Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells.

abstract：OBJECTIVES:The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence up...

journal_title：Annals of the rheumatic diseases

authors： Schaefer CJ,Lawrence WD,Wooley PH

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of incident myocardial infarction (MI), stroke and peripheral vascular disease (PVD) in individuals with systemic sclerosis (SSc) in a general population context. METHODS:We conducted a cohort study using a UK primary care database containing records from 1986 to 2011. SSc diagnoses, ou...

journal_title：Annals of the rheumatic diseases

authors： Man A,Zhu Y,Zhang Y,Dubreuil M,Rho YH,Peloquin C,Simms RW,Choi HK

更新日期：2013-07-01 00:00:00

abstract：:Sixteen patients with classic rheumatoid arthritis (RA) complicated by severe vasculitis were studied and compared with a matched control group of 16 RA patients without vasculitis. Seven of the patients with vasculitis died within 4 to 120 months (median 32 months) after developing vasculitic symptoms. Gangrene of di...

journal_title：Annals of the rheumatic diseases

authors： Geirsson AJ,Sturfelt G,Truedsson L

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:The aim of the study was to better characterise the immunological origin and the behaviour of interleukin (IL)-23-responsive innate lymphoid cells (ILCs) in the gut, synovial fluid (SF) and bone marrow (BM) of patients with ankylosing spondylitis (AS). METHODS:ILC1, ILC2 and ILC3 cells were determined and c...

journal_title：Annals of the rheumatic diseases

authors： Ciccia F,Guggino G,Rizzo A,Saieva L,Peralta S,Giardina A,Cannizzaro A,Sireci G,De Leo G,Alessandro R,Triolo G

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:To explore perceptions, barriers and patterns of social media (SM) use among rheumatology fellows and basic scientists. METHODS:An online survey was disseminated via Twitter, Facebook and by email to members of the Emerging European League Against Rheumatism Network. Questions focused on general demographic...

journal_title：Annals of the rheumatic diseases

authors： Nikiphorou E,Studenic P,Ammitzbøll CG,Canavan M,Jani M,Ospelt C,Berenbaum F,EMEUNET.

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to test the hypothesis that the reason for non-response (caused by immunogenicity or not) to a first tumour necrosis factor (TNF) inhibitor defines whether a second TNF inhibitor will be effective. METHODS:This cohort study consisted of 292 consecutive patients with rheumatoid arthr...

journal_title：Annals of the rheumatic diseases

authors： Jamnitski A,Bartelds GM,Nurmohamed MT,van Schouwenburg PA,van Schaardenburg D,Stapel SO,Dijkmans BA,Aarden L,Wolbink GJ

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Rice bodies can occur in the joints in many rheumatic conditions, but they are most common in rheumatoid arthritis. They are generally believed to occur rarely in patients with osteoarthritis, but one study reported rice bodies with apatite crystals. OBJECTIVE:To report on a series of joint fluids with rice...

journal_title：Annals of the rheumatic diseases

authors： Li-Yu J,Clayburne GM,Sieck MS,Walker SE,Athreya BH,DeHoratius RJ,Schumacher HR Jr

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor (TNF) treatment is clinically efficacious in patients with active ankylosing spondylitis (AS) and leads to improvement of spinal inflammation, as assessed by magnetic resonance imaging. It is unclear whether anti-TNF treatment affects chronic spinal changes in AS. OBJECTIVES:To a...

journal_title：Annals of the rheumatic diseases

authors： Baraliakos X,Listing J,Rudwaleit M,Brandt J,Sieper J,Braun J

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To estimate the effects of biological drugs on the risk of demyelinating events in rheumatoid arthritis (RA). METHODS:Case-control analyses nested in an administrative database cohort. RESULTS:Initially the risk of demyelinating events appeared to be increased after exposure to anakinra and decreased after ...

journal_title：Annals of the rheumatic diseases

authors： Bernatsky S,Renoux C,Suissa S

更新日期：2010-09-01 00:00:00

abstract：:(1) The phagocytosis of human IgG, IgM, and C3 by granulocytes from various rheumatoid and nonrheumatoid sera and synovial fluids (SF) was investigated by direct examination of the patient's leucocytes and indirect testing by incubation of normal donor leucocytes with various sera and SF. (2) In rheumatoid arthritis (...

