Rheumatoid synovial cells in culture produce a growth inhibitor.

abstract：OBJECTIVES:Although TNF-α inhibitors' striking effect on clinical symptoms have revolutionised the treatment of ankylosing spondylitis (AS), no certain influence on the development of spinal ankylosis and joint destruction has been documented. We wished to investigate whether improved treatment has affected the use of ...

journal_title：Annals of the rheumatic diseases

authors： Nystad TW,Furnes O,Havelin LI,Skredderstuen AK,Lie SA,Fevang BT

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:To investigate the association of lifestyle factors with risk of inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). METHODS:The European Prospective Investigation of Cancer, Norfolk, UK (EPIC-Norfolk) gathered lifestyle data from participants aged 40-79 years from 1993 to 1997. Individuals who s...

journal_title：Annals of the rheumatic diseases

authors： Lahiri M,Luben RN,Morgan C,Bunn DK,Marshall T,Lunt M,Verstappen SM,Symmons DP,Khaw KT,Wareham N,Bruce IN

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To see if a group course delivered by rheumatology teams using cognitive-behavioural approaches, plus usual care, reduced RA fatigue impact more than usual care alone. METHODS:Multicentre, 2-year randomised controlled trial in RA adults (fatigue severity>6/10, no recent major medication changes). RAFT (Redu...

journal_title：Annals of the rheumatic diseases

authors： Hewlett S,Almeida C,Ambler N,Blair PS,Choy EH,Dures E,Hammond A,Hollingworth W,Kadir B,Kirwan JR,Plummer Z,Rooke C,Thorn J,Turner N,Pollock J,RAFT Study Group.

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the efficacy and safety of adalimumab+methotrexate (MTX) in Japanese patients with early rheumatoid arthritis (RA) who had not previously received MTX or biologics. METHODS:This randomised, double-blind, placebo-controlled, multicentre study evaluated adalimumab 40 mg every other week+MTX 6-8 mg...

journal_title：Annals of the rheumatic diseases

authors： Takeuchi T,Yamanaka H,Ishiguro N,Miyasaka N,Mukai M,Matsubara T,Uchida S,Akama H,Kupper H,Arora V,Tanaka Y

更新日期：2014-03-01 00:00:00

abstract：:A patient with rheumatoid arthritis (RA), vasculitis, and aortic valve incompetence of the histologically nonspecific type is described. Valve replacement was undertaken, and an excellent haemodynamic result was achieved. Both arthritis and vasculitis subsequently remitted. Valve replacement can be successfully perfor...

journal_title：Annals of the rheumatic diseases

authors： Liew M,Wilson D,Horton D,Fleming A

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVE:Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α). This study was aimed at investigating the role of PGRN in degradat...

journal_title：Annals of the rheumatic diseases

authors： Zhao YP,Liu B,Tian QY,Wei JL,Richbourgh B,Liu CJ

更新日期：2015-12-01 00:00:00

abstract：:Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment. A new era in rheumatoid arthritis (RA) and related chronic autoimmune/inflammatory diseases is now beginning, with a variety of anti-TNFalpha treatments licensed for use in both RA and Crohn's disease. The rationale f...

journal_title：Annals of the rheumatic diseases

authors： Feldmann M,Bondeson J,Brennan FM,Foxwell BM,Maini RN

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:The influence of dexamethasone on interleukin 10 (IL10) production and the type 1 (T1)/type 2 (T2) T cell balance found in rheumatoid arthritis (RA) was studied. METHODS:Peripheral blood mononuclear cells (PB MNC) were isolated from 14 RA patients both before and 7 and 42 days after high dose dexamethasone ...

journal_title：Annals of the rheumatic diseases

authors： Verhoef CM,van Roon JA,Vianen ME,Lafeber FP,Bijlsma JW

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:Assess golimumab's long-term efficacy/safety in psoriatic arthritis (PsA). METHODS:Adults with active PsA (≥3 swollen and tender joints, active psoriasis) were randomly assigned to subcutaneous placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks (q4wks) through wk20. All patients received golimumab ...

journal_title：Annals of the rheumatic diseases

authors： Kavanaugh A,McInnes IB,Mease P,Krueger GG,Gladman D,van der Heijde D,Zhou Y,Lu J,Leu JH,Goldstein N,Beutler A

