Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis: effect of low dose corticosteroids.

abstract：AIM:to evaluate the effects of adalimumab, etanercept and infliximab on disease activity, functional ability and quality of life and the medication costs in a naturalistic design. METHODS:All patients from the Dutch Rheumatoid Arthritis Monitoring (DREAM) register starting on tumour necrosis factor (TNF)alpha-blocking...

journal_title：Annals of the rheumatic diseases

authors： Kievit W,Adang EM,Fransen J,Kuper HH,van de Laar MA,Jansen TL,De Gendt CM,De Rooij DJ,Brus HL,Van Oijen PC,Van Riel PC

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and gastroduodenal safety of a fixed-dose combination of diclofenac sodium 50 mg and misoprostol 200 micrograms twice daily with those of piroxicam 10 mg twice daily and naproxen 375 mg twice daily in patients with osteoarthritis. METHODS:A 4 week, randomised, double-blind, parallel-...

journal_title：Annals of the rheumatic diseases

authors： Melo Gomes JA,Roth SH,Zeeh J,Bruyn GA,Woods EM,Geis GS

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Human osteoarthritic (OA) chondrocytes were previously classified into L (low)- and H (high)-OA according to matrix metalloproteinase-13 (MMP-13) basal levels and interleukin 1beta (IL1beta) inducibility. In H-OA chondrocytes, the regulatory proteins p130(cas) and nuclear matrix protein 4 (NMP4) acting on th...

journal_title：Annals of the rheumatic diseases

authors： Fan Z,Tardif G,Hum D,Duval N,Pelletier JP,Martel-Pelletier J

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To describe the associations between overweight measures in childhood and knee pain, stiffness and dysfunction among adults 25 years later. METHODS:Subjects broadly representative of the Australian population (n=449, aged 31-41 years, female 48%) were selected from the Australian Schools Health and Fitness S...

journal_title：Annals of the rheumatic diseases

authors： Antony B,Jones G,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Ding C

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Increased apoptosis may induce autoimmune conditions. Apoptosis is induced by binding of death receptor ligands, members of the tumour necrosis factor (TNF) superfamily, to their cognate receptors. The Fas-Fas ligand pathway has been studied extensively in relation to systemic lupus erythematosus (SLE). Howe...

journal_title：Annals of the rheumatic diseases

authors： Lub-de Hooge MN,de Vries EG,de Jong S,Bijl M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Ankylosing spondylitis (AS) and periodontal disease (PD) are characterised by dysregulation of the host inflammatory response, resulting in soft and hard connective tissue destruction. AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with infl...

journal_title：Annals of the rheumatic diseases

authors： Pischon N,Pischon T,Gülmez E,Kröger J,Purucker P,Kleber BM,Landau H,Jost-Brinkmann PG,Schlattmann P,Zernicke J,Burmester GR,Bernimoulin JP,Buttgereit F,Detert J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is characterised by the presence of antibodies to double stranded DNA (dsDNA), which are involved in the pathogenesis of SLE. Previous studies showed that at least two thirds of patients develop a clinical relapse within six months after a significant rise in the anti-dsDNA...

journal_title：Annals of the rheumatic diseases

authors： Bijl M,Horst G,Bootsma H,Limburg PC,Kallenberg CG

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ligand in various RA populations and other inflammatory diseases. Thi...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Schoels MM,Nishimoto N,Breedveld FC,Burmester GR,Dougados M,Emery P,Ferraccioli G,Gabay C,Gibofsky A,Gomez-Reino JJ,Jones G,Kvien TK,Murakami M,Betteridge N,Bingham CO 3rd,Bykerk V,Choy EH,Combe B,Cutolo M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation may contribute to accelerated atherosclerosis and increased arterial stiffness in patients with rheumatoid arthritis (RA). In addition to lowering cholesterol, statins have immunomodulatory effects which may be especially beneficial in patients with RA who have systemic immune a...

journal_title：Annals of the rheumatic diseases

authors： Van Doornum S,McColl G,Wicks IP

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout r...

