Arthritogenic potential of the 65 kDa stress protein--an experimental model.

abstract：OBJECTIVES:The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS:B6, B6.MyD88(-/-), B6.TLR7(-/-) and B6.TLR9(-/-) mice were subcutaneou...

journal_title：Annals of the rheumatic diseases

authors： Pan ZJ,Maier S,Schwarz K,Azbill J,Akira S,Uematsu S,Farris AD

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:The RCA alpha block (Regulators of Complement Activation, 1q32) contains critical complement regulatory genes such as CR1 and MCP. This study examined RCA alpha block haplotype associations with both disease susceptibility and diversification of the anti-Ro/La autoantibody response in primary Sjögren syndrome...

journal_title：Annals of the rheumatic diseases

authors： Lester S,McLure C,Williamson J,Bardy P,Rischmueller M,Dawkins RL

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Prior studies have suggested a potential link between nasal microbes and granulomatosis with polyangiitis (GPA; Wegener's), but these studies relied on culture-dependent methods. This study comprehensively examined the entire community of nasal microbiota (bacteria and fungi) in participants with GPA compare...

journal_title：Annals of the rheumatic diseases

authors： Rhee RL,Sreih AG,Najem CE,Grayson PC,Zhao C,Bittinger K,Collman RG,Merkel PA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To investigate the potential clinical benefit of a combination therapy. METHODS:205 patients fulfilling the ACR criteria for rheumatoid arthritis (RA), not treated with disease modifying antirheumatoid drugs previously, with an early (< or = 1 year duration), active (Disease Activity Score (DAS) > 3.0), rhe...

journal_title：Annals of the rheumatic diseases

authors： Dougados M,Combe B,Cantagrel A,Goupille P,Olive P,Schattenkirchner M,Meusser S,Paimela L,Rau R,Zeidler H,Leirisalo-Repo M,Peldan K

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To study the demographic and clinical characteristics of patients with antiphospholipid syndrome (APS) with serious haemorrhagic complications of anticoagulant treatment in an attempt to establish risk factors for bleeding. METHODS:Patients with APS who were attending our lupus unit and who presented with se...

journal_title：Annals of the rheumatic diseases

authors： Castellino G,Cuadrado MJ,Godfrey T,Khamashta MA,Hughes GR

更新日期：2001-05-01 00:00:00

abstract：:The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of ea...

journal_title：Annals of the rheumatic diseases

authors： Garrett R,Manthey B,Vernon-Roberts B,Brooks PM

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVES:MRI scoring systems for hand osteoarthritis (HOA) are currently not available. The present work proposes the Oslo HOA MRI (OHOA-MRI) score and examines the intrareader and inter-reader reliability. METHODS:Relevant HOA features were included in the initial version of the OHOA-MRI score after literature revi...

journal_title：Annals of the rheumatic diseases

authors： Haugen IK,Lillegraven S,Slatkowsky-Christensen B,Haavardsholm EA,Sesseng S,Kvien TK,van der Heijde D,Bøyesen P

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To determine whether 17beta-oestradiol (E2) modulates interleukin (IL) 1beta-induced proteoglycan degradation in chondrocytes, and to analyse the part played by metalloproteinases (MMPs) in this process. METHODS:Primary cultured rabbit articular chondrocytes were prepared and treated with 10 ng/ml IL1beta co...

journal_title：Annals of the rheumatic diseases

authors： Richette P,Dumontier MF,François M,Tsagris L,Korwin-Zmijowska C,Rannou F,Corvol MT

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low birth weight (LBW) and spontaneous abortion associated with leflunomide exposure during pregnancy in humans. METHODS:F...

journal_title：Annals of the rheumatic diseases

authors： Bérard A,Zhao JP,Shui I,Colilla S

更新日期：2018-04-01 00:00:00

abstract：:Chondromalacia patellae is difficult to diagnosis clinically with accuracy. In order to clarify the relevant symptoms and signs, 78 patients presenting with a clinical diagnosis of chondromalacia were examined by arthroscopy. In 49% of the knees no abnormalities were found. Presenting symptoms were similar in the norm...

journal_title：Annals of the rheumatic diseases

authors： Leslie IJ,Bentley G

更新日期：1978-12-01 00:00:00

abstract：:A case is reported of polytenosynovitis in a 31-year-old male during the course of a severe bacteraemic illness caused by Haemophilus influenzae type b. The clinical presentation was similar to tenosynovitis caused by bacterial or viral agents. As the management of the H. influenzae tenosynovitis would differ from tha...

