patients with rheumatoid arthritis with an in...

journal_title：Annals of the rheumatic diseases

authors： Hochberg MC,Tracy JK,Hawkins-Holt M,Flores RH

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVES:To determine whether hormonal dysfunction involving the hypothalamic-pituitary-adrenal (HPA) axis, prolactin (PRL) secretion, and sex hormone status contribute to development of systemic lupus erythematosus (SLE). METHODS:11 patients with SLE and 9 healthy controls were tested for their total anterior pitui...

journal_title：Annals of the rheumatic diseases

authors： Köller MD,Templ E,Riedl M,Clodi M,Wagner O,Smolen JS,Luger A

更新日期：2004-12-01 00:00:00

abstract：:It is postulated that the mobile inflamed joint may be subject to cyclical ischaemic reperfusion injury. Xanthine oxidoreductase is an enzyme thought to contribute to oxidative reperfusion injury, and the detection of this activity in human synovium is described. Three normal and five rheumatoid tissues were assayed w...

journal_title：Annals of the rheumatic diseases

authors： Allen RE,Outhwaite JM,Morris CJ,Blake DR

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:To analyse the association between chondrocalcinosis and osteoarthritis (OA) of the hands and knees in an unselected elderly rural population. METHODS:A community based cross sectional study was performed in individuals randomly selected from a previous epidemiological survey on the prevalence of chondrocal...

journal_title：Annals of the rheumatic diseases

authors： Sanmarti R,Kanterewicz E,Pladevall M,Pañella D,Tarradellas JB,Gomez JM

更新日期：1996-01-01 00:00:00

abstract：:The first biological therapeutics in rheumatology are approaching patent expiration, encouraging development of 'follow-on' versions, known as 'biosimilars'. Biological agents range from simple replacement hormones to complex monoclonal antibodies and soluble receptors: large, intricate proteins with unique tertiary a...

journal_title：Annals of the rheumatic diseases

authors： Dörner T,Strand V,Castañeda-Hernández G,Ferraccioli G,Isaacs JD,Kvien TK,Martin-Mola E,Mittendorf T,Smolen JS,Burmester GR

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The zinc-ZIP8-MTF1 axis induces metallothionein (MT) expression and is a catabolic regulator of experimental osteoarthritis (OA) in mice. The main aim of the current study was to explore the roles and underlying molecular mechanisms of MTs in OA pathogenesis. METHODS:Experimental OA in mice was induced by de...

journal_title：Annals of the rheumatic diseases

authors： Won Y,Shin Y,Chun CH,Cho Y,Ha CW,Kim JH,Chun JS

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To evaluate changes in baseline patient characteristics and entry criteria of randomised, controlled studies of tumour necrosis factor alpha (TNFα) inhibitors in rheumatoid arthritis (RA) patients. METHODS:A systematic literature review was performed using predefined inclusion criteria to identify randomised...

journal_title：Annals of the rheumatic diseases

authors： Rahman MU,Buchanan J,Doyle MK,Hsia EC,Gathany T,Parasuraman S,Aletaha D,Matteson EL,Conaghan PG,Keystone E,van der Heijde D,Smolen JS

更新日期：2011-09-01 00:00:00

abstract：:An 85 year old man with a longstanding history of non-tophaceous gout developed a single large tophus, unassociated with inflammation, on his paretic leg over a six week period following an acute hemiplegia. The rapidity of tophus formation, its localisation to the paretic limb, and the apparent blunting of the acute ...

journal_title：Annals of the rheumatic diseases

authors： Donegan CF,Berman P,Doherty M

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Primary Sjögren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocri...

journal_title：Annals of the rheumatic diseases

authors： Appel S,Le Hellard S,Bruland O,Brun JG,Omdal R,Kristjansdottir G,Theander E,Nordmark G,Kvarnström M,Eriksson P,Rönnblom L,Wahren-Herlenius M,Jonsson R

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Calprotectin is a major leucocyte protein, shown to correlate well with laboratory and clinical assessments in several inflammatory rheumatic diseases, and large concentrations of calprotectin have been found in synovial fluid from patients with rheumatoid arthritis (RA). The objective of the present study wa...

journal_title：Annals of the rheumatic diseases

authors： Hammer HB,Odegard S,Fagerhol MK,Landewé R,van der Heijde D,Uhlig T,Mowinckel P,Kvien TK

更新日期：2007-08-01 00:00:00

abstract：:Cell electrophoresis identifies two main subpopulations of blood polymorphonuclear cells (PMNs), which in terms of the speed of their anodic migration are referred to as the fast and slow population. When blood PMNs from normal healthy subjects were incubated in medium containing 20% RA serum there was a decrease in t...

