Psoriasis, psoriatic arthritis and risk of gout in US men and women.

abstract：OBJECTIVE:To evaluate the role of interleukin 6 (IL-6) in the pathogenesis of bilateral erosive sacroiliitis in human tumour necrosis factor transgenic (hTNFtg) mice, an animal model of ankylosing spondylitis (AS). METHODS:Histological sections of the sacroiliac joints from hTNFtg and IL-6(-/-)hTNFtg mice were evaluat...

journal_title：Annals of the rheumatic diseases

authors： Hayer S,Niederreiter B,Nagelreiter I,Smolen J,Redlich K

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity ...

journal_title：Annals of the rheumatic diseases

authors： Hørslev-Petersen K,Hetland ML,Junker P,Pødenphant J,Ellingsen T,Ahlquist P,Lindegaard H,Linauskas A,Schlemmer A,Dam MY,Hansen I,Horn HC,Ammitzbøll CG,Jørgensen A,Krintel SB,Raun J,Johansen JS,Østergaard M,Stengaard-Pe

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Spondyloarthritis is a group of articular disorders sharing a genetic background. Polymorphisms in the IL-1 gene cluster have previously been associated with ankylosing spondylitis (AS), a subset of spondyloarthritis. This study examined the association between several of these polymorphisms and the whole spo...

journal_title：Annals of the rheumatic diseases

authors： Monnet D,Kadi A,Izac B,Lebrun N,Letourneur F,Zinovieva E,Said-Nahal R,Chiocchia G,Breban M

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:To investigate the hypothesis that synovial fluid (SF) from patients with osteoarthritis (OA) may contain calcium phosphate crystals that are either too small, or too few in number to be identified by conventional light microscopy techniques. METHODS:Twelve SF from 11 patients with established knee OA, five...

journal_title：Annals of the rheumatic diseases

authors： Swan A,Chapman B,Heap P,Seward H,Dieppe P

更新日期：1994-07-01 00:00:00

abstract：:T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through binding to its corresponding cell surface receptor. Three forms of the receptor are recognised based on IL2 binding affinity. The high affinity receptor is a heterotrimer composed of alpha, beta, and gamma(c)-polypeptide chain...

journal_title：Annals of the rheumatic diseases

authors： Morris JC,Waldmann TA

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To improve the understanding of the pathogenesis of rheumatoid arthritis (RA) by identifying novel, disease specific autoantibodies. METHODS:Total protein preparations from synovial membranes were separated electrophoretically and immunoblotted. Sera from RA patients were screened for predominant immunoreact...

journal_title：Annals of the rheumatic diseases

authors： Bläss S,Specker C,Lakomek HJ,Schneider EM,Schwochau M

更新日期：1995-05-01 00:00:00

abstract：:Eighty-one patients with 116 osteoarthritic knees were seen by the author at the University College Hospital (UCH), Ibadan in six years. Below the age of 50 the disease was significantly commoner among Nigerians than Caucasians; 39.5% of our patients were less than 50 years old, compared with 1.1% of Caucasians. In co...

journal_title：Annals of the rheumatic diseases

authors： Ebong WW

更新日期：1985-10-01 00:00:00

abstract：:In the World Health Organisation's supplementary classification of the consequences of disease a distinction is made between impairments, such as are related to the site and nature of joint involvement, and any disabilities in everyday activities to which these may give rise. This paper considers the application of th...

journal_title：Annals of the rheumatic diseases

authors： Badley EM,Wagstaff S,Wood PH

更新日期：1984-08-01 00:00:00

abstract：:A 35 year old woman presented with headache and fever. Computed brain tomography showed diffuse low attenuation in the cerebral white matter. Several months later, serological tests for systemic lupus erythematosus (SLE) became positive. In spite of immunosuppressive therapy she relapsed after six months of treatment,...

journal_title：Annals of the rheumatic diseases

authors： Boulter M,Brink A,Mathias C,Peart S,Stevens J,Stewart G,Unwin R

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:Evidence was sought for genetic anticipation (disease occurring at an earlier age in subsequent generations, with increasing severity) in nodal osteoarthritis (NOA). METHODS:Age at symptom onset and disease severity was compared within 30 parent/offspring pairs with NOA. Correlation between the offspring age...