更新日期：2014-09-01 00:00:00

abstract：:Sixty six patients with systemic lupus erythematosus (SLE) were genotyped using a HindIII restriction fragment length polymorphism identified by CR1.1 cDNA, then were followed up for an average of 50 months to evaluate the stability of their CR1 activities. The gene frequencies for the two alleles which correlate with...

journal_title：Annals of the rheumatic diseases

authors： Satoh H,Yokota E,Tokiyama K,Kawaguchi T,Niho Y

更新日期：1991-11-01 00:00:00

abstract：:In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune...

journal_title：Annals of the rheumatic diseases

authors： French MA,Harrison G,Penning CA,Cunningham J,Hughes P,Rowell NR

更新日期：1985-02-01 00:00:00

abstract：:The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9....

journal_title：Annals of the rheumatic diseases

authors： Tokunaga M,Ohuchi K,Yoshizawa S,Tsurufuji S,Rikimaru A,Wakamatsu E

更新日期：1981-10-01 00:00:00

abstract：:A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other t...

journal_title：Annals of the rheumatic diseases

authors： Allard SA,King RH,Thomas PK,Bourke BE

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:C-C chemokine receptor type 5 (CCR5), a chemokine receptor expressed on T cells and macrophages, and its ligands are found in inflamed synovial tissue (ST) of patients with rheumatoid arthritis (RA). The rationale for testing CCR5 blockade in patients with RA was supported by the effects of a CCR5 antagonist ...

journal_title：Annals of the rheumatic diseases

authors： van Kuijk AW,Vergunst CE,Gerlag DM,Bresnihan B,Gomez-Reino JJ,Rouzier R,Verschueren PC,van der Leij C,Maas M,Kraan MC,Tak PP

更新日期：2010-11-01 00:00:00

abstract：:We have identified regular thermal patterns over normal knee, ankle, and elbow joints and demonstrate how synovitis affecting these joints may be identified by alteration or loss of the thermal pattern. Sixty healthy volunteers were thermographed on a total of 190 occasions, and 614 out of 618 joints conformed to the ...

journal_title：Annals of the rheumatic diseases

authors： Salisbury RS,Parr G,De Silva M,Hazleman BL,Page-Thomas DP

更新日期：1983-10-01 00:00:00

abstract：:The capacity of monocytes from patients with rheumatoid arthritis to generate superoxide anion in vitro after stimulation with serum treated zymosan (STZ) or IgG treated zymosan (IgTZ) was studied before and during therapy with penicillamine (n = 9) or sodium aurothiomalate (AuTM) (n = 12). Significant increases in ra...

journal_title：Annals of the rheumatic diseases

authors： Hurst NP,Bell AL,Nuki G

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:Despite the lower prevalence of obesity (a known risk factor for osteoarthritis (OA)), the prevalence of lateral tibiofemoral OA is higher in Chinese communities compared with Caucasian communities. One potential explanation is the difference in knee alignment between the two populations. We measured various ...

journal_title：Annals of the rheumatic diseases

authors： Harvey WF,Niu J,Zhang Y,McCree PI,Felson DT,Nevitt M,Xu L,Aliabadi P,Hunter DJ

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To determine how acute but transient inflammation affects the cartilage proteoglycan aggrecan and the value of analyses of synovial fluid to study this. METHODS:For 96 hours after a single intra-articular injection of rabbit knees with human interleukin-1 alpha (IL-1 alpha) or vehicle, articular cartilage an...

journal_title：Annals of the rheumatic diseases

authors： Lundberg C,Asberg I,Ionescu M,Reiner A,Smedegård G,Poole AR

更新日期：1996-08-01 00:00:00

abstract：:The pattern of joint involvement on conventional radiographs and the four hour gammacamera image of 99Tc HMDP bone scans were studied in 33 patients with generalised nodal osteoarthritis. Both techniques showed the predominant involvement of the distal interphalangeal, scaphotrapezial, and first carpometacarpal joints...

journal_title：Annals of the rheumatic diseases

authors： Hutton CW,Higgs ER,Jackson PC,Watt I,Dieppe PA

更新日期：1986-08-01 00:00:00

abstract：:Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia an...