journal_title：Annals of the rheumatic diseases

authors： Brown KA,McCarthy D,Perry JD,Dumonde DC

更新日期：1988-05-01 00:00:00

abstract：:The main goal of traditional treatment of idiopathic retroperitoneal fibrosis is limitation of morbidity, and surgery of already formed fibrous masses has been the main therapeutic approach. More recently, the knowledge that the disorder may be the result of an allergic reaction to atherosclerotic lipids has prompted ...

journal_title：Annals of the rheumatic diseases

authors： Marzano A,Trapani A,Leone N,Actis GC,Rizzetto M

更新日期：2001-04-01 00:00:00

abstract：:Of 60 patients with rheumatoid arthritis treated with levamisole 35% showed a persistent decrease in neutrophil counts from pre-treatment levels and 6 (10%) develped severe neutropenia of less than 1.0 X 10(9)/1. One of these neutropenic patients recoverd without stopping therapy and the other 5 patients recovered rap...

journal_title：Annals of the rheumatic diseases

authors： Williams GT,Johnson SA,Dieppe PA,Huskisson EC

更新日期：1978-08-01 00:00:00

abstract：:Two cases of acute monarthritis secondary to asymptomatic renal cell carcinoma are described. This association has not previously been reported. The patients were initially thought to have a septic arthritis, but hot spots were seen on isotope bone scans and biopsy samples showed secondary neoplasms, which were later ...

journal_title：Annals of the rheumatic diseases

authors： Chakravarty KK,Webley M

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of calcium phosphate mineral salt accumulation in degenerative supraspinatus 'tendinitis' compared with a normal sample of human tendons, and to determine whether there is an association of calcium salt deposition with pathological changes in the tendon extracellular matrix. ME...

journal_title：Annals of the rheumatic diseases

authors： Riley GP,Harrall RL,Constant CR,Cawston TE,Hazleman BL

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Several prediction models for rapid radiological progression (RRP) in the first year of rheumatoid arthritis have been designed to aid rheumatologists in their choice of initial treatment. The association was assessed between RRP and disability and joint damage progression in 8 years. METHODS:Patients from t...

journal_title：Annals of the rheumatic diseases

authors： van den Broek M,Dirven L,de Vries-Bouwstra JK,Dehpoor AJ,Goekoop-Ruiterman YP,Gerards AH,Kerstens PJ,Huizinga TW,Lems W,Allaart CF

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not b...

journal_title：Annals of the rheumatic diseases

authors： Belkhir R,Burel SL,Dunogeant L,Marabelle A,Hollebecque A,Besse B,Leary A,Voisin AL,Pontoizeau C,Coutte L,Pertuiset E,Mouterde G,Fain O,Lambotte O,Mariette X

更新日期：2017-10-01 00:00:00

abstract：:Fifteen consecutive patients with acute arthritis were studied. Careful culture and microscopy of swabs from mucosal sites were performed to examine the hypothesis that the acute tropical polyarthritis commonly seen in Zimbabwe is due to undiagnosed gonococcal infection. Rheumatic fever and Reiter's disease accounted ...

journal_title：Annals of the rheumatic diseases

authors： Stein CM,Hanly MG

更新日期：1987-12-01 00:00:00

abstract：:While rheumatoid-factor-producing haemolytic plaque-forming cells (RF--PFC) of the human peripheral blood were easily inhibited by cycloheximide, mouse spleen cells immune to sheep red cells (anti-SRC PFC) were inhibited only after prolonged preincubation in the drug. The RF--PFC were easily inhibited by propranolol, ...

journal_title：Annals of the rheumatic diseases

authors： Moore TL,Rose JE,Vaughan JH

更新日期：1979-06-01 00:00:00

abstract：:Erosions on the triquetrum and pisiform are frequent in early rheumatoid arthritis and occur characteristically at 3 sites. (a) A shallow erosion on the proximal medial triquetral "bare" area is related to synovial proliferation at the margin of the radiocarpal cavity, although compressive forces from an adjacent long...

journal_title：Annals of the rheumatic diseases

authors： Resnick D

更新日期：1976-02-01 00:00:00

abstract：:In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune...

journal_title：Annals of the rheumatic diseases

authors： French MA,Harrison G,Penning CA,Cunningham J,Hughes P,Rowell NR

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

journal_title：Annals of the rheumatic diseases

authors： Akiyama S,Hamdeh S,Micic D,Sakuraba A

更新日期：2020-10-13 00:00:00

abstract：OBJECTIVES:To determine the feasibility of assessing patellofemoral osteoarthritis using the 'skyline' view and to compare its reproducibility with the standard lateral view. METHODS:Fifty patients attending a rheumatology outpatient department with osteoarthritis of the knee had standard radiographs taken of both kne...

journal_title：Annals of the rheumatic diseases

authors： Jones AC,Ledingham J,McAlindon T,Regan M,Hart D,MacMillan PJ,Doherty M

更新日期：1993-09-01 00:00:00