journal_title：Annals of the rheumatic diseases

authors： Wright GD,Regan M,Deighton CM,Wallis G,Doherty M

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of golimumab over 104 weeks in patients with active ankylosing spondylitis. METHODS:At baseline, patients with active ankylosing spondylitis (n=356) were randomly assigned (1:1.8:1.8) to subcutaneous injections of placebo (group 1), golimumab 50 mg (group 2) or golimumab 100...

journal_title：Annals of the rheumatic diseases

authors： Braun J,Deodhar A,Inman RD,van der Heijde D,Mack M,Xu S,Hsu B

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Smoking increases the risk of developing rheumatoid arthritis (RA) and worsens the course of the disease. In the current study we analysed whether smoking can affect gene expression directly in the joints. METHODS:Synovial fibroblasts were incubated with 5% cigarette smoke extract and changes in gene expres...

journal_title：Annals of the rheumatic diseases

authors： Ospelt C,Camici GG,Engler A,Kolling C,Vogetseder A,Gay RE,Michel BA,Gay S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To assess the safety and effectiveness of imatinib mesylate in the treatment of diffuse cutaneous systemic sclerosis (dcSSc). METHODS:In this phase IIa, open-label, single-arm clinical trial, 30 patients with dcSSc were treated with imatinib 400 mg daily. Patients were monitored monthly for safety assessment...

journal_title：Annals of the rheumatic diseases

authors： Spiera RF,Gordon JK,Mersten JN,Magro CM,Mehta M,Wildman HF,Kloiber S,Kirou KA,Lyman S,Crow MK

更新日期：2011-06-01 00:00:00

abstract：:Antibodies to histones (AHA) are commonly found in patients with systemic lupus erythematosus (SLE). However, the full profile of AHA and their clinical associations remains unclear. A total of 111 patients with SLE were studied, including 13 patients in whom multiple serum samples were available over several years. I...

journal_title：Annals of the rheumatic diseases

authors： Cohen MG,Pollard KM,Webb J

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Millions of patients worldwide are treated with therapeutic monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss of response. Fully human biological agents, such as the anti-tumour necrosis factor α (anti-TNFα) antibody adalimu...

journal_title：Annals of the rheumatic diseases

authors： van Schouwenburg PA,van de Stadt LA,de Jong RN,van Buren EE,Kruithof S,de Groot E,Hart M,van Ham SM,Rispens T,Aarden L,Wolbink GJ,Wouters D

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

journal_title：Annals of the rheumatic diseases

authors： Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

更新日期：2015-06-01 00:00:00

abstract：:In a double blind, single observer, 48 week study the effects of sulphasalazine (2 g daily) and hydroxychloroquine (400 mg daily months 0-6, thereafter 200 mg daily) were compared in 60 patients with definite or classical rheumatoid arthritis. They had not been treated previously with second line drugs. The onset of r...

journal_title：Annals of the rheumatic diseases

authors： Nuver-Zwart IH,van Riel PL,van de Putte LB,Gribnau FW

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:To examine the effects of smoking on cartilage loss and pain at the knee in individuals with knee osteoarthritis. METHODS:159 men with symptomatic knee osteoarthritis who participated in a 30-month, prospective, natural history study of knee osteoarthritis were examined. The more symptomatic knee was imaged ...

journal_title：Annals of the rheumatic diseases

authors： Amin S,Niu J,Guermazi A,Grigoryan M,Hunter DJ,Clancy M,LaValley MP,Genant HK,Felson DT

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To study the pathogenesis of pneumomediastinum in polymyositis/dermatomyositis (PM/DM). PATIENTS AND METHODS:The clinical records of 48 patients with PM/DM were reviewed, focusing mainly on the presence of pneumomediastinum and cutaneous vasculopathy, and the chest radiographic changes. A patient with pneum...

journal_title：Annals of the rheumatic diseases

authors： Kono H,Inokuma S,Nakayama H,Suzuki M

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is characterised by the presence of antibodies to double stranded DNA (dsDNA), which are involved in the pathogenesis of SLE. Previous studies showed that at least two thirds of patients develop a clinical relapse within six months after a significant rise in the anti-dsDNA...

journal_title：Annals of the rheumatic diseases

authors： Bijl M,Horst G,Bootsma H,Limburg PC,Kallenberg CG

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic res...

