Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity.

abstract：BACKGROUND:Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a need to revise the instrument. The previous version of BVAS has been revised, according to usage and reviewed by an exper...

journal_title：Annals of the rheumatic diseases

authors： Mukhtyar C,Lee R,Brown D,Carruthers D,Dasgupta B,Dubey S,Flossmann O,Hall C,Hollywood J,Jayne D,Jones R,Lanyon P,Muir A,Scott D,Young L,Luqmani RA

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:To evaluate changes in baseline patient characteristics and entry criteria of randomised, controlled studies of tumour necrosis factor alpha (TNFα) inhibitors in rheumatoid arthritis (RA) patients. METHODS:A systematic literature review was performed using predefined inclusion criteria to identify randomised...

journal_title：Annals of the rheumatic diseases

authors： Rahman MU,Buchanan J,Doyle MK,Hsia EC,Gathany T,Parasuraman S,Aletaha D,Matteson EL,Conaghan PG,Keystone E,van der Heijde D,Smolen JS

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Hand exercises are recommended for patients with hand osteoarthritis (HOA), though evidence for their effect is conflicting. OBJECTIVE:To evaluate, in a randomised controlled trial, the effect of HOA information plus home-based hand exercises (exercise group) compared with information only (control group) i...

journal_title：Annals of the rheumatic diseases

authors： Hennig T,Hæhre L,Hornburg VT,Mowinckel P,Norli ES,Kjeken I

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Although TNF-α inhibitors' striking effect on clinical symptoms have revolutionised the treatment of ankylosing spondylitis (AS), no certain influence on the development of spinal ankylosis and joint destruction has been documented. We wished to investigate whether improved treatment has affected the use of ...

journal_title：Annals of the rheumatic diseases

authors： Nystad TW,Furnes O,Havelin LI,Skredderstuen AK,Lie SA,Fevang BT

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:To assess the effect of an intra-articular presentation of stress (heat shock) proteins (hsp) on joint inflammation. METHODS:Wistar rats were sensitised with a suspension of heat killed Mycobacterium tuberculosis in oil in the scruff of the neck and challenged intra-articularly with stress protein or M tube...

journal_title：Annals of the rheumatic diseases

authors： Winrow VR,Ragno S,Morris CJ,Colston MJ,Mascagni P,Leoni F,Gromo G,Coates AR,Blake DR

更新日期：1994-03-01 00:00:00

abstract：:A study of the walking activities of 243 individuals was carried out. The individuals came from four different occupations and had an age range of 17-83 years. The survey carried out in this investigation showed surprisingly little correlation between variables such as age, height, and weight of individuals and their ...

journal_title：Annals of the rheumatic diseases

authors： Seedhom BB,Wallbridge NC

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVES:To compare glucose tolerance and parameters of insulin sensitivity and β-cell function between chronic glucocorticoid (GC)-using and GC-naive patients with rheumatoid arthritis (RA). METHODS:Frequently sampled 75 g oral glucose tolerance tests were performed in 58 chronic GC-using and 82 GC-naive patients w...

journal_title：Annals of the rheumatic diseases

authors： Hoes JN,van der Goes MC,van Raalte DH,van der Zijl NJ,den Uyl D,Lems WF,Lafeber FP,Jacobs JW,Welsing PM,Diamant M,Bijlsma JW

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:Millions of patients worldwide are treated with therapeutic monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in anti-drug antibody formation which leads to loss of response. Fully human biological agents, such as the anti-tumour necrosis factor α (anti-TNFα) antibody adalimu...

journal_title：Annals of the rheumatic diseases

authors： van Schouwenburg PA,van de Stadt LA,de Jong RN,van Buren EE,Kruithof S,de Groot E,Hart M,van Ham SM,Rispens T,Aarden L,Wolbink GJ,Wouters D

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To further evaluate the role of bacterial antigens in triggering inflammation in the joint in patients with reactive arthritis by studying local antibody synthesis in the joint. METHODS:Yersinia-specific antibodies in paired serum and synovial fluid samples from 29 patients with yersinia triggered reactive ...

journal_title：Annals of the rheumatic diseases

authors： Mäki-Ikola O,Lahesmaa R,Heesemann J,Merilahti-Palo R,Saario R,Toivanen A,Granfors K