journal_title：Annals of the rheumatic diseases

authors： Granfors K,Toivanen A

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:To assess the usefulness of high resolution computed tomography (HRCT) of the lungs in patients with rheumatoid arthritis (RA) with and without respiratory symptoms. PATIENTS AND METHODS:Eighty eight RA patients with a mean duration of disease 12 (SD 8) years were evaluated. Eleven patients were excluded bec...

journal_title：Annals of the rheumatic diseases

authors： Cortet B,Flipo RM,Rémy-Jardin M,Coquerelle P,Duquesnoy B,Rêmy J,Delcambre B

更新日期：1995-10-01 00:00:00

abstract：:The case is described of a 57 year old woman with polyarthritis fulfilling the 1987 revised criteria of the American Rheumatism Association for rheumatoid arthritis, accompanied by clinical carrier state infection of HTLV-I. Anti-HTLV-I IgM antibodies were detected by western blot analysis in her synovial fluid and se...

journal_title：Annals of the rheumatic diseases

authors： Ijichi S,Matsuda T,Maruyama I,Izumihara T,Kojima K,Niimura T,Maruyama Y,Sonoda S,Yoshida A,Osame M

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that pustulosis palmaris et plantaris and psoriatic arthritis (PsA) are two distinct diseases, and that the associated dermatoses are therefore also distinct diseases. METHODS:We prospectively performed clinical, radiological, biological, and bone scan investigations in 23 outpatients ...

journal_title：Annals of the rheumatic diseases

authors： Mejjad O,Daragon A,Louvel JP,Da Silva LF,Thomine E,Lauret P,Le Loët X

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The MEFV gene is responsible for familial Mediterranean fever (FMF). Several disease associated mutations have been identified. The range of genetic variation in MEFV in Greek patients has not been determined. OBJECTIVE:To describe a method that facilitates the routine screening of the entire coding sequenc...

journal_title：Annals of the rheumatic diseases

authors： Ritis K,Giaglis S,Spathari N,Micheli A,Zonios D,Tzoanopoulos D,Deltas CC,Rafail S,Mean R,Papadopoulos V,Tzioufas AG,Moutsopoulos HM,Kartalis G

更新日期：2004-04-01 00:00:00

abstract：:On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by...

journal_title：Annals of the rheumatic diseases

authors： Marshall JL,Fraser JR,Muirden KD

更新日期：1977-04-01 00:00:00

abstract：:Pain in the neck and upper limb is common and contributes considerably to absence from work due to sickness. Evidence suggest that prolonged abnormal posture and repetition contribute to such conditions. Psychosocial risk factors may also play a part in the aetiology of upper limb disorders. ...

journal_title：Annals of the rheumatic diseases

authors： Walker-Bone K,Cooper C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation. OBJECTIVE:To evaluate markers of cartilage and bone turnover in patients with chondromalacia patellae. METHODS:18 patients with chondromalacia patellae were studied. Serum cartilage olig...

journal_title：Annals of the rheumatic diseases

authors： Murphy E,FitzGerald O,Saxne T,Bresnihan B

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). OBJECTIVE:To test the validity and the mechanism of this association between α1AT and AAV. METHODS:The distribution of α1AT deficiency alleles Z and S was co...

journal_title：Annals of the rheumatic diseases

authors： Morris H,Morgan MD,Wood AM,Smith SW,Ekeowa UI,Herrmann K,Holle JU,Guillevin L,Lomas DA,Perez J,Pusey CD,Salama AD,Stockley R,Wieczorek S,McKnight AJ,Maxwell AP,Miranda E,Williams J,Savage CO,Harper L

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:To identify predictors of clinical remission as well as of no x-ray progression in a cohort of early rheumatoid arthritis (ERA) treated with a tight-control protocol. METHODS:A total of 121 consecutive patients with ERA were treated to reach European League Against Rheumatism (EULAR) and/or American College...

journal_title：Annals of the rheumatic diseases

authors： Bosello S,Fedele AL,Peluso G,Gremese E,Tolusso B,Ferraccioli G

更新日期：2011-07-01 00:00:00