journal_title：Annals of the rheumatic diseases

authors： Matsuo H,Yamamoto K,Nakaoka H,Nakayama A,Sakiyama M,Chiba T,Takahashi A,Nakamura T,Nakashima H,Takada Y,Danjoh I,Shimizu S,Abe J,Kawamura Y,Terashige S,Ogata H,Tatsukawa S,Yin G,Okada R,Morita E,Naito M,Tokumasu

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. METHODS:A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres partic...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Sakellariou G,Scirè CA,Carrara G,Rumi F,Bellis E,Adinolfi A,Batticciotto A,Bortoluzzi A,Cagnotto G,Caprioli M,Canzoni M,Cavatorta FP,De Lucia O,Di Sabatino V,Draghessi A,Farina I,Focherini MC,Gabba A,Guti

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:C-C chemokine receptor type 5 (CCR5), a chemokine receptor expressed on T cells and macrophages, and its ligands are found in inflamed synovial tissue (ST) of patients with rheumatoid arthritis (RA). The rationale for testing CCR5 blockade in patients with RA was supported by the effects of a CCR5 antagonist ...

journal_title：Annals of the rheumatic diseases

authors： van Kuijk AW,Vergunst CE,Gerlag DM,Bresnihan B,Gomez-Reino JJ,Rouzier R,Verschueren PC,van der Leij C,Maas M,Kraan MC,Tak PP

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Etanercept monotherapy has been studied and approved for treatment of polyarticular juvenile idiopathic arthritis (JIA). The following study evaluates the safety and efficacy of combination therapy of etanercept and methotrexate compared to etanercept monotherapy in JIA. METHODS:We perfomed an open, non-rand...

journal_title：Annals of the rheumatic diseases

authors： Horneff G,De Bock F,Foeldvari I,Girschick HJ,Michels H,Moebius D,Schmeling H,German and Austrian Paediatric Rheumatology Collaborative Study Group.

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of polymorphisms in the vitamin D receptor (VDR) gene to ethnic variations in bone mass in mother and children from different ethnic origins. METHODS:VDR genotypes and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. Al...

journal_title：Annals of the rheumatic diseases

authors： Nelson DA,Vande Vord PJ,Wooley PH

更新日期：2000-08-01 00:00:00

abstract：:Synovial fluid isolated from 16 patients with rheumatoid arthritis activated luminol dependent chemiluminescence in bloodstream neutrophils, and the maximal activity stimulated varied over a 50-fold range. In contrast, these same fluids only activated a much lower range (two- to threefold) of maximal rates of lucigeni...

journal_title：Annals of the rheumatic diseases

authors： Nurcombe HL,Bucknall RC,Edwards SW

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:To compare median nerve conduction velocity measured using a new, portable electroneurometer with measurements made using conventional hospital nerve conduction apparatus. METHODS:Twenty five patients were studied who were consecutively referred to a hospital neurophysiology department with a clinical diagno...

journal_title：Annals of the rheumatic diseases

authors： Dunne CA,Thompson PW,Cole J,Dunning J,Martyn CN,Coggon D,Cooper C

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The association between progression of knee osteoarthritis and progression of osteoarthritis at sites distant from the knee is unclear because of a lack of multisite longitudinal progression data. OBJECTIVE:To examine the association between radiological progression of knee osteoarthritis and osteoarthritis...

journal_title：Annals of the rheumatic diseases

authors： Hassett G,Hart DJ,Doyle DV,March L,Spector TD

更新日期：2006-05-01 00:00:00

abstract：:The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

journal_title：Annals of the rheumatic diseases

authors： Stevenson AC,Silcock SR,Scott JT

更新日期：1976-04-01 00:00:00

abstract：:Thirty patients with classical or definite rheumatoid disease (RD) with foot pain and radiologically demonstrated erosions were studied electrodiagnostically to ascertain the frequency of the tarsal tunnel syndrome and peripheral neuropathy. Four patients (13.3%) had evidence of the tarsal tunnel syndrome. The electri...

journal_title：Annals of the rheumatic diseases

authors： McGuigan L,Burke D,Fleming A

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that ankylosing spondylitis (AS) is a T helper cell type 2 polarised disease by quantifying the T cell cytokines interferon gamma (IFNgamma), interleukin 4 (IL4), tumour necrosis factor alpha (TNFalpha), and IL10 at the single cell level in patients with AS in comparison with healthy HL...