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To examine the hypothesis that aggrecan, cartilage oligomeric matrix protein (COMP), and bone sialoprotein (BSP) concentrations in synovial fluid could provide information on variations of progression of joint destruction in rheumatoid arthritis. METHODS:Aggrecan, COMP, and BSP were quantified by enzyme link...

journal_title：Annals of the rheumatic diseases

authors： Månsson B,Geborek P,Saxne T

更新日期：1997-02-01 00:00:00

abstract：:Four patients with Neisseria meningitidis infection complicated by arthritis are described. Three patients had an acute polyarthritis which responded quickly to antimicrobial therapy. A fourth patient developed a prolonged arthritis which occurred after the initial infection had been successfully treated. Tenosynoviti...

journal_title：Annals of the rheumatic diseases

authors： Kidd BL,Hart HH,Grigor RR

更新日期：1985-11-01 00:00:00

abstract：:Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia an...

journal_title：Annals of the rheumatic diseases

authors： Granfors K,Toivanen A

更新日期：1986-07-01 00:00:00

abstract：:Fifteen consecutive patients with acute arthritis were studied. Careful culture and microscopy of swabs from mucosal sites were performed to examine the hypothesis that the acute tropical polyarthritis commonly seen in Zimbabwe is due to undiagnosed gonococcal infection. Rheumatic fever and Reiter's disease accounted ...

journal_title：Annals of the rheumatic diseases

authors： Stein CM,Hanly MG

更新日期：1987-12-01 00:00:00

abstract：:Current drug development programs produce high quality data on the efficacy of new drugs, substantial data on safety, but little data on actual applicability of the new product compared to standard of care. After successful registration and launch, such data require years to accumulate and often remain incomplete. Thi...

journal_title：Annals of the rheumatic diseases

authors： Boers M

更新日期：2010-01-01 00:00:00

abstract：AIMS:The aim of this work was to assess the feasibility of using dynamic contrast enhanced (DCE) MRI of bone marrow oedema, to compare it with conventional marrow oedema scoring systems, and to determine the effects of anti-tumour necrosis factor (TNF)alpha therapy. METHODS:The wrist and metacarpophalangeal (MCP) join...

journal_title：Annals of the rheumatic diseases

authors： Hodgson R,Grainger A,O'Connor P,Barnes T,Connolly S,Moots R

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:To perform a systematic literature review of effective strategies for the treatment of rheumatoid arthritis (RA). METHODS:As part of a European League Against Rheumatism (EULAR) Task Force investigation, a literature search was carried out from January 1962 until February 2009 in PubMed/Ovid Embase/Cochrane...

journal_title：Annals of the rheumatic diseases

authors： Knevel R,Schoels M,Huizinga TW,Aletaha D,Burmester GR,Combe B,Landewé RB,Smolen JS,Sokka T,van der Heijde DM

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of interleukin 6 (IL-6) in the pathogenesis of bilateral erosive sacroiliitis in human tumour necrosis factor transgenic (hTNFtg) mice, an animal model of ankylosing spondylitis (AS). METHODS:Histological sections of the sacroiliac joints from hTNFtg and IL-6(-/-)hTNFtg mice were evaluat...

journal_title：Annals of the rheumatic diseases

authors： Hayer S,Niederreiter B,Nagelreiter I,Smolen J,Redlich K

更新日期：2010-07-01 00:00:00

abstract：:Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients...

journal_title：Annals of the rheumatic diseases

authors： McInnes GT,Lawson DH,Jick H

更新日期：1981-06-01 00:00:00

abstract：:Septic arthritis is associated with a definite morbidity which may be related to a delay in diagnosis and hence treatment. The cases of three patients with rheumatoid arthritis and chronic chest disease where the joint sepsis was not the predominant feature are presented. The responsible organism was Streptococcus pne...

journal_title：Annals of the rheumatic diseases

authors： Morley PK,Hull RG,Hall MA

更新日期：1987-06-01 00:00:00

abstract：:Peritoneal serositis is not a widely recognised aspect of systemic lupus erythematosus (SLE). Indeed, ascites in SLE is said to occur only when complicated by the nephrotic syndrome, congestive cardiac failure, or hepatic cirrhosis. We describe two patients who developed ascites that could be attributed to none of the...