journal_title：Annals of the rheumatic diseases

authors： Cats A,Lafeber GJ,Klein F

更新日期：1975-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether the risk allele for systemic lupus erythematosus (SLE) in the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the single nucleotide polymorphism (SNP) rs10181656(G), is associated with vascular events and/or presence of prothrombotic anti-phospholipid ...

journal_title：Annals of the rheumatic diseases

authors： Svenungsson E,Gustafsson J,Leonard D,Sandling J,Gunnarsson I,Nordmark G,Jönsen A,Bengtsson AA,Sturfelt G,Rantapää-Dahlqvist S,Elvin K,Sundin U,Garnier S,Simard JF,Sigurdsson S,Padyukov L,Syvänen AC,Rönnblom L

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Collagen-induced arthritis (CIA) is the most commonly used model of rheumatoid arthritis (RA). In both CIA and RA there is an increase in the cellular content of the synovium, this being dominated by macrophages. OBJECTIVE:To assess the impact of etoposide, a topoisomerase II antagonist known to induce mono...

journal_title：Annals of the rheumatic diseases

authors： Verdrengh M,Jonsson IM,Zaether O,Bajtner E,Holmdahl R,Tarkowski A

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA). METHODS:Immunohistochemistry was performed in synovial biopsies from patients with RA (n=20), osteoarthritis (...

journal_title：Annals of the rheumatic diseases

authors： Chemel M,Le Goff B,Brion R,Cozic C,Berreur M,Amiaud J,Bougras G,Touchais S,Blanchard F,Heymann MF,Berthelot JM,Verrecchia F,Heymann D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of the skin and the internal organs. Except for anticentromere, antitopoisomerase I and antipolymerase III antibodies, there are no reliable circulating markers predicting susceptibility and internal organ complications. This study h...

journal_title：Annals of the rheumatic diseases

authors： van Bon L,Cossu M,Loof A,Gohar F,Wittkowski H,Vonk M,Roth J,van den Berg W,van Heerde W,Broen JC,Radstake TR

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:To investigate the disease-modifying effects of phosphodiesterase 4 (PDE4) inhibition in preclinical models of systemic sclerosis (SSc). METHODS:We studied the effects of PDE4 inhibition in a prevention and a treatment model of bleomycin-induced skin fibrosis, in the topoisomerase mouse model as well as in ...

journal_title：Annals of the rheumatic diseases

authors： Maier C,Ramming A,Bergmann C,Weinkam R,Kittan N,Schett G,Distler JHW,Beyer C

更新日期：2017-06-01 00:00:00

abstract：:Serum immunoglobulins were measured in 122 patients with ankylosing spondylitis (AS) during various phases of disease activity and compared to those in 58 healthy subjects. The mean serum IgA was 38% higher in patients (306.9 mg/dl) than in controls (222.7 mg/dl) (P < 0.005), but there was no significant difference in...

journal_title：Annals of the rheumatic diseases

authors： Cowling P,Ebringer R,Ebringer A

更新日期：1980-12-01 00:00:00

abstract：OBJECTIVE:To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population. METHOD:The screening questionnaire was based on signs and symptoms, previous diagnosis of OA and validated OA criteria. A random sample of telephone nu...

journal_title：Annals of the rheumatic diseases

authors： Roux CH,Saraux A,Mazieres B,Pouchot J,Morvan J,Fautrel B,Testa J,Fardellone P,Rat AC,Coste J,Guillemin F,Euller-Ziegler L,KHOALA Osteoarthritis Group.

更新日期：2008-10-01 00:00:00

abstract：:Cell electrophoresis identifies two main subpopulations of blood polymorphonuclear cells (PMNs), which in terms of the speed of their anodic migration are referred to as the fast and slow population. When blood PMNs from normal healthy subjects were incubated in medium containing 20% RA serum there was a decrease in t...

journal_title：Annals of the rheumatic diseases

authors： Brown KA,McCarthy D,Perry JD,Dumonde DC

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To investigate quantitatively the mRNA expression levels of YKL-40, an established marker of rheumatoid and osteoarthritic cartilage degeneration in synovial fluid and serum, and a closely related molecule YKL-39, in articular chondrocytes. METHODS:cDNA array and online quantitative polymerase chain reaction...

journal_title：Annals of the rheumatic diseases

authors： Knorr T,Obermayr F,Bartnik E,Zien A,Aigner T

更新日期：2003-10-01 00:00:00

abstract：:The prevalence of grade III or IV osteoarthritis was determined in 210 patients with chronic renal failure, of whom 94 were receiving chronic haemodialysis and 116 had functioning renal transplants. The prevalence of grade III or IV osteoarthritis was three times greater in patients under 65 than in a control populati...