journal_title：Annals of the rheumatic diseases

authors： Rudwaleit M,Siegert S,Yin Z,Eick J,Thiel A,Radbruch A,Sieper J,Braun J

更新日期：2001-01-01 00:00:00

abstract：:A 15 year old girl who had pain, oedema of her left hand, and fever of four months' duration is described. Marked demineralisation of her hand was shown by radiography, and increased articular uptake by technetium-99m bone scan. All these changes were indistinguishable from reflex sympathetic dystrophy. After two admi...

journal_title：Annals of the rheumatic diseases

authors： Rodriguez-Moreno J,Ruiz-Martin JM,Mateo-Soria L,Rozadilla A,Roig-Escofet D

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic res...

journal_title：Annals of the rheumatic diseases

authors： Winau L,Hinojar Baydes R,Braner A,Drott U,Burkhardt H,Sangle S,D'Cruz DP,Carr-White G,Marber M,Schnoes K,Arendt C,Klingel K,Vogl TJ,Zeiher AM,Nagel E,Puntmann VO

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:People with spondyloarthritis (SpA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) have identified the importance of understanding how their disease and its treatment impacts on their social roles. This requires a reliable and valid standardised measure, and this study evaluates these measurement...

journal_title：Annals of the rheumatic diseases

authors： Davis AM,Palaganas MP,Badley EM,Gladman DD,Inman RD,Gignac MA

更新日期：2011-10-01 00:00:00

abstract：:Two cases of bilateral shoulder-hand syndrome and symmetrical arthralgia are described in patients with tubo-ovarian carcinoma. Swelling and contracture of the hands continued to develop despite oral corticosteroid therapy, and one patient underwent surgery in an attempt to prevent the development of further deformity...

journal_title：Annals of the rheumatic diseases

authors： Taggart AJ,Iveson JM,Wright V

更新日期：1984-06-01 00:00:00

abstract：:A six month controlled study of 5-fluorouracil in the treatment of scleroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually respond...

journal_title：Annals of the rheumatic diseases

authors： Casas JA,Saway PA,Villarreal I,Nolte C,Menajovsky BL,Escudero EE,Blackburn WD,Alarcón GS,Subauste CP

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:To determine the serum levels of nucleosome in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc. METHODS:Serum nucleosome levels in 91 patients with SSc were examined by ELISA. The expression of Toll-like receptor (TLR) 9 in T and B cells was quantified by flow cy...

journal_title：Annals of the rheumatic diseases

authors： Yoshizaki A,Taniguchi T,Saigusa R,Fukasawa T,Ebata S,Numajiri H,Nakamura K,Yamashita T,Takahashi T,Toyama T,Asano Y,Tedder TF,Sato S

更新日期：2016-10-01 00:00:00

abstract：:After in vitro incubation with 3H-thymidine, the proliferation of synovial lining cells and fibroblasts was investigated in surgically-removed articular tissue. Under normal conditions, in nonrheumatoid arthritis and in osteoarthrosis, low proliferation rates for both cell types were observed. In rheumatoid arthritis,...

journal_title：Annals of the rheumatic diseases

authors： Mohr W,Beneke G,Mohing W

更新日期：1975-06-01 00:00:00

abstract：OBJECTIVE:Evidence was sought for genetic anticipation (disease occurring at an earlier age in subsequent generations, with increasing severity) in nodal osteoarthritis (NOA). METHODS:Age at symptom onset and disease severity was compared within 30 parent/offspring pairs with NOA. Correlation between the offspring age...

journal_title：Annals of the rheumatic diseases

authors： Wright GD,Regan M,Deighton CM,Wallis G,Doherty M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is associated with high morbidity and mortality in rheumatoid arthritis (RA). Citrullinated proteins are observed in RA lung tissues; however, the association of specific anticitrullinated peptide antibodies (ACPA) with ILD in RA is unknown. METHODS:RA patients underwent mult...

journal_title：Annals of the rheumatic diseases

authors： Giles JT,Danoff SK,Sokolove J,Wagner CA,Winchester R,Pappas DA,Siegelman S,Connors G,Robinson WH,Bathon JM

更新日期：2014-08-01 00:00:00