journal_title：Annals of the rheumatic diseases

authors： Mier A,Weir W

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Although natural regulatory T cells (nTregs) can suppress osteoclastogenesis, the role of TGF-β-induced CD4+Foxp3+ Tregs (iTregs) in osteoclastogenesis remains unknown. OBJECTIVE:To determine the effects of iTregs on osteoclastogenesis in vitro and on bone erosion in vivo in collagen-induced arthritis (CIA)...

journal_title：Annals of the rheumatic diseases

authors： Kong N,Lan Q,Su W,Chen M,Wang J,Yang Z,Park R,Dagliyan G,Conti PS,Brand D,Liu Z,Stohl W,Zou H,Zheng SG

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Individuals with psoriasis have increased blood levels of uric acid. However, there is no prospective data on the association between psoriasis and uric acid levels and subsequent development of gout. In this study, we examined the risk of gout among individuals with psoriasis and psoriatic art...

journal_title：Annals of the rheumatic diseases

authors： Merola JF,Wu S,Han J,Choi HK,Qureshi AA

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. METHODS:A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres partic...

journal_title：Annals of the rheumatic diseases

authors： Filippou G,Sakellariou G,Scirè CA,Carrara G,Rumi F,Bellis E,Adinolfi A,Batticciotto A,Bortoluzzi A,Cagnotto G,Caprioli M,Canzoni M,Cavatorta FP,De Lucia O,Di Sabatino V,Draghessi A,Farina I,Focherini MC,Gabba A,Guti

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To compare levels of disability of people with and without hip and knee arthroplasty in a random national sample. METHODS:In 1999 a screening questionnaire to classify people into groups of increasing probabilities of disability was sent to 417 500 people; response rate 86%. The study population was obtaine...

journal_title：Annals of the rheumatic diseases

authors： Boutron I,Poiraudeau S,Ravaud JF,Baron G,Revel M,Nizard R,Dougados M,Ravaud P

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Factors contributing to the development of systemic lupus erythematosus (SLE) remain largely unknown although are likely to include both environmental and genetic components. Studies on murine lupus have indicated a role for an antibody that blocks binding of cytotoxic T lymphocyte associated-4 (CTLA-4) to B...

journal_title：Annals of the rheumatic diseases

authors： Heward J,Gordon C,Allahabadia A,Barnett AH,Franklyn JA,Gough SC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:High resolution ultrasound (HRUS) was used to investigate the effects of tumour necrosis factor alpha (TNFalpha) blockade on pannus formation and vascularisation of small finger joints in patients with active rheumatoid arthritis (RA). METHODS:Five patients with active RA were treated with etanercept, a solu...

journal_title：Annals of the rheumatic diseases

authors： Hau M,Kneitz C,Tony HP,Keberle M,Jahns R,Jenett M

更新日期：2002-01-01 00:00:00

abstract：:Joint damage in rheumatoid arthritis is assessed radiologically. Previous studies have not examined in detail its long term progression. We evaluated the overall changes of peripheral joint damage radiologically in 50 rheumatoid patients followed up at one rheumatology centre for 10 years. All peripheral joints were s...

journal_title：Annals of the rheumatic diseases

authors： Scott DL,Coulton BL,Popert AJ

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVES:There is a lipid paradox in rheumatoid arthritis describing that despite low lipids related to systemic inflammation, there is an increased cardiovascular (CV) risk. Our aim was to evaluate if baseline lipid levels or baseline systemic inflammation were associated with the statin dose sufficient to achieve l...

journal_title：Annals of the rheumatic diseases

authors： Rollefstad S,Ikdahl E,Hisdal J,Kvien TK,Pedersen TR,Holme I,Semb AG

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To compare two plain radiographic methods for sensitivity to detect progression of patellofemoral osteoarthritis. METHODS:Two sets of paired skyline and lateral knee radiographs from 54 hospital referred patients (108 knees) with knee osteoarthritis were taken an average of 31 months apart (range 12-40). Fil...

journal_title：Annals of the rheumatic diseases

authors： Lanyon P,Jones A,Doherty M

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early antigen (EA). In ...

journal_title：Annals of the rheumatic diseases

authors： Jog NR,Young KA,Munroe ME,Harmon MT,Guthridge JM,Kelly JA,Kamen DL,Gilkeson GS,Weisman MH,Karp DR,Gaffney PM,Harley JB,Wallace DJ,Norris JM,James JA

更新日期：2019-09-01 00:00:00