journal_title：Annals of the rheumatic diseases

authors： Winau L,Hinojar Baydes R,Braner A,Drott U,Burkhardt H,Sangle S,D'Cruz DP,Carr-White G,Marber M,Schnoes K,Arendt C,Klingel K,Vogl TJ,Zeiher AM,Nagel E,Puntmann VO

更新日期：2018-11-01 00:00:00

abstract：:Antibiotic treatment of all disease manifestations after infection with Borrelia sensu lato spp aims at resolving the presenting disease manifestation and preventing late stage disease. The goals are resolution of the preventing manifestation and prevention of the spread of bacteria to prevent late disease like arthri...

journal_title：Annals of the rheumatic diseases

authors： Dinser R,Jendro MC,Schnarr S,Zeidler H

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically. OBJECTIVE:To compare evoked potential studies in APS patients and patients with multiple sclerosis with similar neurological disability. METHODS:30 APS patients with CNS manifestat...

journal_title：Annals of the rheumatic diseases

authors： Paran D,Chapman J,Korczyn AD,Elkayam O,Hilkevich O,Groozman GB,Levartovsky D,Litinsky I,Caspi D,Segev Y,Drory VE

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:The aim of this pilot study was to compare clinical examination (CE) and ultrasound (US) with high field MRI (as the reference standard) for the detection of rearfoot and midtarsal joint synovitis and secondly tenosynovitis of the ankle tendons in patients with established rheumatoid arthritis (RA). METHODS...

journal_title：Annals of the rheumatic diseases

authors： Wakefield RJ,Freeston JE,O'Connor P,Reay N,Budgen A,Hensor EM,Helliwell PS,Emery P,Woodburn J

更新日期：2008-12-01 00:00:00

abstract：:Chondromalacia patellae is difficult to diagnosis clinically with accuracy. In order to clarify the relevant symptoms and signs, 78 patients presenting with a clinical diagnosis of chondromalacia were examined by arthroscopy. In 49% of the knees no abnormalities were found. Presenting symptoms were similar in the norm...

journal_title：Annals of the rheumatic diseases

authors： Leslie IJ,Bentley G

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:The contribution of rheumatology nurses to improved patient outcomes is increasingly recognised but more research is needed about the effects of interventions. The patient's role in deciding about healthcare quality is considered pivotal and therefore patients' opinions and expectations should be directional ...

journal_title：Annals of the rheumatic diseases

authors： van Eijk-Hustings Y,Ammerlaan J,Voorneveld-Nieuwenhuis H,Maat B,Veldhuizen C,Repping-Wuts H

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:To develop and validate candidate sets of joints and tendons for assessment of ultrasound (US) joint inflammation in rheumatoid arthritis (RA). METHODS:Patients were included in one of two cohorts from 2010 to June 2013: disease-modifying antirheumatic drug naïve early RA or established RA starting/switchin...

journal_title：Annals of the rheumatic diseases

authors： Aga AB,Hammer HB,Olsen IC,Uhlig T,Kvien TK,van der Heijde D,Fremstad H,Madland TM,Lexberg ÅS,Haukeland H,Rødevand E,Høili C,Stray H,Bendvold AN,Soldal DM,Bakland G,Lie E,Haavardsholm EA

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To show whether intra-articular steroid injections are effective in osteoarthritis; to determine factors that predict response; and to determine whether injection has a beneficial effect on muscle strength. METHODS:Double blind, placebo controlled, crossover study in 59 patients with symptomatic osteoarthri...

journal_title：Annals of the rheumatic diseases

authors： Jones A,Doherty M

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis OA in a 13 week, multicentre, randomised, double blind study. METHODS:After a 37 day washout period for nonsteroidal antiinflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg...

journal_title：Annals of the rheumatic diseases

authors： Tannenbaum H,Berenbaum F,Reginster JY,Zacher J,Robinson J,Poor G,Bliddal H,Uebelhart D,Adami S,Navarro F,Lee A,Moore A,Gimona A

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To evaluate radiographic features of osteoarthritis (OA) to determine which is more closely associated with knee pain and hence might be used as a radiographic definition of OA in the community. To evaluate joint space width in normal subjects. METHODS:452 subjects from a case-control community study of knee...

journal_title：Annals of the rheumatic diseases

authors： Lanyon P,O'Reilly S,Jones A,Doherty M

更新日期：1998-10-01 00:00:00