journal_title：Annals of the rheumatic diseases

authors： Duncan IJ,Hurst NP,Sebben R,Milazzo SC,Disney A

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:To investigate whether patients with primary Sjögren's syndrome (pSS) have an increased tendency to develop other autoimmune diseases. METHODS:A retrospective case note review was carried out on 114 patients in whom a diagnosis of pSS had been made in a department of rheumatology from 1979 onwards. The year...

journal_title：Annals of the rheumatic diseases

authors： Lazarus MN,Isenberg DA

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Ankylosing spondylitis (AS) and periodontal disease (PD) are characterised by dysregulation of the host inflammatory response, resulting in soft and hard connective tissue destruction. AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with infl...

journal_title：Annals of the rheumatic diseases

authors： Pischon N,Pischon T,Gülmez E,Kröger J,Purucker P,Kleber BM,Landau H,Jost-Brinkmann PG,Schlattmann P,Zernicke J,Burmester GR,Bernimoulin JP,Buttgereit F,Detert J

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA). METHODS:A randomised, double-blind, placebo-controlled, dose-e...

journal_title：Annals of the rheumatic diseases

authors： Burmester GR,Feist E,Sleeman MA,Wang B,White B,Magrini F

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS:A total of 116 patients with SSc were classifi...

journal_title：Annals of the rheumatic diseases

authors： Frezza D,Giambra V,Tolusso B,De Santis M,Bosello S,Vettori S,Triolo G,Valentini G,Ferraccioli G

更新日期：2007-09-01 00:00:00

abstract：:During 1978 a survey was carried out on 34 036 people in Nagano Prefecture, Japan, in an epidemiological study of hyperuricaemia; 15 713 males and 18 324 females were examined by means of our health examination car. The subjects of the survey were all volunteers. The results have shown that the serum uric acid (SUA) l...

journal_title：Annals of the rheumatic diseases

authors： Akizuki S

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well established, and accounts for an estimated 30% of the genetic component in RA. The MHC class II transactivator gene (MHC2TA) on chromosome 16p13 has re...

journal_title：Annals of the rheumatic diseases

authors： Bronson PG,Criswell LA,Barcellos LF

更新日期：2008-07-01 00:00:00

abstract：:Two cases of bilateral shoulder-hand syndrome and symmetrical arthralgia are described in patients with tubo-ovarian carcinoma. Swelling and contracture of the hands continued to develop despite oral corticosteroid therapy, and one patient underwent surgery in an attempt to prevent the development of further deformity...

journal_title：Annals of the rheumatic diseases

authors： Taggart AJ,Iveson JM,Wright V

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVE:To investigate anti-apoptogenic mechanism of transforming growth factor beta1 (TGFbeta1) towards synovial cells. METHODS:Isolated synovial cells, treated or not with TGFbeta1, were cultured in the presence or absence of anti-Fas IgM, proteasome inhibitor Z-Leu-Leu-Leu-aldehyde (LLL-CHO), etoposide, or C2-cer...

journal_title：Annals of the rheumatic diseases

authors： Kawakami A,Urayama S,Yamasaki S,Hida A,Miyashita T,Kamachi M,Nakashima K,Tanaka F,Ida H,Kawabe Y,Aoyagi T,Furuichi I,Migita K,Origuchi T,Eguchi K

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:To examine the long term prognosis in patients with fibromyalgia (FM). METHODS:Forty five of 70 patients who had participated in a three week trial six years earlier completed again the same questionnaires used previously. RESULTS:Most symptoms had remained stable. Pain had increased, but some aspects of q...

journal_title：Annals of the rheumatic diseases

authors： Baumgartner E,Finckh A,Cedraschi C,Vischer TL

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The Fc receptor-like 3 (FCRL3) gene -169T>C single nucleotide polymorphism (SNP) has been reported to be associated with several autoimmune diseases (AIDs) in Japanese populations. However, association results in other populations have been conflicting. Therefore, we investigated this SNP in a...

journal_title：Annals of the rheumatic diseases

authors： Eike MC,Nordang GB,Karlsen TH,Boberg KM,Vatn MH,IBSEN study group.,Dahl-Jørgensen K,Rønningen KS,Joner G,Flatø B,Bergquist A,Thorsby E,Førre O,Kvien TK,Undlien DE,Lie BA

更新日期：2008-09-01 00:00:00