journal_title：Annals of the rheumatic diseases

authors： Bansal S,Magnussen CR,Napodano RJ

更新日期：1979-12-01 00:00:00

abstract：OBJECTIVE:To estimate the cost of illness in an incidence based cohort of patients with juvenile idiopathic arthritis. METHODS:Direct costs (healthcare and non-healthcare costs) and indirect costs (productivity loss due to sick leave and work disability) were measured in 215 JIA patients, assessed on an average of 17 ...

journal_title：Annals of the rheumatic diseases

authors： Minden K,Niewerth M,Listing J,Biedermann T,Schöntube M,Zink A

更新日期：2004-07-01 00:00:00

abstract：INTRODUCTION:Endoplasmic reticulum aminopeptidase-1 (ERAP1) protein is highly polymorphic with numerous missense amino acid variants. We sought to determine the naturally occurring ERAP1 protein allotypes and their contribution to Behçet's disease. METHODS:Genotypes of all reported missense ERAP1 gene variants with 10...

journal_title：Annals of the rheumatic diseases

authors： Takeuchi M,Ombrello MJ,Kirino Y,Erer B,Tugal-Tutkun I,Seyahi E,Özyazgan Y,Watts NR,Gül A,Kastner DL,Remmers EF

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Few studies have addressed the natural course of, or prognostic factors for the salivary and lacrimal function in primary Sjögren syndrome (SS). Except for the early stages, glandular function has been seemingly stable, and SS A antigen (SSA) seropositivity and hypocomplementemia may predict a decline in the...

journal_title：Annals of the rheumatic diseases

authors： Haldorsen K,Moen K,Jacobsen H,Jonsson R,Brun JG

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To compare familial inflammatory inclusion body myositis (IBM) with hereditary inclusion body myopathies and sporadic IBM. PATIENTS AND METHODS:Clinical, biological, MRI, and histological data were analysed in two siblings with inflammatory IBM and compared with those of patients with sporadic and hereditary...

journal_title：Annals of the rheumatic diseases

authors： Ranque-Francois B,Maisonobe T,Dion E,Piette JC,Chauveheid MP,Amoura Z,Papo T

更新日期：2005-04-01 00:00:00

abstract：:IgM rheumatoid factor (RF) was measured in the sera of 48 rheumatoid patients and of 48 age and sex-matched normal controls by the Rose-Waaler and latex agglutination tests, a rate nephelometer, and an enzyme-linked immunosorbent assay (ELISA). Good correlation was obtained between all assays. The rate nephelometer as...

journal_title：Annals of the rheumatic diseases

authors： Bampton JL,Cawston TE,Kyle MV,Hazleman BL

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:A systematic literature review (SLR; 2009-2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations. METHODS:Two SLRs focused on clinical trials employing a treatment approach targeting a specifi...

journal_title：Annals of the rheumatic diseases

authors： Stoffer MA,Schoels MM,Smolen JS,Aletaha D,Breedveld FC,Burmester G,Bykerk V,Dougados M,Emery P,Haraoui B,Gomez-Reino J,Kvien TK,Nash P,Navarro-Compán V,Scholte-Voshaar M,van Vollenhoven R,van der Heijde D,Stamm TA

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To analyse tender and swollen joint counts in three cohorts of patients with rheumatoid arthritis (RA), with a focus on the proportions of patients who had fewer than 6-12 tender or swollen joints, as possible evidence based information toward more generalisable inclusion criteria for current and future RA cl...

journal_title：Annals of the rheumatic diseases

authors： Pincus T,Sokka T,Chung CP,Cawkwell G

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To compare two plain radiographic methods for sensitivity to detect progression of patellofemoral osteoarthritis. METHODS:Two sets of paired skyline and lateral knee radiographs from 54 hospital referred patients (108 knees) with knee osteoarthritis were taken an average of 31 months apart (range 12-40). Fil...

journal_title：Annals of the rheumatic diseases

authors： Lanyon P,Jones A,Doherty M

更新日期：1996-12-01 00:00:00

abstract：:The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine patellae was studied. Exogenously added TGF beta up to a concentration of 200 pmol/l had no effect on proteoglycan synthesis in intact articular cartilage. Neutralisat...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,van den Berg WB

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

journal_title：Annals of the rheumatic diseases

authors： Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVE:To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS:In the population based, nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener's granulomatosis, 1969-95, was identified. Through linkage with...

journal_title：Annals of the rheumatic diseases

authors： Knight A,Askling J,Granath F,Sparen P,Ekbom A

更新日期：2004-10-01 00:00:00

abstract：AIM:To assess the prevalence and the nature of autonomic neuropathy (AN) in 17 patients with inactive or mild active systemic lupus erythematosus (SLE). METHODS:Patients were tested using questionnaires related to possible AN symptoms, and four non invasive cardiovascular autonomic function tests at rest, during lying...

journal_title：Annals of the rheumatic diseases

authors： Lioté F,Osterland CK

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To determine if early MRI measures predict X-ray progression at 1 and 2 years in a large RA trial cohort. DESIGN:This study included 256 methotrexate (MTX)-naïve RA patients from a randomised placebo-controlled trial of golimumab (GO-BEFORE). MRIs of wrist and 2nd-5th metacarpophalangeal joints at 0, 12, 24,...

journal_title：Annals of the rheumatic diseases

authors： Baker JF,Ostergaard M,Emery P,Hsia EC,Lu J,Baker DG,Conaghan PG

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:To explore the efficacy of a tumour necrosis factor alpha (TNFalpha) inhibitor (etanercept, Enbrel) in patients with severe sciatica. METHODS:A pilot study of etanercept was conducted in patients admitted to hospital for acute severe sciatica. Ten consecutive patients received three subcutaneous injections ...

journal_title：Annals of the rheumatic diseases

authors： Genevay S,Stingelin S,Gabay C

更新日期：2004-09-01 00:00:00

abstract：:The effects of fasting for 7 days were investigated in 13 patients with rheumatoid arthritis (RA) in comparison with a control regimen in a cross-over trial. The effects of fasting on clinical performance and blood neutrophil functions were studied. During fasting, with a mean weight loss of 5.1 kg, clinical inflammat...

journal_title：Annals of the rheumatic diseases

authors： Udén AM,Trang L,Venizelos N,Palmblad J

更新日期：1983-02-01 00:00:00

abstract：:A 15 year old girl who had pain, oedema of her left hand, and fever of four months' duration is described. Marked demineralisation of her hand was shown by radiography, and increased articular uptake by technetium-99m bone scan. All these changes were indistinguishable from reflex sympathetic dystrophy. After two admi...

journal_title：Annals of the rheumatic diseases

authors： Rodriguez-Moreno J,Ruiz-Martin JM,Mateo-Soria L,Rozadilla A,Roig-Escofet D

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of antithyroid antibodies and the presence of autoimmune thyroiditis among patients with primary Sjögren's syndrome. DESIGN:A case-control study. METHODS:53 consecutive patients with primary Sjögren's syndrome, 30 with rheumatoid arthritis, 12 with secondary Sjögren's syndrome ass...

journal_title：Annals of the rheumatic diseases

authors： Tunc R,Gonen MS,Acbay O,Hamuryudan V,Yazici H

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:To present and analyse the literature sources regarding the management of Behçet disease (BD) identified during the systematic literature research, which formed the basis for the European League Against Rheumatism (EULAR) evidence-based recommendations for the management of BD. METHODS:Problem areas and rel...

journal_title：Annals of the rheumatic diseases

authors： Hatemi G,Silman A,Bang D,Bodaghi B,Chamberlain AM,Gul A,Houman MH,Kötter I,Olivieri I,Salvarani C,Sfikakis PP,Siva A,Stanford MR,Stübiger N,Yurdakul S,Yazici H

更新日期：2009-10-01 00:00:00

abstract：:Pulsed methylprednisolone (PMP) has been shown to produce clinical improvement and reduction in the ESR and acute phase protein concentrations in patients with active rheumatoid arthritis and has been advocated for use either as an alternative to slow-acting antirheumatoid drugs (SAARDs) or in conjunction with SAARDs ...

journal_title：Annals of the rheumatic diseases

authors： Neumann V,Hopkins R,Dixon J,Watkins A,Bird H,Wright V

更新日期：1985-11-01 00:00:00